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A viscoelastic nonlinear energy sink with an electromagnetic energy harvester:Narrow-band random response

Chinese Physics b 2024年第7期33卷 147-156页

作者：廖志晶孙亚辉刘洋 School of Mathematics and Statistics Guangdong University of TechnologyGuangzhou 510520China Exeter Small-Scale Robotics Laboratory Engineering DepartmentUniversity of ExeterNorth Park RoadExeter EX44QFUK

Nonlinear energy sink is a passive energy absorption device that surpasses linear dampers, and has gained significant attention in various fields of vibration suppression. This is owing to its capacity to offer high vibration attenuation and robustness across a wide frequency spectrum. Energy harvester is a device employed to convert kinetic energy into usable electric energy. In this paper, we propose an electromagnetic energy harvester enhanced viscoelastic nonlinear energy sink(VNES) to achieve passive vibration suppression and energy harvesting simultaneously. A critical departure from prior studies is the investigation of the stochastic P-bifurcation of the electromechanically coupled VNES system under narrowband random excitation. Initially, approximate analytical solutions are derived using a combination of a multiple-scale method and a perturbation approach. The substantial agreement between theoretical analysis solutions and numerical solutions obtained from Monte Carlo simulation underscores the method's high degree of validity. Furthermore, the effects of system parameters on system responses are carefully examined. Additionally, we demonstrate that stochastic P-bifurcation can be induced by system parameters, which is further verified by the steady-state density functions of displacement. Lastly,we analyze the impacts of various parameters on the mean square current and the mean output power, which are crucial for selecting suitable parameters to enhance the energy harvesting performance.

关键词： nonlinear energy sink fractional-order damping multiple-scale method energy harvester

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Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for b-cell Acute Lymphoblastic Leukemia

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Current Medical Science 2024年第2期44卷 298-308页

作者： Zhen LU Qian LAI Zhi-feng LI Meng-ya ZHONG Yue-long jIANG Li-ying FENG jie ZHA jing-wei yaO Yin LI Xian-ming DENG bing XU Department of Hematology The First Affiliated Hospital of Xiamen University and Institute of HematologySchool of MedicineXiamen UniversityXiamen361005China Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy Xiamen361005China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China State Key Laboratory of Cellular Stress biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen361003China

Objective:In b-cell acute lymphoblastic leukemia(b-ALL),current intensive chemotherapies for adult patients fail to achieve durable responses in more than 50%of cases,underscoring the urgent need for new therapeutic regimens for this patient *** present study aimed to determine whether HZX-02-059,a novel dual-target inhibitor targeting both phosphatidylinositol-3-phosphate 5-kinase(PIKfyve)and tubulin,is lethal to b-ALL cells and is a potential therapeutic for b-ALL ***:Cell proliferation,vacuolization,apoptosis,cell cycle,and in-vivo tumor growth were *** addition,Genome-wide RNA-sequencing studies were conducted to elucidate the mechanisms of action underlying the anti-leukemia activity of HZX-02-059 in ***:HZX-02-059 was found to inhibit cell proliferation,induce vacuolization,promote apoptosis,block the cell cycle,and reduce in-vivo tumor *** of the p53 pathway and suppression of the phosphoinositide 3-kinase(PI3K)/AKT pathway and the downstream transcription factors c-Myc and NF-κb were responsible for these ***:Overall,these findings suggest that HZX-02-059 is a promising agent for the treatment of b-ALL patients resistant to conventional therapies.

