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Endoscopic enucleation of gastrointestinal stromal tumors of the stomach: Report of five cases

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World Journal of Gastroenterology 2008年第16期14卷 2609-2611页

作者： Toshio Katoh Yoshiyuki itoh Tomomi Mohri Hiroshi Suzuki Division of Surgery Toyama Hospital

Gastrointestinal stromal tumor (GIST) of the stomach was treated by endoscopic enucleation in five patients. They were three men and two woman, aged 36-56 years. Tumors located in the cardia were completely enucleated endoscopically without any serious complication. The largest diameter of removed tumors ranged from 1.2 to 2.5 cm. Histopathological diagnosis was GIST with low risk of malignancy (mitotic index < 5/50 high power field) in all cases. The patients were disease-free for 10.5-42.2 mo after endoscopic enucleation.

关键词： Gastrointestinal stromal tumor Endoscopicenucleation Stomach

Poorly differentiated endocrine carcinoma of the pancreas responded to gemcitabine:Case report

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World Journal of Gastroenterology 2010年第30期16卷 3853-3856页

作者： Shoichi Nakazuru toshiyuki Yoshio Shigeki Suemura Mari itoh Manabu Araki Chiaki Yoshioka Makiyo Ohta Yuka Sueyoshi Takashi Ohta Hiroko Hasegawa Kaori Morita Takashi Toyama Noriyoshi Kuzushita Yoshinori Kodama Masayuki Mano Eiji Mita Department of Gastroenterology and Hepatology National Hos- pital OrganizationOsaka National Hospital2-1-14 HouenzakaChuo-kuOsaka CityOsaka 540-0006Japan Department of Pathology National Hospital OrganizationOsaka National Hospital2-1-14 HouenzakaChuo-kuOsaka CityOsaka 540-0006Japan

Poorly differentiated endocrine carcinoma (PDEC) of the pancreas is a rare and aggressive tumor. First-line treatment is commonly a combination of etoposide and cisplatin, but there is no consensus regarding further treatment recommendations. In this report, we describe a case of pancreatic PDEC treated with gemcitabine as third-line chemotherapy. A 62-year-old man with pancreatic PDEC was administered etoposide plus cisplatin as first-line treatment; he then received irinotecan for tumor relapse. However, because irinotecan induced ileus in this patient, we chose gemcitabine as thirdline chemotherapy. After two cycles of gemcitabine (1000 mg/m2 on days 1, 8 and 15 every 4 wk), a partialtumor response was noted by computed tomography (approximately 68% reduction in tumor size). Our patient survived for 15 mo after diagnosis. This is a rare case of unresectable pancreatic PDEC, which showed a partial response to gemcitabine after the failure of two other regimens. Gemcitabine could be an effective treatment option for pancreatic PDEC that is resistant to other treatments.

关键词： Poorly differentiated endocrine carcinoma Pancreatic endocrine tumor Gemcitabine Chemotherapy

Dedifferentiated liposarcoma of the rectum:A case report

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World Journal of Gastroenterology 2012年第41期18卷 5979-5981页

作者： Atsushi Tsuruta Kenji Notohara Taebum Park Tadashi itoh Department of Surgery Kurashiki Central HospitalOkayama 710-8602Japan Department of Pathology Kurashiki Central HospitalOkayama 710-8602Japan

Liposarcoma is one of the most common soft tissue sarcomas found in adults,and it usually occurs in the retroperitoneum and the ***,we describe a case of dedifferentiated liposarcoma originating from a well-differentiated liposarcoma of the mesorectum that presented as a protruding mass in the rectal ***'s operation with total mesorectal excision was performed and the tumor was removed *** management guidelines are currently available for liposarcoma of the *** propose that complete surgical resection be required for the treatment of rectal liposarcoma and that a long-term detailed follow up is necessary.

关键词： Dedifferentiated liposarcoma Soft tissuesarcoma Rectum Management Surgery

Involvement of SNX1 in regulating EGFR endocytosis in a gefitinib-resistant NSCLC cell lines

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Cancer Drug Resistance 2019年第3期2卷 539-549页

作者： Yukio Nishimura Kazuyuki itoh Division of Pharmaceutical Cell Biology Graduate School of Pharmaceutical SciencesKyushu UniversityFukuoka 812-8582Japan Research Institute Nozaki Tokushukai(RINT) Osaka 574-0074Japan.

