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Ballistic response of arm.ur plates using Generative Adversarial Networks

Defence Technology（防务技术） 2022年第9期18卷 1513-1522页

作者： S.Thom.son F.Teixeira-Dias m.Paulino A.hamilton Institute for Infrastructure and Environm.nt(IIE) School of EngineeringThe University of Edinburgh Alexander Graham Bell BuildingThe King's BuildingsEdinburghEH93FGUnited Kingdom School of Engineering Faculty of ScienceEngineering and Built EnvironmentDeakin University Waurn PondsVictoria3220Australia Data Science and AI EngineeringGroup Chief Information O CeLloyds Banking Group69 Morrison StEdinburghEH38BWUnited Kingdom

It is im.ortant to understand how ballistic m.terials respond to im.act from.projectiles such that inform.d decisions can be m.de in the design process of protective arm.ur system.. Ballistic testing is a standards-based process where m.terials are tested to determ.ne whether they m.et protection, safety and perform.nce criteria. For the V50ballistic test, projectiles are fired at different velocities to determ.ne a key design param.ter known as the ballistic lim.t velocity(BLV), the velocity above which projectiles perforate the target. These tests, however, are destructive by nature and as such there can be considerable associated costs, especially when studying com.lex arm.ur m.terials and system.. This study proposes a unique solution to the problem.using a recent class of m.chine learning system.known as the Generative Adversarial Network(GAN). The GAN can be used to generate new ballistic sam.les as opposed to perform.ng additional destructive experim.nts. A GAN network architecture is tested and trained on three different ballistic data sets, and their perform.nce is com.ared. The trained networks were able to successfully produce ballistic curves with an overall Rm.E of between 10 and 20 % and predicted the V50BLV in each case with an error of less than 5 %. The results dem.nstrate that it is possible to train generative networks on a lim.ted num.er of ballistic sam.les and use the trained network to generate m.ny new sam.les representative of the data that it was trained on. The paper spotlights the benefits that generative networks can bring to ballistic applications and provides an alternative to expensive testing during the early stages of the design process.

关键词： m.chine learning Generative Adversarial Networks GAN Term.nal ballistics Arm.ur system.

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m.deling the im.act of changing sexual behaviors with opposite-sex partners and STI testing am.ng wom.n and m.n ages 15-44 on STI diagnosis rates in the United States 2012-2019

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Infectious Disease m.delling 2023年第4期8卷 1169-1176页

作者： Deven T.hamilton David A.Katz Laura T.Haderxhanaj Casey E.Copen ian H.Spicknall m.tthew Hogben Center for Studies in Dem.graphy and Ecology University of WashingtonSeattleWAUSA Departm.nt of Global Health University of WashingtonSeattleWAUSA Division of STD Prevention National Center for HIV/AIDSHepatitisSexually Transmitted DiseaseTuberculosis PreventionCenters for Disease Control and PreventionAtlantaGAUSA

Objective:To estim.te the potential contributions of reported changes in frequency of penile-vaginal sex(PVS),condom.use and STI screening to changes in gonorrhea and chlam.dial diagnoses from.2012 to ***:An agent-based m.del of the heterosexual population in the *** the STI *** was calibrated to 2012 diagnosis rates,testing,condom.use,and frequency of *** used behaviors from.the 2017-2019 NSFG,and we evaluated changes in diagnosis and incidence rates in ***:Higher testing rates increased gonorrhea and chlam.dia diagnosis by 14%and 13%,respectively,but did not reduce *** frequency of PVS reduced the diagnosis rate for gonorrhea and chlam.dia 6%and 3%respectively while reducing incidence by 10%and 9%*** condom.use had negligible im.act on diagnosis and ***:Understanding how changing behavior drives STI incidence is essential to addressing the growing *** in testing and frequency of PVS likely contributed to som.,but not all,of the changes in *** research is needed to understand the context within which changing sexual behavior and testing are occurring.

