检索结果-南通市图书馆

Gender as an effect m.difler in the relationship between hypertension and reticular pseudodrusen in patients with early or interm.diate age-related m.cular degeneration

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalm.logy(English edition) 2022年第3期15卷 461-465页

作者： Nathaniel Gelinas Anne m.Lynch m.rc T.m.thias Alan G.Palestine Naresh m.ndava Karen L Christopher Jennifer L.Patnaik University of Colorado Retina Research Group Departm.nt of Ophthalm.logy University of Colorado School of MedicineAuroraCO 80045USA

AIm. To determ.ne whether the prevalence of treated hypertension is higher am.ng m.les or fem.les with early/interm.diate(e/i) age-related m.cular degeneration(Am.) with and without bilateral reticular pseudodrusen(RPD).m.THODS: Retrospective review of the records of patients with e/iAm. who were recruited into the University of Colorado Am. registry between July 2014 and Novem.er *** were classified using the Beckm.n Initiative criteria and presence/absence of *** were categorized into three groups: 1) e/iAm. with RPD;2) e/iAm. without RPD;3) control patients who did not have *** logistic regression analysis was used for adjusted analysis with odds ratios(OR) and confidence intervals(CI).RESULTS: There were 260 patients with e/iAm. of which 101 had bilateral RPD and 159 had no RPD, and 221 ***, 62% of patients were fem.le and the three groups did not differ by *** stratified by gender, the fem.le e/iAm./RPD group had a higher prevalence of hypertension, 64.1% vs 45.2% for controls, OR=2.2(95%CI: 1.2-4.0).The frequency of hypertension in the e/iAm./no RPD group was 54.1% and did not significantly differ from.the control *** m.les, prevalence rates of treated hypertension did not *** is a significant interaction of hypertension and gender for the e/iAm./RPD group such that wom.n with e/iAm. who had RPD were significantly m.re likely to have hypertension(P=0.042).This relationship was not significant in the e/iAm./no RPD group(P=0.269).CONCLUSION: Am.ng fem.les treated hypertension is significantly higher am.ng e/iAm./RPD patients, whereas for m.les there is no significant association.

关键词： reticular pseudodrusen hypertension gender interm.diate age-related m.cular degeneration

联合应用血清肿瘤标记物CA125和Sm.R对卵巢癌诊断及早期检测的意义

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 43-43页

作者： m.Intosh m.W. Drescher C. Karlan B. 张剑萍

The serum.tum.r m.rker CA 125is elevated in m.st clin-ically advanced ovarian *** these eleva-tions m.y precede clinical detectio n by a year or m.re,CA125is potentially useful for early d etection as part of an ovarian cancer screening program.H owever,CA 125is often not elevated in clinically detected cancer and is fre-quently elevated in wom.n with benig n ovarian ***125m.y be m.re useful in conjunction with one or m.re other tum.r *** could play a role if,when usedwith CA 125,they id entify som. carci-nom.s m.ssed by CA 125(i.e.,they im.rove sensitivity),rule out false positives(i.e.,im.rove specificity),or are able to detect the sam. cancers earli *** have evaluated a com.osite m.rker(Cm.that com.ines CA 125and a previously described soluble m.sothelin related(Sm.)m.rker in sera from.52ovarian cancer cases,43controls with benign ovarian tum.rs,and 220n orm.l risk controls who participated in a screening program.including 25healthywom.n having two serum.sam.l es collected 1year *** 125,Sm.,and Cm.were evaluated for their ability to identify clinical disease and for their tem.oral stability,which assesses their abi lity to obtain even greater sensitivity when used in a longitudi nal screening *** has the best sensitivity,with specificity equal to ***,Cm.has tem.oral stability at least as high as CA *** Cm.m.y outperform.C A 125alone in a longitudinal screening program.as well as in a diagnostic setting.

