检索结果-南通市图书馆

Pegylated interferon α-2b plus ribavirin for older patients with chronic hepatitis C

World Journal of Gastroenterology 2010年第35期16卷 4400-4409页

作者： Mosaburo Kainuma Norihiro Furusyo Eiji Kajiwara Kazuhiro Takahashi Hideyuki Nomura Yuichi Tanabe Takeaki Satoh Toshihiro Maruyama Makoto Nakamuta Kazuhiro Kotoh Koichi Azuma Junya Shimono shinji Shimoda Jun Hayashi Department of General Internal Medicine Kyushu University Hospital Department of Internal Medicine Nippon Steel Yawata Memorial Hospital Department of Medicine Hamanomachi Hospital The Center for Liver Disease Shin-Kokura Hospital Department of Medicine Fukuoka City HospitalYoshiduka-honmachi Center for Liver Disease National Hospital Organization Kokura Medical Center Department of Medicine Kitakyushu Municipal Medical Center Department of Gastroenterology Kyushu Medical CenterNational Hospital Organization Department of Medicine and Bioregulatory Science Graduate School of Medical ScienceKyushu University Department of Medicine and Clinical Science Graduate School of Medical SciencesKyushu University Saiseikai Yahata General Hospital Harunomachi Department of Medicine and Biosystemic Science Graduate School of Medical ScienceKyushu University

AIM:To analyze the efficacy and safety of a combination therapy of pegylated interferon(PEG-IFN) α-2b plus ribavirin(RBV) in older Japanese patients(65 years or older) infected with hepatitis C virus(HCV).METHODS:This multicenter study included 938 patients with HCV genotype 1 who received 1.5 μg/kg per week PEG-IFN α-2b plus RBV 600-1000 mg/d for 48 wk and 313 HCV genotype 2 patients who received this treatment for 24 ***:At 24 wk after the end of combination therapy,the overall sustained virological response(SVR) for genotypes 1 and 2 were 40.7% and 79.6%,*** SVR rate decreased signif icantly with age in each genotype,and was markedly reduced in genotype 1(P<0.001).Moreover,the SVR was significantly higher in patients with genotype 1 who were less than 65 years(47.3% of 685) than in those 65 years or older(22.9% of 253)(P<0.001) and was higher in patients with genotype 2 who were less than 65 years(82.9% of 252) than in those 65 years or older(65.6% of 61)(P=0.004).When patients received a dosage at least 80% or more of the target dosage of PEG-IFN α-2b and 60% or more of the target dosage of RBV,the SVR rate significantly increased to 66.5% in patients less than 65 years and to 45.2% in those 65 years or older(P<0.001).Adverse effects resulted in treatment discontinuation more often in patients with genotype 1(14.4%) than in patients with genotype 2(7.3%),especially by patients 65 years or older(24.1%).CONCLUSION:PEG-IFN α-2b plus RBV treatment was effective in chronic hepatitis C patients 65 years or older who completed treatment with at least the minimum acceptable treatment dosage.

关键词： Hepatitis C virus Gerontology Pegylated interferon Ribavirin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence and characterization of foodborne Listeria monocytogenes isolates in North China,2005-2007

Prevalence and characterization of foodborne Listeria monocy...

引用

2010年第二届中国科学院博士后学术年会暨高新技术前沿与发展学术会议

作者：闫鹤 shinji Yamasaki Lei Shil 华南理工大学

A total of 2177 food samples collected from nine cities in northern China during 2005 to 2007 were screened for the presence of Listeria monocytogenes,a highly fatal food-borne *** isolates were subjected to serotyping,antimicrobial susceptibility,pulsed-field gel electrophoresis(PFGE) and PCR for tetracycline resistance(tet) gene,transpon Tn916,and class 1 *** pathogen occurred among 4.13%(90/2177) of samples,and the main sources were quick-frozen food(26/252,10.32%) and raw meats(46/733,6.28%).Among the 90 isolates five serotypes(1/2a,1/2b,1/2c,4b,and 3a) existed,serotype 1/2a was dominant(48.88%). Antimicrobial resistance was most frequently observed for ciprofloxacin(17.8%),tetracycline (15.6%) and streptomycin(12.2%).Overall,resistance was observed against 14 out of 18 antimicrobials tested while multiple resistance occurred among 18.9%(17/90) isolates. Interestingly,two isolates were resistant to more than five *** 14 tetracycline-resistant isolates,13 carried tet(M) gene including nine possessing Tn916,and one harbored tet(S) *** PFGE types could be distinguished but no clear-cut affiliation with specific serotype or food category was *** widespread distribution of epidemiologically important serotypes(1/2a,1/2b and 4b),their high genetic diversity and resistance to commonly used antibiotics indicate a potential public health risk.