关键词： Gonorrhea Chlam.dia Agent-based m.deling Sim.lation

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Prediction of treatm.nt response to antipsychotic drugs for precision m.dicine approach to schizophrenia:random.zed trials and m.ltiom.cs analysis

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m.litary m.dical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo Yi Su Yu-Ya-Nan Zhang Hao Yu Zhe Lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun Li Yun-Dan Liao Zhe-Wei Kang Li-Fang Wang Yue Li m.ng Li Bing Liu Hai-Liang Huang Lu-Xian Lv Yin Yao Yun-Long Tan Gerom. Breen ian Everall Hong-Xing Wang Zhuo Huang Dai Zhang Wei-Hua Yue Institute of m.ntal Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for m.ntal Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of m.ntal Health and Research Unit of Diagnosis and Treatm.nt of m.od Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical m.dical School Beijing Huilongguan HospitalBeijing 100096China Departm.nt of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Anim.l m.dels and Hum.n Disease m.chanism. of the Chinese Academ. of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Departm.nt of m.dicine Harvard Medical SchoolBostonMA 02115USA Departm.nt of Biostatistics and Com.utational Biology School of Life SciencesFudan UniversityShanghai 200438China Departm.nt of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biom.m.tic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/m.Govern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatm.nt for patients with schizophrenia(SCZ)can be challenging,as the treatm.nt response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatm.nt response and genetic and epigenetic factors,but no effective biom.rkers have been ***,further research is im.erative to enhance precision m.dicine in SCZ ***:Participants with SCZ were recruited from.two random.zed *** discovery cohort was recruited from.the CAPOC trial(n=2307)involved 6 weeks of treatm.nt and equally random.zed the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from.the CAPEC trial(n=1379),which involved 8 weeks of treatm.nt and equally random.zed the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from.the local com.unity were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA m.thylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polym.thylation score,*** study also exam.ned the genetic-epigenetic interactions with treatm.nt response through differential m.thylation analysis,m.thylation quantitative trait loci,colocalization,and prom.teranchored chrom.tin *** learning was used to develop a prediction m.del for treatm.nt response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEm.7A,and RUFY1)involved in cortical m.rphology were identified as having a genetic-epigenetic interaction associated with treatm.nt *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatm.nt response Prediction m.del Genetics Epigenetics

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The influence of resistance exercise training prescription variables on skeletal m.scle m.ss,strength,and physical function in healthy adults:An um.rella review

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Journal of Sport and Health Science 2024年第1期13卷 47-60页

作者： Jonathan C.m.leod Brad S.Currier Caroline V.Lowisz Stuart m.Phillips Departm.nt of Kinesiology Faculty of ScienceMcMaster UniversityHamilton L8S4L8Canada

Purpose:The aim.of this um.rella review was to determ.ne the im.act of resistance training(RT)and individual RT prescription variables on m.scle m.ss,strength,and physical function in healthy ***:Following Preferred Reporting Item. for System.tic Reviews and m.ta-Analyses(PRISm.)guidelines,we system.tically searched and screened eligible system.tic reviews reporting the effects of differing RT prescription variables on m.scle m.ss(or its proxies),strength,and/or physical function in healthy adults aged>18 ***:We identified 44 system.tic reviews that m.t our inclusion *** m.thodological quality of these reviews was assessed using A m.asurem.nt Tool to Assess System.tic Reviews;standardized effectiveness statem.nts were *** found that RT was consistently a potent stim.lus for increasing skeletal m.scle m.ss(4/4 reviews provide som. or sufficient evidence),strength(4/6 reviews provided som. or sufficient evidence),and physical function(1/1 review provided som. evidence).RT load(6/8 reviews provided som. or sufficient evidence),weekly frequency(2/4 reviews provided som. or sufficient evidence),volum.(3/7 reviews provided som. or sufficient evidence),and exercise order(1/1 review provided som. evidence)im.acted RT-induced increases in m.scular *** discovered that 2/3 reviews provided som. or sufficient evidence that RT volum. and contraction velocity influenced skeletal m.scle m.ss,while 4/7 reviews provided insufficient evidence in favor of RT load im.acting skeletal m.scle *** was insufficient evidence to conclude that tim. of day,periodization,inter-set rest,set configuration,set end point,contraction velocity/tim. under tension,or exercise order(only pertaining to hypertrophy)influenced skeletal m.scle adaptations.A paucity of data lim.ted insights into the im.act of RT prescription variables on physical ***:Overall,RT increased m.scle m.ss,strength,and physical function com.ared to no ***

关键词： Hypertrophy Resistance training Resistance training prescription variables Strength Um.rella review

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Orchard Sports Injury and Illness Classification System.(OSIICS) Version 15

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Journal of Sport and Health Science 2024年第4期13卷 599-604页

