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Science China Chemistry 2012年第5期55卷 850-853页

作者： TAGAYA Akihiro LOU LiPing ide yoko KOIKE Yasuhiro OKAMOTO Yoshiyuki Keio Photonics Research Institute Keio University E-building Shin-Kawasaki Town Campus 7-1 Shin-Kawasaki Saiwai-ku Kawasaki 212-0032 Japan Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama 223-8522 Japan Polymer Research Institute Polytechnic Institute of NYU 6 MetroTech Center Brooklyn New York 11201 USA

Copolymers of N-pentafluorophenyl maleimide (PFPMI) with methyl methacrylate (MMA) were synthesized by a free radical initiator, such as AIBN. The refractive indexes of the copolymers remained nearly constant (1.4970 at 532 nm) regardless of the polymer composition. These copolymers also showed high thermal stability. The orientational and photoelastic birefringence of the copolymers obtained were measured. Since both of the orientational and photoelastic birefringences of PMMA are negative whereas poly(PFPMI) exhibits positive, thus we have obtained nearly zero orientational and photoelastic birefringence polymers when the ratios of MMA/PFPMI were 91.8/8.2 and 97.0/3.0 mol%, respectively. Based on the experimental data, the ratios of MMA/PFPMI for zero birefringence were determined to be 88.9/11.1 and 93.8/6.2 mol% for orientational and photoelastic birefringence, respectively. The Tgs of corresponding copolymers were estimated to be 128 and 122 ℃.

关键词： N-pentafluorophenyl maleimide copolymers orientational birefringence photoelastic birefringence

Genetic relationships among sympatric varieties of Acer mono in the Chichibu Mountains and Central Hokkaido, Japan

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Journal of Forestry Research 2017年第4期28卷 699-704页

作者： Chunping Liu Jian Cong Hailong Shen Cunxue Lin yoko Saito Yuji ide State Key Laboratory of Forest Genetics and Breeding Northeast Forestry UniversityHarbin 150040China Foreign Capital Project Office Forestry Department of Liaoning ProvinceShenyang 110036China Mudanjiang Branch of Heilongjiang Academy of Agricultural Sciences Mudianjiang 157041China Laboratory of Forest Ecosystem Studies Department of Ecosystem StudiesGraduate School of Agriculture and Life ScienceThe University of TokyoYayoi 1-1-1Bunkyo-kuTokyo 113-8657Japan

Acer mono Maxim. is one of the major components of cool temperate forests in Japan. Some of its many varieties are distributed sympatrically. Because of its great variability, the intraspecific taxonomy and nomenclature of the species are controversial. To understand the genetic relationships among these varieties and whether hybridization or introgression occurred among the sympatric varieties, we studied the genetic relationships among sympatric varieties of A. mono in the Chichibu Mountains (A. mono var. ambiguum, A. mono var. connivens, A. mono var. marmoratum) and Central Hokkaido (A. mono var. mayrii and A. mono var. glabrum) in Japan. Our results showed that varieties in Chichibu are genetically close, suggesting that hybridization or introgression might occur between these varieties, which could explain the higher genetic diversity of varieties in Chichibu than in Hokkaido. In contrast to the close relationships between the varieties in Chichibu, varieties in Hokkaido seemed relatively separated from each other; indeed, there may be reproductive isolation between the two varieties. The results provide new insight for the taxonomy of the varieties of A. mono, especially the sympatric varieties, in Japan.

关键词： Genetic differentiation Hybridization Introgression Maple nSSR

Long Pulse Operation of High Performance Plasmas in JT-60U

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Plasma Science and Technology 2006年第1期8卷 1-4页

作者： S.ide the 3T-60 Team Naka Fusion Research Establishment Japan Atomic Energy Agency NakaIbaraki311-0193Japan

Recent experimental progress in JT-60U advanced tokamak research is presented： sustainment of the normalized beta （βN）- 3 in a normal magnetic shear plasma, the bootstrap current fraction （fBs） - 45% in a weak shear plasma and - 75% in a reversed magnetic shear plasma in a nearly fully non-inductive current drive condition for longer than the current relaxation time. Achievement of high-density, high-radiation fraction together with high-confinement in advanced plasmas is demonstrated. Achievements and findings in long pulse operations after system modification are presented as well. A 65 s discharge of Ip = 0.7 MA was successfully obtained. As a result, high-βN of 2.3 was successfully sustained for a very long period of 22.3 s. In addition, a 30 s standard ELMy H-mode plasma of Ip up to 1.4 MA was also obtained. Effectiveness of divertor pumping to control particle recycling and the electron density under the saturated wall retention was demonstrated. These achievements and issues in development are discussed.

