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Accurate prediction of myopic progression and high myopia by machine learning

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Precision Clinical Medicine 2024年第1期7卷 14-20页

作者： Jiahui Li Simiao Zeng Zhihuan Li Jie Xu Zhuo Sun Jing Zhao Meiyan Li Zixing Zou Taihua Guan Jin Zeng Zhuang Liu Wenchao Xiao Ran Wei Hanpei Miao ian Ziyar Junxiong Huang Yuanxu Gao Yangfa Zeng Xing-Tao Zhou Kang Zhang Guangzhou Women and Children's Medical Center Guangzhou Medical UniversityGuangzhou 510120China Guangzhou National Laboratory Guangzhou 510o0oChina Zhuhai International Eye Center of the First Affiliated Hospital of Faculty of Medicine Macao University of Science and TechnologyZhuhai 519000China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100069China Key Laboratory of Myopia Ministry of HealthShanghai Key Laboratory of Visual Impairment and RestorationDepartment of OphthalmologyEye InstituteEye and EarNoseand Throat HospitalFudan UniversityShanghai 200031China DongguanPeople's Hospital The First School of Clinical MedicinelSouthern Medical UniversityDongguan 523059China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Wenzhou Eye Hospital and Institute for Advanced Study on Eye Health and Diseases Wenzhou Medical UniversityWenzhou 32500oChina

Background Myopia is a leading cause of visual impairment in Asia and ***,accurately predicting the progression of myopia and the high risk of myopia remains a *** study aims to develop a predictive model for the development of *** We first retrospectively gathered 612530 medical records from five independent cohorts,encompassing 227543 patients ranging from infants to young ***,we developed a multivariate linear regression algorithm model to predict the progression of myopia and the risk of high *** The model to predict the progression of myopia achieved an R^(2) value of 0.964 vs a mean absolute error(MAE)of 0.119D[95%confidence interval(CI):0.119,1.146]in the internal validation *** demonstrated strong generalizability,maintaining consistent performance across external validation sets:R^(2)=0.950 vs MAE=0.119D(95%CI:0.119,1.136)in validation study 1,R^(2)=0.950 vs MAE=0.121D(95%CI:0.121,1.144)in validation study 2,and R^(2)=0.806 vs MAE=−0.066D(95%CI:−0.066,0.569)in the Shanghai Children Myopia *** the Beijing Children Eye Study,the model achieved an R^(2) of 0.749 vs a MAE of 0.178D(95%CI:0.178,1.557).The model to predict the risk of high myopia achieved an area under the curve(AUC)of 0.99 in the internal validation set and consistently high area under the curve values of 0.99,0.99,0.96 and 0.99 in the respective external validation *** Our study demonstrates accurate prediction of myopia progression and risk of high myopia providing valuable insights for tailoring strategies to personalize and optimize the clinical management of myopia in children.

关键词： myopia progression machine learning prevention precision medicine

Research Advance of Chinese Medicine in Treating Atherosclerosis:Focus on Lipoprotein-Associated Phospholipase A2

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Chinese Journal of Integrative Medicine 2024年第3期30卷 277-288页

作者： WANG Lu-ming ZHANG Wen-lan LYU Nuan SUO Yan-rong YANG Lin YU Bin JianG Xi-juan School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin301617China Department of Traditional Chinese Medicine Ganzhou People’s HospitalGanzhouJiangxi Province341000China School of Medical Technology Tianjin University of Traditional Chinese MedicineTianjin301617China

As a serious cardiovascular disease,atherosclerosis(AS)causes chronic inflammation and oxidative stress in the body and poses a threat to human ***-associated phospholipase A2(Lp-PLA2)is a member of the phospholipase A2(PLA2)family,and its elevated levels have been shown to contribute to ***-PLA2 is closely related to a variety of lipoproteins,and its role in promoting inflammatory responses and oxidative stress in AS is mainly achieved by hydrolyzing oxidized phosphatidylcholine(ox PC)to produce lysophosphatidylcholine(lyso PC).Moreover,macrophage apoptosis within plaque is promoted by localized Lp-PLA2 which also promotes plaque *** paper reviews those researches of Chinese medicine in treating AS via reducing Lp-PLA2 levels to guide future experimental studies and clinical applications related to AS.

关键词： lipoprotein-associated phospholipase A2 atherosclerosis inflammation oxidative stress apoptosis Chinese medicine

2023年Abel奖获得者Luis Angel Caffarelli访谈录

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数学译林 2024年第1期43卷 8-13页

作者： Bjorn ian Dundas Christian F.Skau 陆柱家(译) 童欣(校) 挪威卑尔根大学挪威Trondheim科技大学不详

Dundas&Skau(以下简写为“D&S”):Caffarelli教授,首先我们要祝贺您获得2023年的Abel(阿贝尔)奖,因为您“对非线性偏微分方程正则性理论,包括自由边界问题和Monge-Ampere(蒙日-安培)方程的开创性贡献”.明天挪威国王下将向您颁奖,我们... 详细信息

Dundas&Skau(以下简写为“D&S”):Caffarelli教授,首先我们要祝贺您获得2023年的Abel(阿贝尔)奖,因为您“对非线性偏微分方程正则性理论,包括自由边界问题和Monge-Ampere(蒙日-安培)方程的开创性贡献”.明天挪威国王下将向您颁奖,我们将回到您的数学,但首先了解一下您的背景可能是个好主意.1948年您出生在布宜诺斯艾利斯.您如何描述您的童年?

