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Anti-herpes simplex virus activities of monogalactosyl diglyceride and digalactosyl diglyceride from Clinacanthus nutans, a traditional Thai herbal medicine

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Asian Pacific Journal of Tropical Biomedicine 2016年第3期6卷 192-197页

作者： Sirada Pongmuangmul Supaporn Phumiamorn Phanchana Sanguansermsri Nalin Wongkattiya ian Hamilton Fraser Donruedee Sanguansermsri Faculty of medical Science Naresuan University Regional medical Sciences Center Nakhonswan Department of Medical Sciences Ministry of Health Institute of Biological Products Department of Medical Sciences Ministry of Health Faculty of Science Maejo University School of Chemistry Monash University Centre of Excellence in medical Biotechnology Faculty of Medical Science Naresuan University

Objective: To evaluate the monogalactosyl diglyceride(mGDG) and digalactosyl diglyceride(DGDG) from Clinacanthus nutans(C. nutans) for their in vitro antiviral activities against herpes simplex virus type 1(HSV-1) and type 2(HSV-2) by plaque reduction ***: mGDG and DGDG were extracted with chloroform from C. nutans *** and DGDG were separated from chloroform crude extract using column chromatography, characterized by thin layer chromatography and quantified by high performance liquid chromatography. The anti HSV-1 and 2 activity against pre-treatment and posttreatment of the compounds was evaluated using plaque reduction assay. The cytotoxicity of the extract and the compounds on Vero cells were performed by mTT ***: mGDG and DGDG obtained by column chromatography showed identical profiles as standard mGDG and standard DGDG using thin layer chromatography and high performance liquid chromatography. mGDG and DGDG from C. nutans showed 100%inhibition of HSV-1 replication at the post step of infection at noncytotoxic concentration with IC50 values of 36.00 and 40.00 mg/m L, and HSV-2 at 41.00 and 43.20 mg/mL,respectively. moreover, mGDG and DGDG from C. nutans were demonstrated to have antiherpes simplex activity at the same level as standard synthetic compounds. In contrast, pretreatment of Vero cells with mGDG and DGDG before HSV-1 and HSV-2 infection did not show inhibitory effect against these viruses. mGDG and DGDG exhibited antiviral activity against HSV-1 with selectivity index of 26.00 and 23.00 and HSV-2 of 23.30 and ***: mGDG and DGDG from C. nutans, a traditional Thai herbal medicine illustrated inhibitory activity against HSV-1 and HSV-2, probably by inhibiting the late stage of multiplication, suggesting their promising use as anti-HSV agents.

关键词： Glycoglycerolipids monogalactosyl diglyceride Digalactosyl diglyceride Clinacanthus nutans Herpes simplex virus type 1 Herpes simplex virus type 2 Antiviral activity

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BiFeO_(3)-BaTiO_(3):A new generation of lead-free electroceramics

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Journal of Advanced Dielectrics 2018年第6期8卷 8-42页

作者： Dawei Wang Ge Wang Shunsuke murakami Zhongming Fan Antonio Feteira Di Zhou Shikuan Sun Quanliang Zhao ian m.Reaney Department of materials Science and Engineering University of Sheffield Sheffield S13JDUK Department of materials Science and Engineering Iowa State University AmesIowa 50011USA Christian Doppler Laboratory for Advanced Ferroic Oxides Sheffield Hallam University Sheffield S11WBUK Electronic materials Research Laboratory Key Laboratory of the ministry of Education&International Center for Dielectric Research Xi’an Jiaotong University Xi’an 710049ShaanxiP.R.China School of mechanical and materials Engineering North China University of Technology Beijing 100144 P.R.China

Lead-based electroceramics such as Pb(***)O_(3)(PZT)and its derivatives have excellent piezoelectric,pyroelectric and energy storage properties and can be used in a wide range of *** lead-free replacements for PZT such as potassium sodium niobate(KNN)and sodium bismuth titanate(NBT)have a much more limited range of useful properties and have been optimized primarily for piezoelectric ***,we review the initial results on a new generation of lead-free electroceramics based on BiFeO_(3)-BaTiO_(3)(BF-BT)highlighting the essential crystal chemistry that permits a wide range of functional *** demonstrate that with the appropriate dopants and heat treatment,BF-BT can be used to fabricate commercially viable ceramics for applications,ranging from sensors,multilayer actuators,capacitors and high-density energy storage *** also assess the potential of BF-BT-based ceramics for electrocaloric and pyroelectric applications.

