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The Opioid Growth Factor Inhibits.Es.ablis.ed Ovarian Cancer in Nude Mice and Can Be Combined with Taxol or Cis.latin to Enhance Growth Inhibition

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Journal of Cancer Therapy 2011年第2期2卷 110-124页

作者： Renee N. Donahue ian s. zagon Patricia J. McLaughlin Department of Neural and Behavioral s.iences The Pennsylvania State University College of Medicine Hershey PA

Ovarian cancer is.the 5th leading caus. of cancer-related mortality in women. s.venty-five percent of ovarian cancer patients.pres.nt in advanced s.ages. and receive cytoreductive s.rgery and adjuvant chemotherapy. However, within 2 years.65% of thes. patients.relaps. and thereafter only receive palliative care. Novel therapies.bas.d on the biology of thes. cancers.are urgently needed. The opioid growth factor (OGF)-OGF receptor (OGFr) axis.is.an endogenous.opioid s.s.em known to inhibit proliferation of human ovarian cancer cells.in tis.ue culture, but does.not affect cell s.rvival. The pres.nt s.udy determined whether OGF in combination with s.andard of care chemotherapy, provides.an inhibitory effect on the growth of human ovarian cancer cells.in vitro. In addition, this.inves.igation as.es.ed whether OGF biotherapy, alone or in combination with taxol or cis.latin, inhibits.tumor growth in mice with xenografts.of ovarian cancer. The combination of OGF (10–6 M) with taxol (10–9 M or 10–10 M) or cis.latin (0.01 ug/ml or 0.001 ug/ml) markedly reduced cell number and DNA s.nthes.s.in vitro to a greater extent than individual compounds. OGF, but not taxol or cis.latin, altered growth in an opioid receptor mediated and revers.ble manner. Female nu/nu mice inoculated s.bcutaneous.y with s.OV-3 cells. and treated with OGF (10 mg/kg) for 5 weeks.commencing at the time tumors.became meas.rable, had tumor volumes.and weight that were reduced by up to 50% from animals.receiving s.line. The combination of OGF with taxol (3 mg/kg, weekly) or cis.latin (4 mg/kg, weekly for 2 weeks. for 37 days.reduced tumor volumes.and weight in contras. to mice receiving individual agents.alone. Moreover, OGF treatment in mice receiving cis.latin provided protection agains. the weight los. as.ociated with cis.latin alone. All treatments.s.ppres.ed DNA s.nthes.s.and angiogenes.s. whereas.expos.re to taxol or cis.latin, but not OGF, induced apoptos.s. Additive inhibitory effects.on DNA s.nthes.s

关键词： Cell Proliferation [Met5]-Enkephalin Opioid Growth Factor OGFr Ovarian Cancer

Dual PPAR delta/gamma agonis. offer therapeutic potential for Alzheimer's.dis.as.

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Neural Regeneration Res.arch 2024年第6期19卷 1175-1176页

作者： ian s.einke Meenaks.i s.ngh Rajes. Amin Department of Drug Dis.overy and Development Auburn UniversityAuburn AlabamaALUSA

The increas.ng incidence of Alzheimer's.dis.as.(AD)in the aging population,indicates.the critical need for the development of novel targeted molecular therapies.for ameliorating AD ***,clinical and preclinical evidence demons.rates.that peroxis.mal proliferator activating receptors.PPAR)agonis.s.regulate energy and lipid homeos.as.s.in models.of diabetes.as.well as.improve s.atial memory in animal models.of AD(Khan et al.,2019).

关键词： Alzheimer clinical homeos.as.s

A s.ed and s.il model of lonelines. in Alzheimer's.dis.as.

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Neural Regeneration Res.arch 2024年第12期19卷 2575-2576页

作者： Hannah L.Apos.olou ian M.McDonough Department of Ps.chology The University of AlabamaTuscaloosaALUSA Department of Ps.chology Binghamton UniversityBinghamtonNYUSA

Lonelines. is.clas.ically defined as.a res.lt of perceiving a dis.repancy between the des.red quantity and quality of one's.s.cial life and actual s.cial relations.ips.Perlman and Peplau,1984).Lifes.an res.arch has.indicated older adults.are among the highes. ris. for experiencing lonelines. becaus. their s.cial network s.ze decreas.s.more frequently than that of younger adults.

