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Use of technology and social media in dementia care:Current and future directions

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World Journal of Psychiatry 2021年第4期11卷 109-123页

作者： Sara Shu benjamin KP Woo College of Osteopathic Medicine of the Pacific Western University of Health SciencesPomonaCA 91766United States Department of Psychiatry and Biobehavioral Sciences University of CaliforniaLos Angeles(UCLA)Medical CenterSylmarCA 91104United States

As the population across the globe continues to dramatically increase,the prevalence of cognitive impairment and dementia will inevitably increase as well,placing increasing burden on families and health care *** advancements over the past decade provide potential benefit in not only relieving caregiver burden of caring for a loved one with dementia,but also enables individuals with dementia to age in *** devices have served to improve functioning,tracking and ***,smartphones,tablets and the ubiquitous world wide web have facilitated the dissemination of health information to previously hard to reach populations largely through use of various social media *** this review,we discuss the current and future uses of technology via devices and social media to promote healthy aging in individuals with dementia,and also limitations and challenges to consider in the future.

关键词： Dementia Technology Gerotechnology Social media Geriatrics Wearable technology Health promotion Home health Monitoring

Positivity in electron-positron scattering:testing the axiomatic quantum field theory principles and probing the existence of UV states

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Chinese Physics C 2021年第2期45卷 176-199页

作者： benjamin Fuks Yiming Liu Cen Zhang Shuang-Yong Zhou Sorbonne Université CNRSLaboratoire de Physique Théorique et HautesÉnergiesLPTHEF-75005 ParisFrance Institut Universitaire de France 103 boulevard Saint-Michel75005 ParisFrance Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Center for High Energy Physics Peking UniversityBeijing 100871China Interdisciplinary Center for Theoretical Study University of Science and Technology of ChinaHefei 230026China Peng Huanwu Center for Fundamental Theory Hefei 230026China

We consider the positivity bounds on dimension-8 four-electron operators and study two related phenomenological aspects at future lepton ***,if positivity is violated,probing such violations will revolutionize our understanding of the fundamental pillars of quantum field theory and the S-matrix *** observe that positivity violation at scales of 1-10 TeV can potentially be probed at future lepton colliders even if one assumes that dimension-6 operators are also ***,the positive nature of the dimension-8 parameter space often allows us to either directly infer the existence of UV-scale particles together with their quantum numbers or exclude them up to certain scales in a model-independent *** particular,dimension-8 positivity plays an important role in the test of the Standard *** no deviations from the Standard Model are observed,it allows for simultaneous exclusion limits on all kinds of potential UV-complete *** the dimension-6 case,these limits apply regardless of the UV model setup and cannot be removed by possible cancellations among various UV *** thus consists of a novel and universal test to confirm the Standard *** demonstrate with realistic examples how all the previously mentioned possibilities,including the test of positivity violation,can be ***,we provide an important motivation for studying dimension-8 operators more comprehensively.

关键词： electron-positron collider positivity bound Standard Model Effective Field Theory

Could a phase model help to improve translational animal research?

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Animal Models and Experimental Medicine 2022年第6期5卷 550-556页

作者： benjamin Mayer Jan Tuckermann Rainer Muche Institute of Epidemiology and Medical Biometry Ulm UniversityUlmGermany Institute of Comparative Molecular Endocrinology Ulm UniversityUlmGermany

Background:Animal models are widely applied in medical research for different *** particular,results from translational experiments may be used for subsequent clinical ***,transferability of these findings to the human organism is *** other factors,this may be traced back to a lack of clear differentiation of the evidence(explorative ***)provided by such experimental *** general,inferential statistics(i.e.p values)should not be interpreted in as confirmatory unless crucial methodological requirements are ***:Therefore,we propose a phase model which reflects the well-established process of clinical research,and we discuss its potential to improve decision making in translational *** model aims to clarify the reliability of results derived from animal ***:The phase model proposes subdividing translational,pre-clinical research into pilot,exploration,and confirmation *** for which there is no valid estimation of the expected effect size are designated as pilot *** on these data,experiments in subsequent phases may be planned using both appropriate design and statistical ***:Separating the entire process of translational animal research into three phases could contribute to improved transparency of the evidence derived from such experiments.

关键词： confirmatory trials hypothesis testing results interpretation transferability

Chemical constituents, in vitro antimicrobial and cytotoxic potentials of the extracts from Macaranga barteri Mull-Arg

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Asian Pacific Journal of Tropical Biomedicine 2017年第7期7卷 654-659页

作者： Akintayo Ogundajo benjamin Okeleye Anofi Omotayo Ashafa Phytomedicine and Phytopharmacology Research Group Department of Plant Sciences University of the Free State Qwaqwa Campus Phuthaditjhaba 9866 South Africa

Objectives: To investigate antimicrobial and cytotoxic potentials as well as chemical constituents of extracts from Macaranga barteri(M. barteri).Methods: Antimicrobial activity was carried out using micro-dilution, cell culture and GC–MS methods were employed to determine the cytotoxicity and chemical constituents of the extracts ***: Marked activity was observed in methanol(ME) fraction [MIC_(50):(0.097 7–6.250 0) mg/mL] compared to hexane and ethyl acetate fractions. Aeromonas hydrophila(environmental strain) and Shigella sonnei(ATCC 29930) were the most susceptible pathogens to ME and ciprofloxacin(Cl) at MIC_(50) value of 0.097 7 and < 0.019 5 mg/mL respectively. Cryptococcus neoformans(ATCC 66031) was susceptible to ME at 0.195 3 mg/mL compared to fluconazole at 10.000 0 mg/mL. Decreased viability of the Vero cells was observed at the concentrations of 0.1–1.0 mg/mL. The lethal dose(LC_(50))of hexane, ethyl acetate and methanol fractions were recorded at(0.30 ± 0.07),(0.52 ± 0.05) and(0.22 ± 0.04) mg/mL, respectively. Some of the compounds identified from ME were caryophyllene(25.21%), neophytadiene(11.90%), a-humulene(7.67%),phytol(4.40%), ethyl ester hexadecanoic acid(4.04%) and nerolidol(2.83%) which were known to have various antimicrobial ***: Methanol fraction of M. barteri is a potent and safe antimicrobial and antifungal alternative which can be useful in the search for new antimicrobial drugs. The study also confirmed the orthodox usage of M. barteri in combating infectious diseases.

关键词： Macaranga barteri GC–MS Antimicrobial Cytotoxicity

Preparation and Surface Modification of High-Density Chitosan/Functionalized Multi-walled Carbon Nanotubes Hollow Fibers

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Journal of Donghua University(English Edition) 2015年第4期32卷 602-608页

作者：邵梅玲杜盼杨庆 HSIAO benjamin S College of Material Science and Engineering Donghua University

Functionalized multi-walled carbon nanotubes( fMWNTs) were prepared with chitosan via controlled surface deposition and crosslinking process and scanning electron microscopy( SEM),Fourier translation infrared spectroscopy( FT-IR) and Xray diffraction( XRD) are used to character properties. A novel high-density chitosan( HCS) was dissolved in f-MWNTs dispersed dilute acetic acid with a maximal concentration of 5. 8%. The hollow fibers can be made by extruding the solution into a dilute alkali solution through a wet-spinning process and the tensile properties of the materials were evaluated by universal tester. The surface property of fibers,pretreated by Helium( He) and the following grafted with gelatin was evaluated with X-ray photoelectron spectroscopy( XPS).As the hollow fibers were intended for neural tissue engineering,its suitability was evaluated in vitro using rat Schwann cells( RSC96) as model cells. The cells attachment,proliferation and morphology,were studied by various microscopic techniques. Based on the results,the gelatin grafted HCS / f-MWNTs hollow fibers could be used as a potential cell carrier in neural tissue engineering.

关键词： chitosan multi-walled carbon nanotubes(MWNTs) hollow fibers wet-spinning cold plasma treatment biocompatibility

Ecthyma gangrenosum of the scrotum： a case report

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Frontiers of Medicine 2016年第1期10卷 101-103页

作者： Wei Phin Tan benjamin A. Sherer Jerome Hoeksema Department of Urology Rush University Medical Center Chicago IL 60612 USA

A 43-year-old man with pancytopenia from chemotherapy for acute myeloid leukemia developed left scrotal pain, fever, and rigors. Physical exam revealed an ulcerating lesion with central necrosis and eschar surrounded by a halo of erythema on the inferior aspect of the left scrotum. The condition indicated an early necrofizing soft tissue infection. The patient was started on broad-spectrum antibiotics and taken to the operating room for a wound debridement. Blood and tissue cultures grew Pseudomonas aeruginosa, which confirmed the diagnosis of ecthyma gangrenosum of the scrotum. The fever resolved, and the wound healed without further progression after wet to dry dressing changes.

