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Science China Earth Sciences 2006年第12期49卷 1323-1331页

作者： t. P. jones L. Merolla R. J. Richard Department of Earth Ocean and Planetary Sciences Cardiff UniversityCardiff CF10 3YE UK School of Biosciences Cardiff University PO Box 911 Cardiff CF10 3US UK

Based on the study of Beijing PM10 bioreactivity with the newly developed plasmid DNA assay method, and analysis for trace elements of PM10, the cause of plasmid DNA damage by PM10 was investigated. the study showed that plasmid DNA oxidative damages by PM10 are of difference in different seasons at various areas. the concentrations of tM50 of PM10 in whole samples respectively collected at urban and comparison sites during winter were 900 μg mL?1 and 74 μg mL?1, while those in their corresponding soluble fractions were 540 μg mL?1 and 86 μg mL?1. In contrast, tM50 contents of PM10 from summer whole samples at urban areas and comparison sites were 116 μg mL?1 and 210 μg mL?1, whereas those in their soluble fractions were 180 μg mL?1 and 306 μg mL?1. the difference of bioreactivity of Beijing PM10 resulted from the variation of trace elements. the oxidative damage of plasmid DNA caused by Pb, Zn, As in PM10 (whole sample) was relatively strong. tM50 and Mn, V, Zn display stronger correlation in the soluble fraction. It implies that Zn could be the major trace element in Beijing PM10 which contributes to oxidative damage to plasmid DNA.

关键词： Beijing PM10 trace metals correlation health effect.

Pazopanib in advanced soft tissue sarcomas

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Signal transduction and targeted therapy 2019年第1期4卷 538-547页

作者： Alex t.J.Lee Robin L.jones Paul H.Huang Division of Molecular Pathology The Institute of Cancer ResearchLondonUK Sarcoma Unit The Royal Marsden NHS Foundation TrustLondonUK Division of Clinical Studies Institute of Cancer ResearchLondonUK

Pazopanib is the first and only tyrosine kinase inhibitor currently approved for the treatment of multiple histological subtypes of soft tissue sarcoma(StS).Initially developed as a small molecule inhibitor of vascular endothelial growth factor receptors,preclinical work indicates that pazopanib exerts an anticancer effect through the inhibition of both angiogenic and oncogenic signaling *** the establishment of optimal dosing and safety profiles in early phase studies and approval for the treatment of advanced renal cell carcinoma,pazopanib was investigated in StS.A landmark phase III randomized study demonstrated improved progression-free survival with pazopanib compared to that with placebo in pretreated patients with StS of various *** efficacy of pazopanib in specific StS subtypes has been further described in real-world-based case series in both mixed and subtype-specific StS *** present,there are no clinically validated predictive biomarkers for use in selecting patients with advanced StS for pazopanib therapy,limiting the clinical effectiveness and cost-effectiveness of the *** this review,we summarize the preclinical and clinical data for pazopanib,outline the evidence base for its effect in StS and explore reported studies that have investigated putative biomarkers.

关键词： sarcoma clinical approval

Controlled generation of picosecond-pulsed higher-order Poincaré sphere beams from an ytterbium-doped multicore fiber amplifier

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Photonics Research 2023年第2期11卷 181-188页

作者： KUNHAO JI DI LIN ian A. DAVIDSON SIYI WANG JOEL CARPENtER YOSHIMICHI AMMA YONGMIN JUNG MASSIMILianO GUASONI DAVID J. RICHARDSON Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Institute of Advanced Photonics technology School of Information EngineeringGuangdong University of TechnologyGuangzhou 510006China Guangdong Provincial Key Laboratory of Photonics Information technology Guangdong University of TechnologyGuangzhou 510006China School of Information technology and Electrical Engineering The University of QueenslandBrisbaneQLD 4072Australia Fujikura Ltd. Chiba 285-8550Japan

Higher-order Poincarésphere(HOPS) beams with spatially variable polarization and phase distributions are opening up a host of unique applications in areas ranging from optical communication to ***, the flexible generation of these beams with high peak power from compact laser systems remains a challenge. Here, we demonstrate the controlled generation of HOPS beams based on coherent beam combination from an Yb-doped multicore fiber(MCF) amplifier. Using a spatial light modulator to adaptively adjust the wavefront and polarization of the signals seeded into the individual cores of the MCF various structured beams(including cylindrical vector beams and first-and second-order vortex beams) were generated with peak powers up to 14 k W for ~92 ps pulses.

