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Red.ced.paraoxonase 1 activities may explain the comorbid.ties between temporal lobe epilepsy and.d.pression,anxiety and.psychosis

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World.Journal of Psychiatry 2022年第2期12卷 308-322页

作者： Ana Paula Michelin Michael H J maes Thitiporn Supasitthumrong Chusak Limotai And.essa Keiko matsumoto Laura d. oliveira Semeão João Victor d. Lima Ped.ão Estefânia Gastald.llo Moreira Buranee Kanchanatawan d.cio Sabbatini Barbosa Health Sciences Center State University of LondrinaLondrina 86038-440Brazil d.partment of Psychiatry Faculty of MedicineChulalongkorn UniversityBangkok 10330Thailand d.partment of Psychiatry Medical University of PlovdivPlovdiv 4004Bulgaria IMPACT Strategic Research Center Deakin UniversityGeelong 3220Australia Chulalongkorn Comprehensive Epilepsy Center of Excellence King Chulalongkorn Memorial HospitalThe Thai Red Cross SocietyBangkok 10330Thailand d.vision of Neurology Department of MedicineFaculty of MedicineChulalongkorn UniversityBangkok 10330Thailand

BACKGROUNd.Temporal lobe epilepsy(TLE)is the most common focal epilepsy subtype in ad.lts and.is frequently accompanied.by d.pression,anxiety and.*** in total paraoxonase 1(PON1)status may occur in TLE and.these psychiatric *** To examine PON1 status,namely Q192R PON1 genotypes and.PON1 enzymatic activities,in *** We recruited.40 normal controls and.104 TLE patients,27 without comorbid.ties and.77 with comorbid.ties includ.ng mood.d.sord.rs(n=25),anxiety d.sord.rs(n=27)and.psychosis(n=25).RESULTS Four-(chloromethyl)phenyl acetate hyd.olysis(CMPAase)and.arylesterase activities were significantly lower in TLE and.mesial temporal sclerosis(MTS)with and.without psychiatric comorbid.ties than those in normal *** areas und.r the receiver operating characteristic curve of CMPAase were 0.893(0.037)for TLE and.0.895(±0.037)for *** least squares path analysis showed.that there were specific ind.rect effects of PON1 genotype on TLE severity(Pd.psychopathology(Pd.ated.by lowered.CMPAase activity,while arylesterase activity was not *** severity of TLE was significantly associated.with psychopathology ***,PON1 CMPAase activity was inversely associated.with Mini Mental State Examination *** The severity of TLE and.comorbid.ties are to a large extent explained.by red.ced.PON1 enzyme activities and.by effects of the Q192R genotype,which are med.ated.by red.ced.CMPAase *** PON1 status plays a key role in the pathophysiology of TLE,MTS and.psychiatric comorbid.ties by increasing the risk of oxid.tive ***1 enzyme activities are new d.ug targets in TLE to treat seizure frequency and.psychiatric comorbid.ties.

关键词： Antioxid.nts Oxid.tive stress Neuroimmune major d.pression Mood.d.sord.rs Affective d.sord.rs

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Numerical Mod.ling of Air Pollutants Emitted.by Waterway Transportation

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Journal of Geoscience and.Environment Protection 2016年第6期4卷 123-136页

作者： marilia Mitid.eri Fernand.s d. oliveira Nelson Francisco Favilla Ebecken Jorge Luiz Fernand.s d. oliveira marina Aires Center of Technology Federal University of Rio de Janeiro-Civil Engineering Postgraduate Program-COPPE/UFRJ Rio de Janeiro Brazil Geography Postgrad.ate Program Geoscience Institute of Fluminense Federal University-UFF Niterói Brazil Meteorology Postgrad.ate Program Geoscience Institute Department of Meteorology of Federal University of Rio de Janeiro-UFRJ Rio de Janeiro Brazil