关键词： b-cell acute lymphoblastic leukemia dual-target inhibitor NF-kb c-Myc PI3K/AKT p53

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Cellulosomal hemicellulases:Indispensable players for ensuring effective lignocellulose bioconversion

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Green Carbon 2024年第1期2卷 57-69页

作者： Min Xiao ya-jun Liu Edward A.bayer Akihiko Kosugi Qiu Cui Yingang Feng CAS Key Laboratory of biofuels Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Shandong Provincial Key Laboratory of Synthetic biology Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Shandong Engineering Laboratory of Single Cell Oil Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Shandong Energy Institute Qingdao 266101China Qingdao New Energy Shandong Laboratory Qingdao 266101China University of Chinese Academy of Sciences Beijing 100049China Department of biomolecular Sciences The Weizmann Institute of ScienceRehovot 7610001Israel Department of Life Sciences and the National Institute for biotechnology in the Negev Ben-Gurion University of the NegevBeer-Sheva 8499000Israel biological Resources and Post-harvest Division Japan International Research Center for Agricultural Sciences(JIRCAS)1-1 OhwashiTsukubaIbaraki 305-8686Japan

The bioconversion of lignocellulose has attracted global attention,due to the significant potential of agricultural and forestry wastes as renewable zero-carbon resources and the urgent need for substituting fossil *** cellulosome system is a multi-enzyme complex produced by anaerobic bacteria,which comprises cellulases,hemicellulases,and associated enzymatic and non-enzymatic components that promote biomass *** enhance their efficiency in degrading recalcitrant lignocellulosic matrices,cellulosomes have been employed to construct biocatalysts for lignocellulose bioconversion,such as consolidated bioprocessing and consolidated ***,the second most abundant polysaccharides in plant cell walls,hold valuable application potential but can also induce inhibitory effects on cellulose hydrolysis,thus highlighting the indispensable roles of hemicellulases within the cellulosome *** review evaluated current research on cellulosomal hemicellulases,comparing their types,abundance,and regulation,primarily focusing on eight known cellulosome-producing species of different *** also reviewed their growth conditions,their hemicellulose-degrading capabilities,and the inhibitory effects of hemicellulose on cellulosome-based lignocellulose ***,we proposed strategies for targeted enhancement of hemicellulase in cellulosomes to improve lignocellulose bioconversion in future studies.

关键词： Cellulosome Lignocellulose Hemicellulase Saccharification biocatalyst

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Analytical solution to incident angle quasi-phase-matching engineering for second harmonic generation in a periodic-poled lithium niobate crystal

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Chinese Physics b 2024年第2期33卷 115-123页

作者：洪丽红邱雅婷李晓霓陈宝琴李志远 State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

Phase matching or quasi-phase matching(QPM)is of significant importance to the conversion efficiency of second harmonic generation(SHG)in artificial nonlinear crystals like lithium niobate(LN)crystal or microstructured nonlinear crystals like periodic-poled lithium niobate(PPLN)*** this paper,we propose and show that the incident angle of pump laser light can be harnessed as an alternative versatile tool to engineer QPM for high-efficiency SHG in a PPLN crystal,in addition to conventional means of period adjusting or temperature tuning.A rigorous model is established and analytical solution of the nonlinear conversion efficiency under the small and large signal approximation theory is obtained at different incident *** variation of phase mismatching and walk-off length with incident angle or incident wavelength are also *** simulations for a PPLN crystal with first order QPM structure are used to confirm our theoretical predictions based on the exact analytical solution of the general large-signal *** results show that the narrow-band tunable SHG output covers a range of 532 nm–552.8 nm at the ideal incident angle from 0°to 90°.This theoretical scheme,fully considering the reflection and transmission at the air-crystal interface,would offer an efficient theoretical system to evaluate the nonlinear frequency conversion and help to obtain the maximum SHG conversion efficiency by selecting an optimum incident wavelength and incident angle in a specially designed PPLN crystal,which would be very helpful for the design of tunable narrow-band pulse nanosecond,picosecond,and femtosecond laser devices via PPLN and other microstructured LN crystals.