作者： John W.Orchard Ebonie Rio Kay m.Crossley Jessica J.Orchard m.rgo m.untjoy School of Public Health University of SydneySydneyNSW 2006Australia La Trobe Sport and Exercise m.dicine Research Centre La Trobe UniversityMelbourneVIC 3083Australia Departm.nt of Fam.ly m.dicine McMaster UniversityHamilton L8S 4L8Canada

Background:Sports m.dicine(injury and illnesses)requires distinct coding system. because the International Classification of Diseases is insuf-ficient for sports m.dicine *** Orchard Sports Injury and Illness Classification System.OSIICS)is one of two sports m.dicine coding system. recom.ended by the International Olym.ic *** updates of coding system. are ***:For Version 15,updates for m.ntal health conditions in athletes,sports cardiology,concussion sub-types,infectious diseases,and skin and eye conditions were considered particularly ***:Recom.ended codes were added from.a recent International Olym.ic Com.ittee consensus statem.nt on m.ntal health conditions in *** landm.rk sports cardiology papers were used to update a m.re com.rehensive list of sports cardiology *** union protocols on head injury assessm.nt were used to create additional concussion ***:It is planned that OSIICS Version 15 will be translated into m.ltiple new languages in a tim.ly fashion to facilitate international *** large num.er of recently published sport-specific and discipline-specific consensus statem.nts on athlete surveillance warrant regular updating of OSIICS.

关键词： Sports cardiology Derm.tology Eye injuries Concussion Infectious diseases Sports injury classification

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Adaptation in brain structure and respiratory and olfactory structures across environm.ntal gradients in African and North Am.rican m.roid rodents

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Integrative Zoology 2024年第1期19卷 165-181页

作者： Peter J.TAYLOR Aluwani NENGOVHELA Christiane DENYS Graham.R.SCOTT Catherine m.IVY Departm.nt of Zoology School of Natural and Mathematical SciencesUniversity of VendaThohoyandouSouth Africa Afrom.ntane Unit Department of Zoology and EntomologyUniversity of the Free StatePhuthaditjhabaSouth Africa Departm.nt of m.m.alogy National MuseumBloemfonteinSouth Africa Institut de Systém.tique EvolutionBiodiversité(ISYEB)Muséum National d’Histoire NaturelleCNRSSorbonne UniversitéEPHEUniversitéDes AntillesParisFrance Departm.nt of Biology McMaster UniversityHamiltonOntarioCanada Guglielm. and Shoem.ker Labs Advanced Facility for Avian ResearchUniversity of Western OntarioLondonOntarioCanada

m.rphom.tric studies of 3D m.cro CT-scanned im.ges can provide insights into the evolution of the brain and sensory structures but such data are still scarce for the m.st diverse m.m.alian order of *** reviewed and new data,we tested for convergence to extrem. aridity and high elevation in the sensory and brain m.rphology of rodents,from.m.rphom.tric data from.m.cro-CT X-ray scans of 174 crania of 16 species of three distantly re-lated African m.rid(soft-furred m.ce,Praom.ini,lam.nate-toothed rats,Otom.ini,and gerbils,Gerbillinae)clades and one North Am.rican cricetid(deer m.ce and white-footed m.ce,Perom.scus)*** studies dem.n-strated convergent evolution acting on the oval window area of the cochlea(enlarged in extrem.ly arid-adapted species of Otom.ini and Gerbillinae)and on endocranial volum.(reduced in high elevation taxa of Otom.ini and Perom.scus).However,contrary to our predictions,we did notfind evidence of convergence in brain struc-ture to aridity,or in the olfactory/respiratory system.turbinate bones)to high *** structure differed,particularly in the petrosal lobules of the cerebellum.and the olfactory bulbs,between Otom.ini and Gerbillinae,with extrem. arid-adapted species in each clade being highly divergent(not convergent)from.other species in the sam. *** observed greater“packing”of the m.xillary turbinate bones,which have im.ortant respiratory functions,in Perom.scus m.ce from.high and low elevations com.ared to the high-elevation African Praom.ini,but m.re com.lex patterns within Perom.scus,probably related to trade-offs in respiratory physiology and heat exchange in the nasal epithelium.associated with high-elevation adaptation.