关键词： Listeria monocytogenes antibiotic resistance tetracycline resistance determinants Tn916 conjugative transposon

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Present Status of the Nd:YAG Thomson Scattering System Development for Time Evolution Measurement of Plasma Profile on Heliotron J

引用

Plasma Science and Technology 2013年第3期15卷 240-243页

作者： Takashi MINAMI Shohei ARAI Naoki KENMOCHI Hiroaki YASHIRO Chihiro TAKAHASHI shinji KOBAYASHI Tohru MIZUUCHI Shinsuke OHSHIMA Satoshi YAMAMOTO Hiroyuki OKADA Kazunobu NAGASAKI Yuji NAKAMURA Kiyoshi HANATANI Shigeru KONOSHIMA Fumimichi SANO Institute of Advanced Energy Kyoto University Graduate School of Energy Science Kyoto University Pioneering Research Unit for Next Generation Kyoto University

A new high repetition rate Nd：YAG Thomson scattering system is developed for the Heliotron J helical device. A main purpose of installing the new system is the temporal evolution measurement of a plasma profile for improved confinement physics such as the edge transport barrier （H-mode） or the internal transport barrier of the helical plasma. The system has 25 spatial points with -10 mm resolution. Two high repetition Nd：YAG lasers （〉 550 m J@ 50 Hz） realize the measurement of the time evolution of the plasma profile with ~10 ms time intervals. Scattered light is collected by a large concave mirror （D----800 mm, f/2.25） with a solid angle of -100 mstr and transferred to interference filter polychromators by optical fiber bundles in a staircase form. The signal is amplified by newly designed fast preamplifiers with DC and AC output, which reduces the low frequency background noise. The signals are digitized with a multi-event QDC, fast gated integrators. The data acquisition is performed by a VME-based system operated by the CINOS.

关键词： plasma diagnostic Nd:YAG laser Thomson scattering measurement plasma improved confinement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development of a Heavy Ion Bearn Probe for Measuring Electrostatic Potential Profile and Its Fluctuation in LHD

引用

Plasma Science and Technology 2009年第4期11卷 460-464页

作者： TakeshiI DO Akihiro SHIMIZU Masaki NISHIURA Haruhisa NAKANO shinji KATO Shinsuke OHSHIMA Yasuo YOSHIMURA Shin KUBO Takashi SHIMOZUMA HiroeI GAMI Hiromi TAKAHASHI Kazuo TOI Fumitake WATANABE Kazumichi NARIHARA Ichihiro YAMADA National Institute for Fusion Science

A heavy ion beam probe （HIBP） using a 3-MV tandem accelerator has been installed on large helical device （LHD）. Electrostatic potential in core plasma can be measured under the toroidal magnetic field strength of up to 3 T. By using the HIBP, the transition of potential profiles from electron-root to ion^root is observed in core plasmas during ramp-up of the electron density. Potential fluctuations are also measured electron cyclotron current drive （ECCD）. Two kind of characteristic fluctuations are observed. One is a reversed-shear-induced Alfv^n eigenmode （RSAE）, whose frequency varies during the evolution of the rotational transform profile, and the other is with a constant geodeisc acoustic mode （GAM） frequency.

