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Lithological and Si–O–S isotope geochemistry:constraints on the origin and genetic environment of the selenium(Se)-rich siliceous rocks in Enshi,Hubei Province,China

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Acta Geochimica 2021年第1期40卷 89-105页

作者： Caixia Feng Shen Liu ian m.Coulson State Key Laboratory of Continental Dynamics and Department of Geology Northwest UniversityXi'an 710069China Solid Earth Studies Laboratory Department of GeologyUniversity of ReginaReginaSK S4S 0A2Canada

Se-rich black rock series of the middle and Late Permian system is widely distributed in Enshi Prefecture with an exposed area of 850 km~2,among which the unique Yutangba black rock series independent selenium deposit with industrial mining significance in the world is ***,the source and metallogenic mechanisms of Se are still *** general,terrestrial weathering and submarine hydrothermal processes are the main source end members of Si and Se,and the related siliceous rocks record the deposition process of Si and Se from different *** study of lithofacies and paleogeography shows that western Hubei belongs to the near eastwest turn of the Yangzi platform in the middle and Late Permian and becomes an inter-platform basin with nearly north-south ***,the comparative study of the Yutangba deposit and the selenium-rich black rock series in the northern Shadi with high selenium content is expected to reveal the provenance evolution of the two sections in space,and further restrict the Se mineralization mechanism in the Enshi *** the element geochemistry study,the black rock series in two study areas may have formed in a transitional position of either the continental margin or continental slope,in the process of sedimentary,more terrigenous clastic materials *** are rich in lithophile elements V and Cr.δU>1.0,U/Th and V/(V+Ni)ratio indicate that the Se-rich strata of black rock series in the Enshi areas occurred in an anoxic reducing environment and formed in an environment between the ocean basin and the continental *** Si-O isotope geochemistry,the original Si source of the study area is thought to relate to a volcanic eruption,which leads to the enrichment of Si in the *** determined values of S isotope in the black rock series of the two study areas both show the characteristics related to organic reduction/biogenic.

关键词： Se-rich siliceous rocks Geochemistry Si–O–S isotope Origin Sedimentary environment

Time for a paradigm shift in the classification of muscle injuries

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Journal of Sport and Health Science 2017年第3期6卷 255-261页

作者： Bruce hamilton Juan-manuel Alonso Thomas m.Best High Performance Sport New Zealand Millennium Institute of Sport and HealthMairangi BayAuckland 0110New Zealand Sports medicine Department Qatar Orthopaedic and Sports Medicine HospitalDoha 22922Qatar UHealth Sports medicine Institute University of Miami Miller School of MedicineMiamiFL 33136USA

muscle injuries remain one of the most common injuries in sport,yet despite this,there is little consensus on how to either effectively describe or determine the prognosis of a specific muscle *** approaches to muscle classification and grading of medicine have been applied over the last century,but over the last decade the limitations of historic approaches have been *** a consequence,in the past 10 years,clinical research groups have begun to question the historic approaches and reconsider the way muscle injuries are classified and *** a narrative approach,this manuscript describes several of the most recent attempts to classify and grade muscle injuries and highlights the relative strengths and weaknesses of each *** each of the new classification and grading systems have strengths,there remains little consensus on a system that is both comprehensive and evidence *** of the currently identified features within the grading systems have relevance to accurately determining prognosis.

关键词： Classification Grading magnetic resonance imaging muscle injury Return to play Ultrasound

Population genetics and breeding system of Tupistra pingbianensis (Liliaceae),a naturally rare plant endemic to SW China

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Journal of Systematics and Evolution 2010年第1期48卷 47-57页

作者： Richard ian mILNE Division of Environmental and Evolutionary Biology School of BiologyUniversity of St.AndrewsSt.AndrewsFife KY16 9THUK