关键词： BiFeO_(3)-BaTiO_(3) lead-free piezoelectrics energy storage dielectrics capacitors

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Trends in maternal body mass index in Northern Ireland:a cross-sectional and longitudinal study

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Family medicine and Community Health 2021年第4期9卷 20-30,I0003-I0012页

作者： Lisa Kent Christopher Cardwell ian Young Kelly-Ann Eastwood Administrative Data Research Centre Northern Ireland Centre for Public HealthQueen's University BelfastBelfastUK Institute of Clinical Science Block BCentre for Public HealthQueen's University BelfastBelfastUK Fetal medicine Unit University Hospitals Bristol and Weston NHS Foundation TrustBristolUK

Objectives Explore(1)associations between maternal body mass index(BmI),demographic and clinical characteristics,(2)longitudinal trends in BmI,(3)geographical distributions in prevalence of maternal overweight and *** Retrospective population-based *** Linked,anonymised,routinely collected healthcare data and official statistics from Northern *** All pregnancies in Northern Ireland(2011-2017)with BmI measured at≤16 weeks *** Analysis of variance andχ^(2)tests were used to explore *** linear regression was used to explore longitudinal trends and spatial visualisation illustrated geographical *** outcomes are prevalence of overweight(BmI≥25 kg/m^(2))and obesity(BmI≥30 kg/m^(2)).Results 152961 singleton and 2362 multiple pregnancies were included.A high prevalence of maternal overweight and obesity in Northern Ireland is apparent(singleton:52.4%;multiple:48.3%)and is *** was positively associated with older age,larger numbers of previous pregnancies and unplanned pregnancy(pmI category was also positively associated with unemployment(35%in obese class III vs 22%in normal BmI category)(pmI categories were associated with increased rate of comorbidities,including hypertension(normal BmI:1.8%vs obese III:12.4%),diabetes mellitus(normal BmI:0.04%vs obese III:1.29%)and mental ill-health(normal BmI:5.0%vs obese III:11.8%)(pmaternal obesity varied with deprivation(most deprived:22.8%vs least deprived:15.7%)(pmI was associated with agemployment and mental ill-health(pmaternal BmI>25 kg/m^(2)is increasing over time in Northern *** are entering pregnancy with additional comorbidities likely to impact their life course beyond *** highlights the need for prioritisation of preconception and inter-pregnancy support for management of weight and

关键词： routine index category

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Acai Fruit as a Source of Bioactive Phytochemicals

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Journal of Life Sciences 2016年第8期10卷 391-404页

作者： Randah m. Alqurashi Daniel m. Commane ian R. Rowland Hugh Sinclair Unit. of Human Nutrition Department of Food and Nutritional Sciences University of Reading Reading RG6 6AP United Kingdom The Saudi Arabian ministry of Education Kingdom of Saudi Arabia

The fruit of the acai palm （Euterpe oleracea mart.） is a rich source of potential bioactive phytochemicals, however neither its precise composition nor the putative benefits to health from its consumption have been fully characterised. This study aims to elucidate the composition of acai fruit pulp and to explore the potential of these extracts to confer protection in a cell culture based model of oxidative DNA damage. Extractions ofcai pulps were dissolved in a 80% methanol （methanol： water, 80：20 v/v） based solvent and the phytochemicals present in the extract were analysing by HPLC detector. Lipids were assessed via GC. The Folin-Ciocalteau assay was used to determine the purposes of providing a phytochemical rich food based comparator with established health benefits. Finally, protection against oxidative DNA damage was assessed in HT-29 cell lines exposed to hydrogen peroxide via the comet assay. Acai pulp extracts were found to be rich in flavonoids, anthocyanins and carotenoids. These extracts were found to protect against oxidative DNA damage （anti-genotoxicity）. A^ai extracts were more effective at preventing oxidative DNA damage than the blueberry extracts, although their antioxidant capacities as assessed by the FRAP assay were similar. These data shown that acai is a rich source of plant phytochemicals and that these chemicals may protect against oxidative stress in human colon cells （HT-29）. Further work is needed to establish the digestive fate of these phytochemicals and to prove the beneficial effects in human.

