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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza i.Torrado-Tapias iris K.Salgado Jose M.Santiago Samuel e.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA institute of Neurobiology San JuanPRUSA

in addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain eAAT-1/GLAst eAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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Dissipation of S-metolachlor and butachlor in agricultural soils and responses of bacterial communities:insights from compound-specific isotope and biomolecular analyses

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Journal of environmental Sciences 2020年第6期32卷 163-175页

作者： ehssan Torabi Charline Wiegert Benoit Guyot stéphane Vuilleumier Gwenael imfeld Department of Plant Protection Faculty of Agricultural Science and EngineeringCollege of Agriculture and Natural ResourcesUniversity of TehranDaneshkadeh St.P.O.Box#***-4111KarajIran Laboratory of Hydrology and Geochemistry of strasbourg(LHyGeS) Universitéde StrasbourgUMR 7517 CNRS/EOST1 Rue Blessig67084Strasbourg CedexFrance Génétique Moléculaire GénomiqueMicrobiologie(GMGM)Universitéde StrasbourgUMR 7156 CNRS4 Allee Konrad Roentgen67000StrasbourgFrance

The soil dissipation of the widely used herbicides S-metolachlor(SM)and butachlor(BUT)was evaluated in laboratory microcosms at two environmentally relevant doses(15 and 150μg/g)and for two agricultural soils(crop and paddy).Over 80%of SM and BUT were dissipated within 60 and 30 days,respectively,except in experiments with crop soil at 150μg/*** on compound-specific isotope analysis(CSiA)and observed dissipation,biodegradation was the main process responsible for the observed decrease of SM and BUT in the paddy *** SM,biodegradation dominated over other dissipation processes,with changes of carbon isotope ratios(Δδ13C)of up to 6.5‰after 60 days,and concomitant production of ethane sulfonic acid(eSA)and oxanilic acid(OXA)transformation *** crop soil experiments,biodegradation of SM occurred to a lesser extent than in paddy soil,and sorption was the main driver of apparent BUT *** of the 16 S rRNA gene showed that soil type and duration of herbicide exposure were the main determinants of bacterial community *** contrast,herbicide identity and spiking dose had no significant *** paddy soil experiments,a high(4:1,V/V)eSA to OXA ratio for SM was observed,and phylotypes assigned to anaerobic Clostridiales and sulfur reducers such as Desulfuromonadales and Syntrophobacterales were dominant for both *** soil microcosms,in contrast,were associated with a reverse,low(1:3,V/V)ratio of eSA to OXA for SM,and Alphaproteobacteria,Actinobacteria,and Bacillales dominated regardless of the *** results emphasize the variability in the extent and modes of SM and BUT dissipation in agricultural soils,and in associated changes in bacterial communities.

关键词： Chloroacetanilide herbicides Carbon isotope fractionation Pesticide degradation Bacterial diversity

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BOUNDARY LAYeR GROWTH AND LAPSe RATe CHANGeS DeTeRMiNeD BY LiDAR AND SURFACe HeAT FLUX iN SOFiA

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Acta meteorologica Sinica 1995年第1期9卷 101-111页

作者： e.Donev K.Zeller st.Panchev i.Kolev Department of Meteorology Faculty of PhysicsSofia UniversityBulgaria USDA Forest Service Rocky Mountain Forest and Range Experiment StationFort CollinsColoradoUSA institute of electronics Bulgarian Academy of SciencesBulgaria

in this study the results from a boundary layer experiment,conducted in autumn 1991 over a flat,build-up urban area in Southeast Sofia,together with some models for mixed layer growth rates are used to investigate the layered struc- ture of the vertical atmospheric stability distribution in the Sofia *** measurements of aerosol layer heights and morning boundary layer development are combined with surface eddy correlation measurements of kinematic heat and moisture fluxes,profiles of temperature and humidity,wind speed and wind direction.A diagnostic method is pres- ented for determining vertical lapse rates using surface meteorological measurements and lidar returns observed during the transition from nightti.e.stable stratification to daytime convective boundary layer after the sunrise.

