检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

铜与卵巢癌的研究进展

国际妇产科学杂志 2024年第2期51卷 215-219页

作者：邹乔剑姚书忠陈怡李刘军秀(审校) 中山大学附属第一医院妇产科广州510000

卵巢癌是常见的妇科恶性肿瘤之一,多数患者在发现时已是晚期,治疗效果及预后差,严重影响患者的生存质量。铜是人体内重要的微量元素,参与多种关键生物过程,并与多种恶性肿瘤的进展密切相关。目前,越来越多的研究探索了铜与卵巢癌的关系... 详细信息

卵巢癌是常见的妇科恶性肿瘤之一,多数患者在发现时已是晚期,治疗效果及预后差,严重影响患者的生存质量。铜是人体内重要的微量元素,参与多种关键生物过程,并与多种恶性肿瘤的进展密切相关。目前,越来越多的研究探索了铜与卵巢癌的关系,发现卵巢癌患者血浆、腹水及肿瘤组织中铜水平较健康人群明显升高,并且多种铜转运蛋白的异常表达与卵巢癌铂类药物化疗耐药密切相关。近年来,针对铜代谢的抗肿瘤治疗方式成为了研究的热点,大量的研究证明了铜螯合剂和铜离子载体在体内外对卵巢癌的显著抑制作用。综述铜与卵巢癌的密切关系,深入了解基于铜代谢的药物及治疗方法在卵巢癌中的应用,以期为卵巢癌的治疗提供新的方向。

关键词：卵巢肿瘤铜铜离子转运蛋白类铜转移三磷酸酶类抗肿瘤联合化疗方案顺铂

Development and Extension of An Aggregated Scale Model:Part 2-Extensions to ASMITA

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2016年第5期30卷 651-670页

作者： ian TOWNEND Zheng Bing WANG Marcel STIVE Zeng ZHOU University of Southampton Southampton S0171B JUK TU Delft Delft 2600 AAThe Netherlands Deltares Delft 2600 MHThe Netherlands j.0}gsu Key Laboratory of Coast Ocean Resources Development and Environment Security Hohai UniversityNanjing 210098China

Whilst much attention has been given to models that describe wave, tide and sediment transport processes in sufficient detail to determine the local changes in bed level over a relatively detailed representation of the bathymetry, far less attention has been given to models that consider the problem at a much larger scale （e.g. that of geomorphological elements such as a tidal flat and tidal channel）. Such aggregated or lumped models tend not to represent the processes in detail but rather capture the behaviour at the scale of interest. One such model developed using the concept of an equilibrium concentration is the Aggregated Scale Morphological Interaction between Tidal basin and Adj.cent coast （ASMITA）. In a companion paper （Part 1）, we detail the original model and provide some new insights into the concepts of equilibrium, and horizontal and vertical exchange that are key components of this modelling approach. In this paper, we summarise a range of developments that have been undertaken to extend the original model concept, to illustrate the flexibility and power of the conceptual framework. However, adding detail progressively moves the model in the direction of the more detailed process-based models and we give some consideration to the boundary between the two.

关键词： estuary tidal inlet morphology tides waves sediment transport

Development and Extension of An Aggregated Scale Model: Part 1–Background to ASMITA

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2016年第4期30卷 483-504页

作者： ian TOWNEND Zheng Bing WANG Marcel STIVE Zeng ZHOU University of Southampton Southampton S0171B JUK TU Delfl Delft 2600.44The Netherlands Deltares Delft 2600 MHThe Netherlands j.0}gsu Key Laboratory of Coast Ocean Resources Development and Environment Security Hohai UniversityNanjing 210098China

Whilst much attention has been given to models that describe wave, tide and sediment transport processes in sufficient detail to determine the local changes in bed level over a relatively detailed representation of the bathymetry, far less attention has been given to models that consider the problem at a much larger scale （e.g. that of geomorphological elements such as a tidal fiat and tidal channel）. Such aggregated or lumped models tend not to represent the processes in detail but rather capture the behaviour at the scale of interest. One such model developed using the concept of an equilibrium concentration is the Aggregated Scale Morphological Interaction between Tidal basin and Adj.cent coast （ASMITA）. In this paper we provide some new insights into the concepts of equilibrium, and horizontal and vertical exchange that are key components of this modelling approach. In a companion paper, we summarise a range of developments that have been undertaken to extend the original model concept, to illustrate the flexibility and power of the conceptual framework. However, adding detail progressively moves the model in the direction of the more detailed process-based models and we give some consideration to the boundary between the two.