关键词： electrostatic potential measurement HIBP GAM RSAE

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于虚拟边界概念的无线传感网络测距定位(英文)

引用

仪器仪表学报 2012年第8期33卷 1697-1707页

作者： AliHuseinAlasiry 大山真司泗水电子工程理工学院泗水60111印度尼西亚东京工业大学东京152-8552日本

为获得无线传感网络中节点的精确位置需要足够量的距离数据,特别是在多跳拓扑结构中数据的好坏将受到路由链接稳定性的影响。通常节点间距离测量仅用于定位。为增加数据整合性,在多跳路由结构的链路选择中引入了节点间距离测量信息,为... 详细信息

为获得无线传感网络中节点的精确位置需要足够量的距离数据,特别是在多跳拓扑结构中数据的好坏将受到路由链接稳定性的影响。通常节点间距离测量仅用于定位。为增加数据整合性,在多跳路由结构的链路选择中引入了节点间距离测量信息,为解决无线通信不正常的问题,提出了2种节点的通信区域:正常通信区域是指该节点与区域内的其他节点可以双向成功通信;非正常区域是指该节点与区域内节点很难正常通信。由于通信的不稳定性,现有的一些方法试图完全避开非正常通信区域。提出了虚拟边界的方法,给这些区域分配优先级别。正常区域内的节点有被选为链接顶点的优先权,如果这个区域内没有链接可选,非正常区域的节点将按照到母节点的距离被选择。其结果可使多跳拓扑结构更加鲁棒,减少孤立的节点数,增加基站收集数据的比例,实现传感器节点的高精度定位。

关键词：传感网络测距定位多跳通信

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C

引用

World Journal of Gastroenterology 2004年第5期10卷 733-736页

作者： Kaori Mochizuki Tatehiro Kagawa shinji Takashimizu Kazuya Kawazoe Sei-Ichiro Kojima Naruhiko Nagata Atsushi Nakano Yasuhiro Nishizaki Koichi Shiraishi Masaru Itakura Norihito Watanabe Tetsuya Mine Shohei Matsuzaki Department of Internal Medicine Division of GastroenterologyTokai University School of MedicineBohseidaiIsehara 259-1193Japan

AIM:To test whether in vitro incubation of peripheral blood mononuclear cells (PBMC) with interferon (IFN) could efficiently decrease hepatitis C virus-RNA (HCV-RNA) amount and to analyze whether this effect was associated with clinical response to ***:Twenty-seven patients with histologically proven chronic hepatitis C were given intravenous administration of 6 million units (MU) IFN-β daily for 6 weeks followed by three times weekly for 20 weeks. PBMC collected before IFN therapy were incubated with IFN-β and HCV-RNA in PMBC was semi-quantitatively ***: Twenty-five patients completed IFN *** patients (32%) had sustained loss of serum HCV-RNA with normal serum ALT levels after IFN therapy (complete responders).HCV-RNA in PBMC was detected in all patients,whereas it was not detected in PBMC from healthy *** vitro administration of IFN-β decreased the amount of HCV-RNA in PMBC in 18 patients (72%). Eight of these patients obtained complete response. On the other hand,none of the patients whose HCV-RNA in PBMC did not decrease by IFN-β was complete responders. Multiple logistic regression analysis revealed that the decrease of HCV-RNA amount in PBMC by IFN-β was the only independent predictor for complete response (P<0.05).CONCLUSION:The effect of in vitro IFN-β on HCV in PBMC reflects clinical response and would be taken into account as a predictive marker of IFN therapy for chronic hepatitis C.

关键词： Adult Antiviral Agents dosage Drug Resistance, Viral Female Hepacivirus Hepatitis C, Chronic Humans In Vitro Interferon-beta Leukocytes, Mononuclear Male Middle Aged Predictive Value of Tests RNA, Viral

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

旧石器时代晚期人类在欧亚东部地区的扩散和文化传播

引用

人类学学报 2023年第6期42卷 842-856页

作者：加藤真二奈良国立文化财研究所日本奈良6308577

本论文概述了旧石器时代晚期中国东部、朝鲜半岛、日本列岛等欧亚东部地区的石器工业,并基于“迁徙传播”和“接触传播”的角度就该地区旧石器时代晚期石器群的趋势进行了分析。通过分析阐明,旧石器时代晚期早段(40 kaBP cal以前),运用... 详细信息

