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Antecedents and sex/gender differences in youth suicidal behavior

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World Journal of Psychiatry 2014年第4期4卷 120-132页

作者： Anne E Rhodes michael H Boyle Jeffrey A Bridge mark Sinyor Paul S Links Lil Tonmyr Robin Skinner Jennifer m Bethell Corine Carlisle Sarah Goodday Travis Salway Hottes Amanda Newton Kathryn Bennett Purnima Sundar Amy H Cheung Peter Szatmari Institute for Clinical Evaluative Sciences Toronto M4N 3M5 Ontario Canada Department of Psychiatry University of Toronto Toronto M5T 1R8 Ontario Canada Suicide Studies Unit St. Michael’s Hospital Toronto M5B 1W8 Ontario Canada Dalla Lana School of Public Health University of Toronto Toronto M5T 3M7 Ontario Canada Department of Psychiatry and Behavioural Neurosciences Mc Master University Hamilton L8N 3K7 Ontario Canada The Offord Centre for Child Studies Hamilton L8S 4K1 Ontario Canada The Research Institute at Nationwide Children’s Hospital Columbus OH 43205 United States The Ohio State University College of medicine Columbus OH 43210 United States Sunnybrook Health Sciences Centre Toronto M4N 3M5 Ontario Canada Department of Psychiatry University of Western Ontario London N6A 5W9 Ontario Canada The Injury and Child maltreatment Section Public Health Agency of Canada Ottawa K1A 0K9 Ontario Canada The Centre for Addiction and mental Health Toronto M6J 1H4 Ontario Canada Department of Pediatrics University of Alberta Edmonton Alberta T6G 1C9 Canada The Department of Clinical Epidemiology and Biostatistics Mc Master University Hamilton L8S 4K1 Ontario Canada The Ontario Centre of Excellence for Child and Youth mental Health Ottawa K1G 0Z1 Ontario Canada The Hospital for Sick Children Toronto M5G 1X8 Ontario Canada

Suicide is the second leading cause of death in youth globally; however, there is uncertainty about how best to intervene. Suicide rates are typically higher in males than females, while the converse is true for suicide attempts. We review this "gender paradox" in youth, and in particular, the age-dependency of these sex/gender differences and the developmental mechanisms that may explain them. Epidemiologic, genetic,neurodevelopmental and psychopathological research have identified suicidal behaviour risks arising from genetic vulnerabilities and sex/gender differences in early adverse environments, neurodevelopment, mental disorder and their complex interconnections. Further, evolving sex-/gender-defined social expectations and norms have been thought to influence suicide risk. In particular, how youth perceive and cope with threats and losses(including conforming to others' or one's own expectations of sex/gender identity) and adapt to pain(through substance use and helpseeking behaviours). Taken together, considering brain plasticity over the lifespan, these proposed antecedents to youth suicide highlight the importance of interventions that alter early environment(s)(e.g., childhood maltreatment) and/or one's ability to adapt to them. Further, such interventions may have more enduring protective effects, for the individual and for future generations, if implemented in youth.

关键词： Suicide Attempted suicide Sex Gender Child Adolescent Review

无症状吸烟者的区域性肺泡氧分压变化:利用超极化3He-mR成像评价

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国际医学放射学杂志 2015年第2期 183-183页

作者： H.Hamedani S.J.Kadlecek m.Ishii Y.Xin K.Emami B.Han 李宁 Department of Radiology University of Pennsylvania308 Stemmler Hall 3450 Hamilton Walk Philadelphia PA 19104

摘要目的评估区域性肺泡氧分压(PAO2)3He-mR成像描述吸烟导致的功能性变化的能力,并将其功效与当前诊断技术进行比较。材料与方法本研究经当地伦理委员会批准,

关键词：吸烟者标准差肺泡氧分压无症状 mR 区域性

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非药物性双相障碍病人静息态脑功能连接中断

国际医学放射学杂志 2016年第5期 575-575页

作者： Y.Wang S.m.Zhong Y.B.Jia Y.Sun B.Wang T.Liu 陈斌 Clinical Experimental Center Medical Imaging CenterFirst Affiliated Hospital of Jinan University

摘要目的研究双相障碍(BD)病人全脑固有功能连接模式。方法本项前瞻性研究获得研究伦理委员会批准及所有受检者知情同意。37例非药物性BDⅡ型病人及37例健康对照者均行静息态功能mRI。采用一种图论方法,即功能连接强度(FCS)分析全脑功... 详细信息

摘要目的研究双相障碍(BD)病人全脑固有功能连接模式。方法本项前瞻性研究获得研究伦理委员会批准及所有受检者知情同意。37例非药物性BDⅡ型病人及37例健康对照者均行静息态功能mRI。采用一种图论方法,即功能连接强度(FCS)分析全脑功能连接。并采用24项hamilton抑郁量表和杨氏躁狂量表(YmRS)评价受检者临床状态。统

关键词：双相障碍非药物性脑功能连接静息态病人

探讨脊柱关节炎病人脊柱及骶髂关节mR检查对临床诊断的可信度以及病人治疗方案的影响

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国际医学放射学杂志 2013年第6期 586-586页

作者： R.Carmona S.Harish D.D.Linda G.Ioannidis m.matsos N.A.Khalidi 李京津 Departments of Rheumatology St.Joseph’s Healthcare50 Charlton Ave East Hamilton ONCanada L8N 2A6

摘要目的旨在量化中轴性脊柱炎病人脊柱及骶髂关节mR检查对临床诊断可信度的影响并确定不同mR检查结果是否会影响病人治疗方案。材料与方法本前瞻性观察

关键词：脊柱关节炎病人治疗骶髂关节 mR 临床诊断