关键词： Acai pulp antioxidant activity anti-genotoxicity polyphenols.

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青海湖裸鲤耳石轮纹O-Sr同位素组成及对其洄游行为的指示

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科学通报 2016年第6期61卷 668-675页

作者：周玲金章东 WILLIAmS ian S 张飞中国科学院地球环境研究所黄土与第四纪地质国家重点实验室西安710061 西安交通大学全球环境变化研究院西安710049 Research School of Earth Sciences The Australian National UniversityCanberraACT 0200Australia

以溯河洄游为特征的青海湖裸鲤是青海湖鱼类的优势种,但其洄游行为还知之甚少.利用高分辨率SHRImPⅡ离子探针和激光剥蚀高分辨多接收电感耦合等离子体质谱仪(LA-mC-ICP-mS)分别测定了青海湖裸鲤微耳石轮纹中的氧和锶(O-Sr)同位素组成.... 详细信息

以溯河洄游为特征的青海湖裸鲤是青海湖鱼类的优势种,但其洄游行为还知之甚少.利用高分辨率SHRImPⅡ离子探针和激光剥蚀高分辨多接收电感耦合等离子体质谱仪(LA-mC-ICP-mS)分别测定了青海湖裸鲤微耳石轮纹中的氧和锶(O-Sr)同位素组成.结果表明,微耳石成长带中较低的δ^(18)O记录了青海湖裸鲤春夏时期所洄游的河水化学信息;将δ^(18)O与^(87)Sr/^(86)Sr同位素组成相结合,微耳石轮纹的同位素组成明确指示了多数个体可能更倾向于固定的河流洄游产卵.这一结果对于认识青海湖裸鲤的洄游习性以及鱼类保护和管理有重要的意义.

关键词：青海湖裸鲤微耳石轮纹稳定同位素洄游习性

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Petroleum geoscience in Norden - exploration, production and organization

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Episodes 2008年第1期31卷 115-124页

作者： Anthony m. Spencer Per Ivar Briskeby Lone Dyrmose Christensen Rune Foyn marie KjФlleberg Erling Kvadsheim ian Knight morten Rye-Larsen John Williams StatoilHydro Forushagen 4035 Stavanger Norway. StatoilHydro 0240 Oslo Norway. StatoilHydro 9481 Harstad Norway. ConocoPhillips P.O. Box 220 4098 Tananger Norway. Norwegian Petroleum Directorate P.O. Box 600 4003 Stavanger Norway. StatoilHydro PO Box 7200 5020 Bergen Norway.

Offshore exploration in Norway and Denmark-in the North Sea, the Norwegian Sea and the Barents Sea-has involved drilling about 850 wildcat wells, resulting in about 300 oil and gas finds, of which 84 are fields with production. The recoverable resources of all these finds total about 65 billion barrels of oil equivalent. Almost all these hydrocarbons come from a Jurassic source and the main reservoirs and traps are Jurassic sandstones in fault blocks and Paleocene sandstones or Cretaceous chalks in gentle domes. The article describes four major fields-Ekofisk, Gullfaks, Ormen Lange and SnФhvitto illustrate some of the many challenges in developing and producing the hydrocarbons. Elsewhere in Norden, there has been much less exploration. Drilling results have mostly been negative in mainland Sweden, onshore Denmark, onshore Svalbard and on- and offshore West Greenland. minor oil finds have been made in Palaeozoic rocks in the Baltic Sea. The first wells have recently been drilled off the Faroe Islands, resulting in one discovery. No drilling has taken place on- or offshore East Greenland. As a result of the hydrocarbon activities in Norway and Denmark, petroleum geoscience there has flourished, with 2000 geoscientists currently employed in the industry, many technical innovations made, a wealth of publically available information and a great increase in the understanding of the geology.