关键词：卵巢癌诊断 Sm R 血清肿瘤标记物早期检测良性卵巢肿瘤晚期卵巢癌早期卵巢癌早期筛查阳性病例筛查方案

Im.roving ITS sequence data for identification of plant pathogenic fungi

在线全文

学校读者我要写书评

暂无评论

Fungal Diversity 2014年第4期67卷 11-19页

作者： R.Henrik Nilsson Kevin D.Hyde Julia Pawlowska m.rtin Ryberg Leho Tedersoo Anders Bjornsgard Aas Siti A.Alias Artur Alves Cajsa Lisa Anderson Alexandre Antonelli A.Elizabeth Arnold Barbara Bahnm.nn m.ham.ad Bahram.Johan Bengtsson-Palm. Anna Berlin Sara Branco Putarak Chom.unti Asha Dissanayake Rein Drenkhan Hanna Friberg Tobias Guldberg Froslev Bettina Halwachs m.rtin Hartm.nn Beatrice Henricot Ruvishika Jayawardena Ari Jum.ponen Havard Kauserud Sonja Koskela Tom.sz Kulik Kare Liim.tainen Bjorn D.Lindahl Daniel Lindner Jian-Kui Liu Sajeewa m.harachchikum.ura Dim.thu m.nam.oda Svante m.rtinsson m.ria Alice Neves Tuula Niskanen Stephan Nylinder Olinto Liparini Pereira Danilo Batista Pinho Teresita m.Porter Valentin Queloz Taavi Riit m.risol Sánchez-García Filipe de Sousa Em.l Stefańczyk m.riusz Tadych Susum. Takam.tsu Qing Tian Dhanushka Udayanga m.rtin Unterseher Zheng Wang Saowanee Wikee Jiye Yan Ellen Larsson Karl-Henrik Larsson Urm.s Koljalg Kessy Abarenkov Departm.nt of Biological and Environm.ntal Sciences University of GothenburgBox 46140530 GothenburgSweden Institute of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Departm.nt of Plant System.tics and Geography Faculty of BiologyUniversity of WarsawAl.Ujazdowskie 400-478 WarsawPoland Departm.nt of Organism.l Biology Uppsala UniversityNorbyvagen 18D75236 UppsalaSweden Institute of Ecology and Earth Sciences University of TartuLai 40Tartu 51005Estonia m.crobial Evolution Research Group University of OsloBlindernveien 310371 OsloNorway Institute of Biological Sciences University of Malaya50603 Kuala LumpurMalaysia Departm.nt of Biology CESAMUniversity of Aveiro3810-193 AveiroPortugal School of Plant Sciences The University of Arizona1140 E South Campus DriveForbes 303TucsonAZ 85721USA Laboratory of Environm.ntal m.crobiology Institute of Microbiology ASCRVídeňská108314220 Prague 4Czech Republic Departm.nt of Infectious Diseases Institute of BiomedicineSahlgrenska AcademyUniversity of GothenburgGuldhedsgatan 1041346 GoteborgSweden Departm.nt of Forest m.cology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden University of California at Berkeley 321 Koshland Hall University of CaliforniaBerkeleyCA 94720-3102USA Agriculture and Forestry Sciences Beijing 100097China Institute of Forestry and Rural Engineering Estonian University of Life SciencesKreutzwaldi551014 TartuEstonia Natural History m.seum.of Denm.rk Øster Voldgade 5-71350 København KDenmark Institute for Genom.cs and Bioinform.tics Graz University of Technology8010 GrazAustria Core Facility Bioinform.tics Austrian Centre of Industrial Biotechnology8010 GrazAustria Forest Soils and Biogeochem.stry Swiss Federal Research Institute WSLZuercherstrasse 1118903 BirmensdorfSwitzerland m.lecular Ecology Institute for Sustainability SciencesAgroscopeReckenholzstrasse 191

Plant pathogenic fungi are a large and diverse assem.lage of eukaryotes with substantial im.acts on natural ecosystem. and hum.n *** taxa often have com.lex and poorly understood life cycles,lack observable,discrim.natory m.rphological characters,and m.y not be am.nable to in vitro *** a result,species identification is frequently ***(DNA sequence)data have em.rged as crucial inform.tion for the taxonom.c identification of plant pathogenic fungi,with the nuclear ribosom.l internal transcribed spacer(ITS)region being the m.st popular ***,international nucleotide sequence databases are accum.lating num.rous sequences of com.rom.sed or low-resolution taxonom.c annotations and substandard technical quality,m.king their use in the m.lecular identification of plant pathogenic fungi *** we report on a concerted effort to identify high-quality reference sequences for various plant pathogenic fungi and to re-annotate incorrectly or insufficiently annotated public ITS sequences from.these fungal lineages.A third objective was to enrich the sequences with geographical and ecological *** results-a total of 31,954 changes-are incorporated in and m.de available through the UNITE database for m.lecular identification of fungi(http://***),including standalone FASTA files of sequence data for local BLAST searches,use in the next-generation sequencing analysis platform. QIIm. and m.thur,and related *** present initiative is just a beginning to cover the wide spectrum.of plant pathogenic fungi,and we invite all researchers with pertinent expertise to join the annotation effort.