关键词：自由边界问题非线性偏微分方程阿贝尔开创性贡献

Blockchain for decentralised rural development and governance

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Blockchain(Research and Applications) 2022年第3期3卷 100-108页

作者： ian Merrell National Innovation Centre for Rural Enterprise Centre for Rural EconomyNewcastle UniversityNewcastle-Upon-TyneNE17RUUK

Rural areas are steadily being marginalised in a global economy where‘core/periphery’models of development are *** overcome this,rural areas have experimented with decentralised ***,this process is fraught with political,fiscal,and institutional *** often revolve around transparency and accountability issues and low participation *** technology could act as a social innovation to overcome issues in decentralised governance,and rural areas could even prove to be a fertile environment for future *** this conceptual paper,the potential of blockchain technology is theoretically positioned in regional development *** exploring how blockchain could be applied to rural governance and the barriers it needs to overcome to reach mass adoption,a new distributed model of governance is suggested.

关键词： Rural development Decentralised governance Blockchain Social innovation Regional development Participatory governance

Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo Yi Su Yu-Ya-Nan Zhang Hao Yu Zhe Lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun Li Yun-Dan Liao Zhe-Wei Kang Li-Fang Wang Yue Li Ming Li Bing Liu Hai-Liang Huang Lu-Xian Lv Yin Yao Yun-Long Tan Gerome Breen ian Everall Hong-Xing Wang Zhuo Huang Dai Zhang Wei-Hua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

Scale,Information-Processing,and Complementarities in Old-World Axial Age Societies

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Journal of Social Computing 2022年第2期3卷 119-127页

作者： ian Morris the Department of Classics Stanford UniversityStanfordCA 94305-2145USA

Recent cross-disciplinary work on quantifying historical dynamics has made major contributions to ***,efforts to specify relationships between scale and information-processing always run a risk of shoehorning messy realities into overly rigid *** the case of the first-millennium BCE“Axial Age”in the Old World,networks of collective computing were structured more by cultural systems than by polities,and to understand the relationships between political scale and collective computational abilities,scholars need categories flexible enough to clarify the complementarities between political and cultural systems.

关键词： scale information-processing Axial Age ancient Greece

A fast and accurate model for the creation of explosion fragments with improved fragment shape and dimensions

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Defence Technology（防务技术） 2022年第2期18卷 159-169页

作者： David Felix ian Colwill Paul Harris School of Computing Engineering&MathematicsUniversity of BrightonBrightonUK Engineering and Design(Alumni) University of SussexBrightonUK

Explosion models based on Finite Element Analysis(FEA)can be used to simulate how a warhead *** their execution times are *** protection systems need to make very fast predictions,before a fast attacking weapon hits the *** execution times are also needed in real time simulations where the impact of many different computer models is being ***,FEA explosion models are not appropriate for these real-time *** research presented in this paper delivers a fast simulation model based on Mott’s equation that calculates the number and weight of fragments created by an *** addition,the size and shape of fragments,unavailable in Mott’s equation,are calculated using photographic evidence and a distribution of a fragment’s length to its *** model also identifies the origin of fragments on the warhead’s *** results are verified against experimental data and a fast execution time is achieved using uncomplicated simulation *** developed model then can be made available for real-time simulation and fast computation.

关键词： Distribution of fragments Fragment shape Real-time simulation Cylindrical explosion

Lag times in toe-to-heel air injection(THAI)operations explain underlying heavy oil production mechanisms

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Petroleum Science 2022年第3期19卷 1165-1173页

作者： Wei Wei ian D.Gates Department of Chemical and Petroleum Engineering University of CalgaryCalgaryAlbertaCanada

From a time value of revenue point of view,it is preferred that the time between reservoir stimulation and oil production response is *** oil combustion processes have a lag time between air injection and liquid production,but the common practice in production data analysis uses simultaneous injection and production data when seeking a relationship between *** this research,the time scales of production for the Kerrobert toe-to-heel air injection(THAI)heavy oil project in Saskatchewan,Canada,is analyzed by using cross correlation analysis,*** delay analysis between air injection and oil *** results reveal two time scales with respect to production response with two distinctive recovery mechanisms:(1)a short time scale response(nearly instantaneous)where oil production peaks right after air injection(directly after opening production well)reflecting cold heavy oil production mechanisms,and(2)a longer time scale(of order of 100-300 days)response where peak production occurs associated with the collective phenomena of air injection,heat generating reactions,heat transfer,and finally,heated mobilized heavy oil drainage to the production *** understanding of the two time scales and associated production mechanisms provides a basis for improving the performance of THAI.

关键词： Heavy oil In situ combustion Toe-to-heel air injection(THAI) Production analysis Lag time

Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew Shing Hin Chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin Chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong ian Chi Kei Wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in Hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,P<0.001),compared to *** both acute and post-acute phases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,P<0.001;post-acute:IRR:1.24,95%CI:1.14-1.36,P<0.001)and adverse hepatic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,P<0.001;post-acute:IRR:1.24,95%CI:1.13-1.35,P<0.001),compared to *** Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma