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Measurement of circulating levels of VEGF-A,-C,and -D and their receptors,VEGFR-1 and -2 in gastric adenocarcinoma

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World Journal of Gastroenterology 2008年第24期14卷 3879-3883页

作者： Mansour S Al-Moundhri A Al-Shukaili M Al-Nabhani b Al-bahrani ia burney A Rizivi SS Ganguly Medical Oncology Unit Department of MedicineCollege of Medicine and Health SciencesSultan Qaboos University Department of Microbiology and Immunology (SQU) National Cancer Institute Royal Hospital Department of Epidemiology and Medical Statistics (SQU)

AIM: To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A,-C,and -D,and their receptors,VEGFR-1 and -2 in gastric adenocarcinomas. METHODS: The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. RESULTS: The serum levels of VEGF-A and its receptor,VEGFR-1,were signifi cantly higher in patients with gastric cancer than in healthy donors (t = 2.3,P = 0.02 and t = 4.2,P bjects than in patients (t = 2.9,P = 0.004). There was no significant difference in serum levels of VEGF-C and VEGFR-2 between patients and controls. VEGF-C was associated with advanced tumor stage and presence of metastasis. VEGFR-1 was associated with metastasis,advanced overall stage,tumor differentiation and survival. VEGFR-2 levels were associated with poor tumor differentiation. There was no significant prognostic value for any of the VEGF family members or their receptors except for VEGFR-1 where high levels were associated with a poor overall survival. CONCLUSION: Serum VEGF levels vary significantly in the same cohort of patients with variable clinico-pathological features and prognostic values. The simultaneous measurement of VEGF receptors levels in sera may overcome the limitations of a single biomarker assay.

关键词： Gastric cancer Serum Vascular endothelialgrowth factor Oman

Children Safety Devices in brazil—Why Do People Don’t Use Them after the Law?

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Journal of Transportation Technologies 2014年第3期4卷 205-215页

作者： S.C.V.Abib A.M.Francóia F.Ricci M.V.b.Cezillo b.R.Müller Department of Surgery Paulista School of MedicineFederal University of Sao PauloSao PauloBrazil Criança Segura—Safe Kids brazil Sao PauloBrazil

Introduction: Children safety car devices decrease injuries and death in children. A survey conducted in brazil in 2009 revealed that only 36.1% of children safely transported. In 2010, a brazilian law was implemented, obligating the use of safety devices. The aim of this study is to evaluate the use of such devices after the law and the eventual reasons for non-use. Methods: A significant sample of brazilian population aged 18 years or more, which normally carry children until 10 years old answered a survey between August 16 and 25, 2012. The study was conducted in two phases. The first one aimed to raise the proportion and profile of the target population, while the second investigated the children car safety device use (or not). Results: 622 interviews. Children’s transporters are young males (57%), living in a metropolitan area in the South region, concerned about safety and law supervision, with greater education level and income than non-transporters (31%) who are male with lack of information, living in a non-metropolitan area of the Northeast region that would be motivated to use the device by effective law fiscalization or threat of an accident. Conclusion: Two years after the law it is observed that education, income, age, gender and region of origin influence the use/non-use of the safety seats in brazil. The accident threat and fiscalization are the main reasons for using the device, showing that the lack of information impairs the democratization of its use and the prevention culture has to be enhanced in the country.

关键词： Child Restraint Systems Wounds and Injuries Accidents Traffic Pediatrics

Antifungal activity of natural compounds against Candida species isolated from HIV-positive patients

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Asian Pacific Journal of Tropical biomedicine 2015年第9期5卷 750-752页

作者： Débora Oro Andréia Heissler Eliandra Mirlei Rossi Diane Scapin Patrícia da Silva Malheiros Everton boff Microbiological Research and Diagnostic Laboratory Department of Biological and Health Sciences University of Western Santa Catarina Sao Miguel Oeste Hygiene and Food Microbiology Laboratory Department of Food Sciences Food Science and Technology Institute Federal University of Rio Grande do Sul

Objective: To evaluate the antifungal effect of Cinnamomum zeylanicum(C. zeylanicum) and Melaleuca alternifolia essential oils and honey against strains of Candida sp. from HIV-positive patients in order to subsidize new therapeutic strategies for ***: The study evaluated the antifungal effect of natural antimicrobials against 30 strains of Candida sp. isolated from oral cavities in HIV-infected patients. Then, they were compared to the action of fl uconazole and amphotericin b. Antifungal susceptibility was evaluated by the broth macrodilution technique and the minimum inhibitory concentration and the minimum fungicidal concentration were ***: Among all antifungals evaluated in this study, amphotericin b was the one showing the best results; however, all compounds studied here showed inhibitory activities against isolates of Candida sp. Honey(0.031 3 to 64 μg/m L) demonstrated fungistatic activity inhibiting 70% of the isolates. C. zeylanicum essential oil(0.031 3 to 64 μg/m L) inhibited 93.3% of the Candida strains and Melaleuca alternifolia essential oil(0.031 3 to 64 μg/m L) was able to inhibit 73.3% of ***: Therefore, all natural compounds evaluated in this study, especially C. zeylanicum essential oil, may become promising agents for oral candidiasis therapy including in HIV-positive patients.

关键词： Candida sp. Essential oils Honey HIV Susceptibility

基于系统动力学的企业主流与新流创新动态演进研究

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科技进步与对策 2017年第1期34卷 66-74页

作者：朱斌欧伟强福州大学经济与管理学院福建福州350116

在企业创新系统中,主流与新流创新动态演进,形成持续创新机制,对企业发展和创新能力提升具有重要意义。为了充分促进主流与新流创新协同发展,运用系统动力学方法对企业主流与新流创新动态演进开展了实证研究,构建了基于创新生命周期的... 详细信息

在企业创新系统中,主流与新流创新动态演进,形成持续创新机制,对企业发展和创新能力提升具有重要意义。为了充分促进主流与新流创新协同发展,运用系统动力学方法对企业主流与新流创新动态演进开展了实证研究,构建了基于创新生命周期的主流与新流创新动态演进系统动力学模型。在神州数码公司仿真实证研究的基础上,提出设立识别机制体系、完善政府扶持体系、转变资源分配方式,以有效支持企业主流与新流创新系统。

关键词：主流创新新流创新企业创新动态演进系统动力学

SOME INITiaL-ObLIQUE DERIVATIVE bOUNDARY VALUE PRObLEM FOR QUASILINEAR PARAbOLIC EQUATIONS WITH UNbOUNDED COEFFICIENTS

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Journal of Systems Science & Complexity 2001年第3期14卷 269-277页

作者： ZOU benteng (School Of Mathematics Science, Peking University, beijing 100871, China 15 MLH University Of Iowa, Iowa City, ia 52242-1419, USA) 北京大学北京 100871

In this paper, we consider quasilinear uniformly parabolic equations: Lu = aij (t, x, u)Diju + b(t, x u, Du) - ut = 0, with regular derivative boundary value problems: bu = u/ v + au = h(t, x). by the help of Leray-sc... 详细信息

关键词： Quasilinear equations cordes derivative boundary condition.

Effect of Cooling Rate on Morphology and Oxygen Permeability of Polypropylene

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International Journal of Minerals,Metallurgy and Materials 1999年第3期13卷 219-223页

作者： Wei Tian Raymond T. Whodhams(Material Science and Engineering School, University of Science and Technology beijing, beijing 100083, China)(Department of Chemical Engineering and Applied Chemistry University of Toronto, Toronto M5S ia4, Canada) Material Science and Engineering School University of Science and Technology Beijing Beijing 100083 China Department of Chemical Engineering and Applied Chemistry University of Toronto Toronto Ont. M5S IA4 Canada

The influence of different cooling rates on the morphology and oxygen permeabilityr of polypropylene containing ferrocene has been investigated. The spherulitic crystalline size and structure, which can affect the oxygen permeability are dependent upon the heating temperature, annealing time and cooling rate. The modulus of the composite was measured b}' dynamic mechanical analysis.