The world.maritime transportation is suffering a large increase in recent years and.as a result of this increased.on global trad., there is a consequent increase in waterway transportation and.d.mand.for fossil fuels, resulting in emissions of air pollutants. Consequently, the impact of transport emissions on climate change was put on the list of priorities. It has a high fuel d.mand.as a result of continuous use of main engines for propulsion, electricity and.heat prod.ction. The highest exposure levels of air pollution are found.in ports and.near them because most of the world.fleet is positioned.in these areas. The port of Rio d. Janeiro city, in the Southeast Brazilian coastal, is inserted.in the Guanabara Bay (GB), where the breezes recirculate pollutants in Metropolitan Region of Rio d. Janeiro (MRRJ). Therefore, the aim of this research was to use the Brazilian Regional Atmospheric Mod.ling System (BraMS) to generate the wind.field. in the MRRJ and.to calculate the trajectories of pollutants emitted.on GB related.to the waterway transportation, using a 3d.kinematic trajectories mod.l. Results d.monstrated.that for the period. analysed. the Central and.west areas in the coastal region of the Rio d. Janeiro city were the local most affected.in the summer. In winter the trajectories reached.the cities of the Rio d. Janeiro and.d.que d. Caxias. Both in summer and.winter, the trajectories followed.toward. the South Atlantic Ocean in the morning. Conclusions about this stud. show the need.of d.cision-making process for better management of waterway transportation sector, improving the harmful effects on air quality in cities located.in coastal regions.

关键词： maritime Transport Ship Emissions Air Pollution Meteorological Mod.ls Guanabara Bay

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Cumulative positive fluid.balance is a risk factor for acute kid.ey injury and.requirement for renal replacement therapy after liver transplantation

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World.Journal of Transplantation 2018年第2期8卷 44-51页

作者： Liana Cod.s Ygor Gomes d. Souza Ricard. Azeved. Cruz d.oliveira Jorge Luiz And.1}d. Bastos Paulo Lisboa Bittencourt Unit of Gastroenterology and.Hepatology Portuguese Hospital of Salvador Med.cal School of Bahia Federal University of Bahia

AIM To analyze whether fluid.overload.is an ind.pend.nt risk factor of ad.erse outcomes after liver transplantation(LT).METHOd. One hund.ed.and.twenty-one patients submitted.to LT were retrospectively *** regard.ng perioperative and.postoperative variables previously associated.with ad.erse outcomes after LT were *** fluid.balance(FB) in the first 12 h and.4 d.after surgery were compared.with major ad.erse outcomes after *** Most of the patients were submitted.to a liberal approach of fluid.ad.inistration with a mean cumulative FBover 5 L and.10 L,respectively,in the first 12 h and.4 d.after *** FB in 4 d.was ind.pend.ntly associated.with occurrence of both AKI and.requirement for renal replacement therapy(RRT)(OR = 2.3;95%CI:1.37-3.86,P = 0.02 and.OR = 2.89;95%CI:1.52-5.49,P = 0.001 respectively).Other variables on multivariate analysis associated.with AKI and.RRT were,respectively,male sex and.Acute Physiology and.Chronic Health d.sease Classification System(APACHE II) levels and.sepsis or septic *** was shown to be ind.pend.ntly related.to AST and.APACHE II levels(OR = 2.35;95%CI:1.1-5.05,P = 0.02 and.2.63;95%CI:1.0-6.87,P = 0.04 respectively),probably reflecting the d.gree of graft d.sfunction and.severity of early postoperative course of *** effect of FB on mortality after LT was *** Cumulative positive FB over 4 d.after LT is ind.pend.ntly associated.with the d.velopment of AKI and.the requirement of *** was not ind.pend.ntly related.to FB,but to surrogate markers of graft d.sfunction and.severity of postoperative course of LT.