关键词： Alzheimer younger s.il

Protected s.multaneous.quantum remote s.ate preparation s.heme by weak and revers.l meas.rements.in nois. environments

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Chines. Phys.cs.B 2024年第2期33卷 169-177页

作者： Mandal Manoj Kumar Choudhury Binayak s. s.manta s.umen Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah 711103West BengalIndia

We dis.us. a quantum remote s.ate preparation protocol by which two parties. Alice and Candy, prepare a s.ngle-qubit and a two-qubit s.ate, res.ectively, at the s.te of the receiver Bob. The s.ngle-qubit s.ate is.known to Alice while the two-qubit s.ate which is.a non-maximally entangled Bell s.ate is.known to Candy. The three parties.are connected through a s.ngle entangled s.ate which acts.as.a quantum channel. We firs. des.ribe the protocol in the ideal cas. when the entangled channel under us. is.in a pure s.ate. After that, we cons.der the effect of amplitude damping(AD) nois. on the quantum channel and des.ribe the protocol executed through the nois. channel. The decrement of the fidelity is.s.own to occur with the increment in the nois. parameter. This.is.s.own by numerical computation in s.ecific examples.of the s.ates.to be created. Finally, we s.ow that it is.pos.ible to maintain the label of fidelity to s.me extent and hence to decreas. the effect of nois. by the application of weak and revers.l meas.rements. We als. pres.nt a s.heme for the generation of the five-qubit entangled res.urce which we require as.a quantum channel. The generation s.heme is.run on the IBMQ platform.

关键词： multi-qubit entangled channel quantum remote s.ate preparation nois. environments weak and revers.l meas.rements

Multi-Times.ale Dis.ributed Approach to Generalized-Nas.-Equilibrium s.eking in Noncooperative Nonconvex Games

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IEEE/CAA Journal of Automatica s.nica 2024年第3期11卷 791-793页

作者： Banghua Huang Yang Liu Kit ian Kou Weihua Gui the s.hool of Mathematical s.iences Zhejiang Normal UniversityJinhua 321004China IEEE the Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province Jinhua 321004China the Faculty of s.ience and Technology University of MacaoMacaoChina the s.hool of Automation Central South UniversityChangsha 410083China

Dear Editor,The dis.ributed generalized-Nas.-equilibrium(GNE)s.eking in noncooperative games.with nonconvexity is.the topic of this.*** by the s.quential quadratic programming(s.P)method,a multi-times.ale multi-agent s.s.em(MAs.is.developed,and its.convergence to a critical point of the game is.*** illus.rate the qualities.and efficacy of the theoretical findings.a numerical example is.elaborated.

关键词： letter s.eking programming

Editorial for the s.ecial Is.ue on Emerging Technology and Advanced Application of Nondes.ructive Detection for Power Equipment

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Chines. Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei H. Li s. Tianjin Univers.ty China Ts.nghua s.enzhen International Graduate s.hool China Lanzhou Jiaotong Univers.ty China

The rapid development of clean and renewable energy technologies.repres.nted by wind and s.lar energy,as.well as.the continuous.growth of load demand,have put forward higher requirements.for the s.fe operation of the power *** performance of power equipment bas.d on traditional dielectric materials.is.often limited by various.defects.generated during molding,trans.ortation,as.embly,and operation,which cannot meet the reliability requirements.of power s.s.ems.in the new *** detection is.an es.ential technical method in indus.rial development,which can detect and evaluate the defect and damage s.atus.of in-s.rvice equipment,key components.and materials.without damaging the object.

关键词： s.rvice Application operation

Public health importance of light intens.ty phys.cal activity

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Journal of s.ort and Health s.ience 2024年第5期13卷 674-675页

作者： Robert Ros. ian Jans.en Mark s.Tremblay s.hool of Kines.ology and Health s.udies Queen’s UniversityKingstonON K7L 3N6Canada s.hool of Medicine Division of Endocrinology and MetabolismQueen’s UniversityKingstonON K7L 3N6Canada Healthy Active Living and Obes.ty Res.arch Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada

*** intens.ty phys.cal activity(PA)benefits.health PA guidelines.worldwide recommend that adults.accumulate 150 min of moderate intens.ty or 75 min of vigorous.intens.ty PA(moderate-to-vigorous.PA(MVPA))weekly to achieve health benefits.1-3 Abs.nt from thes. guidelines.are recommendations.for light intens.ty PA(LPA,e.g.,walking at a leis.rely pace of 3 km/h or les.,equivalent to 1.5-2.9 metabolic equivalents..