关键词：石油勘探地球科学资源开发地质特征

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山西省早白垩纪碳酸岩元素同位素和锆石U-Pb定年研究(英文)

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岩石学报 2014年第2期30卷 350-360页

作者：刘燊冯彩霞胡瑞忠赖绍聪 ian m Coulson 冯光英杨毓红大陆动力学国家重点实验室西北大学地质学系西安710069 矿床地球化学国家重点实验室中国科学院地球化学研究所贵阳550002 国体地球研究实验室里贾纳大学地质学系

碳酸岩广泛出露在华北克拉通的山西省。此文中,针对研究区的碳酸岩墙,我们给出新的地球化学、Sr-Nd同位素和锆石U-Pb年龄。LA-ICP-mS锆石定年结果显示,该岩墙的侵位年龄为132.9ma,全岩K-Ar年龄为131.3~132.6 ma。碳酸岩墙具有非常一致... 详细信息

碳酸岩广泛出露在华北克拉通的山西省。此文中,针对研究区的碳酸岩墙,我们给出新的地球化学、Sr-Nd同位素和锆石U-Pb年龄。LA-ICP-mS锆石定年结果显示,该岩墙的侵位年龄为132.9ma,全岩K-Ar年龄为131.3~132.6 ma。碳酸岩墙具有非常一致的主量元素组成,富集轻稀土元素和大离子亲石元素(Ba、U、Pb、Sr),以及亏损K和高场强元素(Ta、P和Ti)。另外,该岩墙具有相对一致的(87Sr/86Sr)i(0.7079~0.7083)和负的εNd(t)(-16.7^-15.2)。以上地球化学特征表明,该岩墙为大陆地壳和此大陆岩石圈地幔混合时期,受明显地壳混染的下岩石圈地幔的部分熔融作用。

关键词：白垩纪碳酸岩墙山西华北克拉通北部

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Developing Wheat for Improved Yield and Adaptation Under a Changing Climate： Optimization of a Few Key Genes

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Engineering 2018年第4期4卷 514-522页

作者： m.A.N. Nazim Ud Dowl ian Edwards Graham O'Hara Shahidul Islam Wujun ma School of Veterinary and Life Sciences Murdoch University Perth WA 6150 Australia Edstar Genetics Pry. Ltd. Perth WA 6150 Australia

Wheat grown under rain-fed conditions is often affected by drought worldwide. Future projections from a climate simulation model predict that the combined effects of increasing temperature and changing rainfall patterns will aggravate this drought scenario and may significantly reduce wheat yields unless appropriate varieties are adopted. Wheat is adapted to a wide range of environments due to the diversity in its phenology genes. Wheat phenology offers the opportunity to fight against drought by modifying crop developmental phases according to water availability in target environments. This review summa- rizes recent advances in wheat phenology research, including vernalization （Vrn）, photoperiod （Ppd）, and also dwarfing （Rht） genes. The alleles, haplotypes, and copy number variation identified for Vrn and Ppd genes respond differently in different climatic conditions, and thus could alter not only the development phases but also the yield. Compared with the model plant Arabidopsis, more phenology genes have not yet been identified in wheat; quantifying their effects in target environments would benefit the breeding of wheat for improved drought tolerance. Hence, there is scope to maximize yields in water-limited envi-ronments by deploying appropriate phenology gene combinations along with Rht genes and other important physiological traits that are associated with drought resistance.

