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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 33-34页

作者： Benedetti s. Bertini E. iannaccone s. s.C. Previtali 周永 Department of Neurology San Raffaele Scientific Institute Via Olgettina 60 20132 Milano Italy

The coexis.ence of neurogenic and myogenic features.in s.apuloperoneal s.ndro me is.rarely as.ribed to a s.ngle gene. Defects.in the nuclear envelope protein lamin A/C, encoded by the LMNA gene, have been s.own to be as.ociated with a var iety of dis.rders.affecting mainly the mus.ular and adipos. tis.ues.and, more re cently, with autos.mal reces.ive Charcot- Marie- Tooth type 2 neuropathy. This.report is.about a patient pres.nting features.of myopathy and neuropathy due to a dominant LMNA mutation, s.gges.ing that the peripheral nerve might be affecte d in primary LMNA myopathy. Our obs.rvations.further s.pport the marked intrafam ilial and interfamilial phenotypic heterogeneity as.ociated with lamin A/C defec ts.

关键词：肌肉萎缩 LMNA 肌源性损伤单基因病核纤层蛋白腓肌萎缩神经源性显性突变肌病脂肪组织

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Harmful Effects.on African Clawed Frog （Xenopus.laevis. Reproduction as.Expres.ion of High Water Phos.hates.Levels

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Journal of Agricultural s.ience and Technology(A) 2015年第7期5卷 632-638页

作者： Marco Campolo Frances.a s.ano Maddalena iannaccone Zoo delle Maitine Contrada delle Maitine 1 Pesco Sannita Benevento 82020 Italy Centro Veterinario Einaudi Via N. Colajanni 23A Bari 70125 Italy Cons.glio Nazionale delle Ricerche lstituto di Biofisica Via de Marini 6 Genoa 16149 Italy Centro Veterinario I1Mondo Degli Animali Es.tici Via S. Martino 67/r Genoa 16131 Italy

Amphibians.are cons.dered as.reliable indicators.of environmental quality. In Europe, a general decline of amphibians.population parallels.a worldwide decline, and s.me of the factors.which are thought to be res.ons.ble to this.decline are habitat los., introduction of exotic s.ecies. dis.as. and decreas.ng water quality. Recent inves.igations.s.gges. that thes. eutrophic conditions.may be as.ociated with frog reproduction problems. Water quality criteria s.ttled for the different s.ecies.of amphibians.do not currently exis., but in the pres.nt paper, the authors.report their obs.rvation about water phos.hate concentrations.in as.ociation with hipofertility in African clawed frogs.（Xenopus.laevis.. The s.udy cons.dered two different groups.of African clawed frog s.owing hypofertility （22 patients. hos.ed in captivity. The animals.were vis.ted, and the filtration s.s.ems.functionality and the water quality were checked, i.e., temperature, pH, ammonia, nitrite, nitrate, phos.hates. hardnes. and alkalinity. In the firs. group, it was.decided to perform ultras.und s.ans. paras.tological tes.s.on fecal s.mples. and micros.opical/macros.opical examination, as.well as.microbiological analys.s.on collected oocytes. In the s.cond group, only fecal s.mples.were collected in order to perform paras.tologiacal exams. No pathological findings.were s.owed by veterinary tes.s. Water changes.were carried out in both facilities.and after two months. the fertility in African clawed frogs.improved, evidencing the involvement of phos.hates.values.in the ons.t of the problem and even more in its.res.lution. More s.udies.are needed to further define this.correlation.

关键词： Xenopus.laevis water phos.hates.level oocytes. quality.

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