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Cerebral Palsy and Stroke—Early and Late Brain Lesion Present Differences in Systemic Biomarkers and Gene Expression Related to Muscle Contractures

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World Journal of Neuroscience 2021年第1期11卷 34-47页

作者： Jessica Pingel Camille Potts Theis Wolter petersen Jens Bo Nielsen Department of Neuroscience University of Copenhagen Copenhagen Denmark The Elsass Foundation Research Unit Charlottenlund Denmark

Background: CNS lesions that are acquired early in life e.g. cerebral palsy (CP) disturb muscle development and growth, while CNS injuries acquired later in life e.g. stroke, affect fully matured muscles and cause paresis and atrophy. These differences may result in different contracture phenotypes. Aim: The purpose of this study was to compare systemic biomarkers and gene expression levels in muscle of individuals with CNS lesions acquired early and later in life. Methods: Blood samples and muscle biopsies were analyzed using Enzyme-linked immunosorbent assay and Real-time PCR from n = 24 control participants, n = 14 individuals with cerebral palsy, and n = 12 stroke survivors. Results: Systemic markers: Myostatin was significantly decreased in both the cerebral palsy (p = 0.0051), and the stroke group (p = 0.036). Creatine Kinase-MB and C-Reactive Protein were significantly elevated in stroke patients only (p 0.034 respectively). Gene expressions: The expression of myostatin (MSTN) was significantly lower in both the ST and the CP group when compared to Ctrl (p = 0.02). In addition, collagen type 4A1 (COL4A1) was significantly lower in the CP group compared to the other groups (p = 0.015). Finally, the troponin 1 slow skeletal muscle type was significantly increased in the ST group when compared to both CP and Ctrl (p = 0.03). Conclusion: The downregulation of myostatin in individuals with both early and late CNS injury is likely a compensatory reaction to muscle weakness, reduced muscle mass and/or muscle atrophy. Changes in gene expression may reflect a specific alteration depending on when in life the CNS lesions were acquired.

关键词： Cerebral Palsy Stroke Biomarkers Creatin Kinase Myostatin C-Reactive Protein

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Solid-State Metal Additive Manufacturing for Structural Repair

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Accounts of Materials Research 2021年第9期2卷 780-792页

作者： Ryan B.Gottwald R.Joey Griffiths Dylan T.petersen Mackenzie E.J.Perry Hang Z.Yu Department of Materials Science and Engineering Virginia TechBlacksburgVirginia 24061United States

CONSPECTUS:Structural metal components play a vital role in a broad range of industries,from aerospace and automotive to infrastructure and *** service,these components can experience substantial wear,thermal fatigue,erosion,corrosion,or chemical reactions,resulting in significant surface or even volumetric *** of these components is often energy-intensive and economically *** repair,which aims to restore the original geometry while enabling good mechanical performance postrepair,can offset the costs *** on the additive capabilities and bonding mechanisms,structural repair technologies can be divided into four categories:nonadditive,nonmelting-based;nonadditive,melting-based;additive,nonmelting-based;additive,*** melting-based approaches can be applied to various repair geometries with good precision,the underlying melting and solidification processes inevitably lead to crucial problems impacting the mechanical performance,such as solidification porosity,high residual stresses,dendritic microstructure formation,elemental segregation,hot cracking,and stress corrosion *** fundamentally solve or minimize these problems,one may employ solid-state technologies that leverage ultrasonic vibration,friction stirring,or particle impact to facilitate metallurgical bond *** robust geometry restoration,an additive capability needs to be incorporated for continuous material feeding and precise deposition path ***,two solid-state technologies satisfy the requirement,cold spray and additive friction stir *** this Account,we discuss the structural repair enabled by solid-state metal additive manufacturing,focusing on(i)cold spray,which is a relatively established process,and(ii)additive friction stir deposition,which is an emerging process recently triggering significant research effortsthe authors are particularly invested in this process and are pioneering th

关键词： friction solidification corrosion

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Lifestyle after Cardiac Rehabilitation: Did the Message Come across, and Was It Feasible? An Analysis of Patients’ Narratives

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Health 2014年第19期6卷 2641-2650页

作者： Marie Veje Knudsen Sussie Laustsen Annemette Krintel petersen Sanne Angel Department of Physiotherapy and Occupational Therapy Aarhus University Hospital Aarhus Denmark Centre of Research in Rehabilitation (CORIR) Department of Clinical Medicine Aarhus University Hospital and Aarhus University Aarhus Denmark Department of Cardiothoracic and Vascular Surgery Aarhus University Hospital Aarhus Denmark Section of Nursing Department of Public Health Aarhus University Aarhus Denmark