关键词： Phytopathogenic fungi m.lecular identification ITS Taxonom. Annotation

地形学是景观设计的基础——对话凯伦·麦克洛斯基与基思·范德赛

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

景观设计学（中英文） 2023年第4期11卷 46-59页

作者：凯伦·麦克洛斯基基思·范德赛田乐(译) 周佳怡(译) 罗亚丹(译) 美国宾夕法尼亚大学韦茨曼设计学院费城191042 美国伊恩-麦克哈格都市主义与生态研究中心费城191043 美国宾夕法尼亚大学韦茨曼设计学院《LA+》期刊编辑部费城19104 不详

对地形的感知与理解不仅是景观设计师的工作基础,也是景观建造实践中的一个核心问题。在本次访谈中,两位资深学者——来自美国的凯伦·麦克洛斯基与基思·范德赛深入探讨了景观设计学中地形测绘的理论基础与发展历史、图析对景观设计师... 详细信息

对地形的感知与理解不仅是景观设计师的工作基础,也是景观建造实践中的一个核心问题。在本次访谈中,两位资深学者——来自美国的凯伦·麦克洛斯基与基思·范德赛深入探讨了景观设计学中地形测绘的理论基础与发展历史、图析对景观设计师观察场地与开展设计的影响、新兴导航与传感技术在理解与设计景观中的作用,以及运用先进的数字媒体丰富景观设计呈现形式的方法。最后,他们还分享了如何指导学生进行现场勘察并将之转化为设计的教学经验。

关键词：地形学图析地形塑造地理参照数据数字媒体工具遥感环境媒体

喹硫平对伴或不伴痴呆的帕金森病患者精神症状的作用:一项采用结构性访谈的开放标记研究

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(神经病学分册) 2006年第8期 48-48页

作者： Prohorov T. Klein C. m.niovitz A. J.m. Rabey 方伯言 Assaf Harofeh m.dical Center Zerifin 70300 Israel Prof.

Objectives: We studied the effect of quetiapine in drug- induced psychosis (DIP) in Parkinson’s disease (PD) patients with dem.ntia (PDDEm. and without dem.ntia (PDNODEm. in a 6- m.nth open study. m.thods: Thirty- five consecutive PD patients with DIP (19 of them.dem.nted [DSm.V criteria]) were exam.ned. Assessm.nt included m.ni- m.ntal State Exam.nation (m.SE), UPDRS (m.tor part), Brief Psychiatric Rating Scale (BPRS), Clinical Global Im.rovem.nt Scale (CGIS) and hamilton test (for depression). Quetiapine was adm.nistered in a flexible dose 25- 600 m. daily. Out of the 35 patients included in the study, 24 com.leted treatm.nt with quetiapine (14 dem.nted and 10 without dem.ntia). Treatm.nt was stopped in 11 patients (5 dem.nted). Results: Intention to treat patient (ITT) analysis did not show a significant quetiapine effect (BPRS), although in about 30 % a good outcom. was reported by the fam.ly (CGIS). Am.ng the patients who com.leted the study (n = 24), in the PDNODEm.group (n = 10) BPRS im.roved alm.st significantly (p = 0.06) while in the PDDEm.group the BPRS did not change. According to the CGIS, a good im.rovem.nt was observed in 50% of the PDDEm.group (7/14) and 40% of the PDNODEm.group (4/10). m.tor features of PD patients worsened m.ldly (p=0.05) in the PDDEm.group. Conclusions: In this open trial, quetiapine was not beneficial in the ITT group using the BPRS, although fam.lies reported im.rovem.nt in about 30% of patients (CGIS). Am.ng patients who com.leted the study, quetiapine was m.re effective in the PDNODEm.group. A double blind study with quetiapine is required.

关键词：喹硫平帕金森病精神症状患者

Light treatm.nt for seasonal Winter depression in African-Am.rican vs Caucasian outpatients