本论文概述了旧石器时代晚期中国东部、朝鲜半岛、日本列岛等欧亚东部地区的石器工业,并基于“迁徙传播”和“接触传播”的角度就该地区旧石器时代晚期石器群的趋势进行了分析。通过分析阐明,旧石器时代晚期早段(40 kaBP cal以前),运用中国南方石器工业人群的向该地区北部区域的扩散;旧石器时代晚期前半段(40-28 kaBP cal)的地方人群形成和人群间的接触及技术传播;旧石器时代晚期后半段(28 kaBP cal以后),运用细石叶工业人群的广泛迁徙和扩散及再扩散,人群间的接触。虽有西方或者北方运用旧石器时代晚期初段或早中段石器工业人群的数次进入痕迹,但表明每次进入时间短暂且进入地也是局部性的。可以说,从石器群的分析角度所看到的石器工业运用人群的趋势和从基因分析结果表明的东亚祖先人群的趋势大致吻合。

关键词：远东欧亚地区旧石器时代晚期迁徙传播接触传播基底东欧亚人群

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dedifferentiated chondrosarcoma of the middle finger arising from a solitary enchondroma:A case report

引用

World Journal of Clinical Cases 2022年第10期10卷 3297-3305页

作者： Hirotaka Yonezawa Norio Yamamoto Katsuhiro Hayashi Akihiko Takeuchi shinji Miwa Kentaro Igarashi Sei Morinaga Yohei Asano Shiro Saito Yasunori Tome Hiroko Ikeda Takayuki Nojima Hiroyuki Tsuchiya Department of Orthopaedic Surgery Graduate School of Medical SciencesKanazawa UniversityKanazawa 920-8641IshikawaJapan Department of Orthopedic Surgery Graduate School of MedicineUniversity of the RyukyusNishihara 903-0215OkinawaJapan Department of Diagnostic Pathology Kanazawa University HospitalKanazawa 920-8641IshikawaJapan

BACKGROUND Dedifferentiated chondrosarcoma(DDCS)accounts for 10%of all chondrosarcomas and has the poorest outcome,with a 5-year survival rate of 7%-25%.DDCS commonly occurs in the femur and pelvis,whereas DDCS of the finger is extremely ***,the histological findings of preexisting solitary enchondroma samples are important and valuable for diagnosing malignant *** SUMMARY We report our experience with DDCS in the proximal phalanx of the left middle finger of an 87-year-old *** had undergone surgery for enchondroma,with curettage and artificial bone grafting,11 years ago,in the same *** years after the primary surgery,the left middle finger gradually started to enlarge,and the growth speed increased in the past *** radiographs showed an expansive osteolytic lesion with calcifications and residual grafting *** to the suspicion of malignancy,we performed ray *** findings revealed an abrupt transition between the low-grade chondrosarcoma and dedifferentiated sarcoma *** dedifferentiated components showed the features of a high-grade undifferentiated pleomorphic *** patient was diagnosed with DDCS arising from a preexisting *** had no local recurrence or distant metastasis and died of pneumonia 6 years and 10 months after the second *** The histological findings of a precursor lesion showed a typical enchondroma,suggesting that DDCS can arise from enchondroma.

关键词： Dedifferentiated chondrosarcoma Enchondroma Finger Phalanx Ray amputation Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

miR-122-5p as a novel biomarker for alpha-fetoproteinproducing gastric cancer

引用

World Journal of Gastrointestinal Oncology 2018年第10期10卷 344-350页

作者： Suguru Maruyama shinji Furuya Kensuke Shiraishi Hiroki Shimizu Hidenori Akaike Naohiro Hosomura Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida Makoto Sudo Shingo Inoue Hiroshi Kono Daisuke Ichikawa First Department of Surgery Faculty of Medicine University of Yamanashi

