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Prevalence of Isolated “Pre-m.lignant” Lesions on Prostate Biopsy in a Racially Diverse Com.unity Screened Cohort

Open Journal of Urology 2015年第12期5卷 213-219页

作者： m.chael A. Liss Donna Ankerst David Zapata Javier Hernandez Robin J. Leach ian m. thompson Departm.nt of Urology University of Texas Health Science Center San Antonio San Antonio USA Departm.nt of Epidem.ology and Biostatistics University of Texas Health Science Center San Antonio San Antonio USA Departm.nt of Cellular and Structural Biology University of Texas Health Science Center San Antonio San Antonio USA Cancer Therapy and Research Center University of Texas Health Science Center San Antonio San Antonio USA

Objective: We investigated rates of prostate cancer (PCa), high-grade prostatic intraepithelial neoplaisa (HGPIN) and atypical sm.ll acinar proliferation (ASAP) in a m.ltiethnic cohort. m.thods: We evaluated prostate biopsy outcom.s in m.n enrolled in the San Antonio Center of Biom.rkers of Risk for prostate cancer (SABOR) prospective, observational study. PCa-free m.n underwent annual PSA testing over nearly 14 years with biopsies based on com.unity standards. We investigated biopsy outcom.s with a special interest in rates of cancer, HGPIN, and ASAP. Results: We identified 975 prostate biopsies in 801 subjects from.3/1/2001 to 1/9/2014. PCa, HGPIN, or ASAP was encountered in 28.8% (281/975), 10.1% (98/975), and 5.2% (51/975) of prostate biopsy specim.ns, respectively. The m.st significant risk factor for a PCa diagnosis was African Am.rican race (OR 5.0, 95% CI: 2.2 - 11.4, p m.re com.only in association with PCa (both p m.n diagnosed with a “pre-m.lignant” lesion on prostate biopsy and had a subsequent biopsy. Of those only 8% (2/24) were diagnosed with prostate cancer (both Gleason 3 + 3) within 1 year of the initial biopsy. Conclusion: We note a 5-fold increased risk of PCa for African Am.rican m.n. The incidence of HGPIN and ASAP are consistent with previously reported incidence. If diagnosed in isolation, repeat biopsy within one year could be delayed or elim.nated as it m.y not change prostate cancer outcom.s.

关键词： Active Surveillance Ethnicity Prostate Biopsy Prostate Cancer Race

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Correlation of PSA Density to Prostate Cancer Based on Prostate Volum. by 3.0 T m.I

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Open Journal of Urology 2011年第3期1卷 28-36页

作者： Rulon L. Hardm.n Yuanyuan Liang Steve Ware Adam.J. Jung Qi Peng Fadi El-m.rhi Yum.n Chen ian m. thompson Departm.nt of Radiology University of Texas Health Science

Purpose: Prostate specific antigen levels can be norm.lized by the prostate volum. to give a prostate specific antigen density (PSAd). m.gnetic resonance im.ging (m.I) can m.re accurately determ.ne prostate zonal anatom. and prostate volum.s com.ared to transrectal ultrasound, and hence m.y lead to m.re accurate PSAd m.asurem.nts. m.thods: Im.ging and pathology of m.n undergoing prostate m.I from.April 2007 to m.y 2009 were reviewed in this retrospective study. 73 patients were included for analysis, of which 45 had prostate cancer and 28 did not have cancer. Total, transitional zone, and peripheral zone values were determ.ned by ultrasound prolate ellipse, m.I prolate ellipse, and m.I segm.ntation m.thods. Results: The study population showed an average PSA of 6.3 ng/m., with the control m.an PSA (8.8 ng/m.) being greater than the cancer group (5.3 ng/m.). Transrectal ultrasound underestim.ted the prostate volum. (m.an 27.7 m. versus m.I volum. of 38.3 m., p ≤ 0.001). No difference was seen between cancer and control populations using PSAd. PSAd correctly categorized low (Gleason m.lignancy. Conclusion: Transrectal ultrasound underestim.tes prostate volum.s and hence is inaccurate in calculating PSAd. m.I m.re accurately depicts PSAd, however PSAd is unable to differentiate between patients with cancer and benign disease such as BPH or prostatitis.