关键词： Phenology Wheat Vernalization Photoperiod Drought Climate change

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Hormonal modulation of reproduction and fertility signaling in polistine wasps

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Current Zoology 2021年第5期67卷 519-530页

作者： Cintia Akemi OI Rafael Carvalho DA SILVA ian STEVENS Helena mendes FERREIRA Fabio Santos NASCImENTO Tom WENSELEERS Laboratory of Socioecology and Social Evolution KU LeuvenLeuven 3000Belgium Faculdade de Filosofia Ciencias e Letras de Ribeirao PretoDepartamento de BiologiaUniversidade de Sao Paulo—USPRibeirao PretoSP 14040-901Brazil

In social insects,it has been suggested that reproduction and the production of particular fertilitylinked cuticular hydrocarbons(CHC)may be under shared juvenile hormone(JH)control,and this could have been key in predisposing such cues to later evolve into full-fledged queen pheromone ***,to date,only few studies have experimentally tested this“hormonal pleiotropy”***,we formally test this hypothesis using data from four species of Polistine wasps,Polistes dominula,Polistes satan,mischocyttarus metathoracicus,and mischocyttarus cassununga,and experimental treatments with JH using the JH analogue methoprene and the anti-JH *** line with reproduction being under JH control,our results show that across these four species,precocene significantly decreased ovary development when compared with both the acetone solvent-only control and the methoprene *** with the hormonal pleiotropy hypothesis,these effects on reproduction were further matched by subtle shifts in the CHC profiles,with univariate analyses showing that in *** and *** the abundance of particular linear alkanes and mono-methylated alkanes were affected by ovary development and our hormonal *** results indicate that in primitively eusocial wasps,and particularly in Polistes,reproduction and the production of some CHC cues are under joint JH *** suggest that pleiotropic links between reproduction and the production of such hydrocarbon cues have been key enablers for the origin of true fertility and queen signals in more derived,advanced eusocial insects.

关键词： Polistinae wasps fertility cues queen pheromones cuticular hydrocarbons juvenile hormone

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Insights into triterpene synthesis and unsaturated fatty-acid accumulation provided by chromosomallevel genome analysis of Akebia trifoliata subsp . australis

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Horticulture Research 2021年第1期8卷 419-433页

作者： Hui Huang Juan Liang Qi Tan Linfeng Ou Xiaolin Li Caihong Zhong Huilin Huang ian max moller Xianjin Wu Songquan Song Key Lab oratory of Resea rch and Utilizati on of Eth nomedic inal Pla nt Reso ur ces of Hunan Province College of Biological and Food EngineeringHuaihua UniversityHuaihua 418000China Kunming Institute of Botany Chinese Academy of Scie ncesKunming 650201China State Key Lab oratory Br eed ing Base of Dao-di Herbs National Resource Center for Chinese Materia MedicaChina Academy of Chinese Medical ScienceBeijing 100700China Department of molecular Biology and Genetics Aarhus UniversityFlakkebjergDK-4200 SlagelseDenmark Institute of Botany Chinese Academy of SciencesBeijing 100093China

Akebia trifoliata *** is a well-known medicinal and potential woody oil plant in *** limited genetic information available for *** *** has hindered its ***,a high-quality chromosomelevel genome sequence of *** *** is *** de novo genome assembly of 682.14 mb was generated with a scaffold N50 of 43.11 *** genome includes 25,598 protein-coding genes,and 71.18%(485.55 mb)of the assembled sequences were identi fi ed as repetitive *** ongoing massive burst of long terminal repeat(LTR)insertions,which occurred~1.0 million years ago,has contributed a large proportion of LTRs in the genome of *** *** analysis shows that *** *** is closely related to Aquilegia coerulea and forms a clade with Papaver somniferum and Nelumbo nucifera,which supports the well-established hypothesis of a close relationship between basal eudicot *** expansion of UDP-glucoronosyl and UDP-glucosyl transferase gene families and fi-amyrin synthase-like genes and the exclusive contraction of terpene synthase gene families may be responsible for the abundant oleanane-type triterpenoids in *** ***,the acyl-ACP desaturase gene family,including 12 stearoyl-acyl-carrier protein desaturase(SAD)genes,has expanded exclusively.A combined transcriptome and fatty-acid analysis of seeds at fi ve developmental stages revealed that homologs of SADs,acyl-lipid desaturase omega fatty acid desaturases(FADs),and oleosins were highly expressed,consistent with the rapid increase in the content of fatty acids,especially unsaturated fatty *** genomic sequences of *** *** will be a valuable resource for comparative genomic analyses and molecular breeding.

关键词： analysis saturated expanded

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