关键词： estuary tidal inlet morphology tides waves sediment transport

The commutant and similarity invariant of analytic Toeplitz operators on Bergman space

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2007年第5期50卷 651-664页

作者： Chun-ian j.0}G Yu-cheng Li Department of Mathematics Hebei Normal UniversityShijiazhuang 050016China

The famous von Neumann-Wold Theorem tells us that each analytic Toeplitz operator with n + 1-Blaschke factors is unitary to n + 1 copies of the unilateral shift on the Hardy space. It is obvious that the von Neumann-Wold Theorem does not hold in the Bergman space. In this paper, using the basis constructed by Michael and Zhu on the Bergman space we prove that each analytic Toeplitz operator M B(z) is similar to n + 1 copies of the Bergman shift if and only if B(z) is an n + 1-Blaschke product. From the above theorem, we characterize the similarity invariant of some analytic Toeplitz operators by using K 0-group term.

关键词： Bergman space analytic Toeplitz operators invariant subspace commutant similarity invariant K 0-group 32A36 46j.0 47A15

Intragroup social dynamics vary with the presence of neighbors in a cooperatively breeding fish

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2019年第1期65卷 21-31页

作者： j.nnifer K. Hellmann ian M. Hamilton Department of Evolution Ecology and Organismal Biology The Ohio State University Columbus OH 43210 USA Department of Mathematics The Ohio State University Columbus OH 43210 USA j.nnifer K. Hellmann Department of Animal Biology School of Integrative Biology University of Illinois Urbana-Champaign 505 S Goodwin Ave Urbana IL 61801 USA

Conflict is an in here nt part of social life in group-living species. Group members may mediate conflict through submissive and affiliative behaviors, which can reduce aggression, stabilize dominance hierarchies, and foster group cohesion. The frequency and resolution of within-group conflict may vary with the presenee of neighboring groups. Neighbors can threaten the territory or resources of the whole group, promoting behaviors that foster within-group cohesion. However, neighbors may also foster conflict of interests among group members: opportunities for subordinate dispersal may alter conflict among dominants and subordinates while opportunities for extrapair reproduction may increase conflict between mates. To understand how neighbors mediate within-group conflict in the cooperatively breeding fish Neolamprologus pulcher, we measured behavioral dynamics and social network structure in isolated groups, groups recently exposed to neighbors, and groups with established neighbors. Aggression and submission between the dominant male and female pair were high in isolated groups, but dominant aggression was directly primarily at subordinates when groups had neighbors. This suggests that neighbors attenuate conflict between mates and foster conflict between dominants and subordinates. Further, aggression and submission between similarly sized group members were most frequent when groups had neighbors, suggesting that neighbors induce rank-related conflict. We found relatively little change in within-group affiliative networks across treatments, suggesting that the presence of neighbors does not alter behaviors associated with promoting group cohesion. Collectively, these results provide some of the first empirical insights into the extent to which intragroup behavioral networks are mediated by intergroup interactions and the broader social context.

关键词： affiliation colony conflict exponential random graph model Neolamprologus pulcher network

Downscaling Landsat-8 land surface temperature maps in diverse urban landscapes using multivariate adaptive regression splines and very high resolution auxiliary data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International j.urnal of Digital Earth 2020年第8期13卷 899-914页

作者： j.anna Zawadzka Ron Corstanj. j.m Harris ian Truckell Centre for Environmental and Agricultural Informatics School of WaterEnergy and EnvironmentCranfield UniversityBedfordshireUK

We propose a method for spatial downscaling of Landsat 8-derived LST maps from 100(30 m)resolution down to 2–4 m with the use of the Multiple Adaptive Regression Splines(MARS)models coupled with very high resolution auxiliary data derived from hyperspectral aerial imagery and large-scale topographic *** applied the method to four Landsat 8 scenes,two collected in summer and two in winter,for three British towns collectively representing a variety of urban *** used several spectral indices as well as fractional coverage of water and paved surfaces as LST predictors,and applied a novel method for the correction of temporal mismatch between spectral indices derived from aerial and satellite imagery captured at different dates,allowing for the application of the downscaling method for multiple dates without the need for repeating the aerial *** results suggest that the method performed well for the summer dates,achieving RMSE of 1.40–1.83 K prior to and 0.76–1.21 K after correction for *** conclude that the MARS models,by addressing the non-linear relationship of LST at coarse and fine spatial resolutions,can be successfully applied to produce high resolution LST maps suitable for studies of urban thermal environment at local scales.

