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Assessment of the consecutive harmful dinoflagellate blooms during 2015 in the Izmit Bay(the Marmara Sea)

Acta Oceanologica Sinica 2018年第8期37卷 91-101页

作者： ERGüL Halim Aytekin AKSAN Serdar ipsiroglu merve Department of Biology Science and Arts FacultyKocaeli UniversityKocaeli 41380Turkey

A series of red tides were observed during 2015 in the Izmit Bay（the Marmara Sea） which is located in the most industrialized and populated region of Turkey. Six samplings were carried out in this area following the red ***-N, nitrate-N, ammonia, silica and orthophosphate concentrations were analyzed *** conditions were measured by CTD probe. Plankton quantification was performed using counting chambers under microscopes. Prorocentrum micans was the most abundant species, except on May 14,2015, when Noctiluca scintillans was dominant. The abundance of P. micans reached average 18×10~6 ind./L on May 3, 2015 in the Karamürsel station, simultaneously with elevated levels of NH_3 and o-PO_4^（3–）. The sample was also abundant in dead amphipods（（72±12） ind./L） that had been covered by mucilage aggregates produced by ***. The highest biomass（calculated by carbon） was recorded as（268±26.0） mg/L on May 14 in the Hereke station. Beside the anthropogenic wastewater discharges, unknown sources and resuspensions caused increases in nutrient levels. After long term northeaster gusts（35 km/h for 5 d） an upwelling occurred on November 6, 2015 after wind-induced sediment resuspension. Although nutrient discharges remarkably decreased over 30 years through established wastewater treatment plants, harmful phytoplankton blooms still occur. Comparing the present results with other studies in nearby Mediterranean seas reveals that the most intense harmful dinoflagellate bloom in recent years occurred in the Izmit Bay. Therefore, additional protection measures necessary for a cleaner Izmit Bay. These incidents also demonstrate that contaminants, accumulated in sediment,may have long-lasting effects on enclosed marine ecosystems.

关键词： red tide harmful algal bloom phytoplankton dinoflagellate Izmit Bay Marmara Sea mucilage

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Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders

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Neural Regeneration Research 2024年第6期19卷 1256-1261页

作者： Helen M.Knight merve Demirbugen ?z Adriana PerezGrovas-Saltijeral Division of Cells Organisms and Molecular Genetics School of Life Sciences University of Notingham Department of Pharmaceutical Toxicology Faculty of Pharmacy Ankara University

The study of modified RNA known as epitranscriptomics has become increasingly relevant in our understanding of disease-modifying mechanisms. Methylation of N6 adenosine(m6A) and C5 cytosine(m5C) bases occur on mRNAs, tRNA, mt-tRNA, and rRNA species as well as non-coding RNAs. With emerging knowledge of RNA binding proteins that act as writer, reader, and eraser effector proteins, comes a new understanding of physiological processes controlled by these systems. Such processes when spatiotemporally disrupted within cellular nanodomains in highly specialized tissues such as the brain, give rise to different forms of disease. In this review, we discuss accumulating evidence that changes in the m6A and m5C methylation systems contribute to neurocognitive disorders. Early studies first identified mutations within FMR1 to cause intellectual disability Fragile X syndromes several years before FMR1 was identified as an m6A RNA reader protein. Subsequently, familial mutations within the m6A writer gene METTL5, m5C writer genes NSUN2, NSUN3, NSUN5, and NSUN6, as well as THOC2 and THOC6 that form a protein complex with the m5C reader protein ALYREF, were recognized to cause intellectual development disorders. Similarly, differences in expression of the m5C writer and reader effector proteins, NSUN6, NSUN7, and ALYREF in brain tissue are indicated in individuals with Alzheimer’s disease, individuals with a high neuropathological load or have suffered traumatic brain injury. Likewise, an abundance of m6A reader and anti-reader proteins are reported to change across brain regions in Lewy bodies diseases, Alzheimer’s disease, and individuals with high cognitive reserve. m6A-modified RNAs are also reported significantly more abundant in dementia with Lewy bodies brain tissue but significantly reduced in Parkinson’s disease tissue, whilst modified RNAs are misplaced within diseased cells, particularly where synapses are located. In parahippocampal brain tissue, m6A modification is en