The levels and partitioning of genetic diversity and inbreeding depression were investigated in Tupistra pingbianensis,a narrow endemic of southeast Yunnan,China,characterized by a naturally fragmented distribution due to extreme specialization on a rare habitat *** genetic diversity and patterns of genetic variation within and among 11 populations were analyzed using amplified fragment length polymorphism markers with 97 individuals across its whole geographical *** levels of genetic variation were revealed both at the species level(P 99 = 96.012%;H t = 0.302) and at the population level(P 99 = 51.41%;H s = 0.224).Strong genetic differentiation among populations was also detected(F ST = 0.2961;θⅡ = 0.281),which corresponded to results reported for typical animal-pollinated,mixed selfing,and outcrossing plant *** result was consistent with mating patterns detected by our pollination *** indirect estimate of gene flow based on θⅡ was low(N m = 0.64).Special habitat and its life history traits might play an important role in shaping the genetic diversity and the genetic structure of this species.A pollination experiment also failed to detect significant inbreeding depression upon F 1 fruit set,seed weight,and germinate rate *** a naturally rare species,*** is not seriously genetically impoverished and likely to have adapted to tolerating a high level of inbreeding early in its history,we propose this species need only periodic monitoring to ensure their continued persistence,but not intervention to remain viable.

关键词： AFLP genetic diversity genetic structure inbreeding depression naturally rare plants Tupistra pingbianensis.

Retransplantation for graft failure in chronic hepatitis C infection: A good use of a scarce resource?

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World Journal of Gastroenterology 2010年第40期16卷 5070-5076页

作者： ian A Rowe Kerri m Barber Rhiannon Birch Elinor Curnow James m Neuberger Liver and Hepatobiliary Unit University Hospital Birmingham NHS Trust Queen Elizabeth Hospital NHS Blood and Transplant

AIm: To investigate the outcome of patients with hepatitis C virus (HCV) infection undergoing liver retransplantation. mETHODS: Using the UK National Registry, patients undergoing liver transplantation for HCV-related liver disease were identified. Data on patient and graft characteristics, as well as transplant and graft survival were collected to determine the outcome of HCV patients undergoing retransplantation and in order to identify factors associated with transplant survival. RESULTS: Between march 1994 and December 2007, 944 adult patients were transplanted for HCV-related liver disease. At the end of follow-up, 617 of these patients were alive. In total, 194 (21%) patients had first graft failure and of these, 80 underwent liver retransplantation, including 34 patients where the first graft failed due to recurrent disease. For those transplanted for HCV-related disease, the 5-year graft survival in those retransplanted for recurrent HCV was 45% [95% confidence interval (CI): 24%-64%] compared with 80% (95% CI: 62%-90%) for those retransplanted for other indications (P = 0.01, log-rank test); the 5-year transplant survival after retransplantation was 43% (95% CI: 23%-62%) and 46% (95% CI: 31%-60%), respectively (P = 0.8, log-rank test). In univariate analysis of all patients retransplanted, no factor analyzed was significantly associated with transplant survival. CONCLUSION: Outcomes for retransplantation in patients with HCV infection approach agreed criteria for minimum transplant benefit. These data support selective liver retransplantation in patients with HCV infection.

关键词： Hepatitis C Liver Recurrence Retransplantation Outcome

Anti-tumour necrosis factor agent and liver injury:literature review,recommendations for management

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World Journal of Gastroenterology 2014年第46期20卷 17352-17359页

作者： Roberta Elisa Rossi Ioanna Parisi Edward John Despott Andrew Kenneth Burroughs James O'Beirne Dario Conte mark ian hamilton Charles Daniel murray Centre for Gastroenterology Royal Free HospitalLondon NW3 2QGUnited Kingdom Department of Pathophysiology and Organ Transplant Universita’ degli Studi di Milano20122 MilanoItaly Division of Gastroenterology and Endoscopy Fondazione IRCCS Ca' GrandaOspedale Maggiore Policlinico20122 MilanoItaly Sheila Sherlock Liver Centre Royal Free Hospital and Institute of Liver and Digestive HealthLondon NW3 2PFUnited Kingdom

