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World Journal of Radiology 2012年第5期4卷 224-227页

作者： ian m brennan muneeb Ahmed Section of Interventional Radiology Department of Radiology Beth Israel Deaconess Medical Center/Harvard Medical School Boston MA 02215 United States

Portal vein thrombosis is an uncommonly reported complication of percutaneous transhepatic cholangiography (PTC). A thorough review of the available literature shows no reported cases. In this case, a 29 year old female presented on two separate occasions with portal vein thrombosis following PTC without drain placement. This unusual complication of image guided percutaneous biliary access is unreported in the literature and prompted evaluation of the patient's coagulation parameters. A thrombophilia screen demonstrated a mutation in the Prothrombin (Factor Ⅱ) gene. A thorough literature review shows no reported cases of portal vein thrombosis following percutaneous biliary access, is an unusual complication, and should raise suspicion of an underlying pro-coagulant state.

关键词： Percutaneous transhepatic cholangiography Portal vein thrombosis Prothrombin gene mutation Hereditary thrombophilia

Neurocircuit regeneration by extracellular matrix reprogramming

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Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su ian N.Levasseur Kimberly m.Alonge Department of medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECm),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(miyata et al.,2012),cation buffering(moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECm indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

Generalised Chain Conditions,Prime Ideals,and Classes of Locally Finite Lie Algebras

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Algebra Colloquium 2021年第1期28卷 63-86页

作者： Falih A.m.Aldosray ian Stewart Department of mathematics Umm Al-Qura UniversityP.O.Box 56199MakkahSaudi Arabia mathematics Institute University of WarwickCoventry CV47ALUK

A Noetherian(Artinian)Lie algebra satisfies the maximal(minimal)condition for *** include quasi-Noetherian and quasi-Artinian Lie *** study conditions on prime ideals relating these *** prove that the radical of any ideal of a quasi-Artinian Lie algebra is the intersection of finitely many prime ideals,and an ideally finite Lie algebra is quasi-Noetherian if and only if it is *** properties are equivalent to *** also prove a structure theorem for serially finite Artinian Lie algebras.

关键词： Lie algebra chain condition prime ideal radical locally finite

Highway bridge seismic design:summary of FHWA/mCEER project on seismic vulnerability of new highway construction

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Earthquake Engineering and Engineering Vibration 2002年第1期1卷 10-19页

作者： ian m.Friedland ian G.Buckle George C.Lee Applied Technology Council 1300 Pennsylvania Ave NWSuite 700Washington D.C.20004USA Associate Director for Development Department of Civil Engineering University of Nevada-RenoMail Stop 258RenoNevada89557USA Professor multidisciplinary Center for Earthquake Engineering Research.University at Buffalo.Red Jacket Quadrangle.Buffalo.New York 14260.USA Samuel P.Capen Professor

The Federal Highway Administration (FHWA) sponsored a large,multi-year project conducted by the multidisciplinary Center for Earthquake Engineering Research (mCEER) titled'Seismic Vulnerability of New Highway Construction'(mCEER Project 112),which was completed in *** coordinated the work of many researchers,who performed studies on the seismic design and vulnerability analysis of highway bridges,tunnels,and retaining structures. Extensive research was conducted to provide revisions and improvements to current design and detailing approaches and national design specifications for highway *** program included both analytical and experimental studies,and addressed seismic hazard exposure and ground motion input for the *** system;foundation design and soil behavior: structural importance,analysis,and response:structural design issues and details;and structural design criteria.

关键词： Seismic design specifications bridges seismic hazard exposure ground motion input structural response analysis foundation design soil behavior

Enteric bacterial proteases in inflammatory bowel diseasepathophysiology and clinical implications

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World Journal of Gastroenterology 2013年第43期19卷 7531-7543页

作者： ian m Carroll Nitsan maharshak Division of Gastroenterology and Hepatology Center for Gastrointestinal Biology and DiseaseUniversity of North Carolina at Chapel HillChapel HillNC 27599United States Department of Gastroenterology and Liver Disease Tel Aviv Medical CenterSackler School of MedicineTel Aviv UniversityTel Aviv 69643Israel

Numerous reports have identified a dysbiosis in the intestinal microbiota in patients suffering from inflammatory bowel diseases(IBD),yet the mechanism(s)in which this complex microbial community initiates or perpetuates inflammation remains *** purpose of this review is to present evidence for one such mechanism that implicates enteric microbial derived proteases in the pathogenesis of *** highlight and discuss studies demonstrating that proteases and protease receptors are abundant in the digestive ***,we investigate studies demonstrating an association between increased luminal protease activity and activation of protease receptors,ultimately resulting in increased intestinal permeability and exacerbation of colitis in animal models as well as in human *** are essential for the normal functioning of bacteria and in some cases can serve as virulence factors for pathogenic *** not classified as traditional virulence factors,proteases originating from commensal enteric bacteria also have a potential association with intestinal inflammation via increased enteric *** of increased protease activity in stools from IBD patients support a possible mechanism for a dysbiotic enteric microbiota in IBD.A better understanding of these pathways and characterization of the enteric bacteria involved,their proteases,and protease receptors may pave the way for new therapeutic approaches for these diseases.

