检索结果-南通市图书馆

Phosphorylation and biosynthesis of high molecular weight proteins of tumor nuclear matrix

Cell Research 1998年第3期8卷 195-207页

作者： BAZARNOVA TM TV BULDYAEVA LS FILATOVA SB AKOPOV ib zbarsky(NK Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 26 Vavilov Street, 117344 Moscow,Russia) NK Koltzov Institute of Developmental Biology Russian Academy of Sciences Moscow Russia

Our previous studies showed a predominance of high molecular weight protein group in tumor nuclear matrices. contrary to normal cells, Proteins of this group are Preferentially phosphorylated. Phosphoproteins of hepatoma nuclear matrix are selectively subjected to rapid proteolysis. By alkali treatment and a monoclonal antibody against phosphotyrosyl residue the presence of two high molecular weight bands of phosphotyrosyl-containing proteins was defected in nuclear matrices of tumor but not of normal liver cells. High molecular weight protein group of tumor nuclear matrices revealed also a rapid turnover and preferential incorporation of labeled amino acids selectively inhibited by chioramphenicol.

关键词： Tumors nuclear matrix phosphoproteins phosphotyrosine nuclear protein biosynthesis

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

On the history of nuclear matrix manifestation

引用

Cell Research 1998年第2期8卷 99-103页

作者： zbarsky ib(NK. Koltzov Institute of Developmental Biology, Russian Academy of Sciences. 26, Vavilov Street, 117334 Moscow,Russia. e-mail: ibzba ibrran.msk-su) N.K. Koltzov Institute of Developmental Biology Russian Academy of Sciences Moscow Russia

The nonchromatin proteinous residue of the cell nucleus was revealed in our laboratory as early aJs in 1948and then identified by light and electron microscoPy as residual nucleoli. intranuclear network and nuclear envelope before 1960. This structure termed afterwards as 'nuclear residue', 'nuclear skeleton', 'nuclear cage' 3 'nuclearcarcass' etc., was much later (in 1974) isolated, studied,and entitled as 'nuclear matrix' by Berezney and Coffey,to whom the discovery of this residual structure is of ten wronly ascribed. The real history of nuclear matrix manifestation is reported in this paper.

关键词： Nuclear matrix nuclear residue nuclear fractions history of nuc1ear fractionation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：