Lifestyle following heart disease is considered important to prevent and reduce cardiovascular risk factors. Thus, cardiac rehabilitation is focused on potential lifestyle changes. Further insight into patients’ perspective on lifestyle after cardiac rehabilitation is needed as changing habits following heart disease is a complex matter. The objective of this study was to explore the characteristics of lifestyle after cardiac rehabilitation. A phenomenological-hermeneutic approach with qualitative interviews was performed in 20 patients six months after completing a hospital-based cardiac rehabilitation programme in 2012 at Aarhus University Hospital, Denmark. The patients were diagnosed with ischemic heart disease, heart failure or left heart valve disease. The interviews were analysed using the interpretation theory by Ricoeur. The variation in reactions to cardiac rehabilitation were: 1) considering prior lifestyle to be appropriate, maybe with minor adjustments;2) acknowledging the need for incorporating lifestyle changes;and 3) reconciling or feeling guilt when being unable to manage changes. Participation in the cardiac rehabilitation programme was a positive experience, but it had minor influence on long-term adherence to recommended lifestyle. The important thing in establishing new routines was whether they aroused interest, and whether the experience of changes was perceived as necessary and manageable. In future cardiac rehabilitation, focusing on patients’ interests and supporting them in incorporating recommendations into their everyday life might be essential following heart disease, also after ending cardiac rehabilitation.

关键词： Cardiac Disease Cardiac Rehabilitation Lifestyle Change Qualitative Study

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Linux 参考大全第3版

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丛书名： 21世纪计算机编程指南系列

2000年

作者：（美）Richard petersen 希望图书创作室译

CD盘放多媒体阅览室

ISBN: (纸本)7900031669

CD盘放多媒体阅览室

关键词：操作系统,Linux

来源：畅想之星图书光盘版（南... 评论

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污泥作为污水厂内碳源的水解特性及工艺选择

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中国给水排水 2011年第22期27卷 30-35页

作者：刘智晓 Sille Bendix Larsen Gert petersen 马宝玲首创爱华天津市政环境工程有限公司天津300191 EnviDan Denmark

随着各地污水厂出水水质对氮、磷要求的日益提高,强化脱氮除磷成为必然要求,但是我国多数污水厂由于多种原因导致进水碳源不足,尤其是进水SCOD、VFAs的匮乏,直接影响了生物脱氮除磷的效率,甚至不得已采用人工投加外碳源脱氮或者化学除... 详细信息

随着各地污水厂出水水质对氮、磷要求的日益提高,强化脱氮除磷成为必然要求,但是我国多数污水厂由于多种原因导致进水碳源不足,尤其是进水SCOD、VFAs的匮乏,直接影响了生物脱氮除磷的效率,甚至不得已采用人工投加外碳源脱氮或者化学除磷方式以满足严格的出水氮、磷要求,但这无疑大大提高了污水厂的产泥率及运行成本。充分挖掘污水厂的"内碳源",利用污泥水解产生VFAs,不仅能有效提高除磷脱氮效率,而且可以降低污水厂的污泥产量,是可持续的资源化技术。比较了初沉污泥和活性污泥的水解特性差异,介绍了污泥水解工艺的常用构型及参数选择,以及国内外一些成功的实施案例。

关键词：初沉污泥活性污泥侧流水解发酵强化生物除磷 RBCOD VFAs

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Changes in Barents Sea ice Edge Positions in the Last 440 years: A Review of Possible Driving Forces

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International Journal of Astronomy and Astrophysics 2020年第2期10卷 97-164页

作者： Nils-Axel Mö rner Jan-Erik Solheim Ole Humlum Stig Falk-petersen Paleogeophysics & Geodynamics Stockholm Sweden Department of Physics and Technology UiT The Arctic University of Norway Troms&oslash Norway The University Centre on Svalbard (UNIS) Longyearbyen Svalbard Norway The Fram Centre Akvaplan-niva Troms&oslash Norway

This is the first report of the Barents Sea Ice Edge (BIE) project. The BIE position has varied between latitude 76°N and above 82°N during the last 440 years. During the period 10,000 to 6000 years ago, Arctic climate was significantly warmer than today. We review various oceanic and atmospheric factors that may have an effect on the BIE position. The Gulf Stream beat with respect to alternations in flow intensity and N-S distribution plays a central role for the changes in climate and BIE position during the last millennium. This occurred in combination with external forcing from total solar irradiation, Earth’s shielding strength, Earth’s geomagnetic field intensity, Earth’s rotation, jet stream changes;all factors of which are ultimately driven by the planetary beat on the Sun, the Earth and the Earth-Moon system. During the last 20 years, we see signs of changes and shifts that may signal the end of the late 20th century warm period. The BIE position is likely to start advancing southward in next decade.