The drug gefitinib, a specific inhibitor of EGFR tyrosine kinase, has been shown to suppress the activation of EGFR signaling for survival and cell proliferation in non-small cell lung cancer cell lines. For many years, EGFR endocytosis has served as a model for investigating ligand-induced, receptor-mediated endocytosis. On EGF stimulation, EGFR is internalized and transported via clathrin-coated vesicles to early endosomes, and EGFR then recruits and phosphorylates signaling molecules, leading to the activation of downstream signaling such as MAPK/PI3K/AKT pathways-an important mechanism for regulating cell growth. Once delivered to the lysosomes, EGFR is degraded to terminate intracellular EGFR signaling via endocytosis;this process is known as receptor downregulation. Therefore, the endocytosis of EGFR is closely related with attenuation of intracellular EGFR signaling. Alternatively, EGFR is returned to cell surface from early endosomes for the continued signaling. Previous reports revealed that a competent EGF-induced endocytosis of EGFR followed by its rapid downregulation efficiently proceeds in the gefitinib-sensitive NSCLC cell lines. In contrast, gefitinib-resistant cell lines showed that EGFR endocytosis is impaired and the internalized EGFR is aggregated in the early endosomes, which is associated with the overexpressed sorting nexin 1 (SNX1), initially identified as a protein that interacts with EGFR. Thus dysregulated EGFR endocytosis is implicated in gefitinib resistance, as it leads to uncontrolled signal transduction. At present, the therapeutic relevance of EGFR endocytosis with regard to drug resistance in lung cancer has not been clarified. This review focused on the mechanism for EGFR endocytosis associated with SNX1 trafficking in gefitinib-resistant lung cancer cells.

关键词： Lung cancer drug-resistance EGFR endocytosis endosomes/lysosomes sorting nexin 1 membrane recycling

New pyrometallurgical process of EAF dust treatment with CaO addition

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International Journal of Minerals,Metallurgy and Materials 2015年第8期22卷 788-797页

作者： Romchat Chairaksa-Fujimoto Yosuke Inoue Naoyoshi Umeda Satoshi itoh Tetsuya Nagasaka Department of Metallurgy Graduate School of Engineering Tohoku University Toho Titanium Co. Ltd. Honda Motor Co. Ltd.

The non-carbothermic zinc pyrometallurgical processing of electric arc furnace(EAF) dust was investigated on a laboratory scale. The main objective of this process was to convert highly stable zinc ferrite(Zn Fe2O4), which accounts for more than half of total zinc in the EAF dust, into Zn O and Ca2Fe2O5 by Ca O addition. The EAF dust was mixed with Ca O powder in various ratios, pressed into pellets, and heated in a muffle furnace in air at temperatures ranging from 700 to 1100°C for a predetermined holding time. All Zn Fe2O4 was transformed into Zn O and Ca2Fe2O5 at a minimum temperature of 900°C within 1 h when sufficient Ca O to achieve a Ca/Fe molar ratio of 1.1 was added. However, at higher temperatures, excess Ca O beyond the stoichiometric ratio was required because it was consumed by reactions leading to the formation of compounds other than Zn Fe2O4. The evaporation of halides and heavy metals in the EAF dust was also studied. These components could be preferentially volatilized into the gas phase at 1100°C when Ca O was added.

关键词： electric arc furnace dust pyrometallurgy zinc oxid

THE INTERACTION BETWEEN SHOCK WAVES AND FOAM IN A SHOCK TUBE

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Acta Mechanica Sinica 2002年第3期18卷 288-301页

作者：施红辉 Kazuhiko Kawai Motoyuki itoh 俞鸿儒姜宗林 Institute of Fluid Engineering Department of Mechanics Zhejiang University Hangzhou China 310027 Department of Mechanical Engineering Nagoya Institute of Technology Gokiso-cho Showa-ku Nagoya 466-8555 Japan LHD Institute of Mechanics Chinese Academy of Sciences Beijing China 100080

An experimental study and a numerical simulation were conducted to investigate the mechanical and thermodynamic processes involved in the interaction between shock waves and low density foam. The experiment was done in a stainless shock tube (80 mm in inner diameter, 10 mm in wall thickness and 5 360 mm in length). The velocities of the incident and reflected compression waves in the foam were measured by using piezo-ceramic pressure sensors. The end-wall peak pressure behind the reflected wave in the foam was measured by using a crystal piezoelectric sensor. It is suggested that the high end-wall pressure may be caused by a rapid contact between the foam and the end-wall surface. Both open-cell and closed-cell foams with different length and density were tested. Through comparing the numerical and experimental end-wall pressure, the permeability coefficients α and β are quantitatively determined.

