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Retraction Note:Screening and identification of bioactive compounds from citrus against non-structural protein 3 protease of hepatitis C virus genotype 3a by fluorescence resonance energy transfer assay and mass spectrometry

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World Journal of Hepatology 2022年第7期14卷 1528-1529页

作者： Mahim Khan Waqar Rauf Fazal-E-Habib Moazur Rahman mazhar iqbal Health Biotechnology Division National Institute for Biotechnology and Genetic EngineeringFaisalabad 38000PunjabPakistan

Retraction note:Khan M,Rauf W,Habib F,Rahman M,iqbal *** and identification of bioactive compounds from citrus against non-structural protein 3 protease of hepatitis C virus genotype 3a by fluorescence resonance energy transfer assay and mass *** J Hepatol 2020;12(11):976-992 PMID:33312423 DOI:10.4254/*** online version of the original article can be found at https://***/1948-5182/full/v12/i11/***.

关键词： Non-structural protein 3 Hepatitis C virus Genotype 3a Fluorescence resonance energy transfer

Genuine entanglement under squeezed generalized amplitude damping channels with memory

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Chinese Physics B 2024年第2期33卷 158-163页

作者： mazhar Ali Department of Electrical Engineering Faculty of EngineeringIslamic University MadinahMadinah 107Saudi Arabia

We study genuine entanglement among three qubits undergoing a noisy process that includes dissipation, squeezing,and decoherence. We obtain a general solution and analyze the asymptotic quantum states. We find that most of these asymptotic states can be genuinely entangled depending upon the parameters of the channel, memory parameter, and the parameters of the initial states. We study Greenberger–Horne–Zeilinger(GHZ) states and W states, mixed with white noise,and determine the conditions for them to be genuinely entangled at infinity. We find that for these mixtures, it is possible to start with a bi-separable state(with a specific mixture of white noise) and end with genuine entangled states. However, the memory parameter μ must be very high. We find that in contrast to the two-qubit case, none of the three-qubit asymptotic states for n → ∞ are genuinely entangled.

关键词： genuine entanglement squeezed thermal baths multipartite states

In vitro larvicidal potential against Anopheles stephensi and antioxidative enzyme activities of Ginkgo biloba,Stevia rebaudiana and Parthenium hysterophorous

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Asian Pacific Journal of Tropical Medicine 2011年第3期4卷 169-175页

作者： Nisar Ahmad Hina Fazal Bilal H Abbasi mazhar iqbal Department of Biotechnology Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabad 45320Pakistan Nuclear Institute for Food and Agriculture(NIFA) Peshawar 2500Pakistan Department of Plant Sciences Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabad 45320Pakistan Pakistan Council of Scientific and Industrial Research(PCSIR)Laboratories Complex Peshawar 2500Pakistan

Objective:To investigate in vitro larvicidal and antioxidant enzymes potential of the medicinal plants Ginkgo biloba（***）,Stevia rebaudiana（***） and Parthenium hysterophorous（***） against Anopheles stephensi（***） 4th instars larvae. Methods:For evaluation of larvicidal potential,the ethanolic,methanolic and dichloromethane leaves extracts of three different plants were used in dose-dependent experiments in two media, while the antioxidant enzymes activities were investigated using four different methods viz., superoxide dismutase,peroxidase,ascorbate and ***:*** has developed resistance to various synthetic insecticides,making its control increasingly *** comparative performance of ethanolic extracts（65%-90%） was found better than the methanolic extract（70%-87%） and dichloromethane extract（60%-70%）.Among the three plants extracts tested in two media,*** exhibited higher larvicidal activity with LC50（24 h） in methanolic extract than *** and *** and *** exhibited the strongest antioxidative enzymes activity and *** were less active and no significant difference was ***:These three plants exhibit larvicidal potential and can be further used for vector control alternative to synthetic insecticide due to eco-friendly and diseases control,furthermore these plant species have potent antioxidative enzyme activities, therefore,making them strong natural candidate particularly for diseases which are caused due to free radicals.

