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Neurocircuit regeneration by extracellular matrix reprogramming

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Neural regeneration research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su ian N.Levasseur Kimberly M.Alonge department of Medicinal Chemistry University of WashingtonSeattleWAUSA department of Chemistry University of WashingtonSeattleWAUSA department of Medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAUrABH r.KIrAN d.SINGH r.VAISH V.S.CHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSdT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(Hr), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Effects of symmetric and asymmetric salt conditions on a selective solid-state nanopore assay

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Nano research 2022年第11期15卷 9936-9942页

作者： ian d.Wadsworth Adam r.Hall Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences Wake Forest School of MedicineWinston-SalemNC 27101USA Comprehensive Cancer Center Wake Forest School of MedicineWinston-SalemNC 27157USA

Conventional solid-state nanopore measurements sense all translocating entities,necessitating meticulous analysis to differentiate target *** address this,we have established a selective assay with the platform that has shown utility in quantifying several nucleic acid ***,limited detection efficiency and intrinsic noise have so far limited assay resolution to 10 *** in this value require manipulation of translocation ***,we report the effects of NaCl conditions on assay *** first investigate symmetric conditions,finding sensitivity increases with salt concentration but selectivity is maximized at 1.0 M *** then probe asymmetric conditions,showing a remarkable impact on assay sensitivity and selectivity when measurement buffer NaCl concentration in the reservoir with the translocating molecules is low and the opposite reservoir is *** optimum conditions,we demonstrate detection of target biomolecules down to a concentration of 100 pM which is an improvement of 2 orders of magnitude over past results.

关键词： solid-state nanopores biomarkers amplification-free detection salt gradient nucleic acids

Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord

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Neural regeneration research 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbard Liwen Zhou Cathy Z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George d.Bittner dale r.Sengelaub Program in Neuroscience Indiana UniversityBloomingtonINUSA department of Neuroscience University of Texas at AustinAustinTXUSA

Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic *** have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor ***,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target *** this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic *** adult male and female rats(Sprague–dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of *** action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury *** success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days *** 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish ***-fusion repair reestablished axonal *** to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal ***,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repa

关键词： axotomy dorsal horn peripheral nerve injury plasticity polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase

Lag times in toe-to-heel air injection(THAI)operations explain underlying heavy oil production mechanisms

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Petroleum Science 2022年第3期19卷 1165-1173页

作者： Wei Wei ian d.Gates department of Chemical and Petroleum Engineering University of CalgaryCalgaryAlbertaCanada

From a time value of revenue point of view,it is preferred that the time between reservoir stimulation and oil production response is *** oil combustion processes have a lag time between air injection and liquid production,but the common practice in production data analysis uses simultaneous injection and production data when seeking a relationship between *** this research,the time scales of production for the Kerrobert toe-to-heel air injection(THAI)heavy oil project in Saskatchewan,Canada,is analyzed by using cross correlation analysis,*** delay analysis between air injection and oil *** results reveal two time scales with respect to production response with two distinctive recovery mechanisms:(1)a short time scale response(nearly instantaneous)where oil production peaks right after air injection(directly after opening production well)reflecting cold heavy oil production mechanisms,and(2)a longer time scale(of order of 100-300 days)response where peak production occurs associated with the collective phenomena of air injection,heat generating reactions,heat transfer,and finally,heated mobilized heavy oil drainage to the production *** understanding of the two time scales and associated production mechanisms provides a basis for improving the performance of THAI.

关键词： Heavy oil In situ combustion Toe-to-heel air injection(THAI) Production analysis Lag time

Time averaged consensus in a direct coupled coherent quantum observer network

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Control Theory and Technology 2017年第3期15卷 163-176页

作者： ian r. PETErSEN research School of Engineering The Australian National University Canberra ACT 2601 Australia

This paper considers the problem of constructing a direct coupling quantum observer for a closed linear quantum system. The proposed distributed observer consists of a network of quantum harmonic oscillators and it is shown that the observer network converges to a consensus in a time averaged sense in which each element of the observer estimates the specified output of the quantum plant. An example and simulations are included to illustrate the properties of the observer network.

关键词： Quantum systems quantum observers quantum networks

Emerging noble metal-free Mo-based bifunctional catalysts for electrochemical energy conversion

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Nano research 2022年第12期15卷 10234-10267页

作者： Saswati Santra Verena Streibel ian d.Sharp Walter Schottky Institute and Physics department Technical University of MunichAm Coulombwall 485748GarchingGermany

The transition from a global economy dependent on fossil fuels to one based on sustainable energy conversion technologies presents the primary challenge of the *** water electrolyzers and metal-air batteries with earth-abundant bifunctional transition metal(TM)catalysts that efficiently catalyse the hydrogen and oxygen evolution reactions(HEr and OEr)and the oxygen reduction and evolution reactions(Orr and OEr),respectively,reduces the cost and system complexity,while also providing prospects for accelerated scaling and sustainable material *** the TMs,earth-abundant molybdenum(Mo)-based multifunctional catalysts are especially promising and have attracted considerable attention in recent *** with a brief introduction to HEr,OEr,and Orr mechanisms and parameters governing their bifunctionality,this comprehensive review focuses on such Mo-based multifunctional *** review and discuss recent progress achieved through the formation of Mo-based compounds,heterostructures,and nanoscale composites,as well as by doping,defect engineering,and nanoscale sculpting of Mo-based *** systems discussed in detail are based on Mo chalcogenides,carbides,oxides,nitrides,and phosphides,as well as Mo alloys,highlighting specific opportunities afforded by synergistic interactions of Mo with both non-metals and non-noble ***,we discuss the future of Mo-based multifunctional electrocatalysts for HEr/OEr,Orr/OEr,and HEr/Orr/OEr,analysing emerging trends,new opportunities,and underexplored avenues in this promising materials space.