Abnormalities in liver function tests,including transient and self-limiting hypertransaminasemia,cholestatic disease and hepatitis,can develop during treatment with anti-tumour-necrosis-factor(TNF)*** optimal management of liver injury related to antiTNF therapy is still a matter of *** some authors recommend discontinuing treatment in case of both a rise of alanine aminotransferase more than5 times the upper limit of normal,or the occurrence of jaundice,there are no standard guidelines for the management of anti-TNF-related liver *** searches were performed in Pub med,using the following key words:inflammatory bowel disease(IBD);TNF inhibitors;hypertransaminasemia;drugrelated liver injury;*** to published data,elevation of transaminases in patients with IBD treated with anti-TNF is a common finding,but resolution appears to be the usual ***-TNF agents seem to be safe with a low risk of causing severe drugrelated liver *** to our centre experience,we found that hypertransaminasemia was a common,mainly self-limiting finding in our IBD cohort and was not correlated to infliximab treatment on both univariate and multivariate *** algorithm for the management of liver impairment occurring during antiTNF treatment is also proposed and this highlights the need of a multidisciplinary approach and suggests liver biopsy as a key-point in the management decision in case of severe rise of ***,hepatic injury is generally self-limiting and drug withdrawal seems to be an exception.

关键词： Inflammatory bowel disease Tumour necrosis factor inhibitors Hypertransaminasemia Drug-related liver injury Infliximab

Finite element investigation of steel built-up shear links subjected to inelastic deformations

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Earthquake Engineering and Engineering Vibration 2004年第2期3卷 195-203页

作者： Peter Dusicka Ahmad m.Itani ian G.Buckle Department of Civil and Environmental Engineering Portland State UniversityP O.Box 751PortlandOregon97207USA Assistant Professor Department of Civil Engineering Mail Stop 258University of NevadaRenoNevada89557USA Associate Professor Department of Civil Engineering Mail Stop 258University of NevadaRenoNevada89557USA Professor

Non-linear finite element models accounting for large displacements have been used to investigate the behavior of steel built-up shear links that had previously been tested using large-scale experiments. The links were designed using steel grades with yield points ranging from high to low strengths. The objectives of the numerical analyses were to further investigate the non-linear behavior and to correlate the numerical results with experimental observations. Elasto-plastic as well as cyclic stress-strain material properties were incorporated to study the influence of material behavior on the overall shear link response. Non-linear monotonie analyses of the shear links incorporating the cyclic stress-strain steel properties resulted in similar trends in the response as the backbone curves recorded from the physical experiments. The numerical models of built-up shear links utilizing structural grade steels closely correlated to the experimentally recorded shear strength. models utilizing low yield point steels overestimated the shear strength, which was caused by the characteristics of cyclic behavior of those steels. The detailed numerical models also allowed for investigation of the plastic strain demands on the different components of the link. It was shown that finite element models combined with appropriate stress-strain relationship may be used with confidence to check the design of shear links of different steel grades and sectional geometries.

关键词： finite element investigation steel built-up shear link inelastic deformation

Technological developments enable measuring and using patientreported outcomes data in orthopaedic clinical practice

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World Journal of Orthopedics 2020年第12期11卷 584-594页

作者： David F hamilton Johannes m Giesinger Karlmeinrad Giesinger School of Health and Social Care Edinburgh Napier UniversityEdinburgh EH114BNUnited Kingdom University Hospital of Psychiatry II Medical University of InnsbruckInnsbruck 6020Austria Department of Orthopaedics and Traumatology Kantonsspital St GallenSt Gallen 9000Switzerland

Patient-reported outcomes measures form the backbone of outcomes evaluation in orthopaedics,with most of the literature now relying on these scoring tools to measure change in patient health *** patient-reported information is increasingly collected routinely by orthopaedic providers but use of the data is typically restricted to academic *** in electronic data capture and the outcome tools themselves now allow use of this data as part of the clinical *** review evaluates the role of patient reported outcomes data as a tool to enhance daily orthopaedic clinical practice,and documents how developments in electronic outcome measures,computer-adaptive questionnaire design and instant graphical display of questionnaire can facilitate enhanced patientclinician shared decision making.