关键词： Larvicidal activity Antioxidative enzymes activities Anopheles stephensi

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复合推进剂弹道特性的配方调节研究(英文)

含能材料 2006年第2期14卷 81-85页

作者： Muhammad mazhar iqbal 汪亮西北工业大学航天学院陕西西安710072

实验研究了含铝AP/HTPB推进剂的配方,讨论了燃速及压力指数与配方参数的关系。结果表明,推进剂燃速随平均AP粒子直径的增大而降低,但在大直径范围,这种趋势减缓。液体二茂铁催化剂可提高50%的推进剂燃速,而固体氧化铁可提高22%。液体二... 详细信息

实验研究了含铝AP/HTPB推进剂的配方,讨论了燃速及压力指数与配方参数的关系。结果表明,推进剂燃速随平均AP粒子直径的增大而降低,但在大直径范围,这种趋势减缓。液体二茂铁催化剂可提高50%的推进剂燃速,而固体氧化铁可提高22%。液体二茂铁催化剂能比固体氧化铁更有效地提高燃速。燃速与压力指数的实验结果同燃烧模型的理论计算结果进行了比较,预估结果与实验数据符合较好。

关键词：物理化学复合推进剂燃速压力指数催化剂配方设计

Screening and identification of bioactive compounds from citrus against non-structural protein 3 protease of hepatitis C virus genotype 3a by fluorescence resonance energy transfer assay and mass spectrometry

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World Journal of Hepatology 2020年第11期12卷 976-992页

作者： Mahim Khan Waqar Rauf Fazal-e-Habib Moazur Rahman mazhar iqbal Health Biotechnology Division National Institute for Biotechnology and Genetic Engineering CollegePakistan Institute of Engineering and Applied Sciences(NIBGE-CPIEAS)Faisalabad 38000PunjabPakistan School of Biological Sciences University of the PunjabLahore 54810PunjabPakistan

BACKGROUND Hepatitis C virus genotype 3a(HCV G3a)is highly prevalent in *** to the elevated cost of available Food and Drug Administration-approved drugs against HCV,medicinal natural products of potent antiviral activity should be screened for the cost-effective treatment of the ***,from natural products,active compounds against vital HCV proteins like non-structural protein 3(NS3)protease could be identified to prevent viral proliferation in the *** To develop cost-effective HCV genotype 3a NS3 protease inhibitors from citrus fruit *** Full-length NS3 without co-factor non-structural protein 4A(NS4A)and codon optimized NS3 protease in fusion with NS4A were expressed in Escherichia *** expressed protein was purified by metal ion affinity chromatography and gel *** fruit extracts were screened using fluorescence resonance energy transfer(FRET)assay against the protease and polyphenols were identified as potential inhibitors using electrospray ionization-mass spectrometry(MS)/MS *** different polyphenols,highly potent compounds were screened using molecular modeling approaches and consequently the most active compound was further evaluated against HCV NS4A-NS3 protease domain using FRET *** NS4A fused with NS3 protease domain gene was overexpressed and the purified protein yield was high in comparison to the lower yield of the full-length NS3 ***,in enzyme kinetic studies,NS4A fused with NS3 protease proved to be functionally active compared to full-length *** it was concluded that co-factor NS4A fusion is essential for the purification of functionally active *** assay was developed and validated by the half maximal inhibitory concentration(IC50)values of commercially available *** of citrus fruit extracts against the native purified fused NS4A-NS3 protease domain showed that the grapefruit mesocarp extract exhibits the highest percentage

关键词： Hepatitis C virus genotype 3a Non-structural protein 3 protease Fluorescence resonance energy transfer assay Citrus extract Mass spectrometry Hesperidin

Cellular preconditioning and mesenchymal stem cell ferroptosis

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World Journal of Stem Cells 2024年第2期16卷 64-69页

