检索结果-南通市图书馆

Neuroprotection by resveratrol-g.ucuronide and quercetin-g.ucuronide via binding.to polyphenol-and g.ycosaminog.ycan-binding.sites in the laminin receptor

在线全文

学校读者我要写书评

暂无评论

Neural Reg.neration Research 2025年第3期20卷 819-820页

作者： Rayudu g.palakrishna jennifer Ag.ilar Emily Lee William J.Mack Department of Integ.ative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurolog.cal Surg.ry Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodeg.nerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the g.ucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Identification of SNP-containing.reg.latory motifs in the myelodysplastic syndromes model using.SNP arrays and g.ne expression arrays

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2013年第4期32卷 170-185页

作者： Jing.Fan jennifer g. dy Chung.Che Chang.Xiaobo Zhou Department of Electrical and Computer Eng.neering Northeastern University Department of Patholog. Florida Hospital University of Central Florida Department of Radiolog. The Methodist Hospital Research Institute Weill Medical College & Cornell University

Myelodysplastic syndromes have increased in frequency and incidence in the American population, but patient prog.osis has not sig.ificantly improved over the last decade. Such improvements could be realized if biomarkers for accurate diag.osis and prog.ostic stratification were successfully identified. In this study, we propose a method that associates two state-of-the-art array technolog.es-sing.e nucleotide polymorphism (SNP) array and g.ne expression array-with g.ne motifs considered transcription factor -binding.sites (TFBS). We are particularly interested in SNP-containing.motifs introduced by g.netic variation and mutation as TFBS. The potential reg.lation of SNP-containing.motifs affects only when certain mutations occur. These motifs can be identified from a g.oup of co-expressed g.nes with copy number variation. Then, we used a sliding.window to identify motif candidates near SNPs on g.ne sequences. The candidates were filtered by coarse thresholding.and fine statistical testing. Using.the reg.ession-based LARS-EN alg.rithm and a level-wise sequence combination procedure, we identified 28 SNP-containing.motifs as candidate TFBS. We confirmed 21 of the 28 motifs with ChIP-chip frag.ents in the TRANSFAC database. Another six motifs were validated by TRANSFAC via searching.binding.frag.ents on coreg.lated g.nes. The identified motifs and their location g.nes can be considered potential biomarkers for myelodysplastic syndromes. Thus, our proposed method, a novel strateg. for associating.two data categ.ries, is capable of integ.ating.information from different sources to identify reliable candidate reg.latory SNP-containing.motifs introduced by g.netic variation and mutation.

关键词： Association study, g.netic variation and mutation, transcription factor-binding sites, myelodysplastic syndromes

A functional tacrolimus-releasing.nerve wrap for enhancing.nerve reg.neration following.surg.cal nerve repair

在线全文

学校读者我要写书评

暂无评论

Neural Reg.neration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.W.So Konstantin Feinberg.Marina Manoraj Jenny Cheung.jennifer Zhang.Kaveh Mirmoeini JPaul Santerre Tessa g.rdon g.eg.ry HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Eng.neering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surg.ry the Hospital for Sick ChildrenTorontoONCanada Translational Biolog. and Eng.neering.Prog.am Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal reg.neration following.surg.cal nerve repair is slow and often incomplete,resulting.in poor functional recovery which sometimes contributes to lifelong.***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal reg.neration,but systemic side effects presently outweig. its potential benefits for peripheral nerve *** authors describe herein a biodeg.adable polyurethane-based drug.delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming.to promote nerve reg.neration and functional recovery with minimal systemic drug.*** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to g.nerate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug.loading.are adjustable for applications in small and larg. caliber nerves,and the wrap deg.ades within 120 days into biocompatible *** released from the nerve wrap promotes axon elong.tion in vitro and accelerates nerve reg.neration and functional recovery in preclinical nerve repair models while off-targ.t systemic drug.exposure is reduced by 80%compared with systemic *** its surg.cal suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal reg.neration and recovery in patients underg.ing.nerve surg.ry.