关键词： Barents Sea Ice Edge Cyclic Changes Gulf Stream Beat Planetary-Solar Forcing

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Changes in Barents Sea Ice Edge Positions in the Last 442 Years. Part 2: Sun, Moon and Planets

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International Journal of Astronomy and Astrophysics 2021年第2期11卷 279-341页

作者： Jan-Erik Solheim Stig Falk-petersen Ole Humlum Nils-Axel Mö rner Retired Department of Physics and Technology UiT The Arctic University of Norway Troms&oslash Norway Akvaplan-niva The Fram Centre Troms&oslash Norway The University Centre on Svalbard (UNIS) Longyearbyen Svalbard Norway Department of Geosciences University of Oslo Oslo Norway Deceased Paleogeophysics & Geodynamics Stockholm Sweden

This is the second paper in a series of two, which analyze the position of the Barents Sea ice-edge (BIE) based on a 442-year long dataset to understand its time variations. The data have been collected from ship-logs, polar expeditions, and hunters in addition to airplanes and satellites in recent times. Our main result is that the BIE position alternates between a southern and a northern position followed by Gulf Stream Beats (GSBs) at the occurrence of deep solar minima. We decompose the low frequency BIE position variations in cycles composed of dominant periods which are related to the Jose period of 179 years, indicating planetary forcings. We propose that the mechanism transferring planetary signals into changes in BIE position is the solar wind (SW), which provides magnetic shielding of the Earth in addition to geomagnetic disturbances. Increase in the solar wind produces pressure which decelerates the Earth’s rotation. It also transfers electrical energy to the ring current in the earth’s magnetosphere. This current magnetizes the earth’s solid core and makes it rotate faster. To conserve angular momentum the earth’s outer fluid mantle rotates slower with a delay of about 100 years. In addition will geomagnetic storms, initiated by solar coronal mass ejections (CMEs) penetrate deep in the Earth’s atmosphere and change pressure pattern in the Arctic. This effect is larger during solar minima since the magnetic shielding then is reduced. The Arctic may then experience local warming. The transition of solar activities to a possibly deep and long minimum in the present century may indicate Arctic cooling and the BIE moving south this century. For the North Atlantic region, effects of the BIE expanding southward will have noticeable consequences for the ocean bio-production from about 2040.

关键词： Barents Sea Ice Edge Position Cyclic and Non-Linear Changes Lunar and Solar Forcing Planetary Orbit Synchronization

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低碳源条件下利用侧流活性污泥水解技术强化生物脱氮除磷

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给水排水 2013年第1期39卷 53-57页

作者：刘智晓 Gert petersen 张伟 Alexander Grossmann 詹卫东首创爱华天津市政环境工程有限公司天津300191 EnviDan A/S 2770 KastrupDenmark Lund Institute of Technology Lund 北京首创股份有限公司北京100028

污水水质特性是决定生物脱氮除磷工艺处理效能的关键性影响因素,尤其是进水中可快速降解有机物(rbCOD)及挥发性脂肪酸(VFA)浓度与N、P浓度比值的高低,直接制约了N、P的去除效率,补加外部碳源往往成为污水处理厂迫不得已的选择,但是外部... 详细信息

污水水质特性是决定生物脱氮除磷工艺处理效能的关键性影响因素,尤其是进水中可快速降解有机物(rbCOD)及挥发性脂肪酸(VFA)浓度与N、P浓度比值的高低,直接制约了N、P的去除效率,补加外部碳源往往成为污水处理厂迫不得已的选择,但是外部商业碳源会导致高昂的运行费用及其他运行问题。近十年来,充分挖掘优先利用污水处理厂内碳源技术在国外得到发展和应用。介绍了回流活性污泥(RAS)进行水解补充碳源的技术优势及工艺选择,就采用RAS侧流水解发酵在国内某厂实施技术示范项目进行了介绍,以期为国内在开发活性污泥可持续性利用技术方面提供借鉴。

关键词：活性污泥污泥水解可快速降解有机物挥发性脂肪酸生物脱氮除磷内碳源

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Fecal microbiota transplantation for the treatment of irritable bowel syndrome:A systematic review and meta-analysis

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World Journal of Gastroenterology 2023年第20期29卷 3185-3202页