作者： Doaa Hussein Zineldeen mazhar Mushtaq Khawaja Husnain Haider Basic Sciences Sulaiman AlRajhi UniversityAlbukairiyah 52736AlQaseemSaudi Arabia Department of Medical Biochemistry and Molecular Biology Faculty of MedicineTanta UniversityTanta 6632110Egypt

In this editorial,we comment on the article published in the recent issue of the World Journal of Stem *** focus on stem cell preconditioning to prevent ferroptosis by modulating the cystathionineγ-lyase/hydrogen sulfide(H_(2)S)pathway as a novel approach to treat vascular disorders,particularly pulmonary *** stem cells are gaining popularity in regenerative medicine due to their unique ability to survive by resisting the harsh,unfavorable microenvironment of the injured *** also secrete various paracrine factors against apoptosis,necrosis,and ferroptosis to enhance cell ***,a regulated form of cell death characterized by iron accumulation and oxidative stress,has been implicated in various pathologies encompassing dege-nerative disorders to *** lipid peroxidation cascade initiates and sustains ferroptosis,generating many reactive oxygen species that attack and damage multiple cellular *** these intertwined mechanisms provi-des significant insights into developing therapeutic modalities for ferroptosis-related *** editorial primarily discusses stem cell preconditioning in modulating ferroptosis,focusing on the cystathionase gamma/H_(2)S ferroptosis *** presents a significant challenge in mesenchymal stem cell(MSC)-based therapies;hence,the emerging role of H_(2)S/cystathionase gamma/H_(2) S signaling in abrogating ferroptosis provides a novel option for therapeutic *** research into understanding the precise mechanisms of H_(2)S-mediated cytoprotection against ferroptosis is warranted to enhance the thera-peutic potential of MSCs in clinical settings,particularly vascular disorders.

关键词： Cell survival Cell therapy Hydrogen sulfide Ferroptosis Preconditioning Stem cells Umbilical cord

Estimation of infiltration models parameters and their comparison to simulate the onsite soil infiltration characteristics

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International Journal of Agricultural and Biological Engineering 2019年第3期12卷 84-91页

作者： Hafiz Umar Farid Zahid Mahmood-Khan Ijaz Ahmad Aamir Shakoor Muhammad Naveed Anjum Muhammad mazhar iqbal Muhammad Mubeen Muhammad Asghar Department of Agricultural Engineering Bahauddin Zakariya UniversityMultan-Pakistan Center of Excellence in Water Resources Engineering(CEWRE) University of Engineering and TechnologyLahore-Pakistan Division of Hydrology Water-Land Resources in Cold and Arid Regions Cold and Arid Region Environmental and Engineering InstituteChinese Academy of SciencesLanzhou 730000China Graduate School of Water Resources Sungkyunkwan UniversitySuwon-si 2066Korea Department of Environmental Sciences COMSATS Institute of Information TechnologyVehari-Pakistan

Detailed knowledge about soil characteristics and site-specific final steady infiltration rate could help to increase the irrigation water use efficiency and decrease water losses in agricultural *** experiments were conducted on Agricultural Research Farm of Bahauddin Zakariya University,Multan,Pakistan during *** cumulative infiltration depth was measured using double ring infiltrometer at selected six points of the study *** commonly used infiltration models such as Kostikov’s,Philip’s and Horton’s were fitted to the field infiltration data for determination of model parameters and to find the best fit model for the study ***’s infiltration model’s parameters such as empirical constant‘c’and infiltration decay constants‘k’were obtained in the ranges of 0.140-0.290 and 0.307-0.433,***’s infiltration model’s parameters such as sorptivity‘S’and conductivity constant‘A’were found in the ranges of 0.167-0.288 cm/min1/2 and-0.001 to-0.009 cm/min,***,the Horton’s model’s‘parameter‘k’was obtained in the range of-1.619 *** value of infiltration capacity at onset of infiltration(fo)was obtained as 1.744 to 3.491 for all the six *** analysis showed that the infiltration models using the estimated parameters have satisfactory prediction capability at all the selected ***’s model provided the lowest mean values for RMSE(0.235)and highest mean values for ME(94%);and the lowest mean values for MPD(0.127).This indicated that infiltration can be well-described by the Horton’s model at the selected site.