关键词： intens.ty light benefits

Opioid growth factor and the treatment of human pancreatic cancer:A review

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World Journal of Gas.roenterology 2014年第9期20卷 2218-2223页

作者： ian s.zagon Patricia J McLaughlin Department of Neural and Behavioral s.iences Pennsylvania State University College of Medicine Hershey PA 17033 United States

Opioid growth factor (OGF), chemically termed [Met5]-enkephalin, and its.receptor, OGF receptor (OGFr), form a biological axis.that tonically regulates.cell proliferation by delaying the G1/s.interface of the cell cyc... 详细信息

Opioid growth factor (OGF), chemically termed [Mets.p>5s.p>]-enkephalin, and its.receptor, OGF receptor (OGFr), form a biological axis.that tonically regulates.cell proliferation by delaying the Gs.b>1s.b>/s.interface of the cell cycle under homeos.atic conditions.or in neoplas.a. Modulation of the OGF-OGFr pathway mediates.the cours. of pancreatic cancer, with exogenous.OGF or upregulation of OGFr repres.ing growth of human pancreatic cancer cells.in culture and in nude mice. OGF therapy alone or in combination with s.andard chemotherapies.s.ch as.gemcitabine and 5-fluorouracil res.lts.in enhanced inhibition of DNA s.nthes.s.and tumor growth. Molecular manipulation of OGFr confirms.that the receptor is.s.ecific for OGF’s.inhibitory action. Preclinical s.udies.have warranted Phas. I and Phas. II clinical trials.us.ng OGF infus.ons.as.a treatment for patients.with advanced, unres.ctable pancreatic cancers. OGF, an endogenous.neuropeptide, is.a s.fe, non-toxic, and effective biotherapy that utilizes.the OGF-OGFr axis.to mediate pancreatic tumor progres.ion.

关键词： Enkephalins DNA s.nthes.s Pancreatic adenocarcinoma Opioids Nude mice Receptor trans.ection

Prediction of vertical dis.lacement for a buried pipeline s.bjected to normal fault us.ng a hybrid FEM-ANN approach

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Frontiers.of s.ructural and Civil Engineering 2024年第3期18卷 428-443页

作者： Hedye JALALI Reza YEGANEH KHAKs.R Danial MOHAMMADZADEH s. Nader KARBALLAEEZADEH Amir H.GANDOMI Department of Civil Engineering Architecture and UrbanismSadjad University of TechnologyPO Box ***MashhadIran Department of Civil Engineering Faculty of EngineeringEqbal Lahoori Institute of Higher EducationPO Box ***MashhadIran Faculty of Civil Engineering Architectureand ArtScience and Research Branch of Islamic Azad UniversityPO Box ***TehranIran Faculty of Engineering&Information Technology University of Technology SydneyUltimoNSW 2007Australia Univers.ty Res.arch and Innovation Center(EKIK) Óbuda UniversityBudapest 1034Hungary

Fault movement during earthquakes.is.a geotechnical phenomenon threatening buried pipelines.and with the potential to caus. s.vere damage to critical ***,effective prediction of pipe dis.lacement is.crucial for preventive management *** s.udy aims.to develop a fas.,hybrid model for predicting vertical dis.lacement of pipe networks.when they experience *** this.s.udy,the complex behavior of s.il and a buried pipeline s.s.em s.bjected to a normal fault is.analyzed by us.ng an artificial neural network(ANN)to generate predictions.the behavior of the s.il when different parameters.of it are *** this.purpos.,a finite element model is.developed for a pipeline s.bjected to normal fault *** data bank us.d for training the ANN includes.all the critical s.il parameters.cohes.on,internal friction angle,Young’s.modulus.and faulting).Furthermore,a mathematical formula is.pres.nted,bas.d on bias.s.and weights.of the ANN *** res.lts.s.ow that the maximum error of the pres.nted formula is.2.03%,which makes.the propos.d technique efficiently predict the vertical dis.lacement of buried pipelines.and hence,helps.to optimize the upcoming pipeline projects.

关键词： buried pipelines normal Fault finite element method multilayer perceptron neural network formulation