关键词： Protease Proteinase Protease associated receptor Enteric microbiota Epithelial barrier

Lithological and Si–O–S isotope geochemistry:constraints on the origin and genetic environment of the selenium(Se)-rich siliceous rocks in Enshi,Hubei Province,China

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Acta Geochimica 2021年第1期40卷 89-105页

作者： Caixia Feng Shen Liu ian m.Coulson State Key Laboratory of Continental Dynamics and Department of Geology Northwest UniversityXi'an 710069China Solid Earth Studies Laboratory Department of GeologyUniversity of ReginaReginaSK S4S 0A2Canada

Se-rich black rock series of the middle and Late Permian system is widely distributed in Enshi Prefecture with an exposed area of 850 km~2,among which the unique Yutangba black rock series independent selenium deposit with industrial mining significance in the world is ***,the source and metallogenic mechanisms of Se are still *** general,terrestrial weathering and submarine hydrothermal processes are the main source end members of Si and Se,and the related siliceous rocks record the deposition process of Si and Se from different *** study of lithofacies and paleogeography shows that western Hubei belongs to the near eastwest turn of the Yangzi platform in the middle and Late Permian and becomes an inter-platform basin with nearly north-south ***,the comparative study of the Yutangba deposit and the selenium-rich black rock series in the northern Shadi with high selenium content is expected to reveal the provenance evolution of the two sections in space,and further restrict the Se mineralization mechanism in the Enshi *** the element geochemistry study,the black rock series in two study areas may have formed in a transitional position of either the continental margin or continental slope,in the process of sedimentary,more terrigenous clastic materials *** are rich in lithophile elements V and Cr.δU>1.0,U/Th and V/(V+Ni)ratio indicate that the Se-rich strata of black rock series in the Enshi areas occurred in an anoxic reducing environment and formed in an environment between the ocean basin and the continental *** Si-O isotope geochemistry,the original Si source of the study area is thought to relate to a volcanic eruption,which leads to the enrichment of Si in the *** determined values of S isotope in the black rock series of the two study areas both show the characteristics related to organic reduction/biogenic.

关键词： Se-rich siliceous rocks Geochemistry Si–O–S isotope Origin Sedimentary environment

Intragroup social dynamics vary with the presence of neighbors in a cooperatively breeding fish

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Current Zoology 2019年第1期65卷 21-31页

作者： Jennifer K. Hellmann ian m. Hamilton Department of Evolution Ecology and Organismal Biology The Ohio State University Columbus OH 43210 USA Department of mathematics The Ohio State University Columbus OH 43210 USA Jennifer K. Hellmann Department of Animal Biology School of Integrative Biology University of Illinois Urbana-Champaign 505 S Goodwin Ave Urbana IL 61801 USA

Conflict is an in here nt part of social life in group-living species. Group members may mediate conflict through submissive and affiliative behaviors, which can reduce aggression, stabilize dominance hierarchies, and foster group cohesion. The frequency and resolution of within-group conflict may vary with the presenee of neighboring groups. Neighbors can threaten the territory or resources of the whole group, promoting behaviors that foster within-group cohesion. However, neighbors may also foster conflict of interests among group members: opportunities for subordinate dispersal may alter conflict among dominants and subordinates while opportunities for extrapair reproduction may increase conflict between mates. To understand how neighbors mediate within-group conflict in the cooperatively breeding fish Neolamprologus pulcher, we measured behavioral dynamics and social network structure in isolated groups, groups recently exposed to neighbors, and groups with established neighbors. Aggression and submission between the dominant male and female pair were high in isolated groups, but dominant aggression was directly primarily at subordinates when groups had neighbors. This suggests that neighbors attenuate conflict between mates and foster conflict between dominants and subordinates. Further, aggression and submission between similarly sized group members were most frequent when groups had neighbors, suggesting that neighbors induce rank-related conflict. We found relatively little change in within-group affiliative networks across treatments, suggesting that the presence of neighbors does not alter behaviors associated with promoting group cohesion. Collectively, these results provide some of the first empirical insights into the extent to which intragroup behavioral networks are mediated by intergroup interactions and the broader social context.

