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Journal of Geriatric Cardiology 2019年第6期16卷 482-489页

作者： Lourdes Vicent Vanesa Bruna Carolina Devesa Jorge García-Carreno iago sousa-casasnovas Miriam Juárez Francisco Fernández-Avilés Manuel Martínez-Sellés Servicio de Cardiología Hospital Universitario Gregorio Maranon CIBERCV Madrid Spain Universidad Complutense de Madrid Madrid Spain Universidad Europea de Madrid Madrid Spain

Introduction Cardiovascular (CV) diseases are the most common causes of death and causes frequent hospital admissions.[1] The increase in life expectancy and the appearance of new treatments,[2] is changing in the clinical profile of CV disease, with a rise in chronic processes and concomitant comorbidities.[ 3] These changes are probably reflected in the current profile of patients admitted to cardiology departments, and in their causes of mortality.

关键词： Cardiovascular death Mortality Withdraw of life-sustaining therapies

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.sousa Andreia Monteiro António J.Salgado Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Social buffer or avoidance depends on the similarity of stress between queen ants

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Current Zoology 2023年第2期69卷 181-191页

作者： iago Sanmartin-Villar Universidade de Vigo ECOEVO LabEscola de Enxenaria ForestalCampus Universitario A Xunqueira36005 PontevedraGalizaSpain

The association of unrelated ant queens(pleometrosis)is supposed to improve nest foundation and competitiveness under environmental stress,but its evolutionary maintenance is difficult to explain because only one of the queens survives after nest *** aim was to test the potential effect of queen association as a social buffer,that is,as a mechanism reducing stress and improving fitness due to the benefits of social contact.I analyzed the survival,fecundity,and behavior of isolated and paired Lasius flavus queens exposed and not exposed to stressors(disturbing environmental conditions).I found no difference in survivorship between isolated and paired queens or between stressed and unstressed isolated *** in which 1 or 2 paired queens were stressed showed higher *** queens died similarly to their stressed nestmates,suggesting stress transmission.A trend suggested that paired queens produced eggs more quickly,but eggs were produced similarly between isolated and paired *** avoidance was observed in groups with 1 stressed and 1 unstressed ***,the groups with 2 stressed queens showed the expected behaviors according to social buffering:lower mobility and more interindividual *** findings suggest the synergistic effect of pleometrosis and stress and the dependence of stress level similarity between nestmates on social buffering or rejection on ant queens.

关键词： fitness haplometrosis population pressure reproductive strategy social insects

Early social context does not influence behavioral variation at adulthood in ants

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Current Zoology 2022年第3期68卷 335-344页

作者： iago SANMARTÍN-VILLAR Raphaël JEANSON Centre de Recherches Sur la Cognition Animale Centre de Biologie IntégrativeUniversitéde ToulouseCNRSUPSToulouseFrance Universidade de Vigo ECOEVO LabEscola de Enxeñaría ForestalCampus A XunqueiraPontevedraSpain

Early experience can prepare offspring to adapt their behaviors to the environment they are likely to encounter later in life. In several species of ants, colonies show ontogenic changes in the brood-to-worker ratio that are known to have an impact on worker morphology. However, little information is available on the influence of fluctuations in the early social context on the expression of behavior in adulthood. Using the ant Lasius niger, we tested whether the brood-to-worker ratio during larval stages influenced the level of behavioral variability at adult stages. We raised batches of 20 or 180 larvae in the presence of 60 workers until adulthood. We then quantified the activity level and wall-following tendency of callow workers on 10 successive trials to test the prediction that larvae reared under a high brood-to-worker ratio should show greater behavioral variations. We found that manipulation of the brood-to-worker ratio influenced the duration of development and the size of individuals at emergence. We detected no influence of early social context on the level of between- or within-individual variation measured for individual activity level or on wall-following behavior. Our study suggests that behavioral traits may be more canalized than morphological traits.

关键词： brood care canalization locomotion metamorphosis ontogeny variability

Direct and cross-generational effects of reproduction on fitness and behavioral variability in male-biased environments

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Current Zoology 2023年第3期69卷 339-353页

作者： iago Sanmartin-Villar Xin Yu Adolfo Cordero-Rivera Universidade de Vigo ECOEVO LabEscola de Enxenaria ForestalCampus Universitario A Xunqueira36005 PontevedraGalizaSpain College of Life Sciences Chongqing Normal UniversityDaxuecheng Middle RdShapingba DistrictChongqing 401333China