作者： Sofie Ingdam Halkjaer Bobby Lo Frederik Cold Alice Hojer Christensen Savanne Holster Julia Konig Robert Jan Brummer Olga C Aroniadis Perttu Lahtinen Tom Holvoet Lise Lotte Gluud Andreas Munk petersen Gastro Unit Medical DivisionCopenhagen University Hospital HvidovreHvidovre 2650Denmark Copenhagen IBD Center Copenhagen University Hospital HvidovreHvidovre 2650Denmark Department of Gastroenterology Aleris-Hamlet Hospitals CopenhagenSøborg 2860Denmark Nutrition-Gut-Brain Interactions Research Centre Faculty of Medicine and HealthSchool of Medical SciencesÖrebro UniversityÖrebro 70362Sweden Department of Internal Medicine Division of GastroenterologyRenaissance School of MedicineStony Brook University HospitalNew YorkNY 11794-8434United States Department of Internal Medicine Päijät-Häme Central HospitalLahti 15850Finland Department of Medicine University of HelsinkiHelsinki 00014Finland Department of Gastroenterology University Hospital GhentGhent 9000Belgium Department of Clinical Medicine University of CopenhagenCopenhagen 2200Denmark Department of Clinical Microbiology Copenhagen University Hospital HvidovreHvidovre 2650Denmark

BACKGROUND Irritable bowel syndrome(IBS)is the most prevalent gastrointestinal disorder in developed countries and reduces patients’quality of life,hinders their ability to work,and increases health care costs.A growing number of trials have demonstrated an aberrant gut microbiota composition in IBS,also known as‘gut dysbiosis’.Fecal microbiota transplantation(FMT)has been suggested as a treatment for *** To assess the efficacy and safety of FMT for the treatment of *** We searched Cochrane Central,MEDLINE,EMBASE and Web of Science up to 24 October 2022 for randomised controlled trials(RCTs)investigating the effectiveness of FMT compared to placebo(including autologous FMT)in treating *** primary outcome was the number of patients with improvements of symptoms measured using a validated,global IBS symptoms *** outcomes were changes in quality-of-life scores,non-serious and serious adverse *** ratios(RR)and corresponding 95%CI were calculated for dichotomous outcomes,as were the mean differences(MD)and 95%CI for continuous *** Cochrane risk of bias tool was used to assess the quality of the *** criteria were used to assess the overall quality of the *** Eight RCTs(484 participants)were included in the *** resulted in no significant benefit in IBS symptoms three months after treatment compared to placebo(RR 1.19,95%CI:0.68-2.10).Adverse events were reported in 97 participants in the FMT group and in 45 participants in the placebo group(RR 1.17,95%CI:0.63-2.15).One serious adverse event occurred in the FMT group and two in the placebo group(RR 0.42,95%CI:0.07-2.60).Endoscopic FMT delivery resulted in a significant improvement in symptoms,while capsules did *** did not improve the quality of life of IBS patients but,instead,appeared to reduce it,albeit non significantly(MD-6.30,95%CI:-13.39-0.79).The overall quality of the evidence was low due to moderate-high inconsistency,the small number of

关键词： Fecal microbiota transplantation Irritable bowel syndrome Meta-analysis Systematic review

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Implementation of Automated Sample Quality Control in Whole Exome Sequencing

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Journal of Life Sciences 2017年第6期11卷 261-268页

作者： Elisa Viering Jana Molitor Leslie Friedmann Jana petersen Marie Beckhaus Stephan Wolf Agilent Technologies Inc. Waldbronn 76337 Germany DKFZ Genomics and Proteomics Core Facility High Throughput Sequencing Unit Heidelberg 69120 Germany

Aims： High-quality DNA as input material for a NGS （next-generation sequencing） workflow is essential for the successful preparation of a DNA library. Additionally, DNA quality has a strong impact on sequencing results. Therefore, it is important to include QC （quality control） steps to assess size, concentration, molarity, and integrity of the DNA during the workflow. Material and Methods： The WES （Whole Exome Sequencing） workflow at the Genomics and Proteomics Core Facility of DKFZ （the German Cancer Research Center） was performed with several QC steps： QC of the input material, QC of intermediate products during library preparation, and QC of final libraries. The Agilent 4200 TapeStation system, which offers automated sample processing, was used to evaluate quantity, size, molarity, and integrity of the samples. Key Findings： The Agilent Genomic DNA ScreenTape assay offers an unbiased genomic DNA integrity assessment, which enables protocol adaption for optimized library preparation, for example, selection of a suitable shearing protocol. Additionally, QC steps during library preparation such as evaluation of library size, concentration, and molarity ensure maximal sequencing output. Significance： The automated and fast high-throughput analysis of genomic DNA with the 4200 TapeStation system helps to save labor time and costs. Additionally, the easy-to-use system can be integrated as a QC tool into the NGS workflow to ensure successful library preparation. QC steps enable the confirmation of suitable library size and concentration for the workflow.

关键词： NGS FFPE (Formalin-fixed Paraffin-embedded) WES DIN (DNA Integrity Number) QC 4200 TapeStation system.

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