关键词： nonlinear frequency conversion transmission reflection lithium niobate

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SRY-box transcription factor 9 triggers yaP nuclear entry via direct interaction in tumors

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： Hui Qian Chen-Hong Ding Fang Liu Shi-jie Chen Chen-Kai Huang Meng-Chao Xiao Xia-Lu Hong Ming-Chen Wang Fang-Zhi yan Kai Ding ya-Lu Cui bai-Nan Zheng jin Ding Cheng Luo Xin Zhang Wei-Fen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastroenterology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Gastroenterology First Affiliated Hospital of Nanchang UniversityNanchangChina Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The translocation of yaP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor ***,the precise molecular mechanisms governing the nuclear import of yaP are not fully *** this study,we have uncovered a crucial role of SOX9 in the activation of ***9 promotes the nuclear translocation of yaP by direct ***,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of yaP is essential for SOX9-yaP interaction and subsequent nuclear entry of ***,we have discovered a novel asymmetrical dimethylation of yaP at Arg-124(yaP-R124me2a)catalyzed by ***-R124me2a enhances the interaction between yaP and SOX9 and is associated with poor prognosis in multiple ***,we disrupted the interaction between SOX9 and yaP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits yaP nuclear translocation and effectively suppresses tumor *** study provides the first evidence of SOX9 as a pivotal regulator driving yaP nuclear translocation and presents a potential therapeutic strategy for yaP-driven human cancers by targeting SOX9-yaP interaction.

关键词： interaction interaction precise

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jianpi-Huatan-Huoxue-Anshen formula ameliorates gastrointestinal inflammation and microecological imbalance in chemotherapytreated mice transplanted with H22 hepatocellular carcinoma

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World journal of Gastrointestinal Oncology 2024年第10期16卷 4209-4231页

作者： ya-Nan Wang Xiang-yang Zhai Zheng Wang Chun-Ling Gao Sui-Cai Mi Wen-Li Tang Xue-Min Fu Huai-bang Li Li-Feng Yue Peng-Fei Li Sheng-yan Xi Department of TCM Xiang’an HospitalSchool of MedicineXiamen UniversityXiamen 361102Fujian ProvinceChina Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao 999078China Department of Radiotherapy Chenggong Hospital of Xiamen UniversityPLA 73rd Army HospitalXiamen 361003Fujian ProvinceChina Department of Oncology Xiamen Hospital of Traditional Chinese MedicineXiamen 361015Fujian ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China

bACKGROUND jianpi-Huatan-Huoxue-Anshen formula[Tzu-Chi cancer-antagonizing&lifeprotecting II decoction(TCCL)]is a Chinese medical formula that has been clinically shown to reduce the gastrointestinal side effects of chemotherapy in cancer patients and improve their quality of ***,its effect and mechanism on the intestinal microecology after chemotherapy are not yet *** To discover the potential mechanisms of TCCL on gastrointestinal inflammation and microecological imbalance in chemotherapy-treated mice transplanted with hepatocellular carcinoma(HCC).METHODS Ninety-six mice were inoculated subcutaneously with HCC *** week later,the mice received a large dose of 5-fluorouracil by intraperitoneal injection to establish a HCC chemotherapy ***-six mice were randomly selected before administration,and feces,ileal tissue,and ileal contents were collected from each *** remaining mice were randomized into normal saline,continuous chemotherapy,yangzheng Xiaoji capsulestreated,and three TCCL-treated *** treatment,feces,tumors,liver,spleen,thymus,stomach,jejunum,ileum,and colon tissues,and ileal contents were *** changes,serum levels of il-1β,il-6,il-8,il-10,il-22,TNF-α,and TGF-β,intestinal SIgA,and protein and mRNA expression of ZO-1,NF-κb,Occludin,MUC-2,Claudin-1,and Iκb-αin colon tissues were *** effect of TCCL on the abundance and diversity of intestinal flora was analyzed using 16S rDNA *** TCCL treatment improved thymus and spleen weight,thymus and spleen indexes,and body weight,decreased tumor volumes and tumor tissue cell density,and alleviated injury to gastric,ileal,and colonic mucosal *** proteins and genes associated with inflammation,il-10,TGF-β,SIgA,ZO-1,MUC-2,and Occludin were upregulated,whereas NF-κb,il-1β,il-6,TNF-α,il-22,il-8,and Iκb-αwere ***,TCCL increased the proportions of fecal Actinobacteria,AF12,Adlercreutzia,Clostridium,Coriobac