关键词： convective boundary layer lidar heat flux lapse rate

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Asymmetric reinforcement in Lucania killifish:assessing reproductive isolation when both sexes choose

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Current Zoology 2021年第2期67卷 215-224页

作者： Michelle e.st.JOHN Rebecca C.FULLeR School of integrative Biology University of liois Urbana-ChampaignChampaignIL 61820USA

Reinforcement can occur when maladaptive hybridization in sympatry favors the evolution of con-specific preferences and target traits that promote behav ioral isolation(Bi).in many systems,enhanced Bi is due to increased female preference for *** others,Bi is driven by male preference,and in other systems both sexes exert *** of these patterns can be atributed to classic sex-specific costs and benefits of ***,sex differences in conspecific preference can emerge due to asymmetric postzygotic isolation(e.g.,hybrid offspring from female A × male B have lower fitness than hybrid offspring from female B × male A),which can lead to asymmetric Bi(e.g.,female A and male B are less likely to mate than female B and male A).Understanding reinforcement requires understanding how conspecific preferences evolve in ***,estimating conspecific preferences can be difficult when both sexes are *** this study,we use Lucania killifish to test the hypothesis that patterns of reinforcement are driven by asymmetric postzygotic isolation between *** true,we predicted that sympatric female Lucania goodei and sympatric male *** should have lower levels of Bi compared with their sympatric counterparts,as they produce hybrid offspring with the highest *** address the problem of measuring Bi when both sexes are choosy,we inferred the contribution to Bi of each partner using assays where one sex in the mating pair comes from an allopatric population with potentially low preference,whereas the other comes from a sympatric population with high *** one hybrid cross direction,we found that both female *** and male *** have high contributions to Bi in *** the other hybrid cross direction,we found that only female *** contribute to *** male *** readily engaged in hybrid spawnings with allo-patric *** *** results indicate that both asymmetric postzygotic isolation

关键词： reinforcement behavioral isolatin female mate choice male mate choice asymmetric costs to hybridization

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An exact Solution for Heat Transfer of a Jet Co-Axially impinging on a Rotating Disk and its Comparisons with stagnation Point experiments

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Journal of Thermal Science 2002年第1期11卷 53-59页

作者： i.V. Shevchuk (institute of engineering Thermophysics, Ukrainian National Academy of Sciences, 2a, Zhelyabov st., Kiev, 03057, Ukraine. e-mail: ivshevch@i.com.ua) institute of engineering Thermophysics Ukrainian National Academy of Sciences Ukraine

An exact solution of laminar heat transfer problem for a uniform flow perpendicular to a rotating disk was obtained. Radial velocity at the outer edge of the boundary layer increases linearly in the radial direction, while the temperature difference between the disk and outer flow follows a power law. The problem is solved using self-similar velocity and temperature profiles. Nusselt numbers were computed for the Prandtl numbers Pr=1 and 0.71 at different values of parameters affecting flow and heat transfer. Special flow regime was identified where rotating disk heat transfer is determined only by peculiarities of the impinging flow. Results of predictions agree well with known experiments in the vicinity of the stagnation point.

关键词： impinging jet rotating disk Nusselt number laminar flow heat transfer boundary layer exact solution

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evaluating the biosignature potential of ammonium in Proterozoic red beds and implications for the search for life on Mars

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earth and Planetary Physics 2024年第6期8卷 836-853页

作者： eva e.stüeken Philip Fralick stephen Hillier Anthony R.Prave School of earth and environmental Sciences University of St AndrewsSt AndrewsKY169TSUK Department of Geology Lakehead UniversityThunder BayON P7B 5E1Canada The James Hutton institute CraigiebucklerAberdeenAB158QHUK Department of Soil and environment Swedish University of Agricultural Sciences(SLU)SE-75007 UppsalaSweden

Over the past two decades,it has become increasingly apparent that early Mars may once have been warmer,wetter and more habitable for microbial life than it is today,which has spurred discussions about potential biosignatures that may be preserved in Martian *** impediment to this line of research is the pervasive oxidation of Mars’surface due to photochemical oxidants that have likely destroyed remnants of organic ***,we investigate whether nitrogen(N)transferred from biomass to phyllosilicate minerals during diagenesis can be preserved in oxidized *** investigate two sequences of terrestrial Proterozoic red beds,namely the Sibley Group(1.4 Ga)in Canada and the stoer Group(1.2 Ga)in Scotland,and we find enrichments in authigenic N in the range of several tens of ppm in both *** highest concentrations(ca.100 ppm on average)are found in the most desiccated red beds of the stoer Group,concurrent with enrichments in potassium(K).We discuss similarities and differences between the two sets of rocks with regards to salinity,pH,biological productivity and K-metasomatism,and we conclude that the ideal mechanism for the preservation of biogenic N in red beds may be in-situ release of ammonium from microbial mats into the clay substrate,possibly facilitated by early diagenetic,biologically induced *** and smectite have been observed on Mars,and experiments suggest that Martian waters contained moderate amounts of dissolved ***,it is conceivable that a similar K and N enrichment process could have occurred as to what we document for the Proterozoic,preserving evidence of life that may have survived to the modern day.