关键词： transport properties magnetohydrodynamics tokamaks

Bred Vectors of the Lorenz63 System

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Advances in Atmospheric Sciences 2015年第11期32卷 1533-1538页

作者： Ying ZHANG Kayo ide Eugenia KALNAY Department of Atmospheric and Oceanic Science University of MarylandCollege Park

The breeding method has been widely used in studies of data assimilation, predictability and instabilities. The bred vectors （BVs）, which are the nonlinear difference between the control and perturbed runs, represent the time-evolving rapidly growing errors in dynamic systems. The Lorenz （1963） model （hereafter Lorenz63 model） has chaotic dynamics similar to weather and climate. This study investigates the features of BVs of the Lorenz63 model and its impact on regime prediction of the Lorenz63 model. The results show that the Lorenz63 model has two different BVs for each breeding cycle, and the two BVs approach being identical when growth rate is high. The duration of the current and next regime is associated with the relative directions between the BV with high growth rate and the model trajectory.

关键词： bred vectors chaos Lorenz63 model regime prediction

MASTER PLAN TO ROBUST PRACTICE: THE EVOLUTION OF SUSTAINABLE LANDSCAPE PRACTICES AT GEORGIA INSTITUTE OF TECHNOLOGY

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Journal of Green Building 2018年第3期13卷 181-192页

作者： Hyacinth ide Jessica Rose Landscape Services&Fleet Services Georgia Institute of Technology Analytics and Communications Facilities ManagementGeorgia Institute of Technology

Universities across the globe are recognizing the need to implement sustainable landscaping practices in order to support wildlife, improve water quality and positively impact human health and wellbeing. Georgia Institute of Technology learned that such sustainable practices, when properly aligned with overarching campus goals, can also enable continuous, collaborative decision-making and student engagement. The Georgia Institute of Technology (Georgia Tech) is a leading research university situated on 426 acres of land in midtown Atlanta, Georgia, with a student population of 27,000 (Fall 2017). An urban oasis in the center of town, Georgia Tech’s campus offers 312.5 landscaped acres, 3.5 naturalized acres and 110 acres of buildings. The campus is also a level II certified arboretum boasting 12,000+ trees in its urban forest. Prior to the 1990s, Georgia Tech was commonly referred to as a concrete and brick campus with very little landscape. However, in 1999 all that changed when the Georgia Tech administration decided to invest in sustainable landscaping, including the recruitment of qualified staff with specific skill sets to take on this challenge. The Institute’s initial landscape master plan objectives were to reduce impervious surfaces such as surface parking lots, increase woodland coverage and enlarge the tree canopy. A significant amount of sustainable landscape practices and collaborative methods grew from these initial objectives. Establishing a plan with clear goals, having the support of executive leadership and employing the right team members enabled the Georgia Tech campus to be transformed from a concrete jungle to a forested, urban oasis in less than 20 years.

关键词： sustainable landscape practices Campus Landscape Master Plan service learning projects living laboratory Tree Campus USA

Enzyme-digested Colla Corii Asini(E’jiao) prevents hydrogen peroxide-induced cell death and accelerates amyloid beta clearance in neuronal-like PC12 cells

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Neural Regeneration Research 2020年第12期15卷 2270-2277页

作者： Li Xiao Feng Liao Ryoji ide Tetsuro Horie Yumei Fan Chikako Saiki Nobuhiko Miwa Department of Pharmacology The Nippon Dental UniversitySchool of Life Dentistry at TokyoTokyoJapan National Engineering Research Center for Gelatin-based Traditional Chinese Medicine Dong-E-E-Jiao Co.Ltd.LiaochengShandong ProvinceChina Department of Physiology The Nippon Dental UniversitySchool of Life Dentistry at TokyoTokyoJapan Research Center The Nippon Dental UniversitySchool of Life Dentistry at TokyoTokyoJapan Department of Life Sciences Prefectural University of HiroshimaHiroshimaJapan

