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肺结节

英国医学杂志中文版 2021年第4期24卷 231-237页

作者： i t H au-yong W Hamilton J Rawlinson D R Baldwin 吴芳(译) 张宏艳(校) Department of Radiology Nottingham University HospitalsNottinghamUK University of Exeter Medical School St Luke′s CampusExeter EX12LUUK British thoracic Oncology Group(advocate steering committee member) NCRI Lung subgroup(consumer)and European Lung Foundation LC Patient advisory groupSandwellUK Respiratory Medicine Nottingham University HospitalsNottinghamUK 中南大学湘雅二医院肿瘤中心解放军总医院第五医学中心肿瘤学部

你需要知道的内容胸部Ct检查时常常发现肺结节。大多数肺结节是良性的,少数是早期肺癌。最佳诊断方法可使恶性肺结节得到及时有效的根治并避免对良性肺结节的不必要的干预。应熟悉英国胸科协会(BtS)和Fleischner协会2015年对偶然发现的... 详细信息

你需要知道的内容胸部Ct检查时常常发现肺结节。大多数肺结节是良性的,少数是早期肺癌。最佳诊断方法可使恶性肺结节得到及时有效的根治并避免对良性肺结节的不必要的干预。应熟悉英国胸科协会(BtS)和Fleischner协会2015年对偶然发现的肺结节制定的管理指南。另外还有针对肺癌筛查过程中发现的肺结节的管理指南。为方便管理患者,可考虑开展虛拟的肺结节门诊。

关键词：早期肺癌管理指南肺结节肺癌筛查胸部Ct检查偶然发现最佳诊断方法胸科

Crystallization Modulation and Holistic Passivation Enables Efficient two‑terminal Perovskite/Cuin(Ga)Se_(2)tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen Jiang Fei Long Liyuan Han Qifeng Han Yi‑Bing Cheng yong Peng State Key Laboratory of Advanced technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

two-terminal(2-t)perovskite(PVK)/Cuin(Ga)Se_(2)(CiGS)tandem solar cells(tSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CiGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CiGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-t PVK/CiGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-t PVK/CiGS tSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CiGS tandem solar cells.

关键词： PVK/CiGS tSCs irregular rough surfaces Modulating the growth PVK/C60 interface recombination

ZEitLUPE is required for shade avoidance in the wild tobacco Nicotiana attenuata^FA

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Journal of integrative Plant Biology 2020年第9期62卷 1341-1351页

作者： yong Zou Ran Li ian t.Baldwin Department of Molecular Ecology Max-Planck-Institute for Chemical EcologyJena 07745Germany institute of insect Sciences Zhejiang UniversityHangzhou 310058China

Being shaded is a common environmental stress for plants, especial y for densely planted crops. Shade de-creases red: far-red (R:FR) ratios that inactivate phyto-chrome B (PHYB) and subsequently release phytochrome interaction factors (PiFs). Shaded plants display elongated hypocotyls, internodes, and petioles, hyponastic leaves, early flowering and are inhibited in branching: traits col ectively cal ed the shade avoidance syndrome (SAS). ZEitLUPE (ZtL) is a circadian clock component and blue light photoreceptor, which is also involved in floral rhythms and plant defense in Nicotiana attenuata. ztl mutants are hypersensitive to red light and ZtL physical y interacts with PHYB, suggesting the involvement of ZtL in R:FR light signaling. Here, we show that N. attenuata ZtL-silenced plants display a phenotype op-posite to that of the SAS under normal light. After simulated shade, the normal y induced transcript levels of the SAS mar-ker gene, AtHB2 are attenuated in ZtL-silenced plants. the auxin signaling pathway, known to be involved in SAS, was also significantly attenuated. Furthermore, NaZtL directly in-teracts with NaPHYBs, and regulates the transcript levels of PHYBs, PiF3a, PiF7 and PiF8 under shade. Our results suggest that ZtL may regulate PHYB- and the auxin-mediated sig-naling pathway, which functions in the SAS of N. attenuata.