关键词： 5-methylcytosine methylation Alzheimer's disease cognitive diseases epitranscriptomics intellectual disability Lewy body diseases N6 adenosine RNA modification

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Exogenous testosterone therapy on choroid in androgen deficiency

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1489-1494页

作者： Volkan Yeter Nurullah Koçak merve Kalyoncu Ramazan Aşçi Nurşen Aritürk Department of Ophthalmology Ondokuz Mayıs UniversitySamsun 55139Turkey Department of Urology Ondokuz Mayıs UniversitySamsun 55139Turkey

AIM:To investigate the effects of exogenous testosterone treatment on the choroidal parameters in patients with androgen ***:Right eyes of 24 patients with androgen deficiency and 31 healthy volunteers were included in the *** eyes were scanned for subfoveal choroidal thickness(SFCT),choroidal vascularity index(CVI),choroidstromal area(C-SA),choroid-luminal area(C-LA),choroidstromal to luminal area ratio(CSLR),and the choroidal parameters within central 1500μm of the macula(CVI1500,C-LA1500,C-SA1500,and CSLR1500)by enhanced-depth imaging optical coherence tomography(EDI-OCT)at baseline,6th and 18th weeks of the exogenous testosterone ***:The mean SFCT values of the androgen deficient groups and healthy controls were 307.7±27.0 and 303.2±37.2μm(P=0.8).However,CVI,C-SA,CSLR,CVI1500,C-LA1500,and CSLR1500 were significantly different between the groups(all P0.05).However,CVI1500 and LA1500 significantly increased at the end of the follow-up period(P<0.001).CONCLUSION:CVI is lower in androgen-deficient patients than in healthy *** alterations in the choroid during the testosterone peak are transient in the treatment of patients with androgen ***,the increase in CVI within the central 1500μm of the macula persists even after 4mo.

关键词： testosterone androgen deficiency choroid vascularity index

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Investigation of the Acceptability of Cultured Meat in University Students

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Food and Nutrition Sciences 2024年第2期15卷 151-169页

作者： merve Kumru Hulya Demir Nutrition and Dietetic Department Health Science Faculty Yeditepe University Istanbul Türkiye

Background: Over the past 20 years, cultured meat has drawn a lot of public attention as a potential solution to issues with animal husbandry, including inadequate use of natural sources, improper animal welfare practices, and possible risks to public health and safety. The novel method of producing meat through culture reduces the need for animals to produce muscle fiber, thereby obviating the necessity for animal slaughter. Apart from its ethical advantages, cultured meat presents a possible way to fulfill the expanding need for food among growing populations. The purpose of this research was to find out whether Turkish students would be willing to pay for and accept cultured meat. Technique: Method: 371 university students who willingly consented to fill out a questionnaire and provide demographic data make up the research sample. Questions from previous studies on the acceptability of cultured meat were compiled to create the survey. The research’s data collection took place in March and April of 2022. The research was completed in June 2022 after the data had been processed and analyzed. Results: The results showed that the majority of participants were female and had omnivorous eating habits. Based on the results of the Bonferroni correction test, students with a higher intention to purchase and consume cultured meat were those who received economics and business education. Students with two years of university education had a higher overall survey score than those with four years of education (p < 0.05). Furthermore, it is discovered that there is a negative correlation between the participants’ ages and their Factor 2 (using cultured meat as an alternative to industrial meat) and Factor 3 (consuming and purchasing it) section points (r = -109, p = 0.036) (r = -0.121, p = 0.019). In conclusion, university students generally have a negative outlook on health-related issues, such as eating cultured meat as an alternative.

关键词： Cultured Meat University Students

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Occupant friendly seismic retrofit by concrete plates

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第11期14卷 789-804页

作者： Mehmet BARAN merve AKTAS Department of Civil Engineering Engineering and Natural Sciences Faculty Yildirim Beyazit University06110 Ulus Ankara Turkey Institute of Science Kirikkale UniversityYahsihan 71450 Kirikkale Turkey

An innovative occupant friendly retrofitting technique has been developed for reinforced concrete(RC) building structures with hollow brick infill walls used as partition walls which constitute the major portion of the existing building stock in Turkey. The idea is to convert the existing hollow brick infill wall into a load carrying system acting as a cast-in-place RC wall by reinforcing it with relatively thin concrete plates bonded to the mortar coated infill wall by use of tile adhesive and fixed by 6(6 mm diameter) bolts. Test parameters were the shape and thickness of the plates, presence of reinforcement in plates, number and arrangement of 6 bolts. It was observed that lateral strength, stiffness, energy dissipation capacity, and ductility of the strengthened infill walls were improved and behaviour was enhanced by the proposed technique. Plates with two different basic shapes were used to strengthen the test specimens.

