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Neuroscience Bulletin 2019年第2期35卷 295-300页

作者： Daniel Erskine John-Paul Taylor Alan Thomas Daniel Collerton ian mckeith Ahmad Khundakar Johannes Attems Christopher Morris Institute of Neuroscience Newcastle University Northumberland Tyne and Wear NHS Trust School of Science Engineering and Design Teesside University

Introduction Recurrent complex visual hallucinations are a core clinical feature of dementia with Lewy bodies(DLB)and are typically well-formed,often consisting of figures,such as people or animals(1)Despite the profound impact upon patients and caregivers in DLB,the aetiopathology of visual hallucinations remains largely *** this article we discuss the anatomy of the human visual system,hypotheses of the genesis of visual hallucinations in DLB,and imaging and neuropathological studies that have attempted to understand visual hallucinations on a functional and anatomical basis.

关键词： Pathological Visual System Lewy Bodies

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Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations

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Translational Neurodegeneration 2022年第1期11卷 514-531页

作者： Federico Rodriguez-Porcel Kathryn A.Wyman-Chick Carla Abdelnour Ruiz Jon B.Toledo Daniel Ferreira Prabitha Urwyler Rimona S.Weil Joseph Kane Andrea Pilotto Arvid Rongve Bradley Boeve John-Paul Taylor ian mckeith Dag Aarsland Simon J.G.Lewis the Lewy Body Dementias Clinical Trials Workgroup from the Lewy Body Dementias Professional Interest Area-Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment(ISTAART) Department of Neurology Medical University of South Carolina208b Rutledge Av.CharlestonSC 29403USA Department of Neurology Center for Memory and AgingHealthPartnersSaint PaulMNUSA Autonomous University of Barcelona BarcelonaSpain Fixel Institute for Neurological Diseases University of FloridaGainesvilleFLUSA Division of Clinical Geriatrics Department of NeurobiologyCare Sciencesand SocietyCenter for Alzheimer’s ResearchKarolinska InstitutetStockholmSweden Department of Radiology Mayo ClinicRochesterMNUSA ARTORG Center for Biomedical Engineering Research University of BernBernSwitzerland Dementia Research Centre University College LondonLondonUK Centre for Public Health Queen’s UniversityBelfastUK Neurology Unit Department of Clinical and Experimental SciencesUniversity of BresciaBresciaItaly Department of Research and Innovation Helse FonnaHaugesund HospitalHaugesundNorway Institute of Clinical Medicine(K1) The University of Ber-genBergenNorway Department of Neurology Center for Sleep MedicineMayo ClinicRochesterMNUSA Translational and Clinical Research Institute Newcastle UniversityNewcastle upon TyneUK Department of Old Age Psychiatry Institute of Psychiatry Psychology and Neuroscience King’s College LondonLondonUK ForeFront Parkinson’s Disease Research Clinic Brain and Mind CentreSchool of Medical SciencesUniversity of Sydney100 Mallett StreetCamperdownNSW 2050Australia. 不详

The selection of appropriate outcome measures is fundamental to the design of any successful clinical trial. Although dementia with Lewy bodies (DLB) is one of the most common neurodegenerative conditions, assessment of therapeutic benefit in clinical trials often relies on tools developed for other conditions, such as Alzheimer’s or Parkinson’s disease. These may not be sufficiently valid or sensitive to treatment changes in DLB, decreasing their utility. In this review, we discuss the limitations and strengths of selected available tools used to measure DLB-associated outcomes in clinical trials and highlight the potential roles for more specific objective measures. We emphasize that the existing outcome measures require validation in the DLB population and that DLB-specific outcomes need to be developed. Finally, we highlight how the selection of outcome measures may vary between symptomatic and disease-modifying therapy trials.

关键词： Dementia with Lewy bodies Clinical trials Outcomes Measurement properties

卡巴拉汀治疗路易体痴呆的疗效——一项随机双盲安慰剂对照的国际研究(译文)

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中国神经免疫学和神经病学杂志 2002年第3期9卷 183-185页

作者： ian mckeith Teodoro Del Sel Pier-Franco Spano Murat Emre Keith Wesnes Ravi Anand Ana Cicin-Sain Roberto Ferrara René Spiegel 北京诺华制药有限公司

1 前言路易体痴呆在过去10年中已被认定是老年人痴呆的常见类型,占痴呆的15%～20%.表现为波动性认知障碍和注意受损并常伴有反复的视幻觉及帕金森病表现.妄想、抑郁情绪、睡眠障碍、听幻觉是路易体痴呆的常见神经精神症状.对这一大组... 详细信息