关键词： Land surface temperature downscaling urban multivariate adaptive regression splines remote sensing

Decreasing Birth Rate Determining Worldwide Incidence and Regional Variation of Female Breast Cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Breast Cancer Research 2018年第1期7卷 1-14页

作者： Wenpeng You ian Symonds Frank j. Rühli Maciej.Henneberg Adelaide Medical School The University of Adelaide Adelaide Australia Institute of Evolutionary Medicine University of Zurich Zürich Switzerland

Purpose: Urbanization, obesity and ageing associated with lifestyle changes (Westernized diet patterns, pollution, physical inactivity) have been proposed as the maj.r contributing factors for the global rise in breast cancer (BCa) and have been the variables used to predict the future breast cancer rate. At the same time, socio-economic level, instead of birth rate, has been proposed for explanation of dramatic regional variations of breast cancer incidence. We sought to determine which factor plays the determining role in predicting worldwide breast cancer incidence rates and regional variations. Methods: Bivariate correlation was conducted to examine the relationships between country-specific estimates of birth rate, BCa incidence, urbanization, overweight, ageing and GDP. Partial correlation was performed to identify the correlation between BCa incidence with each independent variable while we controlled the other four variables. Multiple linear regression was used to identify the most significant predictors of BCa incidence. Post hoc Scheff and independent T-Test analysis were performed to compare mean differences in BCa incidence rates and residuals of BCa standardised on birth rate in the WHO regions, and UN developed and developing regions respectively. Results: Worldwide, BCa incidence rate tends to increase while birth rate decreases and urbanization, overweight, ageing and GDP increase. However, birth rate was the only variable that had a significant correlation with BCa incidence when controlled for the other four variables. Birth rate was the only significant predictor of BCa incidence in regression analysis. Multiple mean differences of BCa incidence between regions were significant, but all disappeared when the contributing effect of birth rate on BCa incidence rate was removed. Conclusions: Birth rate plays a determining role in worldwide BCa incidence rate and regional variations. Current BCa proj.ction methods may estimate future rates of BCa poorl

关键词： Regional Variations Hormones Breast Cancer Birth Rate Mean Difference Comparison

Characterisation of Neonicotinoid and Pymetrozine Resistance in Strains of Bemisia tabaci(Hemiptera:Aleyrodidae)from China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

j.urnal of Integrative Agriculture 2012年第2期11卷 321-326页

作者： RAO Qiong XU Yong-hua LUO Chen ZHANG Hong-yu Christopher M j.nes Greg j.Devine KevinGorman ian Denholm College of Plant Science and Technology Huazhong Agricultural University Wuhan 430070 P.R.China Institute of Plant and Environmental Protection Beijing Academy of Agriculture ＆ Forestry Sciences Beijing 100097 P.R.China Plant and Invertebrate Ecology Department Rothamsted Research Harpenden Herts .4L5 2JQ United Kingdom Zhej.0}g Chemical Industry Research Institute Zhejiang Branch of National Pesticide R＆D South Center Hangzhou 310023 P.R. China

Four strains of the Q biotype and one of the B biotype of the whitefly Bemisia tabaci collected from China were characterised for resistance to four neonicotinoid insecticides and pymetrozine.Q biotype strains showed moderate to strong resistance to imidacloprid,thiamethoxam and acetamiprid,but little or no cross-resistance to *** to neonicotinoids was consistently associated with resistance to pymetrozine,despite the latter having a distinct（though unresolved）mode of *** single B biotype strain proved largely susceptible to all the insecticides *** in the Q biotype strains was associated with over-expression of a cytochrome P450 monooxygenase gene,CYP6CM1,whose substrate specificity presumably accounts for the observed cross-resistance profiles.

关键词： P450 cross-resistance pymetrozine imidacloprid thiamethoxam acetamiprid dinotefuran neonicotinoids

Ab initio vibrational free energies including anharmonicity for multicomponent alloys

在线全文

学校读者我要写书评

暂无评论

npj.Computational Materials 2019年第1期5卷 454-459页

作者： Blazej.Grabowski Yuj. Ikeda Prashanth Srinivasan Fritz Körmann Christoph Freysoldt Andrew ian Duff Alexander Shapeev j.rg Neugebauer Institute of Materials Science University of StuttgartPfaffenwaldring 5570569 StuttgartGermany Department for Computational Materials Design Max-Planck-Institut für Eisenforschung GmbHMax-Planck-Str.140237 DüsseldorfGermany Department of Materials Science and Engineering Delft University of TechnologyMekelweg 22628 CD DelftNetherlands Scientific Computing Department STFC Daresbury LaboratoryHartree CentreWarringtonUK Skolkovo Institute of Science and Technology Skolkovo Innovation CenterNobel St.3Moscow 143026Russia

The unique and unanticipated properties of multiple principal component alloys have reinvigorated the field of alloy design and drawn strong interest across scientific *** vast compositional parameter space makes these alloys a unique area of exploration by means of computational ***,as of now a method to compute efficiently,yet with high accuracy the thermodynamic properties of such alloys has been *** of the underlying reasons is the lack of accurate and efficient approaches to compute vibrational free energies—including anharmonicity—for these chemically complex multicomponent *** this work,a density-functional-theory based approach to overcome this issue is developed based on a combination of thermodynamic integration and a machine-learning *** demonstrate the performance of the approach by computing the anharmonic free energy of the prototypical five-component VNbMoTaW refractory high entropy alloy.

关键词： alloys alloy thermodynamic