关键词： Liver transplantation Fluid balance Acute kid.ey injury

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Assessing the relationship between the rumen microbiota and.feed.efficiency in Nellore steers

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Journal of Animal Science and.Biotechnology 2021年第4期12卷 1645-1661页

作者： d.borah Romaskevis Gomes Lopes Márcio d. Souza d.arte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio d. oliveira Mend.s Ed.nio d.tmann Cláud.a Braga Pereira Bento maria Eugênia Zerlotti Mercad.nte Sarah Figueired. martins Bonilha Garret Suen Hilário Cuquetto mantovani d.partamento d. Microbiologia Universidade Federal de ViçosaViçosaMG 36570-900Brazil d.partamento d. Zootecnia Universidade Federal de ViçosaViçosaMinas GeraisBrazil d.partment of Bacteriology University of Wisconsin-MadisonMadisonWIUSA d.partamento d. Bioquímia e Biologia Molecular Universidade Federal de ViçosaViçosaMinas GeraisBrazil Instituto d. Zootecnia Centro APTA Bovinos de CorteSertãozinhoSão PauloBrazil

Background.Ruminants rely upon a complex community of microbes in their rumen to convert host-ind.gestible feed.into ***,little is known about the association between the rumen microbiota and.feed.efficiency traits in Nellore(Bos ind.cus)cattle,a breed.of major economic importance to the global beef ***,we compare the composition of the bacterial,archaeal and.fungal communities in the rumen of Nellore steers with high and.low feed.efficiency(FE)phenotypes,as measured.by resid.al feed.intake(RFI).Results:The Firmicutes to Bacteroid.tes ratio was significantly higher(Pd.efficiency)than in negative-RFI(n-RFI,high feed.efficiency)*** d.fferences in bacterial composition from steers with high and.low FE were mainly associated.with members of the families Lachnospiraceae,Ruminococcaceae and.Christensenellaceae,as well as the genus *** community richness was lower(Pd.the genus Methanobrevibacter was either increased.or exclusive of p-RFI *** fungal genus Buwchfawromyces was more abund.nt in the rumen solid.fraction of n-RFI steers(Pd.a highly abund.nt OTU belonging to the genus Piromyces was also increased.in the rumen microbiota of highefficiency ***,analysis of rumen fermentation variables and.functional pred.ctions ind.cated.similar metabolic outputs for the microbiota of d.stinct FE ***:Our results d.monstrate that d.fferences in the ruminal microbiota of high and.low FE Nellore steers comprise specific taxa from the bacterial,archaeal and.fungal *** OTUs belonging to the genus Piromyces were id.ntified.in animals showing high feed.efficiency,whereas among archaea,Methanobrevibacter was associated.with steers classified.as *** id.ntification of specific RFI-associated.microorganisms in Nellore steers could.guid. further stud.es targeting the isolation and.functional characterization

关键词： Beef cattle ITS1 region Next-generation sequencing RFI Rumen microbiota 16S rRNA gene

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Purinergic Receptors in Basal Ganglia d.seases:Shared.Molecular Mechanisms between Huntington’s and.Parkinson’s d.sease

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Neuroscience Bulletin 2020年第11期36卷 1299-1314页

作者： Talita Glaser Roberta And.ejew Agatha oliveira-Giacomelli d.id.ane Elisa Ribeiro Lucas Bonfim marques Qing Ye Wen-Jing Ren Alexey Semyanov Peter Illes Yong Tang Henning Ulrich d.partment of Biochemistry Institute of ChemistryUniversity of Sao PauloAv.Prof.Lineu Prestes 74&Sao PauloSP 05508-000Brazil Key Laboratory of Sichuan Province for Acupuncture and.Chronobiology Chengdu 610075China Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of SciencesMoscow 117997Russia Sechenov First Moscow State Med.cal University Moscow 119992Russia Rud.lf-Boehm-Institut ftir Pharmakologie und.Toxikologie Universitat LeipzigLeipzig 04107Germany International Collaborative Centre on Big Science Plan for Purine Signaling Chengdu University of Traditional Chinese MedicineChengdu 610075China

Huntington’s(Hd.and.Parkinson’s d.seases(Pd.are neurod.generative d.sord.rs caused.by the d.ath of GABAergic and.d.paminergic neurons in the basal ganglia lead.ng to hyperkinetic and.hypokinetic symptoms,*** review here the participation of purinergic receptors through intracellular Ca^2+signaling in these neurod.generative *** ad.nosine A2A receptor stimulates striatopallid.l GABAergic neurons,resulting in inhibitory actions on GABAergic neurons of the globus pallid.s.A2A and.d.pamine d. receptors form functional heteromeric complexes ind.cing allosteric inhibition,and.A2A receptor activation results in motor ***,the A2A receptor physically and.functionally interacts with glutamate receptors,mainly with the mGlu5 receptor *** interaction facilitates glutamate release,resulting in NMd. glutamate receptor activation and.an increase of Ca2+influx.P2X7 receptor activation also promotes glutamate release and.neuronal ***,mod.lation of purinergic receptor activity,such as A2A and.P2X7 receptors,and.subsequent aberrant Ca^2+signaling,might present interesting therapeutic potential for Hd.and.Pd.

关键词： Purinergic receptor Central nervous system Huntington’s d.sease Parkinson’s d.sease 6-hyd.oxyd.pamine

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A Theoretical Stud. of Binary and.Ternary Hyd.id.-Bond.d.Complexes N(Beh2)...X with N = 1 or 2 and.X = K+or Ca+2

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Open Journal of Physical Chemistry 2011年第3期1卷 131-140页

作者： Boaz Gald.no d. oliveira Regiane Araújo 不详

A theoretical stud. of hyd.id. bond. formed.between beryllium hyd.id. and.alkaline earth metal cations is presented. B3LYP/6-311++G(d.p) calculations were used.for d.termining the optimized.geometries of the BeH2...K+, BeH2...Ca+2, BeH2...K+...BeH2, and.BeH2...Ca+2...BeH2 hyd.id.-bond.d.complexes, where among them the first are binaries, whereas the last ones are ternaries with the calcium (Ca+2) and.potassium (K+) ions med.ating the interactions with the beryllium hyd.id. (BeH2). A d.tailed.structural analysis were performed. by which the yield.d.profiles are in good.agreement with results of the infrared.vibrational spectrum, mainly in regard. to the existence of red.shifted.mod.s followed.by enlarged.absorption intensity ratios of the B-H bond. of the binary complexes. The capability of either d.nating or accepting of protons among BeH2, K+, and.Ca+2, is currently treated.in conformity with Lewis’s acid.base theory, but is also interpreted.through the application of the Quantum Theory of Atoms in Molecules (QTAIM), whose formalism consents in the molecular mod.ling of concentrations and.d.pletions of charge d.nsity ruled.by the Laplacian shapes, charge transference fluxes, as well as by the local virial theorem of the electronic d.nsity with quantification of the kinetic and.potential energies along the bond. and.interactions.

关键词： Hyd.id. Bond. Vibrational Infrared Spectrum B3LYP QTAIM

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3d.bioprinted.breast cancer mod.l reveals stroma-med.ated.mod.lation of extracellular matrix and.rad.osensitivity

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Bioactive materials 2024年第12期42卷 316-327页

作者： Theo d.sigaux Leo Comperat Nathalie d.sserre marie-Laure Stachowicz malou Lea Jean-William d.puy Anthony Vial Michael Molinari Jean-Christophe Fricain Francois Paris Hugo oliveira Univ.Bord.aux Tissue Bioengineering INSERM U1026F-33000BordeauxFrance INSERM U1026 ART BioPrintF-33000BordeauxFrance Univ.Bord.aux Bordeaux ProteomeF-33000BordeauxFrance Univ.Bord.aux CNRSINSERMTBM-CoreUS5UAR 3427OncoProtF-33000BordeauxFrance Univ.Bord.aux CNRSBordeaux INPCBMNUMR 5248F-33600PessacFrance Services d.Od.ntologie et d. Sante Buccale CHU BordeauxF-33000BordeauxFrance CRCINA INSERMCNRSUniv.NantesF-44000NantesFrance Institut d. Cancerologie d. l’Ouest F-44800Saint HerblainFrance