关键词： red beds biosignature Mars nitrogen ammonium clay minerals

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Cyclic stability of Superelasticity in[001]‑Oriented Quenched Ni_(44)Fe_(19)Ga_(27)Co_(10)and Ni_(39)Fe_(19)Ga_(27)Co_(15)Single Crystals

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Acta Metallurgica Sinica(english Letters) 2023年第4期36卷 650-660页

作者： e.e.Timofeeva e.Yu.Panchenko A.S.eftifeeva A.i.Tagiltsev N.Yu.Surikov A.B.Tokhmetova e.i.Yanushonite M.V.Zherdeva i.Karaman Yu.i.Chumlyakov Tomsk state University Novosobornaya Square 1Tomsk 634050Russia Texas A&M University College StationTX 77843USA

The study of the influence of the cobalt content on the cyclic stability of superelasticity(Se)was carried out in quenched Ni_(44)Fe_(19)Ga_(27)Co_(10)and Ni_(39)Fe_(19)Ga_(27)Co_(15)(at.%)single crystals under *** is shown that an increase in the cobalt content leads to embrittlement of the material and a decrease in the cyclic stability of *** Ni_(44)Fe_(19)Ga_(27)Co_(10)single crystals,during the first 20 loading/unloading cycles,the elastic energy relaxation occurs along with the formation of dislocations and residual martensite,which leads to a decrease in critical stress of martensite formation and in stress *** the next 80 cycles,Se becomes more *** is accompanied by a slight change in the *** the contrary,Ni_(39)Fe_(19)Ga_(27)Co_(15)single crystals are characterized by high-strength characteristics,which lead to high Se stability during the first 20 loading/unloading ***,after 20 cycles,a strong degradation of the Se is observed through the formation of microcracks,which ultimately leads to the destruction of the *** results of work are replicable for cycling at different temperatures from all temperature ranges of superelasticity.

关键词： Martensitic transformations Superelasticity Single crystals Cyclic stability Microstructure

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enhancing perianal disease management with integrated physical and psychological approaches

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World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

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Tungsten ion source under double-pulse laser ablation system

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Chinese Physics B 2017年第9期26卷 285-296页

作者： Ahmed Asaad i Khalil Ashraf i Hafez Mahmoud e elgohary Mohamed A Morsy Department of Laser Sciences and interactions National Institute of Laser Enhanced SciencesCairo UniversityGiza 12613Egypt Central Laboratory of Ministry of electricity CairoEgypt Atomic Research Center Atomic Energy AuthorityCairo 13759Egypt Department of Nuclear engineering Jordan University of Science and Technology IrbidJordan Department of Chemistry King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia

New tungsten ion source is produced by using single and double-pulse laser ablation system. Combined collinear Nd：YAG laser beams（266＋1064 nm） are optimized to focus on the sample in air. Optimization of the experimental parameters is achieved to enhance the signal-to-noise ratio of the emission spectra. The velocity distribution of the emitted plasma cloud is carefully measured. The influences of the potential difference between the bias electrodes, laser wavelength and intensity on the current signal are also studied. The results show that the increase in the tungsten ion velocity under the double-pulse lasers causes the output current signal to increase by about three folds. The electron density and temperature are calculated by using the stark-broadened line profile of tungsten line and Boltzmann plot method of the upper energy levels, respectively. The signal intensity dependence of the tungsten ion angular distribution is also analyzed. The results indicate that the double-pulse laser ablation configuration is more potent technique for producing more metal ion source deposition, thin film formation, and activated plasma-facing component material.

关键词： tungsten ion beam double-pulse lasers ablation system laser ablation system optical instrumentation

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Review on high repetition rate and mass production of the cryogenic targets for laser iFe

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High Power Laser Science and engineering 2017年第2期5卷 28-51页

作者： i.V.Aleksandrova e.R.Koresheva Lebedev Physical institute Russian Academy of SciencesMoscow119991Russia National Research Nuclear University MePhl(Moscow engineering Physics institute) Moscow115409Russia

in inertial fusion energy(iFe) research, a considerable attention has recently been focused on the issue of large target fabrication for MJ-class laser facilities. The ignition and high-gain target designs require a condensed uniform layer of hydrogen fuel on the inside of a spherical shell. in this report, we discuss the current status and further trends in the area of developing the layering techniques intended to produce ignition, and layering techniques proposed to high repetition rate and mass production of iFe targets.

关键词： free-standing and line-moving targets high-repetition-rate fuel supply inertial fusion energy target mass production

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