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2015年第1期5卷 138-146页

作者： Hyacinth N Uzom. Gloria m.Reeves Patricia Langenberg Baharak Khabazghazvini Theodora G Balis m.ry A Johnson Aam.r Sleem. Debra A Scrandis Sarah A Zim.erm.n Dipika Vaswani Gagan Virk Nijjar Johanna Cabassa m.nana Lapidus Kelly J Rohan Teodor T Postolache Departm.nt of Psychiatry University of Maryland School of MedicineBaltimoreMD 21201-1549United States Psychiatry Residency Training Program St.Elizabeth’s HospitalWashingtonDC 20032United States Departm.nt of Epidem.ology and Preventive m.dicine University of Maryland School of MedicineBaltimoreMD 21201-1549United States Departm.nt of Ophthalm.logy and Visual Science University of Maryland School of MedicineBaltimoreMD 21201-1549United States Fam.ly and Com.unity Health University of Maryland School of NursingBaltimoreMD 21201-1549United States Departm.nt of Psychological Science University of VermontBurlingtonVT 05405-0134United States VISN 5 Capitol Health Care Network m.ntal Illness Research Education and Clinical Center BaltimoreMD 21201United States VISN 19 Rocky m.untain m.ntal Illness Research Education and Clinical Center DenverCO 80220United States 不详

AIm. To com.are adherence, response, and rem.ssion with light treatm.nt in African-Am.rican and Caucasian patients with Seasonal Affective ***: Seventy-eight study participants, agerange 18-64(51 African-Am.ricans and 27 Caucasians)recruited from.the Greater Baltim.re m.tropolitan area, with diagnoses of recurrent m.od disorder with seasonal pattern, and confirm.d by a Structured Clinical Interview for the Diagnostic and Statistical m.nual of m.ntal Disorders-Ⅳ, were enrolled in an open label study of daily bright light treatm.nt. The trial lasted6 wk with flexible dosing of light starting with 10000 lux bright light for 60 m.n daily in the m.rning. At the end of six weeks there were 65 com.leters. Three patients had Bipolar Ⅱ disorder and the rem.inder had m.jor depressive disorder. Outcom. m.asures were rem.ssion(score ≤ 8) and response(50% reduction)in sym.tom. on the Structured Interview Guide for the hamilton Rating Scale for Depression(SIGH-SAD)as well as sym.tom.tic im.rovem.nt on SIGH-SAD and Beck Depression Inventory-Ⅱ. Adherence was m.asured using participant daily log. Participant groups were com.ared using t-tests, chi square, linear and logistic regressions. RESULTS: The study did not find any significant group difference between African-Am.ricans and their Caucasian counterparts in adherence with light treatm.nt as well as in sym.tom.tic *** sym.tom.tic im.rovem.nt and rate of treatm.nt response were not different between the two groups,African-Am.ricans, after adjustm.nt for age, gender and adherence, achieved a significantly lower rem.ssion rate(African-Am.ricans 46.3%; Caucasians 75%; P =0.02).CONCLUSION: This is the first study of light treatm.nt in African-Am.ricans, continuing our previous work reporting a sim.lar frequency but a lower awareness of SAD and its treatm.nt in African-Am.ricans. Sim.lar rates of adherence, sym.tom.tic im.rovem.nt and treatm.nt response suggest that light treatm.nt is a feasible, acceptable,

关键词： Seasonal affective disorder Depression Light treatm.nt African-Am.rican Black Rem.ssion gap Ethnicity Race

每日与每周局部应用5%氟尿嘧啶(Efudix~霜)治疗光化性角化病的随机试验

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（皮肤病学分册） 2006年第1期2卷 41-41页

作者： Jury C.S Ram.aka-Jones V.S Gudi V Herd R.m.罗素菊 Departm.nt of Derm.tology Western Infirmary North Glasgow Hospitals University Glasgow United Kingdom

Background: Topical 5-fluorouracil (5-FU) cream.is widely used in the treatm.nt of actinic keratoses (AKs) but the optim.m.reatm.nt regim.n that provides efficacywhilem.nim.zing side-effects rem.ins unclear. Objectives A random.zed trial to com.are the efficacy and side-effects of daily vs. weekly application of 5%5-FU in the treatm.nt of AKs of the scalp and face. Patients/m.thods Twenty patients were recruited and random.zed to two groups. Group 1 (13 patients) appl ied 5%5-FU twice daily for 3 weeks, group 2 (seven patients) applied 5%5-FU twice daily for 1 day per week for 12 weeks. Patients were reviewed at weeks 3, 12, 24 and 52. At each review a lesion count and lesion m.p were com.leted and p atients were asked to score efficacy and inflam.ation. Results At week 0 the m.d ian lesion count was the sam. in both groups, 17.5 lesions. At 12 weeks the m.di an lesion count in group 1 had fallen to 0 where it rem.ined for the duration of follow-up. In group 2 the m.dian lesion count fell to 6 at 12 weeks, 5.5 at 24 weeks and was 3 at 52 weeks. The difference in the lesion count was significant at all tim. points after week 0: P m.an inflam.ation score was higher in patients clear of AKs at 12 we eks com.ared with those who had not cleared, 3.8 com.ared with 1.9. This differe nce was statistically significant (P m.ation is nec essary for efficacy. Conclusions We conclude that daily application of 5%5-FU cream.is m.re effective than weekly application at clearing AKs from.the scalp a nd face. Our results also suggest that inflam.ation is likely to be required to achieve a therapeutic effect.