关键词： molybdenum-based electrocatalysts bifunctional electrocatalysts hydrogen evolution reaction oxygen reduction reaction oxygen evolution reaction

A revised Mississippian lithostratigraphy of County Galway(western Ireland) with an analysis of carbonate lithofacies, biostratigraphy, depositional environments and palaeogeographic reconstructions utilising new borehole data

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Journal of Palaeogeography 2015年第1期4卷 1-26页

作者： Markus Pracht ian d.Somerville Geological Survey of Ireland Beggars Bush Dublin 4 Ireland UCd School of Geological Sciences University College DublinBelfield Dublin 4 Ireland

An integrated study of borehole data and outcrop of Mississippian （late Tournaisian to late Visean） rocks in Co. （County） Galway, western Ireland has enabled a more detailed geological map and lithostratigraphy to be constructed for the region. Several carbonate formations have been distinguished by microfacies analysis and their precise ages established by micropalaeontological investigations using foraminifers and calcareous algae. In addition, palaeogeographic maps have been constructed for the late Tournaisian, and early to late Visoan intervals in the region. The oldest marine Mississippian （late Tournaisian） deposits are recorded in the south of the study region from the Loughrea/Tynagh area and further south in the Gort Borehole; they belong to the Limerick Province. They comprise the Lower Limestone Shale Group succeeded by the Ballysteen Group, Waulsortian Limestone and Kilbryan Limestone Formations. These rocks were deposited in increasing water depth associated with a transgression that moved northwards across Co. Galway. In the northwest and north of the region, marginal marine and non-marine Tournaisian rocks are developed, with a shoreline located NW of Galway City （Galway High）. The central region of Co. Galway has a standard Visdan marine succession that can be directly correlated with the Carrick-on- Shannon succession in counties Leitrim and roscommon to the northeast and east as far as the river Shannon. It is dominated by shallow-water limestones （Oakport, Ballymore and Croghan Limestone Formations） that formed the Galway-roscommon Shelf. This facies is lat- erally equivalent to the Tubber Formation to the south which developed on the Clare-Galway Shelf. In the southeast, basinal facies of the Lucan Formation accumulated in the Athenry Basin throughout much of the Visean. This basin formed during a phase of extensional tectonics in the early Visean and was probably connected to the Tynagh Basin to the east. In the late Visean, shallow-water limes

关键词： Carboniferous Mississippian western Ireland carbonate microfaciesbiostratigraphy foraminifers shelf and basin environments palaeogeography

Polyethylene glycol fusion repair of severed sciatic nerves accelerates recovery of nociceptive sensory perceptions in male and female rats of different strains

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Neural regeneration research 2025年第9期20卷 2667-2681页

作者： Liwen Zhou Karthik Venkudusamy Emily A.Hibbard Yessenia Montoya Alexa Olivarez Cathy Z.Yang Adelaide Leung Varun Gokhale Guhan Periyasamy Zeal Pathak dale r.Sengelaub George d.Bittner department of Neuroscience University of TexasAustinTXUSA Program in Neuroscience Indiana UniversityBloomingtonINUSA department of Molecular Biosciences University of TexasAustinTXUSA

Successful polyethylene glycol fusion(PEG-fusion)of severed axons following peripheral nerve injuries for PEG-fused axons has been reported to:(1)rapidly restore electrophysiological continuity;(2)prevent distal Wallerian degeneration and maintain their myelin sheaths;(3)promote primarily motor,voluntary behavioral recoveries as assessed by the Sciatic Functional Index;and,(4)rapidly produce correct and incorrect connections in many possible combinations that produce rapid and extensive recovery of functional peripheral nervous system/central nervous system connections and reflex(e.g.,toe twitch)or voluntary *** preceding companion paper describes sensory terminal field reo rganization following PEG-fusion repair of sciatic nerve transections or ablations;howeve r,sensory behavioral recovery has not been explicitly explored following PEG-fusion *** the current study,we confirmed the success of PEG-fusion surgeries according to criteria(1-3)above and more extensively investigated whether PEG-fusion enhanced mechanical nociceptive recovery following sciatic transection in male and female outbred Sprague-dawley and inbred Lewis *** nociceptive responses were assessed by measuring withdrawal thresholds using von Frey filaments on the dorsal and midplantar regions of the *** von Frey filament tests were a more reliable method than plantar von Frey filament tests to assess mechanical nociceptive sensitivity following sciatic nerve *** withdrawal thresholds of the sciatic-mediated lateral dorsal region differed significantly across strain but not *** thresholds did not change significantly from baseline in chronic Unoperated and Sham-operated *** sciatic transection,all rats exhibited severe hyposensitivity to stimuli at the lateral dorsal region of the hindpaw ipsilateral to the ***,PEG-fused rats exhibited significantly earlier return to baseline withdrawal thresholds than Negative

关键词： autophagia axotomy collateral sprouting neuropathic pain peripheral nerve repair polyethylene glycol fusion(PEG-fusion) saphenous nerve sensory neurons sex and strain Wallerian degeneration