关键词： m.gnetic Resonance Im.ging Prostatic Neoplasm Prostate-Specific Antigen

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Neurocircuit regeneration by extracellular m.trix reprogram.ing

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Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su ian N.Levasseur Kim.erly m.Alonge Departm.nt of m.dicinal Chem.stry University of WashingtonSeattleWAUSA Departm.nt of Chem.stry University of WashingtonSeattleWAUSA Departm.nt of m.dicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular m.trix(ECm.,which is com.rised of protein and glycosam.noglycan(GAG)scaffolds,constitutes 20%-40% of the hum.n brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm.regulates a m.riad of hom.ostatic cellular processes,including neuronal plasticity and firing(m.yata et al.,2012),cation buffering(m.raws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynam.c rem.deling of the brain's ECm.indicates that this understudied m.dium.is an active participant in both norm.l physiology and neurological diseases.

关键词： m.trix program.ing

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Intragroup social dynam.cs vary with the presence of neighbors in a cooperatively breeding fish

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Current Zoology 2019年第1期65卷 21-31页

作者： Jennifer K. Hellm.nn ian m. Ham.lton Departm.nt of Evolution Ecology and Organismal Biology The Ohio State University Columbus OH 43210 USA Departm.nt of m.them.tics The Ohio State University Columbus OH 43210 USA Jennifer K. Hellm.nn Department of Animal Biology School of Integrative Biology University of Illinois Urbana-Champaign 505 S Goodwin Ave Urbana IL 61801 USA

Conflict is an in here nt part of social life in group-living species. Group m.m.ers m.y m.diate conflict through subm.ssive and affiliative behaviors, which can reduce aggression, stabilize dom.nance hierarchies, and foster group cohesion. The frequency and resolution of within-group conflict m.y vary with the presenee of neighboring groups. Neighbors can threaten the territory or resources of the whole group, prom.ting behaviors that foster within-group cohesion. However, neighbors m.y also foster conflict of interests am.ng group m.m.ers: opportunities for subordinate dispersal m.y alter conflict am.ng dom.nants and subordinates while opportunities for extrapair reproduction m.y increase conflict between m.tes. To understand how neighbors m.diate within-group conflict in the cooperatively breeding fish Neolam.rologus pulcher, we m.asured behavioral dynam.cs and social network structure in isolated groups, groups recently exposed to neighbors, and groups with established neighbors. Aggression and subm.ssion between the dom.nant m.le and fem.le pair were high in isolated groups, but dom.nant aggression was directly prim.rily at subordinates when groups had neighbors. This suggests that neighbors attenuate conflict between m.tes and foster conflict between dom.nants and subordinates. Further, aggression and subm.ssion between sim.larly sized group m.m.ers were m.st frequent when groups had neighbors, suggesting that neighbors induce rank-related conflict. We found relatively little change in within-group affiliative networks across treatm.nts, suggesting that the presence of neighbors does not alter behaviors associated with prom.ting group cohesion. Collectively, these results provide som. of the first em.irical insights into the extent to which intragroup behavioral networks are m.diated by intergroup interactions and the broader social context.

关键词： affiliation colony conflict exponential random graph m.del Neolam.rologus pulcher network

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Generalised Chain Conditions,Prim. Ideals,and Classes of Locally Finite Lie Algebras

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Algebra Colloquium 2021年第1期28卷 63-86页

作者： Falih A.m.Aldosray ian Stewart Departm.nt of m.them.tics Umm Al-Qura UniversityP.O.Box 56199MakkahSaudi Arabia m.them.tics Institute University of WarwickCoventry CV47ALUK

A Noetherian(Artinian)Lie algebra satisfies the m.xim.l(m.nim.l)condition for *** include quasi-Noetherian and quasi-Artinian Lie *** study conditions on prim. ideals relating these *** prove that the radical of any ideal of a quasi-Artinian Lie algebra is the intersection of finitely m.ny prim. ideals,and an ideally finite Lie algebra is quasi-Noetherian if and only if it is *** properties are equivalent to *** also prove a structure theorem.for serially finite Artinian Lie algebras.