关键词： Chinese medicine Chemotherapy H22 hepatocellular carcinoma Intestinal barrier function Intestinal microecological balance

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褪黑素通过改善胆汁酸代谢减轻胆汁淤积肝损伤

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陆军军医大学学报 2024年第11期46卷 1187-1193页

作者：张弘佳谭雅赵楠柴进陆军军医大学(第三军医大学)第一附属医院消化内科全军消化病研究所胆汁淤积肝病中心代谢相关脂肪性肝病中心重庆400038

目的初步探究褪黑素(melatonin,Mel)减轻胆酸(cholic acid,CA)诱导的胆汁淤积肝损伤的机制。方法将15只8周龄雄性C57bL/6j小鼠按随机数字表法分为3组(n=5):对照组、1%CA组和1%CA+Mel组,对照组喂养正常饮食,1%CA组和1%CA+Mel组喂养1%CA饮... 详细信息

目的初步探究褪黑素(melatonin,Mel)减轻胆酸(cholic acid,CA)诱导的胆汁淤积肝损伤的机制。方法将15只8周龄雄性C57bL/6j小鼠按随机数字表法分为3组(n=5):对照组、1%CA组和1%CA+Mel组,对照组喂养正常饮食,1%CA组和1%CA+Mel组喂养1%CA饮食14 d构建胆汁淤积小鼠模型,1%CA+Mel组同时腹腔注射褪黑素(100 mg/kg)。对1%CA组和1%CA+Mel组小鼠的肝组织进行α-SMA免疫组化染色,采用RT-qPCR检测小鼠肝纤维化相关指标的mRNA表达水平。采用液相色谱-串联质谱联用技术检测肝脏总胆汁酸,自动生化分析仪检测血清总胆汁酸。为了进一步了解胆汁酸代谢的机制,采用RT-qPCR检测小鼠胆汁酸合成和肝脏解毒酶相关指标的mRNA表达水平,Western blot检测胆汁酸合成和肝脏解毒酶相关指标的蛋白表达水平。结果与1%CA组相比,1%CA+Mel组的小鼠肝纤维化相关指标Tgfβ1、ColⅠa1、ColⅡa1和α-SMA的mRNA表达水平明显降低(Pb1的mRNA水平均显著降低,肝脏解毒酶Cyp2b10和尿苷二磷酸葡萄糖醛基酶1A1(udp-glucuronosyltransferase,Ugt1a1)的mRNA水平明显升高,Cyp2b10和胆盐磺基转移酶(sulfotransferase family 2A member 1,Sult2a1/2)的蛋白水平明显升高(P<0.05)。结论褪黑素通过减少胆汁酸合成和增加肝脏解毒酶的方式改善胆汁淤积。

关键词：肝损伤胆汁淤积褪黑素胆汁酸代谢

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抗N-甲基-D-天冬氨酸受体脑炎睡眠障碍研究进展

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中国现代神经疾病杂志 2024年第5期24卷 315-319页

作者：黄瑀廖金池舒崖清中山大学附属第三医院神经内科广州510630

抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎患者睡眠障碍表现形式多样,易误诊,机制复杂,需早期鉴别诊断与治疗。本文从抗NMDAR脑炎睡眠障碍的临床表现、电生理学特征、发病机制及治疗原则等方面进行综述,以为临床医师识别和治疗抗NMDAR脑炎睡... 详细信息

抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎患者睡眠障碍表现形式多样,易误诊,机制复杂,需早期鉴别诊断与治疗。本文从抗NMDAR脑炎睡眠障碍的临床表现、电生理学特征、发病机制及治疗原则等方面进行综述,以为临床医师识别和治疗抗NMDAR脑炎睡眠障碍提供帮助。