关键词： Patient reported outcome measures Electronic patient-reported outcome Computer adaptive design Outcomes evaluation

modeling the impact of changing sexual behaviors with opposite-sex partners and STI testing among women and men ages 15-44 on STI diagnosis rates in the United States 2012-2019

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Infectious Disease modelling 2023年第4期8卷 1169-1176页

作者： Deven T.hamilton David A.Katz Laura T.Haderxhanaj Casey E.Copen ian H.Spicknall matthew Hogben Center for Studies in Demography and Ecology University of WashingtonSeattleWAUSA Department of Global Health University of WashingtonSeattleWAUSA Division of STD Prevention National Center for HIV/AIDSHepatitisSexually Transmitted DiseaseTuberculosis PreventionCenters for Disease Control and PreventionAtlantaGAUSA

Objective:To estimate the potential contributions of reported changes in frequency of penile-vaginal sex(PVS),condom use and STI screening to changes in gonorrhea and chlamydial diagnoses from 2012 to ***:An agent-based model of the heterosexual population in the *** the STI *** was calibrated to 2012 diagnosis rates,testing,condom use,and frequency of *** used behaviors from the 2017-2019 NSFG,and we evaluated changes in diagnosis and incidence rates in ***:Higher testing rates increased gonorrhea and chlamydia diagnosis by 14%and 13%,respectively,but did not reduce *** frequency of PVS reduced the diagnosis rate for gonorrhea and chlamydia 6%and 3%respectively while reducing incidence by 10%and 9%*** condom use had negligible impact on diagnosis and ***:Understanding how changing behavior drives STI incidence is essential to addressing the growing *** in testing and frequency of PVS likely contributed to some,but not all,of the changes in *** research is needed to understand the context within which changing sexual behavior and testing are occurring.

关键词： Gonorrhea Chlamydia Agent-based modeling Simulation

Which intensities, types, and patterns of movement behaviors are most strongly associated with cardiometabolic risk factors among children?

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Journal of Sport and Health Science 2021年第3期10卷 368-378页

作者： Laura K.Callender michael m.Borghese ian Janssen School of Kinesiology and Health Studies Queen’s UniversityKingstonON K7L 3N6Canada Department of Public Health Sciences Queen’s UniversityKingstonON K7L 3N6Canada

Purpose:The purpose of this study was to determine which intensities,patterns,and types of 24-h movement behaviors are most strongly associated with cardiometabolic risk factors among ***:A total of 369 children aged 1013 years were *** wore an Actical accelerometer and a Garmin Forerunner 220 Global Positioning System logger and completed an activity and sleep log for 7 *** from these instruments were combined to estimate average minute per day spent in 14 intensities,11 types,and 14 patterns of *** mass index,resting heart rate,and systolic blood pressure values were combined to create a cardiometabolic risk factor *** least squares regression analysis was used to examine associations between the 39 movement behavior characteristics and the cardiometabolic risk factor *** variable importance in projection(VIP)values were used to determine and rank important movement behavior *** was evidence of interaction by biological maturity,and the analyses were conducted separately in the 50%least mature and 50%most mature ***:For the least biologically mature participants,fifteen of the 39 movement behavior characteristics had important VIP value scores;eight of these reflected movement intensities(particularly moderate and vigorous intensities),six reflected movement patterns,and one reflected a movement *** the most mature participants,thirteen of the 39 movement behavior characteristics had important VIP value scores,with five reflecting intensities(particularly moderate and vigorous intensities),five reflecting patterns,and three reflecting types of ***:more than 12 movement behavior characteristics were associated with cardiometabolic risk factors within both the most and least mature *** intensities within the moderate and vigorous intensity ranges were the most consistent correlates of these risk factors.

关键词： Child Physical activity Risk factors Sedentary behavior Sleep