检索结果-南通市图书馆

阿尔茨海默病小鼠模型:MR引导聚焦超声定位到海马并突破血脑屏障,改善病理异常和行为

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2015年第1期 74-74页

作者： A.Burgess S.Dubey S.Yeung O.Hough N.Eterman i.aubert Physical Sciences Platform Sunnybrook Research Institute

目的旨在利用小鼠模型验证重复MR引导超声聚焦靶向治疗与阿尔茨海默病(AD)相关的大脑结构海马是否可以调节病理异常、可塑性和行为。材料与方法所有动物

关键词：聚焦超声 MR 病理异常海马边缘系统阿尔茨海默病大脑结构小鼠模型定位

Arctic sea-ice extent: No record minimum in 2023 or recent years

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Atmospheric and Oceanic Science Letters 2025年第1期18卷 52-55页

作者： Ola M.Johannessen Tor i.Olaussen Nansen Scientific Society BergenNorway Nansen Environmental and Remote Sensing Center BergenNorway

Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(***^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 ***^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. in general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing CO_(2) in the atmosphere, where the increase of CO_(2) in recent decades explains about 80% of the decrease in sea ice in September, while the remainder is caused by natural variability.

关键词： Sea ice Arctic Minimum ice Climate

Coarse to Fine: The Role of Severe Plastic Deformation in Advancing Titanium-Based Medical implants - A Comprehensive Review

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 295-306页

作者： Dragana R Mihajlović Bojan i Međo ivana Lj Cvijović-Alagić Veljko R Djokić Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča institute of Nuclear Sci-ences-National institute of the Republic of Serbia University of Belgrade11001BeogradSerbia innovation Centre of the Faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico i.Bohnen Department of Radiology University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of Excellence for Parkinson’s Disease Research University of MichiganAnn ArborMIUSA institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia Department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research Center of Excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

The therapeutic potential of nerve growth factor combined with blood-brain barrier modulation by focused ultrasound for neurodegenerative disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第9期16卷 1783-1785页

作者： Kristiana Xhima isabelle aubert Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Hurvitz Brain Sciences Research Program Sunnybrook Research InstituteTorontoONCanada Biological Sciences Sunnybrook Research InstituteTorontoONCanada

Nerve growth factor(NGF) is a neurotrophic factor critical for cholinergic neuronal survival, phenotypic maintenance and plasticity in the mammalian brain. NGF has been implicated in the pathogenesis of neurodegenerat... 详细信息

关键词： degenerative disorders therapeutic

Apolipoprotein A-i binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury i.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Nano-Enhanced Dairy Scum Biodiesel Blends:Unleashing the Power of Aluminium Oxide for Sustainable and Efficient Engine Performance

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2025年第1期34卷 283-302页

作者： Veeranna MODi Prasad B.RAMPURE Sunil Kumar SHETTY Madeva NAGARAL Channa Keshava NAiK N Johar MGM Muhammad irsyad ABDULLAH Abdullah i.AL-MANSOUR Shamshad ALAM KLE College of Engineering and Technology ChikodiVisvesvaraya Technological University Nitte (Deemed to be University) NMAM Institute of Technology (NMAMIT)Department of Mechanical Engineering Aircraft Research and Design Centre HAL Department of Mechanical Engineering BGS College of Engineering and TechnologyBengaluruAffiliated to Visvesvaraya Technological University Management and Science University Department of Civil Engineering College of EngineeringKing Saud University

This study investigates the effect of aluminium oxide nanoparticlesaddition to biodiesel blends made from dairy milk scum on performance and combustion characteristics of the diesel *** dispersion of Al2O3nanoparticles in B20 blends at different concentrations was done with the help of *** number of blends were prepared for the *** Machine learning algorithms(Random Forest（RF）and CatBoost) was used for the *** results show that in comparison to biodiesel blends without nanoparticles,the kinematic viscosity and density is higher for fuel blends with *** these Fuel blends have higher calorific *** blends exhibited reduced Brake Specific Fuel Consumption（BSFC） of2.85% than the blends without nano particles(Dairy Scum Methyl Ester Biodiesel 20%+Neat Diesel 80%（in volume）,DSMEB20),57.14% less CO,40.8% less hydrocarbon,and increased NOxemissions compared to conventional diesel,contributing to the development of environmentally friendly and renewable biofuel blends with *** B20NP30 is the optimal blend for performance and emission *** study concludes with findings on enhanced Brake Thermal Efficiency（BTE） of 26.29% in 3×10-5（in volume） Al2O3nanoparticle-blended DSME B20 and other DSME B20 fuel blends,emphasizing the importance of optimal nanoparticle *** correlation matrix shows how engine load,efficiency measures（BTE,BSFC）,and emissions（CO,CO2,NOx,Smoke） are connected in complex *** results help us understand the complicated dynamics of engine performance and emission characteristics ***'s diagram for BTE and BSFC shows that CatBoost-based BTE models perform superior to RF-based models during the training as well as testing *** results were obtained for CO and CO2emission results.