关键词： shock tube interaction of shock wave with foam end wall pressure velocities of incident and reflected compression waves numerical simulation

Use of color Doppler ultrasonography in the diagnosis of anomalous connection in pancreatobiliary disease

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World Journal of Gastroenterology 2005年第7期11卷 1018-1022页

作者： Hiroki Kawashima Yoshiki Hirooka Akihiro itoh Senju Hashimoto Terutomo itoh Kazuo Hara Akira Kanamori Naoki Ohmiya Yasumasa Niwa Hidemi Goto Department of Gastroenterology Department of Endoscopy

AIM: To estimate the detectability of anomalous connection in pancreatobiliary disease (ACPBD) cases, measuring gallbladder wall blood flow (GWBF).METHODS: In the retrospective study, we enrolled 42subjects with gallbladder wall thickening. GWBF velocity was determined as an average value of the peak velocity of color signals on the gallbladder wall, three times in each case. Based on the findings on endoscopic ultrasonography (EUS) or endoscopic retrograde cholangiopancreatography (ERCP), the 42 subjects were divided into 11 cases with ACPBD and 31 cases without ACPBD. In the prospective study, the subjects were 92 cases with gallbladder wall thickening. Using the cut-off level of the flow velocity obtained in the retrospective study, the usefulness of measuring GWBF velocity in diagnosing ACPBD was ***: In the retrospective study, imaging of GWBF was obtained in 40 of the 42 subjects. The mean GWBF velocity of the ACPBD cases was 29.4±3.9 cm/s(mean±SD), which was significantly different (P＜0.0001;95% CI 5.48-13.2) from that of the without ACPBD cases(20.1±5.9 cm/s). Based on this result, we prepared a receiver operating characteristic curve, and the cut-off level appropriate for diagnosing ACPBD was estimated to be 25 cm/s. In the prospective study, GWBF was detected in 86 of the 92 subjects. Based on the EUS or ERCP findings, the 92 subjects were divided into 15 cases with ACPBD and 77 cases without ACPBD. When a cut-off level of 25 cm/s was employed, ACPBD could be diagnosed with a sensitivity of 87.0% (13/15) and a specificity of87.3% (62/71).CONCLUSION: Measurement of GWBF velocity, which is less invasive and provides objective values, is very useful for diagnosing ACPBD prior to the development of malignant tumors in cases with gallbladder wall thickening.

关键词： Color Doppler ultrasonography Anomalous connection in pancreatobiliary disease Gallbladder cancer Gallbladder wall blood flow Endoscopic ultrasonography

Is sarcopenic obesity superior to sarcopenia as a predicting indicator in patients with hepatocellular carcinoma following hepatic resection?

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 202-204页

作者： Shinji itoh Tomoharu Yoshizumi Masaki Mori Department of Surgery and Science Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

The most common primary cancer derived from the liver is hepatocellular carcinoma(HCC),and its incidence is increasing globally(1).Hepatic resection has been established as a safe and effective treatment in patients with ***,the number of patients who develop recurrence after hepatic resection remains high(2).The body composition,which consists of the skeletal muscle mass and fat area,is an important used to determine the perioperative risk and prognosis in patients with cancer.

关键词： patients resection hepatic

HOT WIRE MEASUREMENT OF TURBULENT BOUNDARY LAYER ON A FILM COOLING PLATE WITH DIFFUSION HOLES

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Journal of Hydrodynamics 2001年第2期13卷 15-23页

作者： Shi, H.H. Kiriyama, K. itoh, M. Dept. of Mechanics Zhejiang Univ. Hangzhou 310027 China

This study experimentally investigated the film cooling flowfield of a single row of diffusion holes, from which the secondary air flow was injected into a turbulent boundary layer with zero pressure gradient on a flat plate. Circular-shaped holes were also tested as a basis for comparison. All the holes were inclined downstream at 35° with respect to the surface and the lateral spacing between the holes was 3 diameters of the hole. The mainstream velocity was maintained at 17 m/s and the Reynolds number based on the injection hole diameter was almost 11000. The density ratio of the jet to mainstream was 1.0, and the jet-to-mainstream velocity ratios M were 0.5 and 1.5. Normal-type and X-type hot wire anemometries were used to measure the streamwise mean velocity and its components, the normal and shear turbulent Reynolds stress components at the locations from the backward edge of the injection hole to 25 diameters downstream.

关键词： Boundary layer flow Cooling Turbulent flow Vectors Velocity Wind tunnels