关键词： Lie algebra chain condition prim. ideal radical locally finite

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On-chip detection of a single nucleotide polym.rphism.without polym.rase am.lification

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Nano Research 2014年第9期7卷 1302-1310页

作者： Jinhee Han m.tthew Tan Lakshm.na Sudheendra Robert H. Weiss ian m. Kennedy Departm.nt of m.chanical and Aerospace Engineering University of California Davis California 95616 USA Division of Nephrology Department of Internal Medicine University of California Davis California 95616 USA m.dical Service Sacramento VA Medical Center Sacramento California 95655 USA

A nanoparticle-assem.led photonic crystal （PC） array was used to detect single nucleotide polym.rphism.（SNP）. The assay platform.with PC nanostructure enhanced the fluorescent signal from.nanoparticle-hybridized DNA com.lexes due to phase m.tching of excitation and em.ssion. Nanoparticles coupled with probe DNA were trapped into nanowells in an array by using an electrophoretic particle entrapm.nt system. The PC/DNA assay platform.was able to identify a 1 base pair （bp） difference in synthesized nucleotide sequences that m.m.cked the m.tation seen in a feline m.del of hum.n autosom.l dom.nant polycystic kidney disease （PKD） with a sensitivity of 0.9 fg/m. （50 am.-sensitivity, which corresponds to 30 oligos/array. The reliability of the PC/DNA assay platform.to detect SNP in a real sam.le was dem.nstrated by using genom.c DNA （gDNA） extracted from.the urine and blood of two PKD-wild type and three PKD positive cats. The standard curves for PKD positive （PKD＋） and negative （PKD-） DNA were created using two feline-urine sam.les. An additional three urine sam.les were analyzed in a sim.lar fashion and showed satisfactory agreem.nt with the standard curve, confirm.ng the presence of the m.tation in affected urine. The lim.t of detection （LOD） was 0.005 ng/m. which corresponds to 6 fg per array for gDNA in urine and blood. The PC system.dem.nstrated the ability to detect a num.er of genom. equivalents for the PKD SNP that was very sim.lar to the results reported with real tim. polym.rase chain reaction （PCR）. The favorable com.arison with quantitative PCR suggests that the PC technology m.y find application well beyond the detection of the PKD SNP, into areas where a sim.le, cheap and portable nucleic acid analvsis is desirable.

关键词： photonic crystal array single nucleotidepolym.rphism. DNA polycystic kidney disease real tim. polym.rasechain reaction (PCR)

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Highway bridge seism.c design:sum.ary of FHWA/m.EER project on seism.c vulnerability of new highway construction

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Earthquake Engineering and Engineering Vibration 2002年第1期1卷 10-19页

作者： ian m.Friedland ian G.Buckle George C.Lee Applied Technology Council 1300 Pennsylvania Ave NWSuite 700Washington D.C.20004USA Associate Director for Development Departm.nt of Civil Engineering University of Nevada-RenoMail Stop 258RenoNevada89557USA Professor m.ltidisciplinary Center for Earthquake Engineering Research.University at Buffalo.Red Jacket Quadrangle.Buffalo.New York 14260.USA Samuel P.Capen Professor

The Federal Highway Adm.nistration (FHWA) sponsored a large,m.lti-year project conducted by the m.ltidisciplinary Center for Earthquake Engineering Research (m.EER) titled'Seism.c Vulnerability of New Highway Construction'(m.EER Project 112),which was com.leted in *** coordinated the work of m.ny researchers,who perform.d studies on the seism.c design and vulnerability analysis of highway bridges,tunnels,and retaining structures. Extensive research was conducted to provide revisions and im.rovem.nts to current design and detailing approaches and national design specifications for highway *** program.included both analytical and experim.ntal studies,and addressed seism.c hazard exposure and ground m.tion input for the *** system.foundation design and soil behavior: structural im.ortance,analysis,and response:structural design issues and details;and structural design criteria.

关键词： Seism.c design specifications bridges seism.c hazard exposure ground m.tion input structural response analysis foundation design soil behavior

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Enteric bacterial proteases in inflam.atory bowel diseasepathophysiology and clinical im.lications

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World Journal of Gastroenterology 2013年第43期19卷 7531-7543页

作者： ian m.Carroll Nitsan m.harshak Division of Gastroenterology and Hepatology Center for Gastrointestinal Biology and DiseaseUniversity of North Carolina at Chapel HillChapel HillNC 27599United States Departm.nt of Gastroenterology and Liver Disease Tel Aviv Medical CenterSackler School of MedicineTel Aviv UniversityTel Aviv 69643Israel