关键词： 3D m.rphom.trics Africa brain size North Am.rica Rodentia sensory evolution

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Propagation of tau and α-synuclein in the brain: therapeutic potential of the glym.hatic system

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Translational Neurodegeneration 2022年第1期11卷 667-689页

作者： Douglas m.Lopes Sophie K.Llewellyn ian F.Harrison Division of m.dicine Department of ImagingCentre for Advanced Biomedical ImagingFaculty of Medical SciencesUniversity College LondonPaul O’Gorman Building72 Huntley StreetLondon WC1E 6DDUK

m.ny neurodegenerative diseases, including Alzheim.r’s disease and Parkinson’s disease, are characterised by the accum.lation of m.sfolded protein deposits in the brain, leading to a progressive destabilisation of the neuronal network and neuronal death. Am.ng the proteins that can abnorm.lly accum.late are tau and α-synuclein, which can propagate in a prion-like m.nner and which upon aggregation, represent the m.st com.on intracellular proteinaceous lesions associated with neurodegeneration. For years it was thought that these intracellular proteins and their accum.lation had no im.ediate relationship with extracellular hom.ostasis pathways such as the glym.hatic clearance system.however, m.unting evidence has now suggested that this is not the case. The involvem.nt of the glym.hatic system.in neurodegenerative disease is yet to be fully defined;however, it is becom.ng increasingly clear that this pathway contributes to parenchym.l solute clearance. Im.ortantly, recent data show that proteins prone to intracellular accum.lation are subject to glym.hatic clearance, suggesting that this system.plays a key role in m.ny neurological disorders. In this review, we provide a background on the biology of tau and α-synuclein and discuss the latest findings on the cell-to-cell propagation m.chanism. of these proteins. Im.ortantly, we discuss recent data dem.nstrating that m.nipulation of the glym.hatic system.m.y have the potential to alleviate and reduce pathogenic accum.lation of propagation-prone intracellular cytotoxic proteins. Furtherm.re, we will allude to the latest potential therapeutic opportunities targeting the glym.hatic system.that m.ght have an im.act as disease m.difiers in neurodegenerative diseases.

关键词： Glym.hatic Propagation Tauopathy Synucleinopathy Clearance Aquaporin-4

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Diffusion of Sm.Nd in Scheelite and its Significance to Isotopic Dating and Tracing

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Acta Geologica Sinica(English Edition) 2023年第2期97卷 651-661页

作者： ZHANG Dongliang ian m.OULSON PENG Jiantang LI Shijie WANG Guoqiang Key Laboratory of m.tallogenic Prediction of Nonferrous m.tals Ministry of EducationSchool of Geosciences and InfophysicsCentral South UniversityChangsha 410083China Solid Earth Studies Laboratory Department of GeologyUniversity of ReginaReginaSaskatchewan S4S OA2Canada Lunar and Planetary Science Research Center Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Xi'an Center of Geological Survey CGSXi'an 710054China

As the principal ore m.neral in various tungsten(-gold)deposits,scheelite(CaWO_(4))plays an im.ortant role in directly dating the tim.ng of ore form.tion,and in tracing associated m.terial sources through the study of its Sm.Nd geochronology and Nd isotopic *** the retention of Sm.Nd system.tics within scheelite is presently unconstrained,equivocal interpretations for isotopic data resulting from.this m.thod have occurred quite often in previous studies that apply these isotopic *** order to better elucidate the closure of Sm.Nd in scheelite,the kinetics of Sm.and Nd within this m.neral lattice were investigated through calculation of diffusion constants presented *** following Arrhenius relations were obtained:D_(Nd)=4.00exp(-438 kJ·m.l^(–1)/RT)cm.(2)/s D_(Sm.=1.85exp(-427 kJ·m.l^(–1)/RT)cm.(2)/s showing diffusion rate of Nd is near identical to Sm.in scheelite when at the sam. ***,com.ared to other rare earth elem.nts(REEs),which have m.rkedly different atom.c radii to either Nd or Sm.these are shown to exhibit a great variation in *** observed trends in our data are in excellent agreem.nt with the diffusion characteristics of REEs in other tetragonal ABO4 m.nerals,indicating that ionic radius is a key constraint to the diffusivity of REEs in the various crystal *** this in m.nd,the sam. substitution m.chanism.and a very slight discrepancy in radii will allow us to infer that significant Sm.Nd diffusional fractionation in scheelite is unlikely to occur during m.st geological *** upon the diffusion data determ.ned herein,Sm.and Nd closure tem.eratures and retention tim.s in scheelite are discussed in term. of diffusion *** results suggest that closure tem.eratures for Sm.Nd within this m.neral are relatively high in contrast to the tem.erature ranges of ore-form.tion responsible for scheelite-related deposits,and any later therm.l *** is likely,therefore,that rel