关键词： Reinforced concrete(RC) Strengthening Concrete plate Lateral strength Stiffness Hollow brick infills Reversed-cyclic lateral loads

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Anodization of titanium alloys for orthopedic applications

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 28-45页

作者： merve Izmir Batur Ercan Department of Metallurgical and Materials Engineering Middle East Technical University 06800 Ankara Turkey Biomedical Engineering Program Middle East Technical University 066800 Ankara Turkey

In recent years, nanostructured oxide films on titanium alloy surfaces have gained significant interest due to their electrical, catalytic and biological properties. In literature, there is variety of different approaches to fabricate nanostructured oxide films. Among these methods, anodization technique, which allows fine-tuning of oxide film thickness, feature size, topography and chemistry, is one of the most popular approaches to fabricate nanostructured oxide films on titanium alloys, and it has been widely investigated for orthopedic applications. Briefly, anodization is the growth of a controlled oxide film on a metallic component attached to the anode of an electrochemical cell. This review provides an overview of the anodization technique to grow nanostmctured oxide films on titanium and titanium alloys and summarizes the interactions between anodized titanium alloy surfaces with cells in terms of cellular adhesion, proliferation and differentiation. It will start with summarizing the mechanism of nanofeatured oxide fabrication on titanium alloys and then switch its focus on the latest findings for anodization of titanium alloys, including the use of fluoride free electrolytes and anodization of 3D titanium foams. The review will also highlight areas requiring further research to successfully translate anodized titanium alloys to clinics for orthopedic applications.

关键词： titanium alloys anodization biocompatibility orthopedics

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Effect of arc re-melting on microstructure,mechanical and tribological properties of commercial 390A alloy

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Transactions of Nonferrous Metals Society of China 2021年第8期31卷 2264-2276页

作者： Ali Pasa HEKIMOGLU merve CALIS Department of Mechanical Engineering Recep Tayyip Erdogan University53100RizeTurkey

To investigate the effect of the arc re-melting on the microstructure,mechanical and tribological properties of the 390 A alloy,its ingot produced by the conventional induction melting method was subjected to the arc re-melting *** microstructure of the 390 A alloy was examined by OM and *** properties of the 390 A alloy were determined by the Brinell method and tensile *** properties were investigated with a ball-on-disc type *** was observed that the microstructure of both conventional induction melted and arc re-melted 390 A alloys consisted ofα(Al),eutectic Al-12 Si,primary silicon particles,θ-CuAl_(2),β-Al_(5) FeSi,δ-Al_(4) FeSi_(2),andα-Al_(15)(FeMnCu)3 Si_(2) ***-melting with the arc process caused grain refinement in these *** addition,after this process,theα(Al)phase and primary silicon particles were dispersed more uniformly,and sharp edges of primary silicon particles became *** arc re-melting process resulted in an increase in the hardness of the 390 A alloy produced by the conventional method from 102 HB to 118 HB and the tensile strength from 130 to 240 *** also caused an increase in the wear resistance of the 390 A alloy and a decrease in the friction coefficient.

关键词： 390A alloy microstructure mechanical properties tribological properties arc melting

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Effects of titanium addition on structural, mechanical, tribological, and corrosion properties of Al-25Zn-3Cu and Al-25Zn-3Cu-3Si alloys

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Transactions of Nonferrous Metals Society of China 2020年第2期30卷 303-317页

作者： Ali Pa?a HEK?MO?LU merve ?ALI? Mechanical Engineering Department Engineering Faculty Recep Tayyip Erdo?an University