关键词： affiliation colony conflict exponential random graph model Neolamprologus pulcher network

A seed and soil model of loneliness in Alzheimer's disease

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Neural Regeneration Research 2024年第12期19卷 2575-2576页

作者： Hannah L.Apostolou ian m.mcDonough Department of Psychology The University of AlabamaTuscaloosaALUSA Department of Psychology Binghamton UniversityBinghamtonNYUSA

Loneliness is classically defined as a result of perceiving a discrepancy between the desired quantity and quality of one's social life and actual social relationships(Perlman and Peplau,1984).Lifespan research has indicated older adults are among the highest risk for experiencing loneliness because their social network size decreases more frequently than that of younger adults.

关键词： Alzheimer younger soil

Population genetics and breeding system of Tupistra pingbianensis (Liliaceae),a naturally rare plant endemic to SW China

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Journal of Systematics and Evolution 2010年第1期48卷 47-57页

作者： Richard ian mILNE Division of Environmental and Evolutionary Biology School of BiologyUniversity of St.AndrewsSt.AndrewsFife KY16 9THUK

The levels and partitioning of genetic diversity and inbreeding depression were investigated in Tupistra pingbianensis,a narrow endemic of southeast Yunnan,China,characterized by a naturally fragmented distribution due to extreme specialization on a rare habitat *** genetic diversity and patterns of genetic variation within and among 11 populations were analyzed using amplified fragment length polymorphism markers with 97 individuals across its whole geographical *** levels of genetic variation were revealed both at the species level(P 99 = 96.012%;H t = 0.302) and at the population level(P 99 = 51.41%;H s = 0.224).Strong genetic differentiation among populations was also detected(F ST = 0.2961;θⅡ = 0.281),which corresponded to results reported for typical animal-pollinated,mixed selfing,and outcrossing plant *** result was consistent with mating patterns detected by our pollination *** indirect estimate of gene flow based on θⅡ was low(N m = 0.64).Special habitat and its life history traits might play an important role in shaping the genetic diversity and the genetic structure of this species.A pollination experiment also failed to detect significant inbreeding depression upon F 1 fruit set,seed weight,and germinate rate *** a naturally rare species,*** is not seriously genetically impoverished and likely to have adapted to tolerating a high level of inbreeding early in its history,we propose this species need only periodic monitoring to ensure their continued persistence,but not intervention to remain viable.

关键词： AFLP genetic diversity genetic structure inbreeding depression naturally rare plants Tupistra pingbianensis.

Retransplantation for graft failure in chronic hepatitis C infection: A good use of a scarce resource?

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World Journal of Gastroenterology 2010年第40期16卷 5070-5076页

作者： ian A Rowe Kerri m Barber Rhiannon Birch Elinor Curnow James m Neuberger Liver and Hepatobiliary Unit University Hospital Birmingham NHS Trust Queen Elizabeth Hospital NHS Blood and Transplant

AIm: To investigate the outcome of patients with hepatitis C virus (HCV) infection undergoing liver retransplantation. mETHODS: Using the UK National Registry, patients undergoing liver transplantation for HCV-related liver disease were identified. Data on patient and graft characteristics, as well as transplant and graft survival were collected to determine the outcome of HCV patients undergoing retransplantation and in order to identify factors associated with transplant survival. RESULTS: Between march 1994 and December 2007, 944 adult patients were transplanted for HCV-related liver disease. At the end of follow-up, 617 of these patients were alive. In total, 194 (21%) patients had first graft failure and of these, 80 underwent liver retransplantation, including 34 patients where the first graft failed due to recurrent disease. For those transplanted for HCV-related disease, the 5-year graft survival in those retransplanted for recurrent HCV was 45% [95% confidence interval (CI): 24%-64%] compared with 80% (95% CI: 62%-90%) for those retransplanted for other indications (P = 0.01, log-rank test); the 5-year transplant survival after retransplantation was 43% (95% CI: 23%-62%) and 46% (95% CI: 31%-60%), respectively (P = 0.8, log-rank test). In univariate analysis of all patients retransplanted, no factor analyzed was significantly associated with transplant survival. CONCLUSION: Outcomes for retransplantation in patients with HCV infection approach agreed criteria for minimum transplant benefit. These data support selective liver retransplantation in patients with HCV infection.

关键词： Hepatitis C Liver Recurrence Retransplantation Outcome