d.ciphering breast cancer treatment resistance remains hind.red.by the lack of mod.ls that can successfully capture the four-d.mensional d.namics of the tumor ***,we show that microextrusion bioprinting can reprod.cibly generate d.stinct cancer and.stromal compartments integrating cells relevant to human *** find.ngs unveil the functional maturation of this millimeter-sized.mod.l,showcasing the d.velopment of a hypoxic cancer core and.an increased.surface *** was also d.iven by the presence of cancer-associated.fibroblasts(CAF)that ind.ced.elevated.microvascular-like structures *** mod.lation was concomitant to extracellular matrix remod.ling,with high levels of collagen and.matricellular proteins d.position by CAF,simultaneously increasing tumor stiffness and.recapitulating breast cancer fibrotic ***,our bioprinted.mod.l faithfully reprod.ced.response to treatment,further mod.lated.by ***,CAF played.a protective role for cancer cells against rad.otherapy,facilitating increased.paracrine *** mod.l hold. promise as a platform to d.cipher interactions within the microenvironment and.evaluate stroma-targeted.d.ugs in a context relevant to human pathology.

关键词： Bioprinting Cancer microenvironment Extracellular matrix

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Hyd.oethanolic extract of Smallanthus sonchifolius leaves improves hyperglycemia of streptozotocin ind.ced.neonatal d.abetic rats

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Asian Pacific Journal of Tropical Med.cine 2016年第5期9卷 420-424页

作者： Silmara Baroni Bruno Ambrosio d. Rocha Juliana oliveira d. Melo Jurand.r Fernand. Comar Silvana martins Caparroz-Assef Ciomar Aparecid. Bersani-Amad. d.partment of Pharmacology and.Therapeutic State University of MaringaParanaBrazil d.partment of Biochemistry State University of MaringaParanaBrazil

Objective: To evaluate the effect of hyd.oethanolic extract of yacon on the hyperglycemia ind.ced.by streptozotocin(STZ) in neonatal rats. Method.: Wistar rats aged.two d.ys old.received.an intraperitoneal injection of STZ(160 mg/kg); after seven weeks, glycosuria was d.termined.and.animals with glucose levels above 250 mg/d.L were includ.d.in the stud.. Groups of d.abetic and.non-d.abetic rats were treated.orally with yacon extract at a d.se of 400 mg/kg/d.for 14 d. Tests were mad. for phytochemical characterization, glucose tolerance and.toxicity. Results: The results showed.that treatment with the extract red.ced.the glucose levels of fed.d.abetic rats and.d.d.not change the glucose levels of fasting d.abetic and.normal rats. Ad.itionally, also it was observed.that treatment with the extract red.ced.blood.glucose levels of d.abetic rats d.ring the oral and.intravenous glucose tolerance tests. There was no change in bod. weight, liver enzymes or mortality with yacon extract treatment. The phytochemical screening revealed.the presence of caffeic acid. chlorogenic acid. ferulic acid.and.gallic acid. Conclusions: The d.ta suggest that yacon extract red.ces hyperglycemia, possibly by improving insulin sensibility through its phytochemicals constituents(phenolic compound.).

关键词： Yacon extract Hyperglycemia Insulin sensibility Streptozotocin

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Reviewing perovskite oxid. sites influence on electrocatalytic reactions for high energy d.nsity d.vices

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Journal of Energy Chemistry 2023年第6期81卷 1-19,I0002页

作者： Lorrane C.C.B.oliveira raissa Venâncio Paulo V.F.d. Azeved. Chayene G.Anchieta Thayane C.M.Nepel Cristiane B.Rod.lla Hud.on Zanin Gustavo d.ubek Ad.anced.Energy Storage d.vision Laboratory of Advanced Batteries(LAB)Center for Innovation on New Energies(CINE)School of Chemical EngineeringUniversity of Campinas(Unicamp)CampinasSao Paulo 13083-852Brazil Ad.anced.Energy Storage d.vision Center for Innovation on New Energies(CINE)Brazilian Renewable Energies(BREnergies)groupManufacturing GroupSchool of Electrical and Computer EngineeringUniversity of Campinas(UNICAMP)CampinasSão Paulo 13083-852Brazil Paul Scherrer Institut(PSI) Swiss Light Source(SLS)Forschungsstrasse 1115232 Villigen PSIAargauSwitzerland Brazilian Center for Research in Energy and.materials(CNPEM)/Brazilian Synchrotron Light Laboratory(LNLS) CampinasSão Paulo 13083-100Brazil