Population structure determines individuals’interactions and trade-offs with evolutionary ***-biased populations increase intrasexual competition and intersexual harassment,reducing female resource acquisition,and thus,resources availability for the following *** analyzed direct and cross-generational effects of male harassment in two generations of damselflies(Odonata).We exposed adult females to treatments with different sex-ratio and density(balanced and male-biased)to modify the male harassment *** analyzed female fecundity,fertility,and number of faecal deposits as an indirect measure of resources *** studied female flight performance after repeated exposures to *** analyzed survivorship,development,exploration,thigmotaxis,and feeding latency of larvae produced by the experimental *** both generations,we analyzed four metrics of behavior:mean value,interindividual differences in plasticity,intra-individual unpredictability,and *** duration increased in male-biased treatment,whereas female resources acquisition and fertility *** that mated longer showed higher fecundity when they were exposed to balanced treatment,but not if they were exposed to male-biased *** from the male-biased treatment showed interindividual differences in plasticity and no repeatability in flight *** showed balanced sex-ratio and similar survivorship,development,and feeding latency independently of the parental treatment;however,females exposed to male-biased treatment produced offspring with higher differences in exploration plasticity and daughters less explorative and with higher unpredictable *** propose prolonged copulation as courtship at balanced sex-ratio but a cost to females under male-biased ***-generational effects in behavioral variability may be a mechanism to cope with predicted future environments.

关键词： activity environmental perception Ischnura graellsii male harassment sex allocation

Design and optimization of supersonic turbines for detonation combustors

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Chinese Journal of Aeronautics 2022年第11期35卷 33-44页

作者： Jorge sousa Elena COLLADO-MORATA Guillermo PANIAGUA Flemish InstituteforTechnological Research Mol 2400Belgium Commissariat à lénergie atomique et aux énergies alternatives Le Barp 33114France Mechanical Engineering Purdue UniversityWest-Lafayette IN 47906USA

Detonation-based engines offer a potential surge in efficiency for compact thermal power systems. However, these cycles require ad-hoc components adapted to the high outlet velocity from the detonation combustors. This paper presents the design methodology of turbine stages suitable for supersonic inlet conditions and provides a detailed analysis of optimized turbine geometries. A reduced-order solver examines the supersonic blade rows’ functional design space, quantifies the turbine’s non-isentropic performance, and budgets the turbine loss for different optimized leading-edge designs and chord to pitch ratios. The shock-wave interactions were identified as the predominant contributor to turbine losses, and optimal pitch-chord ratios were determined for various inlet Mach numbers. Finally, with this tool, the specific-power output for a wide range of design configurations was computed;and the metal angle that ensures flow starting and maximizes power extraction was calculated. The detailed numerical study describes the flow interactions in a supersonic turbine and offers new correlations to guide the design of future supersonic turbines.

关键词： Rotating detonation Shock waves Supersonic flow Turbines Unstarting

Status of research on lactones used as aroma:A bibliometric review

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Food Bioscience 2022年第6期50卷 17-31页

作者： Juliete Pedreira Nogueira iago Hudson da Silva Souza Julianna Karla Santana Andrade Narendra Narain Laboratory of Flavor and Chromatographic Analyzes Federal University of SergipeSão CristóvãoSEBrazil

The lactones belong to a class of organic compounds relevant to the flavors and fragrances industry by imparting fruity,creamy,and aromatic notes with application in various products in the food,beverage,and *** aim of this review was providing the status of the published research and the panorama of patents filed under biotechnological production of aroma lactones(BPAL).Therefore,a bibliometric analysis and a technological prospection were carried out on the BPAL between 2000 and *** tools permitted to identify relevant publications,research networks,and prominent journals,authors,institutions,and *** hundred and nine scientific publications were recovered in Scopus®and Web of Science™,while in 1161 patent documents were reviewed in The Lens *** results showed that both scientific and technological productions on BPAL have been developing in recent *** Letters and Applied Microbiology and Biotechnology were the two journals with more BPAL research *** stood out in the number of scientific publications,and China had the highest number of patent *** Institute of Technology and Konkuk University have not only excelled in scientific production,but also in production *** low prevalence of international cooperation consolidated networks was ***,the research focused on the production ofγ-decalactone from the biotransformation of methyl ricinoleate by Yarrowia lipolytica *** review revealed that,in recent years,the researchers have also investigated the production of other lactones,e.g.γ-dodecalactone,from non-hydroxylated fatty acids using enzymatic hydrolysis.