To investigate the effect of grain refinement on the material properties of recently developed Al-25 Zn-3 Cu based alloys,Al-25 Zn-3 Cu,Al-25 Zn-3 Cu-0.01 Ti,Al-25 Zn-3 Cu-3 Si and Al-25 Zn-3 Cu-3 Si-0.01 Ti alloys were produced by permanent mold casting *** of the alloys were examined by *** and mechanical properties of the alloys were determined by Brinell method and tensile tests,*** characteristics of the alloys were investigated by a ball-on-disc type test *** properties of the alloys were examined by an electrochemical corrosion experimental *** was observed that microstructure of the ternary A1-25 Zn-3 Cu alloy consisted ofα,α+ηandθ(Al2Cu)*** was also observed that the addition of 3 wt.%Si to A1-25Zn-3Cu alloy resulted in the formation of silicon particles in its *** addition of 0.01 wt.%Ti to the Al-25Zn-3Cu and Al-25 Zn-3 Cu-3 Si alloys caused a decrement in grain size by approximately 20%and 39%and an increment in hardness from HRB 130 to 137 and from HRB 141 to 156,*** strengths of these alloys increased from 278 to 297 MPa and from 320 to 336 MPa while their tensile strengths increased from 317 to 340 MPa and from 334 to 352 *** resistance of the alloys increased,but corrosion resistance decreased with titanium addition.

关键词： Al-Zn-Cu alloy as-cast microstructure characterization corrosion fracture friction and wear characteristics mechanical properties

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Effect of Annealing on Microstructure and Microhardness of Co-Fe-Ni-Ta-B-Si Bulk Metallic Glass

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Journal of Materials Science & Technology 2015年第2期31卷 148-152页

作者： Aytekin Hitit merve Gecgin Pelin Oztürk Department of Materials Science and Engineering Afyon Kocatepe UniversityAfyonkarahisar 03200Turkey Department of Materials Science and Engineering Anadolu UniversityEskisehir 26555Turkey

Effects of annealing temperature and time on microstructure and microhardness of Co41Ni2Fe20Ta5.5B26.5Si5 amorphous alloy have been investigated. Microhardness of the as-cast alloy is found to be 1170 HV. The maximum microhardness,1798 HV,is achieved after annealing the amorphous alloy at 1250 K for 10 *** of the microstructure reveals that(Co,Fe)2B,(Co,Fe)21Ta2B6 and(Co,Fe)16Ta6Si7 phases precipitate in the matrix after annealing. Intrinsic hardness and Hall-Petch coefficients of the precipitates indicate that high hardness values result from precipitation of(Co,Fe)2B and(Co,Fe)21Ta2B6 phases. It is also observed that increasing the annealing time results in the decrease in microhardness values because of the increase in particle sizes of the precipitates.

关键词： Metallic glass Annealing Microhardness

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Cylinder Pressure Prediction of An HCCI Engine Using Deep Learning

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Chinese Journal of Mechanical Engineering 2021年第2期34卷 160-167页

作者： Halit Yaşar GültekinÇağıl Orhan Torkul merveŞişci Department of Mechanical Engineering Engineering FacultySakarya UniversityEsentepe Campus54187 SerdivanSakaryaTurkey Department of Industrial Engineering Engineering FacultySakarya UniversityEsentepe Campus54187 SerdivanSakaryaTurkey

Engine tests are both costly and time consuming in developing a new internal combustion ***,it is of great importance to predict engine characteristics with high accuracy using artificial ***,it is possible to reduce engine testing costs and speed up the engine development *** Learning is an effective artificial intelligence method that shows high performance in many research areas through its ability to learn high-level hidden features in data *** present paper describes a method to predict the cylinder pressure of a Homogeneous Charge Compression Ignition(HCCI)engine for various excess air coefficients by using Deep Neural Network,which is one of the Deep Learning methods and is based on the Artificial Neural Network(ANN).The Deep Learning results were compared with the ANN and experimental *** results show that the difference between experimental and the Deep Neural Network(DNN)results were less than 1%.The best results were obtained by Deep Learning *** cylinder pressure was predicted with a maximum accuracy of 97.83%of the experimental value by using *** the other hand,the accuracy value was increased up to 99.84%using *** results show that the DNN method can be used effectively to predict cylinder pressures of internal combustion engines.

关键词： Artificial neural network Deep neural network HCCI engine Cylinder pressure Excess air coefficient

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