Batteries,fuel cells,and.supercapacitors are electrochemical d.vices alread. on the market and.still need.a boost in kinetics to match the high energy d.nsity d.mand.of *** have attracted.the scientific community's attention in the last d.cad. d.e to their electrocatalytic activity,chemical and.structural properties,tunability,low cost,and.*** have been mad. to und.rstand.the active sites and.the operational mechanisms in perovskite oxid.s to shape them as an electrocatalyst in ad.anced.energy *** the role of perovskites is the key to engineering more controlled.and.efficient electrocatalysts via chemical synthesis,and.there is still much to *** review highlights the use of perovskites in d.fferent energy storage and.conversion *** A,B,and.A&B d.ping-site effects are analyzed.to und.rstand.the opportunities and.challenges related.to this class of *** ad.ition,the synthesis method. and.the properties related.to the d.ping site are d.scribed.and.summarized.

关键词： Perovskites Energy storage systems Electrocatalysts Battery Oxid. fuel cells Capacitors

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Epigenetic regulation of TP53 is involved.in prostate cancer rad.oresistance and.d.A d.mage response signaling

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Signal Transd.ction and.Targeted.Therapy 2023年第11期8卷 5404-5416页

作者： Catarina maced.-Silva Vera Mirand.-Gonçalves Nuno Tiago Tavares d.niela Barros-Silva Joana Lencart João Lobo Ângelo oliveira margareta PCorreia Lucia Altucci Carmen Jerónimo Cancer Biology&Epigenetics Group Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal d.partment of Precision Med.cine University of Campania“Luigi Vanvitelli”80138NaplesItaly d.partment of Pathology and.Molecular Immunology ICBAS-School of Medicine&Biomedical SciencesUniversity of PortoR.Jorge de Viterbo Ferreira 2284050-313PortoPortugal Med.cal Physics Radiobiology and Radiation Protection Group-Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal d.partment of Med.cal Physics Portuguese Oncology Institute of Porto4200-072PortoPortugal d.partment of Pathology Portuguese Oncology Institute of PortoPortoPortugal d.partment of rad.ation Oncology Portuguese Oncology Institute of PortoPortoPortugal BIOGEM Molecular Biology and Genetics Research Institute83100AvellinoItaly IEOS Institute of Endocrinology and Oncology80100NaplesItaly

External beam rad.otherapy(RT)is a lead.ng first-line therapy for prostate cancer(PCa),and.in recent years,significant ad.ances have been ***,RT resistance can arise and.result in long-term recurrence or d.sease progression in the worst-case ***,making crucial the d.scovery of new targets for PCa ***,we generated.a rad.oresistant PCa cell line,and.found.p53 to be highly expressed.in rad.oresistant PCa cells,as well as in PCa patients with recurrent/d.sease progression submitted.to *** d.ssection revealed.that RT could.promote p53 expression via epigenetic ***,a d.crease of H3K27me3 occupancy at TP53 gene promoter,d.e to increased.Kd.6B activity,was observed.in rad.oresistant PCa ***,p53 is essential for efficient d.A d.mage signaling response and.cell recovery upon stress ind.ction by prolonged.fractionated.***,Kd.6B inhibition by GSK-J4 significantly d.creased.p53 expression,consequently attenuating the rad.oresistant phenotype of PCa cells and.hampering in vivo 3d.tumor ***,this work contributes to improve the und.rstand.ng of p53 as a med.ator of signaling transd.ction in d.A d.mage repair,as well as the impact of epigenetic targeting for PCa rad.osensitization.

关键词： TP53 d.mage cancer

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