关键词： polypropylene oxygen permeability cooling rate

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灰桥湾滑板公园

景观设计 2011年第1期 22-27页

作者： Dtrek DeLand ia．AIbC b.Sc b．Arch Jim barnum 刘丹春（翻译） Spectrum Skatepark Creations Ltd. 不详

该项目对于滑板爱好者而言可谓是一个将街道景观与滑板文化集于一体的经典设计——不拘泥于单调乏味的传统滑板公园。过去，由于受运动场地的限制，滑板爱好者如同困兽一般无处施展；如今，滑板爱好者渴望一处集都市庭院，公园和人行道... 详细信息

该项目对于滑板爱好者而言可谓是一个将街道景观与滑板文化集于一体的经典设计——不拘泥于单调乏味的传统滑板公园。过去，由于受运动场地的限制，滑板爱好者如同困兽一般无处施展；如今，滑板爱好者渴望一处集都市庭院，公园和人行道于一体的公共场所。该项目造型美观，沿用了来自世界各地关于“滑板建筑”的设计创意。使街头滑板爱好者的梦想成真，

关键词：滑板公园设计创意街道景观运动场地公共场所造型美观爱好

25－羟维生素D和甲状旁腺激素与高血压的相关性

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中华高血压杂志 2014年第6期22卷 587-588页

作者： van ballegooijen AJ Kestenbaum b Sachs MC de boer IH Siscovick DS Hoofnagle AN Ix JH Visser M brouwer ia 练桂丽叶鹏机构不详

有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高... 详细信息

有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素D和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素D[25(OH)D]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)D水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素D缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。

关键词： 25-羟维生素D 甲状旁腺激素高血压相关性维生素D缺乏肾素血管紧张素系统血管炎性反应 25(OH)D

bioactive Steroid from the Root bark of Psorospermum corymbiferum

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中国天然药物 2011年第4期9卷 264-266页

作者： Zubair MF Oladosu ia Olawore NO Usman LA Fakunle CO Hamid AA Ali MS Department of Chemistry University of llorinNigeria Department of Chemistry University of IbadanNigeria Department of Chemistry Ladoke Akintola University of TechnologyOgbomoso Department of Chemistry Bowen UniversityIwoNigeria International Centre for Chemical and biological Studies(ICCbS) Pakistan

AIM:To isolate,characterize and investigate the antifungal activity of the root bark of Psorospermum corymbiferum(Clusiaceae).METHODS:The finely ground root bark of Psorospermum corymbiferum was cold-extracted by percolation with 98% ethanol(5.0 L) for two *** ethanol extract was macerated with n-hexane,chloroform,ethylacetate and methanol successively to give the respective solvent *** of the extract was done using column chromatography on silica gel with cyclohexene:ethylacetate(1:1) as eluents,and the subfractions were purified by TLC using cyclohexane:ethylacetate(7:3).The structures were elucidated based on spectral analysis(IR,1H NMR and 13C NMR) in comparison with the data with those reported in the *** minimum inhibitory concentration(MIC) was determined on Candida alblican and Candida ***:Three known compounds,acetylvismione F,prenylated bianthrone and 1,8-dihydroxyanthraquinone and a steroid were isolated from the *** determined on Candida alblican and *** were 20 and 15 μ***-1,*** steroidal compound(diosgenin) was characterized for the first time from Psorospermum corymbiferum(Clusiaceae).CONCLUSION:The results suggested that the isolation has anticandidal properties,supporting the use of this plant in folk *** current drug of choice for disseminated Candidiasis is amphotericin b with MIC of 0.39 μ***-1,which could be a promising lead for a new antifungal drug especially if subjected to SAR in antifungal drug design.

关键词：生物活性化合物胆汁酸化学分析