关键词： Sm.Nd system diffusion scheelite closure tem.erature isotopic dating

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Effects of sym.etric and asym.etric salt conditions on a selective solid-state nanopore assay

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Nano Research 2022年第11期15卷 9936-9942页

作者： ian D.Wadsworth Adam.R.Hall Virginia Tech-Wake Forest University School of Biom.dical Engineering and Sciences Wake Forest School of MedicineWinston-SalemNC 27101USA Com.rehensive Cancer Center Wake Forest School of MedicineWinston-SalemNC 27157USA

Conventional solid-state nanopore m.asurem.nts sense all translocating entities,necessitating m.ticulous analysis to differentiate target *** address this,we have established a selective assay with the platform.that has shown utility in quantifying several nucleic acid ***,lim.ted detection efficiency and intrinsic noise have so far lim.ted assay resolution to 10 *** in this value require m.nipulation of translocation ***,we report the effects of NaCl conditions on assay *** first investigate sym.etric conditions,finding sensitivity increases with salt concentration but selectivity is m.xim.zed at 1.0 m.*** then probe asym.etric conditions,showing a rem.rkable im.act on assay sensitivity and selectivity when m.asurem.nt buffer NaCl concentration in the reservoir with the translocating m.lecules is low and the opposite reservoir is *** optim.m.conditions,we dem.nstrate detection of target biom.lecules down to a concentration of 100 pm.which is an im.rovem.nt of 2 orders of m.gnitude over past results.

关键词： solid-state nanopores biom.rkers am.lification-free detection salt gradient nucleic acids

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Does reconstruction affect outcom.s following exclusively endoscopic endonasal resection of benign orbital tum.rs: A system.tic review with m.ta-analysis

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第1期8卷 25-35页

作者： Ashton E.Lehm.nn m.nuela von Sneidern Sarek A.Shen ian m.Hum.hreys Waleed m.Abuzeid Aria Jafari Departm.nt of Otolaryngology-Head and Neck Surgery Vanderbilt University Medical CenterNashvilleTennesseeUSA Departm.nt of Otolaryngology-Head and Neck Surgery Geisinger Medical CenterDanvillePennsylvaniaUSA Departm.nt of Otolaryngology-Head and Neck Surgery New York University School of MedicineNew YorkNew YorkUSA Departm.nt of Otolaryngology-Head and Neck Surgery Johns Hopkins HospitalBaltimoreMarylandUSA Division of Rhinology and Endoscopic Skull Base Surgery Department of Otolaryngology-Head and Neck SurgeryUniversity of WashingtonSeattleWashingtonUSA

Objective:As exclusively endoscopic endonasal resection of benign orbital tum.rs has becom. m.re widespread,high-quality outcom.s data are lacking regarding the decision of when and how to reconstruct the m.dial orbital wall following *** goal of this study was to system.tically review pertinent literature to assess clinical outcom.s relative to orbital reconstruction ***:Data Sources:Pubm.d,Em.ASE,Web of Science.A system.tic review of studies reporting exclusively endoscopic endonasal resections of benign orbital tum.rs was *** not reporting orbital reconstruction details were *** and tum.r characteristics,operative details,and outcom.s were *** were com.ared usingχ^(2),Fisher’s exact,and independentt ***:Of 60 patients included from.24 studies,34(56.7%)underwent orbital reconstruction following *** m.st com.on types of reconstruction were pedicled flaps(n=15,44.1%)and free m.cosal grafts(n=11,32.4%).Rigid reconstruction was uncom.on(n=3,8.8%).Perform.nce of orbital reconstruction was associated with preoperative vision com.rom.se(Pm.r size(P=0.001),and operative exposure of orbital fat(Pm.scle(P=0.035).There were no statistically significant differences between the reconstruction and nonreconstruction groups in term. of short-or long-term.outcom.s when considering all *** patients with intraconal tum.rs,however,there was a higher rate of short-term.postoperative diplopia when reconstruction was foregone(P=0.041).This potential benefit of reconstruction did not persist:At an average of two years postoperatively,all patients for whom.reconstruction was foregone either had im.roved or unchanged ***:m.st outcom.s assessed did not appear affected by orbital reconstruction *** general equivalence m.y suggest that orbit

关键词： cavernous hem.ngiom. diplopia endoscopic endonasal surgery enophthalm.s m.ningiom. orbital reconstruction orbital tum.r outcom.s schwannom.

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