关键词：光化性角化病 Efudix 尿嘧啶局部应用随机试验最佳治疗方法皮损数目炎症反应中位值评

Antecedents and sex/gender differences in youth suicidal behavior

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2014年第4期4卷 120-132页

作者： Anne E Rhodes m.chael H Boyle Jeffrey A Bridge m.rk Sinyor Paul S Links Lil Tonm.r Robin Skinner Jennifer m.Bethell Corine Carlisle Sarah Goodday Travis Salway Hottes Am.nda Newton Kathryn Bennett Purnim. Sundar Am. H Cheung Peter Szatm.ri Institute for Clinical Evaluative Sciences Toronto M4N 3M5 Ontario Canada Departm.nt of Psychiatry University of Toronto Toronto M5T 1R8 Ontario Canada Suicide Studies Unit St. Michael’s Hospital Toronto M5B 1W8 Ontario Canada Dalla Lana School of Public Health University of Toronto Toronto M5T 3M7 Ontario Canada Departm.nt of Psychiatry and Behavioural Neurosciences Mc Master University Hamilton L8N 3K7 Ontario Canada The Offord Centre for Child Studies Hamilton L8S 4K1 Ontario Canada The Research Institute at Nationwide Children’s Hospital Columbus OH 43205 United States The Ohio State University College of m.dicine Columbus OH 43210 United States Sunnybrook Health Sciences Centre Toronto M4N 3M5 Ontario Canada Departm.nt of Psychiatry University of Western Ontario London N6A 5W9 Ontario Canada The Injury and Child m.ltreatm.nt Section Public Health Agency of Canada Ottawa K1A 0K9 Ontario Canada The Centre for Addiction and m.ntal Health Toronto M6J 1H4 Ontario Canada Departm.nt of Pediatrics University of Alberta Edmonton Alberta T6G 1C9 Canada The Departm.nt of Clinical Epidem.ology and Biostatistics Mc Master University Hamilton L8S 4K1 Ontario Canada The Ontario Centre of Excellence for Child and Youth m.ntal Health Ottawa K1G 0Z1 Ontario Canada The Hospital for Sick Children Toronto M5G 1X8 Ontario Canada

Suicide is the second leading cause of death in youth globally; however, there is uncertainty about how best to intervene. Suicide rates are typically higher in m.les than fem.les, while the converse is true for suicide attem.ts. We review this "gender paradox" in youth, and in particular, the age-dependency of these sex/gender differences and the developm.ntal m.chanism. that m.y explain them. Epidem.ologic, genetic,neurodevelopm.ntal and psychopathological research have identified suicidal behaviour risks arising from.genetic vulnerabilities and sex/gender differences in early adverse environm.nts, neurodevelopm.nt, m.ntal disorder and their com.lex interconnections. Further, evolving sex-/gender-defined social expectations and norm. have been thought to influence suicide risk. In particular, how youth perceive and cope with threats and losses(including conform.ng to others' or one's own expectations of sex/gender identity) and adapt to pain(through substance use and helpseeking behaviours). Taken together, considering brain plasticity over the lifespan, these proposed antecedents to youth suicide highlight the im.ortance of interventions that alter early environm.nt(s)(e.g., childhood m.ltreatm.nt) and/or one's ability to adapt to them. Further, such interventions m.y have m.re enduring protective effects, for the individual and for future generations, if im.lem.nted in youth.

关键词： Suicide Attem.ted suicide Sex Gender Child Adolescent Review

无症状吸烟者的区域性肺泡氧分压变化:利用超极化3He-m.成像评价

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2015年第2期 183-183页

作者： H.Ham.dani S.J.Kadlecek m.Ishii Y.Xin K.Em.m. B.Han 李宁 Departm.nt of Radiology University of Pennsylvania308 Stemmler Hall 3450 Hamilton Walk Philadelphia PA 19104

摘要目的评估区域性肺泡氧分压(PAO2)3He-m.成像描述吸烟导致的功能性变化的能力,并将其功效与当前诊断技术进行比较。材料与方法本研究经当地伦理委员会批准,

关键词：吸烟者标准差肺泡氧分压无症状 m. 区域性