关键词： amplifier polarization fiber

Combustion Reactivity of Rice Husk: An Experimental and Numerical Investigation

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Journal of thermal Science 1993年第2期2卷 152-156页

作者： Q.t.Pham I.R.Brown J.C.jones School of Chemical Engineering and Industrial Chemistry University of New South Wales Australia

the combustion reactivity of rice husk from New South Wales,ustralia was measured by heating cubical baskets in controlled environment and monitoring the centre ***-Kamenetskii's ignition theory was used to calculate the activation energy,Results agreed well with tests on other cellulosic materials,Numerical simulations of temperature changes were carried out,using a special technique to deal with non-linearities in the heat conduction *** numerical Results indicate that the time factor should be taken into account when evaluating self-combustion risks.

关键词：燃烧稻壳试验能源

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Bentham's Panopticon

英语世界 2022年第6期 125-126页

作者： ian Betteridge

Who was Bentham?Jeremy Bentham was a philosopher who was born in London in 1748. He believed in lots of things that people thought were very strange. For example, he believed that women should be completely equal to men. He also believed that people should be kinder to animals. Before Bentham, most people thought it was okay to hurt animals because they aren’t clever like people are.

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Factor analysis identifies subgroups of constipation

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World Journal of Gastroenterology 2011年第11期17卷 1468-1474页

作者： Philip G Dinning Mike jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J talley ian J Cook Department of Gastroenterology St.George HospitalUniversity of New South WalesKogarahNSW 2217Australia Department of Psychology Macquarie UniversityNSW 2109Australia Gastroenterology Research Unit Nepean HospitalUniversity of SydneySydneyNSW 2050Australia Department of Colorecta Surgery St.George HospitalKogarahNSW 2217Australia Gastroenterology and Hepatology Mayo ClinicJacksonvilleFL 32224United States

AIM:to determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic ***:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport *** hundred of these patients had colonic transit measured *** analysis determined whether constipation-related symptoms grouped into distinct aspects of *** analysis was used to determine whether indi-vidual patients naturally group into distinct ***:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main *** all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool *** majority of patients with these characteristics also reported regular laxative ***:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated ***,clear stratification into clinically identifiable groups remains imprecise.

关键词：大便秘结因子分析识别亚群润肠通便聚类分析病理生理功能紊乱

Genetic testing in Professional Football:Perspectives of Key Stakeholders

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Journal of Science in Sport and Exercise 2022年第1期4卷 49-59页

作者： Alexander B.t.McAuley David C.Hughes Loukia G.tsaprouni ian Varley Bruce Suraci homas R.Roos Adam J.Herbert Adam L.Kelly Faculty of Health Education and Life SciencesBirmingham City UniversityBirminghamWest MidlandsUK Department of Sport Science Nottingham Trent UniversityNottinghamUK Academy Coaching Department AFC BournemouthBournemouthUK the International Academy of Sports Science and technology(AIStS) University of LausanneLausanneSwitzerland Department of Life Sciences Birmingham City UniversityCity South CampusWestbourne RoadEdgbastonBirmingham B153TNUK

Purpose Genetic research in football is currently in it’s infancy but is growing ***,the practical application of genetic testing in football and the views concerning its use are ***,the purpose of this study was to assess the current practical application of genetic testing in professional football and provide an insight into the perspectives of key stakeholders(i.e.,coaches,practitioners,players).Methods In total,122 participants completed an online anonymous *** consisted of 21 multiple choice and Likert scale questions,with the option of providing an explanation for each *** Findings revealed genetic testing is rarely utilised by key stakeholders(10%)or their respective organisations(14%).However,three quarters(75%)had the opinion that genetic testing will have great utility in the *** majority(72%)believed genetic testing should be used for athlete development and injury risk,whilst 35%believed that genetic testing should be utilised for talent identification ***,most key stakeholders viewed their own(89%)and their col-leagues’(79%)knowledge related to genetic testing as insufficient;mainly due to ineffective current communication methods(91%).Most believed educational workshops are required(71%),whilst nearly all(91%)were interested in developing their expertise on the utility of genetic *** Genetic testing is rarely used within professional football,although key stakeholders anticipate that it will be utilised more in the *** such,educational support may prove valuable in improving key stakeholder knowledge and the practical application of genetic testing in professional football.