1 前言路易体痴呆在过去10年中已被认定是老年人痴呆的常见类型,占痴呆的15%～20%.表现为波动性认知障碍和注意受损并常伴有反复的视幻觉及帕金森病表现.妄想、抑郁情绪、睡眠障碍、听幻觉是路易体痴呆的常见神经精神症状.对这一大组患者的治疗比较困难,因为在大多数其他疾病中作为治疗精神行为症状主要手段的抗精神病药物用于这种类型痴呆时却可以诱发严重的、不可逆的、并常是致命的敏感反应.尸检研究发现,对抗精神病药物的敏感反应可使路易体痴呆的死亡率增加2～3倍,这种反应至少部分是通过急性阻断纹状体突触后多巴胺D2受体介导的.本研究的目的是评价卡巴拉汀2次/d口服,日剂量最大量12 mg,疗程20周对可能的路易体痴呆的疗效、耐受性和安全性.

关键词：路易体痴呆卡巴拉汀治疗疗效

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Correction:Clinical outcome measures in dementia with Lewy bodies trials:critique and recommendations

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Translational Neurodegeneration 2022年第1期11卷 588-588页

作者： Federico Rodriguez-Porcel Kathryn A.Wyman-Chick Carla Abdelnour Ruiz Jon B.Toledo Daniel Ferreira Prabitha Urwyler Rimona S.Weil Joseph Kane Andrea Pilotto Arvid Rongve Bradley Boeve John-Paul Taylor ian mckeith Dag Aarsland Simon J.G.Lewis the Lewy Body Dementias Clinical Trials Workgroup from the Lewy Body Dementias Professional Interest Area-Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment(ISTAART) Department of Neurology Medical University of South Carolina208b Rutledge Av.CharlestonSC 29403USA Department of Neurology Center for Memory and AgingHealthPartnersSaint PaulMNUSA Autonomous University of Barcelona BarcelonaSpain Fixel Institute for Neurological Diseases University of FloridaGainesvilleFLUSA Division of Clinical Geriatrics Department of NeurobiologyCare Sciencesand SocietyCenter for Alzheimer’s ResearchKarolinska InstitutetStockholmSweden Department of Radiology Mayo ClinicRochesterMNUSA ARTORG Center for Biomedical Engineering Research University of BernBernSwitzerland Dementia Research Centre University College LondonLondonUK Centre for Public Health Queen’s UniversityBelfastUK Neurology Unit Department of Clinical and Experimental SciencesUniversity of BresciaBresciaItaly Department of Research and Innovation Helse FonnaHaugesund HospitalHaugesundNorway Institute of Clinical Medicine(K1) The University of Ber-genBergenNorway Department of Neurology Center for Sleep MedicineMayo ClinicRochesterMNUSA Translational and Clinical Research Institute Newcastle University Newcastle upon TyneUK Department of Old Age Psychiatry Institute of Psychiatry Psychology and Neuroscience King’s College LondonLondonUK ForeFront Parkinson’s Disease Research Clinic Brain and Mind CentreSchool of Medical SciencesUniversity of Sydney100 Mallett StreetCamperdownNSW 2050Australia. 不详

Correction to:Translational Neurodegeneration(2022)11:24 https://***/10.1186/s40035-022-00299-w Following publication of the original article[1],the authors identified some errors in the Additional files *** original ... 详细信息

关键词： degeneration Clinical measures

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压电传感器机电校准用的一种干涉技术

中国检验检测 1978年第6期 23-25页

作者： N.E.mckeith 林劲

一、引言1962年 Ramsay 和 Mugridge 研制了一种由陶瓷片和电极叠堆形式(外包环氧树脂)做成的压电机电传感器。它们是作法布里-珀罗干涉仪(和1958年 Dupeyrot 的类似)的机械扫描用。从此以后,压电扫描的法布里-珀罗分光计已日益普及,特... 详细信息

一、引言1962年 Ramsay 和 Mugridge 研制了一种由陶瓷片和电极叠堆形式(外包环氧树脂)做成的压电机电传感器。它们是作法布里-珀罗干涉仪(和1958年 Dupeyrot 的类似)的机械扫描用。从此以后,压电扫描的法布里-珀罗分光计已日益普及,特别因为它们适合于快速的光谱扫描。然而,当使用压电陶瓷作精细的移动控制时,会引起如非线性

关键词：压电陶瓷电压试件压电传感器 PZT 干涉技术片状材料法布里测微螺丝干涉仪测量仪器

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屠宰一整修过程中电刺激对山羊胴体肉的影响

肉类研究 1988年第4期2卷 14-15页

作者： F.K.mckeith,吴信法美

新西兰、英伦及澳洲的不少研究者,如Carse(1973)和Smith等(1979),曾经指出电刺激法是增进肉嫩度的有效方法.其好处还包括肉的适口性增加,“热环”(Heat—ring)的发生减少,能增进肌肉的结实程度,使大理石化的发展更快,肌肉的颜色更鲜亮,... 详细信息