关键词： Al2O3 concentration Ci engine Dairy Scum Methyl Ester Biodiesel

Numerical investigation of Flutter Stability in Subsonic Space Turbine Blisk with Emphasis on Cut-on/Cut-off Modes and interblade Phase Angles

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2012年第6期21卷 492-499页

作者： Hakim Ferria Pascal Ferrand Franois Pacull Stéphane aubert Laboratoire de Mécanique des Fluides et d'Acoustique CNRS UMR 5509 Université de LyonUniversité Claude Bernard Lyon 1INSA Lyon 36avenue Guy de Collongue69134 EcullyFrance Fluorem 64 chemin des Mouilles69134 EcullyFrance

The so-called blisks,*** bladed disks,are characterized by very low viscous material damping and make the flutter prediction much more *** that framework,a two-dimensional numerical study of a space turbine blisk featuring complex deformation of blades and high eigenfrequency(>40kHz)is *** simulations are based on unsteady Reynolds Averaged Navier Stokes computations linearized in the frequency domain and consist in the superposition of an unsteady linear(in time)pressure field,generated by a harmonic perturbation,upon a steady nonlinear(in space)*** aerodynamic damping coefficient is calculated over a range of nodal diameters,and the blades are predicted aeroelastically ***,violent changes occur and are rather critical since sudden and large deviations in stability *** that context,the nature of the waves propagating from the cascade are *** an approach provides fundamental knowledge about the perturbations which can either propagate to the far-field(cut-on mode)or decay(cut-off mode).it is expected that the ability of the flow to damp or to amplify the blade motion is strongly affected by the way unsteady perturbations are transferred from the cascade to the *** nature of the waves are first assessed from the aforementioned linearized results,then they are evaluated analytically and finally compared.A good agreement is found despite the strong assumptions of the analytical *** results show a clear correlation between the cut-on/cut-off conditions and *** least stable configuration corresponds to cut-off mode at the inlet and no wave at the *** outgoing waves from the cascade,the blade is prone to be less stable:the energy from the blades vibration is necessarily dissipated or sent out by the cascade.

关键词： subsonic flutter LRANS blisk cut-on/cut-off mode interblade phase angle nodal diameter.

Prognostic impact of inflammatory and nutritional biomarkers in pancreatic cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2025年第1期16卷 5-9页

作者： Macarena Teja María i Garrido Abrahams Ocanto Felipe Counago Department of Radiation Oncology GenesisCare-San Francisco de Asís University HospitalMadrid 28002Spain Department of Radiation Oncology GenesisCare-Vithas La Milagrosa University HospitalMadrid 28010Spain National Director GenesisCare SpainMadrid 28043Spain Department of Medicine School of MedicineHealth and SportEuropean University of MadridMadrid 28670Spain

Pancreatic cancer is usually associated with a poor *** is the main curative treatment but pancreatic operations are aggressive and new tools that help clinicians to predict surgical and prognostic outcomes are *** et al recently published a retrospective,single centre cohort study evaluating the impact of seven nutritional and inflammatory markers in pancreatic cancer surgical patients:The albumin-to-globulin ratio,prognostic nutritional index(PNi),systemic immune-inflammation index(Sii),neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),nutritional risk index,and the geriatric nutritional risk index.A significant correlation was found between the PNi,Sii,NLR,and PLR and a hospital discharge of less than 15 *** a univariable analysis,PNi,Sii,NLR and PLR were significantly related to recurrence-free survival and,in a multivariable analysis PNi was associated with overall *** meta-analyses corroborate the results in terms of prognosis but individual studies are discordant on their ***,the cut-off values for these markers vary significantly between studies and there are no clinical trials comparing them to identify the most relevant *** are limitations when implementing nutritional and inflammatory biomarkers into clinical practice and further studies are needed in order to answer these questions.

关键词： inflammatory biomarkers Nutritional biomarkers Pancreatic cancer Prognosis Surgical complications