关键词： biodeg.adable local drug.delivery nerve injury nerve reg.neration nerve wrap tacrolimus

Stepping.up after spinal cord injury:neg.tiating.an obstacle during.walking

在线全文

学校读者我要写书评

暂无评论

Neural Reg.neration Research 2025年第7期20卷 1919-1929页

作者： Alain Frig.n Charly g.Lecomte Department of Pharmacolog.-Physiolog. Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking.consists of frequent voluntary modifications in the g.it pattern to neg.tiate *** spinal cord injury,stepping.over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including.the parietal cortex,premotor cortex,and motor *** information and planning.are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including.humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping.over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiolog. obstacle neg.tiation spinal cord injury

An SPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of g.otechnical Structures

在线全文

学校读者我要写书评

暂无评论

Computer Modeling.in Eng.neering.& Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil Eng.neering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses sig.ificant risks to the stability of g.otechnical structures *** understanding.of the liquefaction trig.ering.and the post-failure larg. deformation behaviour is essential for desig.ing.resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of g.otechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading.is described using.the PM4Sand model implemented in a three-phase,sing.e-layer SPH framework.A stag.ered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energ. modes and tensile ***,non-reflecting.boundary conditions for seismic analysis of semi-infinite soil domains using.the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level g.ound site,and liquefaction-induced failure of the Lower San Fernando *** ag.eement for liquefaction trig.ering.and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading.on field-scale g.otechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake g.otechnical eng.neering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

Bioelectronic medicine in modulation of cortical spreading.depolarization and beyond

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Reg.neration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurg.ry Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trig.minal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading.depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurolog.cal *** pharmacolog.cal interventions have demonstrated initial potential in addressing.CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerg.ng.bioelectronic methodolog.es for addressing.CSDs,particularly emphasizing.TNS,and to underscore TNS’s capacity to enhance neurovascular coupling.and cerebral perfusion.

关键词： cerebral perfusion electronic

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Reg.neration Research 2025年第6期20卷 1644-1664页

作者： g.briela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang.J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surg.ry Morehouse School of MedicineAtlantaGAUSA Department of Neurobiolog. Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurolog.cal Surg.ry and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurg.ry Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurolog.cal disorders that share common pathophysiolog.cal mechanisms involving.neuroinflammation. One sequela of neuroinflammation includes the patholog.c hyperphosphorylation of tau protein, an endog.nous microtubule-associated protein that protects the integ.ity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding.and subsequent accumulation of tau tang.es forming.neurotoxic ag.reg.tes. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including.assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of sig.aling.molecules resulting.in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key reg.lator of tau phosphorylation where it has been shown that prolong.d NOD-like receptor protein 3 activation acts as a causal factor in patholog.cal tau accumulation and spreading. This review beg.ns by describing.the epidemiolog. and pathophysiolog. of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we hig.lig.t neuroinflammation as an overriding.theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throug.out the brain. We then propose a novel framework linking.traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent patholog.es that exist along.a temporal continuum. Finally, we discuss potential therapeutic targ.ts that may intercept this pathway and ultimately minimize long.term neurolog.cal decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodeg.neration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Impact of Zika virus non-structural protein mutations on hippocampal damag.

在线全文

学校读者我要写书评

暂无评论

Neural Reg.neration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurog.nômica/Imunopatolog.a Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunolog.a Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurolog.cal effects,notably microcephaly in newborns,first reported during.the 2015 epidemic in ***,its impact g.es beyond fetal and neonatal abnormalities,also affecting.the central nervous system(CNS)in both children and adults,leading.to enduring.cog.itive and behavioral impairments.

关键词： damag. fetal neonatal

Iterative Learning.Control With Incomplete Information： A Survey

在线全文

学校读者我要写书评

暂无评论

ieee/CAA Journal of Automatica Sinica 2018年第5期5卷 885-901页

作者： Dong.Shen Senior Member ieee ieee beijing.university of chemical technolog.

Abstract--This paper conducts a survey on iterative learn- ing.control （ILC） with incomplete information and associated control system desig., which is a frontier of the ILC field. The incomplete information, including.passive and active types, can cause data loss or frag.ent due to various factors. Passive incomplete information refers to incomplete data and information caused by practical system limitations during.data collection, storag., transmission, and processing. such as data dropouts, delays, disordering. and limited transmission bandwidth. Active incomplete information refers to incomplete data and information caused by man-made reduction of data quantity and quality on the premise that the g.ven objective is satisfied, such as sampling.and quantization. This survey emphasizes two aspects： the first one is how to g.arantee g.od learning.performance and tracking.performance with passive incomplete data, and the second is how to balance the control performance index and data demand by active means. The promising.research directions along.this topic are also addressed, where data robustness is hig.ly emphasized. This survey is expected to improve understanding.of the restrictive relationship and trade-off between incomplete data and tracking.performance, quantitatively, and promote further developments of ILC theory. Index Terms--Data dropout, data robustness, incomplete in- formation, iterative learning.controi（ILC）, quantized control, sampled control, varying.leng.hs.

关键词： Data dropout data robustness incomplete information iterative learning.control(ILC) quantized control sampled control varying.leng.hs