关键词： ecthyma gangrenosum scrotum genitalia

Selected Recent Applications of Sparse Grids

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Numerical Mathematics(Theory,Methods and Applications) 2015年第1期8卷 47-77页

作者： benjamin Peherstorfer Christoph Kowitz Dirk Pfluger Hans-Joachim Bungartz Scientific Computing Group Dept.of Computer ScienceBoltzmannstr.385748 GarchingGermany Institutefor Advanced Study Technische UniversitätMünchenLichtenbergstr.2a85748 GarchingGermany Institute for Parallel and Distributed Systems University of StuttgartUni-versitätsstr.3870569 StuttgartGermany

Sparse grids have become a versatile tool for a vast range of applications reaching from interpolation and numerical quadrature to data-driven problems and uncertainty *** review four selected real-world applications of sparse grids:financial product pricing with the Black-Scholes model,interactive explo-ration of simulation data with sparse-grid-based surrogate models,analysis of simu-lation data through sparse grid data mining methods,and stability investigations of plasma turbulence simulations.

关键词： Sparse grids hierarchical decomposition adaptivity combination technique

Are we Athens or Florence? COVID-19 in historical context

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Family Medicine and Community Health 2021年第1期9卷 43-45页

作者： benjamin R Doolittle Internal Medicine&Pediatrics Yale UniversityNew HavenConnecticutUSA

We have been here *** 430 BCE,a plague struck Athens,killing as much as 25%of the *** 1347 CE,the bubonic plague afflicted western Europe for 4 years,killing as much as 50%of the *** plague of Athens led to a collapse of their religion,cultural norms and *** contrast,the bubonic plague led eventually to the Renaissance,a growth of art,science and *** we contend with the COVID-19 global pandemic,will we become Athens or Florence?

关键词： population. eventually Renaissance

Conjugated linoleic acid isomers and their precursor fatty acids regulate peroxisome proliferator-activated receptor subtypes and major peroxisome proliferator responsive element-bearing target genes in HepG2 cell model

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第2期14卷 115-123页

作者： Sailas benjamin Silke FLOTHO Torsten BRCHERS Friedrich SPENER Department of Biochemistry University of Münster48149 MünsterGermany Enzyme Technology Laboratory Biotechnology DivisionDepartment of BotanyUniversity of CalicutKerala 673 635India Department of Molecular Biosciences Lipidomics Research CenterUniversity of GrazHeinrichstrasse 318010 GrazAustria

The purpose of this study was to examine the induction profiles （as judged by quantitative reverse tran- scription polymerase chain reaction （qRT-PCR）） of peroxisome proliferator-activated receptor （PPAR） α,β, y subtypes and major PPAR-target genes bearing a functional peroxisome proliferator responsive element （PPRE） in HepG2 cell model upon feeding with cis-9,trans-11-octadecadienoic acid （9-CLA） or trans-10,cis-12-octadecadienoic acid （10-CLA） or their precursor fatty acids （FAs）. HepG2 cells were treated with 100 pmol/L 9-CLA or 10-CLA or their precursor FAs, viz., oleic, linoleic, and trans-11-vaccenic acids against bezafibrate control to evaluate the induc- tion/expression profiles of PPAR （α, β, γ subtypes and major PPAR-target genes bearing a functional PPRE, i.e., fatty acid transporter （FAT）, glucose transporter-2 （GLUT-2）, liver-type FA binding protein （L-FABP）, acyl CoA oxidase-1 （ACOX-1）, and peroxisomal bifunctional enzyme （PBE） with reference to β-actin as house keeping gene. Of the three housekeeping genes （glyceraldehyde 3-phosphate dehydrogenase （GAPDH）, β-actin, and ubiquitin）, β-actin was found to be stable. Dimethyl sulfoxide （DMSO）, the common solubilizer of agonists, showed a significantly higher induction of genes analyzed, qRT-PCR profiles of CLAs and their precursor FAs clearly showed upregulation of FAT, GLUT-2, and L-FABP （-0.5-.0-fold）. Compared to 10-CLA, 9-CLA decreased the induction of the FA metabolizing gene ACOX-1 less than did PBE, while 10-CLA decreased the induction of PBE less than did ACOX-I. Both CLAs and precursor FAs upregulated PPRE-beadng genes, but with comparatively less or marginal activation of PPAR subtypes This indicates that the binding of CLAs and their precursor FAs to PPAR subtypes results in PPAR activation, thereby induction of the target transporter genes coupled with downstream lipid metabolising genes such as ACOX-1 and PBE. To sum up, the expression profiles of these candidate genes showed that CLAs and th

关键词： Conjugated linoleic acid HepG2 cell model qRT-PCR Peroxisome proliferator-activated receptor Peroxisome proliferator responsive element-bearing genes Lipid agonists