AIM To investigate the clinical utility of alpha-fetoprotein(AFP)-producing gastric cancer(AFPGC)-specific microRNA(mi RNA)for monitoring and prognostic prediction of *** We performed a comprehensive miRNA array-based approach to compare miRNA expression levels between AFP-positive and AFP-negative cells in three patients with primary *** next examined the expression levels of the selected miRNAs in five AFPGC and ten non-AFPGC tissue samples by quantitative reverse transcription-polymerase chain reaction to validate their *** also investigated the expression levels of the selected miRNA not only in tissue but also in plasma ***,we investigated the relationship between plasma AFP levels and plasma selected miRNA expression levels,and also investigated the correlation of the selected miRNA expression levels and malignant *** Among the five miRNAs selected from the miRNA array results,the expression levels of miR-122-5p were significantly higher in the AFPGC patients than in the non-AFPGC patients(P<0.05).In tissue samples,mi R-122-5p expression level tended to be lower in the non-AFPGC tissue than the normal gastric ***,in the AFPGC tissue,miR-122-5p expression level was significantly higher in the AFPGC tissue than both the normal gastric mucosa and the nonAFPGC tissue samples(P<0.05).Plasma mi R-122-5p expression levels were also significantly higher in the AFPGC patients than the health volunteers and the nonAFPGC patients(P<0.05)and were strongly correlated with plasma AFP levels(r=0.7975,P<0.0001).Moreover,the correlation of miR-122-5p expression in tissue samples with malignant potential was stronger than that of plasma AFP level in the AFPGC *** contrast,no correlation was found between mi R-122-5p expression levels and liver metastasis in the non-AFPGC *** miR-122-5p might be a useful biomarker for early detection and disease monitoring in AFPGC.

关键词： Gastric cancer Alpha-fetoprotein Alphafetoprotein producing gastric cancer MicroRNA miR-122-5p

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats

引用

World Journal of Hepatology 2014年第2期6卷 72-84页

作者： Tomohide Hori shinji Uemoto Feng Chen Lindsay B Gardner Ann-Marie T Baine Toshiyuki Hata Takayuki Kogure Justin H Nguyen Division of Hepato-Biliary-Pancreatic and Transplant Surgery Department of Surgery Kyoto University Graduate School of Medicine Department of Neuroscience Mayo Clinic Department of Gastroenterology Tohoku University Graduate School of Medicine Division of Transplant Surgery Department of Transplantation Mayo Clinic

AIM:To investigate oxidative stress(OS)-mediated damage and the behavior of extracellular matrices in various rat models because shear stress with portal hypertension and cold ischemia/warm reperfusion injury trigger the liver regeneration cascade after surgery. These injuries also cause fatal liver ***: Rats were divided into four groups according to the surgery performed: control; hepatectomy with 40% liver remnant(60% hepatectomy); orthotopic liver transplantation(OLT) with whole liver graft(100% OLT); and split OLT(SOLT) with 40% graft(40% SOLT). Survival was evaluated. Blood and liver samples were collected at 6 h after surgery. Biochemical and histopathological examinations were performed. OSinduced damage, 4-hydroxynonenal, ataxia-telangiectasia mutated kinase, histone H2AX, phosphatidylinositol 3-kinase(PI3K) and Akt were evaluated by western blotting. Behavior of extracellular matrices, matrix metalloproteinase(MMP)-9, MMP-2, tissue inhibitor of metalloproteinase(TIMP)-1 and TIMP-2 were also evaluated by western blotting and zymography. RESULTS: Although 100% OLT survived, 60% hepatectomy and 40% SOLT showed poor survival. Histopathological, immunohistological, biochemical and protein assays revealed that 60% hepatectomy, 100% OLT and 40% SOLT showed liver damage. PI3K and Akt were decreased in 60% hepatectomy and 40% SOLT. For protein expression, 40% SOLT showed differences in MMP-9, MMP-2 and TIMP-2. TIMP-1 showed differences in 60% hepatectomy and 40% SOLT. For protein activity, MMP-9 demonstrated significant differences in 60% hepatectomy, 100% OLT and 40% SOLT. CONCLUSION: Under conditions with an insufficient liver remnant, prevention of OS-induced damage via the Akt/PI3K pathway may be key to improve the postoperative course. MMP-9 may be also a therapeutic target after surgery.

关键词： Free radicals Akt Phosphatidylinositol 3-ki-nase Matrix metalloproteinase Tissue inhibitors of metalloproteinase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：