As an aging-associated degenerative disease,Alzheimer’s disease is characterized by the deposition of amyloid beta(Aβ),oxidative stress,inflammation,dysfunction and loss of cholinergic *** Corii Asini(CCA)is a traditional Chinese medicine which has been used for feebleness-related diseases and *** might delay aging-induced degenerative changes in *** the present study,we evaluated antioxidant activity,cytoprotective effects,and Aβremovability of enzyme-digested Colla Corii Asini(CCAD).Oxygen radical absorbance capacity(ORAC)activity assay showed that,as compared to gelatins from the skin of porcine,bovine and cold water fish,CCA exhibited the highest ORAC *** ORAC activity of CCA and CCAD was increased gradually by the length of time in *** analysis by scanning electron microscopy showed that among CCA manufactured in 2008,2013,2017 and gelatin from cold water fish skin,CCA manufactured in 2008 presented the smoothest surface *** further tested the protective effects of CCAD(manufactured in 2008)and enzyme-digested gelatin from cold water fish skin(FGD)on hydrogen peroxide(H2O2)-induced cell death in nerve growth factor-differentiated neuronal-like PC12 *** blue assay showed that both FGD and CCAD at 0.5 mg/m L increased cell viability in H2O2-treated neuronal-like PC12 *** protection of CCAD was significantly superior to that of ***(Ach E)assay showed that both FGD and CCAD inhibited Ach E activity in nerve growth factor-differentiated neuronal-like PC12 cells to 89.1%and 74.5%of that in non-treated cells,*** data suggest that CCAD might be able to increase the neurotransmitter *** CCAD inhibited Ach E activity in neuronal-like PC12 cells,CCAD prevented H2O2-induced abnormal deterioration of Ach *** and neprilysin activity assay results indicated that CCAD reduced amyloid beta accumulation and increased neprilysin activity in Aβ1–

关键词： acetylcholinesterase activity Alzheimer’s disease amyloid beta clearance antioxidant Colla Corii Asini collagen neuroprotection PC12 cells

Points regarding cell transplantation for the treatment of spinal cord injury

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Neural Regeneration Research 2016年第7期11卷 1046-1049页

作者： Chizuka ide Kenji Kanekiyo Institute of Regeneration and Rehabilitation Aino University School of Health Science

Transplantation of somatic cells,including bone marrow stromal cells（BMSCs）,bone marrow mononuclear cells（BMNCs）,and choroid plexus epithelial cells（CPECs）,enhances the outgrowth of regenerating axons and promotes locomotor *** are not integrated into the host spinal cord,but disappear within 2-3 weeks after *** axons extend at the spinal cord lesion through the astrocyte-devoid area that is filled with connective tissue *** axons have characteristics of peripheral nerves：they are associated with Schwann cells,and embedded in connective tissue *** has been suggested that neurotrophic factors secreted from BMSCs and CPECs promote “intrinsic” ability of the spinal cord to *** Schwann cells survive long-term,and are integrated into the host spinal cord,serving as an effective scaffold for the outgrowth of regenerating axons in the spinal *** disadvantage that axons are blocked to extend through the glial scar at the border of the lesion is *** cells have been approved for clinical *** stem/progenitor cells（NSPCs） survive long-term,proliferate,and differentiate into glial cells and/or neurons after *** method is available at present to manipulate and control the behaviors of NPSCs to allow them to appropriately integrate into the host spinal *** transplantation is not necessarily effective for locomotor improvement.

关键词： Schwann progenitor glial astrocyte neurotrophic differentiate scaffold connective survive proliferate

Double Filtration Plasmapheresis and (PEG) Interferon/Ribavirin Combination Therapy in Patients with Chronic Hepatitis C (Abstract)

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Double Filtration Plasmapheresis and (PEG) Interferon/Ribavi...