关键词：抗N-甲基-D-门冬氨酸受体脑炎睡眠障碍综述

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基于车轮-桥面相干激励的大跨连续梁桥振动响应

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吉林大学学报（工学版） 2024年第2期54卷 436-444页

作者：韩智强谢刚卓亚娟骆佐龙李华腾太原科技大学车辆与交通工程学院太原030024 太原科技大学先进控制与装备智能化山西省重点实验室太原030024 山西大学电力与建筑学院太原030024

为获取桥面相干激励下大跨连续梁桥动力响应规律,基于虚功原理,建立五轴重载车辆动力学模型,采用模态叠加法建立桥梁动力方程,通过谐波叠加法建立桥面相干激励模型,根据轮-桥间几何和力学耦合关系,组建车轮-桥面相干激励模型,采用Matla... 详细信息

为获取桥面相干激励下大跨连续梁桥动力响应规律,基于虚功原理,建立五轴重载车辆动力学模型,采用模态叠加法建立桥梁动力方程,通过谐波叠加法建立桥面相干激励模型,根据轮-桥间几何和力学耦合关系,组建车轮-桥面相干激励模型,采用Matlab软件编译大跨连续梁桥车桥耦合振动分析系统,并开展不同等级的相干桥面激励模型对大跨连续梁桥动力响应影响研究。结果表明:当未考虑桥面不平顺影响时,桥梁冲击系数均小于规范取值,但随着桥面状况的恶化,结构典型截面的动力响应增长较快,且完全相干模型对桥梁动力响应的影响均大于部分相干激励模型,均超过规范值,其中挠度幅值最大偏差约为7.7%,弯矩幅值最大偏差约为20%,挠度冲击系数相对误差为4%~34%,弯矩冲击系数相对误差为2%~43%;随着车速的增大,桥梁冲击系数呈先增大后减小变化。最后,给出了大跨连续梁桥挠度和弯矩冲击系数包络图。相关研究成果可为连续梁桥的结构动力响应的分析与研究提供参考。

关键词：桥梁工程桥面相干激励模型车桥耦合动力响应冲击系数

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Chiral universality class of normal-superconducting and exciton condensation transitions on surface of topological insulator

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Frontiers of physics 2015年第3期10卷 65-82页

作者： Dingping Li baruch Rosenstein b. ya. Shapiro I. Shapiro School of Physics Peking University Beijing 100871 China Collaborative Innovation Center of Quantum Matter Beijing 100084 China Electrophysics Department National Chiao Tung University Hsinchu 30050 Taiwan China physics Department Ariel University Ariel 40700 Israel Physics Department Bar-Ilan University 52900 Ramat-Gan Israel

New two-dimensional systems such as the surfaces of topological insulators （TIs） and graphene offer the possibility of experimentally investigating situations considered exotic just a decade ago. These situations include the quantum phase transition of the chiral type in electronic systems with a relativistic spectrum. Phonon-mediated （conventional） pairing in the Dirac semimetal appearing on the surface of a TI causes a transition into a chiral superconducting state, and exciton condensation in these gapless systems has long been envisioned in the physics of narrow-band semiconductors. Starting from the microscopic Dirac Hamiltonian with local attraction or repulsion, the bardeen- Cooper-Schrieffer type of Gaussian approximation is developed in the framework of functional integrals. It is shown that owing to an ultrarelativistic dispersion relation, there is a quantum critical point governing the zero-temperature transition to a superconducting state or the exciton condensed state. Quantum transitions having critical exponents differ greatly from conventional ones and belong to the chiral universality class. We discuss the application of these results to recent experiments in which surface superconductivity was found in TIs and estimate the feasibility of phonon pairing.

关键词： topological insulator Weyl semimetal superconductivity quantum criticality

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