关键词： infiltration characteristics infiltration models parameters estimation perdition capability

Hepatitis C virus prevalence and genotype distribution inPakistan:Comprehensive review of recent data

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World Journal of Gastroenterology 2016年第4期22卷 1684-1700页

作者： muhammad umer mazhar iqbal Health Biotechnology Division National Institute for Biotechnology and Genetic EngineeringFaisalabad 38000Pakistan

Hepatitis C virus(HCV) is endemic in Pakistan and its burden is expected to increase in coming decades owing mainly to widespread use of unsafe medical procedures. The prevalence of HCV in Pakistan has previously been reviewed. However, the literature search conducted here revealed that at least 86 relevant studies have been produced since the publication of these systematic reviews. A revised updated analysis was therefore needed in order to integrate the fresh data. A systematic review of data published between 2010 and 2015 showed that HCV seroprevalence among the general adult Pakistani population is 6.8%, while active HCV infection was found in approximately 6% of the population. Studies included in this review have also shown extremely high HCV prevalence in rural and underdeveloped peri-urban areas(up to 25%), highlighting the need for an increased focus on this previously neglected socioeconomic stratum of the population. While a 2.45% seroprevalence among blood donors demands immediate measures to curtail the risk of transfusion transmitted HCV, a very high prevalence in patients attending hospitals with various non-liver disease related complaints(up to 30%) suggests a rise in the incidence of nosocomial HCV spread. HCV genotype 3a continues to be the most prevalent subtype infecting people in Pakistan(61.3%). However, recent years have witnessed an increase in the frequency of subtype 2a in certain geographical sub-regions within Pakistan. In Khyber Pakhtunkhwa and Sindh provinces, 2a was the second most prevalent genotype(17.3% and 11.3% respectively). While the changing frequency distribution of various genotypes demands an increased emphasis on research for novel therapeutic regimens, evidence of high nosocomial transmission calls for immediate measures aimed at ensuring safe medical practices.

关键词： Hepatitis C Pakistan Hepatitis C virus Liver cancer Hepatitis C virus genotypes Epidemiology

Composite Fractional Trapezoidal Rule with Romberg Integration

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2729-2745页

作者： iqbal M.Batiha Rania Saadeh iqbal H.Jebril Ahmad Qazza Abeer A.Al-Nana Shaher Momani Department of Mathematics Al Zaytoonah University of JordanAmman11733Jordan Nonlinear Dynamics Research Center(NDRC) Ajman UniversityAjman 346United Arab Emirates Department of Mathematics Faculty of ScienceZarqa UniversityZarqa13110Jordan Department of Mathematics Prince Sattam Bin Abdulaziz UniversityAlkharj11942Saudi Arabia Department of Mathematics The University of JordanAmman11942Jordan

The aim of this research is to demonstrate a novel scheme for approximating the Riemann-Liouville fractional integral *** would be achieved by first establishing a fractional-order version of the 2-point Trapezoidal rule and then by proposing another fractional-order version of the(n+1)-composite Trapezoidal *** particular,the so-called divided-difference formula is typically employed to derive the 2-point Trapezoidal rule,which has accordingly been used to derive a more accurate fractional-order formula called the(n+1)-composite Trapezoidal ***,in order to increase the accuracy of the proposed approximations by reducing the true errors,we incorporate the so-called Romberg integration,which is an extrapolation formula of the Trapezoidal rule for integration,into our proposed *** numerical examples are provided and compared with a modern definition of the Riemann-Liouville fractional integral operator to illustrate the efficacy of our scheme.

关键词： Composite fractional Trapezoidal rule Romberg integration