Impact of smoking habit on surgical outcomes in non-B non-C patients with curative resection for hepatocellular carcinoma

第三届全国重型肝病及人工肝血液净化学术年会

作者： Tatsuya ide 日本久留米大学医学院

[Backgroud/Aim] Since the double filtration plasmapberesis (DFPP) can reduce the hepatitis C virus (HCV) load in sera,we are conducting the DFPP and (PEG) interferon/ribavirin(IFN/Rib) combination therapy in chronic hepatitis patients infected with genotype 1b and high viral load.[Patients/Method] DFPP were performed 3-5 sessions from the initiation of (PEG)IFN/Rib within one ***-1) From January 2003 to November 2004,IFN α-2b/Rib was administered 48 and 24 weeks *** cases were enrolled.

关键词： Double filtration plasmapheresis Hepatitis C virus Interferon and ribavirin Combination therapy.

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World Journal of Gastroenterology 2017年第8期23卷 1397-1405页

作者： Keita Kai Hiroki Koga Shinichi Aishima Atsushi Kawaguchi Koutaro Yamaji Takao ide Junji Ueda Hirokazu Noshiro Department of Pathology Saga University Hospital Departments of Surgery Saga University Hospital Pathology and Microbiology Saga University Hospital Center for Comprehensive Community Medicine Saga University Faculty of Medicine

To analyzed the correlation between smoking status and surgical outcomes in patients with non-B non-C hepatocellular carcinoma (NBNC-HCC), and we investigated the patients’ clinicopathological characteristics according to smoking *** retrospectively analyzed the consecutive cases of 83 NBNC-HCC patients who underwent curative surgical treatment for the primary lesion at Saga University Hospital between 1984 and December 2012. We collected information about possibly carcinogenic factors such as alcohol abuse, diabetes mellitus, obesity and smoking habit from medical records. Smoking habits were subcategorized as never, ex- and current smoker at the time of surgery. The diagnosis of non-alcoholic steatohepatitis (NASH) was based on both clinical information and pathological *** abuse, diabetes mellitus, obesity and NASH had no significant effect on the surgical outcomes. Current smoking status was strongly correlated with both overall survival (P = 0.0058) and disease-specific survival (P = 0.0105) by multivariate analyses. Subset analyses revealed that the current smokers were significantly younger at the time of surgery (P = 0.0002) and more likely to abuse alcohol (P = 0.0188) and to have multiple tumors (P = 0.023).CONCLUSIONCurrent smoking habit at the time of surgical treatment is a risk factor for poor long-term survival in NBNC-HCC patients. Current smokers tend to have multiple HCCs at a younger age than other patients.

关键词： Hepatocellular carcinoma Non-B Non-C Smoking Surgery Prognosis

Stem cell therapy for central nerve system injuries: glial cells hold the key

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Neural Regeneration Research 2014年第13期9卷 1253-1260页

作者： Li Xiao Chikako Saiki Ryoji ide Pharmacology Department The Nippon Dental University School of Life Dentistry at Tokyo Tokyo Japan Physiology Department The Nippon Dental University School of Life Dentistry at Tokyo Tokyo Japan

Mammalian adult central nerve system （CNS） injuries are devastating because of the intrinsic difficulties for effective neuronal regeneration. The greatest problem to be overcome for CNS recovery is the poor regeneration of neurons and myelin-forming cells, oligodendrocytes. Endogenous neural progenitors and transplanted exogenous neuronal stem cells can be the source for neuronal regeneration. However, because of the harsh local microenvironment, they usually have very low efficacy for functional neural regeneration which cannot compensate for the loss of neurons and oligodendrocytes. Glial cells （including astrocytes, microglia, oligodendrocytes and NG2 glia） are the majority of cells in CNS that provide support and protection for neurons. Inside the local microenvironment, glial cells largely influence local and transplanted neural stem cells survival and fates. This review critically analyzes current finding of the roles of glial cells in CNS regeneration, and highlights strategies for regulating glial cells＇ behavior to create a permissive microenvironment for neuronal stem cells.

关键词： Neuron regeneration stem cell therapy glial cells microenvironment oligodendrocyteregeneration CNS injury