关键词： Aroma compounds Bibliometrics Biotransformation Intellectual property

Spent coffee grounds as a renewable source of energy: An analysis of bulk powder flowability

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Particuology 2019年第2期17卷 92-100页

作者： L. Massaro sousa M.C. Ferreira Drying Center for Pastes Suspensions and Seeds. Chemical Engineering Department Federal University of Sao Carlos. P.O. Box 676 13565-905 Sao Carlos Brazil

The main use for spent coffee grounds (SCG) produced in the soluble coffee industry is thermal energy generation in the industry itself. The SCG are processed using operations that are strongly dependent on powder flow behavior. In this study, we evaluated two classical flowability in dices of non-consolidated SCG powders: the angle of repose (AoR), and the Hausner ratio (HR). The influences of the mean particle diameter, particle size distribution (PSD), and water content on the AoR and HR values of SCG were analyzed for powders with a mean particle size range of 225-550 μm. For powders with a mean particle size close to 350 μm and for mixtures containing more than 40% fine particles, the HR (>1.35) and AoR (>45 °) values were characteristic of poor flowability. The AoR was sensitive to the powder PSD, and powders with similar mean particle sizes had higher AoR values when the PSD was larger. For powders w让h water contents up to 50%, the flowability indices were not greatly affected by the water content. A modified linear-mixture packing model was used to predict the packed bed void fractions for binary and ternary mixtures of the three base powders. The model was used to construct a ternary diagram to estimate the HR values of the mixtures. An equation was fitted to correlate HR and AoR. The proposed diagram and the equation provide insight into flow behavior and could be used for process design of industrial plants that handle SCG.

关键词： Spent coffee ground Biomass Flowability Hausner ratio Angle of repose

Digital Soil Mapping Using Artificial Neural Networks and Terrain-Related Attributes

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Pedosphere 2015年第4期25卷 580-591页

作者： Mohsen BAGHERI BODAGHABADI José Antonio MARTINEZ-casasnovas Mohammad Hasan SALEHI Jahangard MOHAMMADI Isa ESFANDIARPOOR BORUJENI Norair TOOMANIAN Amir GANDOMKAR Department of Geography Najafabad Branch Islamic Azad University Department of Environmental and Soil Science University of Lleida Department of Soil Science College of Agriculture Shahrekord University Department of Soil Science College of Agriculture Vali-e-Asr University Agriculture and Natural Resource Research Center

Detailed soil surveys involve costly and time-consuming work and require expert knowledge. Since soil surveys provide information to meet a wide range of needs, new methods are necessary to map soils quickly and accurately. In this study, multilayer perceptron artificial neural networks(ANNs) were developed to map soil units using digital elevation model(DEM) attributes. Several optimal ANNs were produced based on a number of input data and hidden units. The approach used test and validation areas to calculate the accuracy of interpolated and extrapolated data. The results showed that the system and level of soil classification employed had a direct effect on the accuracy of the results. At the lowest level, smaller errors were observed with the World Reference Base(WRB)classification criteria than the Soil Taxonomy(ST) system, but more soil classes could be predicted when using ST(7 soils in the case of ST vs. 5 with WRB). Training errors were below 11% for all the ANN models applied, while the test error(interpolation error) and validation error(extrapolation error) were as high as 50% and 70%, respectively. As expected, soil prediction using a higher level of classification presented a better overall level of accuracy. To obtain better predictions, in addition to DEM attributes, data related to landforms and/or lithology as soil-forming factors, should be used as ANN input data.

关键词： digital elevation model attributes multilayer perceptron soil classification soil-forming factors soil survey

Numerical and safety considerations about the Daguangbao landslide induced by the 2008 Wenchuan earthquake

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第5期11卷 1019-1035页

作者： Manchao He L.Ribeiro e sousa AndréMüller Eurípedes Vargas Jr. R.L.sousa C.sousa Oliveira Weili Gong State Key Laboratory of Geomechanics and Deep Underground Engineering(SKLGDUE) China University of Mining and TechnologyBeijingChina Tongji University ShanghaiChina Pontifical Catholic University of Rio de Janeiro Rio de JaneiroBrazil Khalifa University of Science and Technology Abu DhabiUnited Arab Emirates Technical Institute University of LisbonLisbonPortugal

The 2008 Wenchuan earthquake resulted in a large number of fatalities and caused significant economic *** of landslides,many of which are very large,were triggered by the earthquake.A majority of catastrophic landslides were distributed along the central Longmenshan fault system,at the eastern margin of the Tibetan *** of the landslides resulted in sudden damming of rivers causing flooding,which in turn induced secondary sliding *** the most significant landslides,the Daguangbao landslide was the largest in volume with the maximum *** this,a numerical model of the Daguangbao landslide,using the material point method(MPM),was developed to simulate the interaction of the seismic loads imposed on the *** numerical results then are compared with the post-earthquake *** a consequence of the landslide,a nearly vertical head scarp with a maximum height of about 700 m was *** is considered as a high risk situation that requires constant monitoring and ***,we propose a methodology based on Bayesian networks(BNs)to manage the risk associated with the stability of the rockwall at the Daguangbao landslide site.

关键词： Wenchuan earthquake Longmenshan fault Daguangbao landslide Material point method(MPM) Rockwall