关键词： Soccer talent identification Athlete development Genetics

Exploring the light-quark interaction

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Chinese Physics C 2009年第12期33卷 1189-1196页

作者：常雷 ian C. CLOЁt Bruno El-BENNICH thomas KLHN Craig D. ROBERtS Institute of Applied Physics and Computational Mathematics Department of Physics University of Washington Seattle WA 98195 USA Physics Division Argonne National Laboratory Argonne Illinois 60439 USA Department of Physics Peking University

two basic motivations for an upgraded JLab facility are the needs： to determine the essential nature of light-quark confinement and dynamical chiral symmetry breaking （DCSB）; and to understand nucleon structure and spectroscopy in terms of QCD＇s elementary degrees of freedom. During the next ten years a programme of experiment and theory will be conducted that can address these questions. We present a Dyson- Schwinger equation perspective on this effort with numerous illustrations, amongst them： an interpretation of string^breaking; a symmetry-preserving truncation for mesons; the nucleon＇s strangeness σ-term; and the neutron＇s charge distribution.

关键词： Bethe-Salpeter equations bound-states confinement dynamical chiral symmetry breaking,Dyson-Schwinger equations Faddeev equation nucleon electromagnetic form factors

Heterosis in locally adapted sorghum genotypes and potential of hybrids for increased productivity in contrasting environments in Ethiopia

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the Crop Journal 2016年第6期4卷 479-489页

作者： taye t.Mindaye Emma S.Mace ian D.Godwin David R.Jordan the University of Queensland QueenslandAlliance for Agriculture and Food InnovationHermitage Research Facility Ethiopian Institute of Agricultural Research Melkassa Research Center Department of Agriculture and Fisheries Hermitage Research Facility the University of Queensland School of Agriculture and Food Sciences

Increased productivity in sorghum has been achieved in the developed world using *** their yield advantage,introduced hybrids have not been adopted in Ethiopia due to the lack of adaptive traits,their short plant stature and small grain *** study was conducted to investigate hybrid performance and the magnitude of heterosis of locally adapted genotypes in addition to introduced hybrids in three contrasting environments in *** total,139 hybrids,derived from introduced seed parents crossed with locally adapted genotypes and introduced R lines,were ***,the hybrids matured earlier than the adapted parents,but had higher grain yield,plant height,grain number and grain weight in all *** lowland adapted hybrids displayed a mean better parent heterosis(BPH) of19%,equating to 1160 kg ha-1and a 29% mean increase in grain yield,in addition to increased plant height and grain weight,in comparison to the hybrids derived from the introduced R *** mean BPH for grain yield for the highland adapted hybrids was 16% in the highland and 52%in the intermediate environment equating to 698 kg ha-1and 2031 kg ha-1,respectively,in addition to increased grain *** magnitude of heterosis observed for each hybrid group was related to the genetic distance between the parental *** majority of hybrids also showed superiority over the standard check *** general,hybrids from locally adapted genotypes were superior in grain yield,plant height and grain weight compared to the high parents and introduced hybrids indicating the potential for hybrids to increase productivity while addressing farmers' required traits.

关键词： Farmers preferred traits High parent heterosis Locally adapted genotypes Sorghum hybrids

the thermoelectric Properties of n-type Bismuth telluride:Bismuth Selenide Alloys Bi_(2)te_(3−x)Se_(x)

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Research 2020年第1期2020卷 724-738页

作者： ian t.Witting Francesco Ricci thomas C.Chasapis Geoffroy Hautier G.Jeffrey Snyder Department of Materials Science and Engineering Northwestern University2220 Campus DriveCook Hall 2036EvanstonIL 60208USA Institute of Condensed Matter and Nanosciences UniversitéCatholique de LouvainLouvain-la-Neuve 1348Belgium

Alloying bismuth telluride with antimony telluride and bismuth selenide for p-and n-type materials,respectively,improves the thermoelectric quality factor for use in room temperature *** the electronic and thermal transports can vary substantially,the alloy composition is a key engineering *** n-type Bi_(2)te_(3-x)Se_(x)alloy lags its p-type counterpart in thermoelectric performance and does not lend itself as readily to simple transport modeling which complicates *** literature data with recent results across the entire alloy composition range,the complex electronic structure dynamics and trends in lattice thermal conductivity are ***-orbit interaction plays a critical role in determining the position and degeneracy of the various conduction band *** behavior is incorporated into a two-band effective mass model to estimate the transport parameters in each *** alloy scattering model is utilized to demonstrate how phonon scattering behaves differently on either side of the intermediate ordered compound Bi2te2Se due to chalcogen site occupancy *** parametrization of the electronic and thermal transports presented can be used in future optimization efforts.

关键词： alloy bismuth transport