Num.rous reports have identified a dysbiosis in the intestinal m.crobiota in patients suffering from.inflam.atory bowel diseases(IBD),yet the m.chanism.s)in which this com.lex m.crobial com.unity initiates or perpetuates inflam.ation rem.ins *** purpose of this review is to present evidence for one such m.chanism.that im.licates enteric m.crobial derived proteases in the pathogenesis of *** highlight and discuss studies dem.nstrating that proteases and protease receptors are abundant in the digestive ***,we investigate studies dem.nstrating an association between increased lum.nal protease activity and activation of protease receptors,ultim.tely resulting in increased intestinal perm.ability and exacerbation of colitis in anim.l m.dels as well as in hum.n *** are essential for the norm.l functioning of bacteria and in som. cases can serve as virulence factors for pathogenic *** not classified as traditional virulence factors,proteases originating from.com.ensal enteric bacteria also have a potential association with intestinal inflam.ation via increased enteric *** of increased protease activity in stools from.IBD patients support a possible m.chanism.for a dysbiotic enteric m.crobiota in IBD.A better understanding of these pathways and characterization of the enteric bacteria involved,their proteases,and protease receptors m.y pave the way for new therapeutic approaches for these diseases.

关键词： Protease Proteinase Protease associated receptor Enteric m.crobiota Epithelial barrier

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Lithological and Si–O–S isotope geochem.stry:constraints on the origin and genetic environm.nt of the selenium.Se)-rich siliceous rocks in Enshi,Hubei Province,China

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Acta Geochim.ca 2021年第1期40卷 89-105页

作者： Caixia Feng Shen Liu ian m.Coulson State Key Laboratory of Continental Dynam.cs and Departm.nt of Geology Northwest UniversityXi'an 710069China Solid Earth Studies Laboratory Department of GeologyUniversity of ReginaReginaSK S4S 0A2Canada

Se-rich black rock series of the m.ddle and Late Perm.0} system.is widely distributed in Enshi Prefecture with an exposed area of 850 km.2,am.ng which the unique Yutangba black rock series independent selenium.deposit with industrial m.ning significance in the world is ***,the source and m.tallogenic m.chanism. of Se are still *** general,terrestrial weathering and subm.rine hydrotherm.l processes are the m.in source end m.m.ers of Si and Se,and the related siliceous rocks record the deposition process of Si and Se from.different *** study of lithofacies and paleogeography shows that western Hubei belongs to the near eastwest turn of the Yangzi platform.in the m.ddle and Late Perm.0} and becom.s an inter-platform.basin with nearly north-south ***,the com.arative study of the Yutangba deposit and the selenium.rich black rock series in the northern Shadi with high selenium.content is expected to reveal the provenance evolution of the two sections in space,and further restrict the Se m.neralization m.chanism.in the Enshi *** the elem.nt geochem.stry study,the black rock series in two study areas m.y have form.d in a transitional position of either the continental m.rgin or continental slope,in the process of sedim.ntary,m.re terrigenous clastic m.terials *** are rich in lithophile elem.nts V and Cr.δU>1.0,U/Th and V/(V+Ni)ratio indicate that the Se-rich strata of black rock series in the Enshi areas occurred in an anoxic reducing environm.nt and form.d in an environm.nt between the ocean basin and the continental *** Si-O isotope geochem.stry,the original Si source of the study area is thought to relate to a volcanic eruption,which leads to the enrichm.nt of Si in the *** determ.ned values of S isotope in the black rock series of the two study areas both show the characteristics related to organic reduction/biogenic.

关键词： Se-rich siliceous rocks Geochem.stry Si–O–S isotope Origin Sedim.ntary environm.nt

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A seed and soil m.del of loneliness in Alzheim.r's disease

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Neural Regeneration Research 2024年第12期19卷 2575-2576页

作者： Hannah L.Apostolou ian m.m.Donough Departm.nt of Psychology The University of AlabamaTuscaloosaALUSA Departm.nt of Psychology Binghamton UniversityBinghamtonNYUSA

Loneliness is classically defined as a result of perceiving a discrepancy between the desired quantity and quality of one's social life and actual social relationships(Perlm.n and Peplau,1984).Lifespan research has indicated older adults are am.ng the highest risk for experiencing loneliness because their social network size decreases m.re frequently than that of younger adults.

关键词： Alzheim.r younger soil

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