新西兰、英伦及澳洲的不少研究者,如Carse(1973)和Smith等(1979),曾经指出电刺激法是增进肉嫩度的有效方法.其好处还包括肉的适口性增加,“热环”(Heat—ring)的发生减少,能增进肌肉的结实程度,使大理石化的发展更快,肌肉的颜色更鲜亮,可减少肉达到嫩化所需的后熟时间.但在肉联厂内,因受空间限制,大多数屠宰一整修线上对胴体应用电刺激有问题.在屠宰加工线上于什么场合施行电刺激为最适当?有待于实验测定.本试验目的即在评定屠宰工序的不同期间,施行电刺激法对山羊

关键词：肌节长度电刺激法嫩度品质特性腰肉电刺激长肌电激洞体山羊劈半高温处理宰后剪切力值

Effects of Sodium Citrate plus Sodium Diacetate and Buffered Vinegar on Quality Attributes of Enhanced Beef Top Rounds

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Food and Nutrition Sciences 2012年第3期3卷 354-362页

作者： Amudhan Ponrajan Mark A. Harrison Timothy D. Pringle Jacob R. Segers Bradley K. Lowe Russell O. mckeith Alexander M. Stelzleni 1Department of Animal and Dairy Sciences Meat Science Technology Center University of Georgia Athens USA 2Department of Food Science and Technology University of Georgia Athens USA. Department of Animal and Dairy Sciences Meat Science Technology Center University of Georgia Athens USA Department of Food Science and Technology University of Georgia Athens USA.

The effect of two antimicrobials in the enhancement solution was investigated in this study. Sensory and shelf-life characteristics were measured for beef top rounds enhanced to 110% with 0.5% sodium chloride and 0.4% sodium tripolyphosphate (CNT);CNT with a 1% solution of 80% sodium citrate plus 20% sodium diacetate (SC + D);or CNT with 2% buffered vinegar (VIN) in the final product. SC + D and VIN had less (P 0.05). However, SC + D had lower (P 0.05) for all enhancement solutions within each day. After 7 days of retail display, SC + D retarded (P < 0.05) lipid oxidation to a greater extent than VIN or CNT samples. Sodium citrate plus sodium diacetate or buffered vinegar may be included in enhancement solutions without having a large influence on subjective color, and may aid in improving sensory tenderness.

关键词： Beef Enhancement Quality Sensory Shelf-Life

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左旋多巴在治疗Lewy小体痴呆中的作用

世界核心医学期刊文摘（神经病学分册） 2005年第12期1卷 39-39页

作者： Molloy S. mckeith I.G. O'Brien J.T. Burn D.J. 邓剑平 Dr.Regional Neurosciences Centre Newcastle General Hospital Westgate Road Newcastle upon Tyne NE46BE United Kingdom

Background: One of the core clinical features of dementia with Lewy bodies (DLB) is extrapyramidal syndrome (EPS). Levodopa is currently the gold standard oral therapy for Parkinson’s disease (PD), but its use in DLB has been tempered by concerns of exacerbating neuropsychiatric symptoms. Aim: To assess the efficacy and tolerability of L-dopa in managing EPS in DLB and to compare the motor response with that seen in PD and PD with dementia (PDD). Method: EPS assessment consisted of the Unified Parkinson’s Disease Rating Scale, motor subsection (UPDRS III), and finger tapping and walking tests. Patients with DLB were commenced on L-dopa. After 6 months, patients were examined in the “off”state, given L-dopa and assessed for motor responses. Identical assessments were performed in patients with PD and PDD also receiving L-dopa. Results: Acute L-dopa challenge in 14 DLB patients yielded a mean 13.8%(p = 0.02) improvement in UPDRS III score, compared with 20.5%in PD (n = 28, p < 0.0001) and 23%in PDD (n = 30, p < 0.0001) respectively. Finger tapping scores increased (12.3%v 20%and 23%), while walking test scores decreased (32%v 41%and 67%). Of the DLB patients, 36%were classified as “responders”on L-dopa challenge, compared with 70%of the PDD and 57%of the PD patients. Nineteen DLB patients were treated for 6 months with L-dopa (mean daily dose 323 mg). Two withdrew prematurely with gastrointestinal symptoms and two with worsening confusion. Conclusion: L-dopa was generally well tolerated in DLB but produced a significant motor response in only about one third of patients. Younger DLB cases were more likely to respond to dopaminergic treatment.

关键词：左旋多巴 Lewy小体痴呆帕金森病多巴胺能肠道症状神经精神症状锥体外系意识错乱金标准等级量表

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