关键词： traits planted branching

3D Printing of tough Hydrogel Scaffolds with Functional Surface Structures for tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-t,cross-linking-C,PtC&PCt)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(t).Finally,the training results are fixed by photo-cross-linking processing(C).the tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PtC or PCt *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing tough hydrogel scaffold Functional surface structure tissue regeneration Biomaterials

Joint user association and resource partition for downlink-uplink decoupling in multi-tier HetNets

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Frontiers of information technology & Electronic Engineering 2017年第6期18卷 817-829页

作者： Zhi-yong FENG Ze-bing FENG t.Aaron GULLiVER MOE Key Laboratory of Universal Wireless Communications Beijing University of Posts and Telecommunications Department of Electrical and Computer Engineering University of Victoria

traditional cellular networks require the downlink (DL) and uplink (UL) of mobile users (MUs) to be associated with a single base station (BS). However, the power gap between BSs and MUs in different transmission environments results in the BS with the strongest downlink differing from the BS with the strongest uplink. in addition, the significant increase in the number of wireless machine type communication (MtC) devices accessing cellular networks has created a DL/UL traffic imbalance with higher traffic volume on the uplink. in this paper,a joint user association and resource partition framework for downlink-uplink decoupling (DUDe) is developed for a tiered heterogeneous cellular network (HCN). Different from the traditional association rules such as maximal received power and range extension, a coalition game based scheme is proposed for the optimal user association with DUDe. the stability and convergence of this scheme are proven and shown to converge to a Nash equilibrium at a geometric rate. Moreover, the DL and UL optimal bandwidth partition for BSs is derived based on user association considering fairness. Extensive simulation results demonstrate the effectiveness of the proposed scheme,which enhances the sum rate compared with other user association strategies.

关键词： Downlink-uplink decoupling User association Resource partition Heterogeneous cellular network Coalition game

A study of real-world micrograph data quality and machine learning model robustness

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npj Computational Materials 2021年第1期7卷 1463-1473页

作者： Xiaoting Zhong Brian Gallagher Keenan Eves Emily Robertson t.Nathan Mundhenk t.yong-Jin Han Materials Science Division Lawrence Livermore National LaboratoryLivermoreCAUSA Center for Applied Scientific Computing Lawrence Livermore National LaboratoryLivermoreCAUSA Defense technologies Engineering Division Lawrence Livermore National LaboratoryLivermoreCAUSA Computational Engineering Division Lawrence Livermore National LaboratoryLivermoreCAUSA

Machine-learning(ML)techniques hold the potential of enabling efficient quantitative micrograph analysis,but the robustness of ML models with respect to real-world micrograph quality variations has not been carefully *** collected thousands of scanning electron microscopy(SEM)micrographs for molecular solid materials,in which image pixel intensities vary due to both the microstructure content and microscope instrument *** then built ML models to predict the ultimate compressive strength(UCS)of consolidated molecular solids,by encoding micrographs with different image feature descriptors and training a random forest regressor,and by training an end-to-end deep-learning(DL)*** show that instrument-induced pixel intensity signals can affect ML model predictions in a consistently negative *** a remedy,we explored intensity normalization *** is seen that intensity normalization helps to improve micrograph data quality and ML model robustness,but microscope-induced intensity variations can be difficult to eliminate.

关键词： instrument image eliminate

Statistically Extrapolated Nowcasting of Summertime Precipitation over the Eastern Alps

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Advances in Atmospheric Sciences 2017年第7期34卷 925-938页

作者： Min CHEN Benedikt BiCA Lukas tCHLER Alexander KANN yong WANG institute of Urban Meteorology China Meteorological Administration Beijing 100089 China Central institute for Meteorology and Geodynamics Vienna 1190 Austria

this paper presents a new multiple linear regression（MLR） approach to updating the hourly, extrapolated precipitation forecasts generated by the iNCA（integrated Nowcasting through Comprehensive Analysis） system for the Eastern *** generalized form of the model approximates the updated precipitation forecast as a linear response to combinations of predictors selected through a backward elimination algorithm from a pool of predictors. the predictors comprise the raw output of the extrapolated precipitation forecast, the latest radar observations, the convective analysis, and the precipitation analysis. For every MLR model, bias and distribution correction procedures are designed to further correct the systematic regression errors. Applications of the MLR models to a verification dataset containing two months of qualified samples,and to one-month gridded data, are performed and evaluated. Generally, MLR yields slight, but definite, improvements in the intensity accuracy of forecasts during the late evening to morning period, and significantly improves the forecasts for large thresholds. the structure-amplitude-location scores, used to evaluate the performance of the MLR approach,based on its simulation of morphological features, indicate that MLR typically reduces the overestimation of amplitudes and generates similar horizontal structures in precipitation patterns and slightly degraded location forecasts, when compared with the extrapolated nowcasting.

关键词： Precipitation forecast convective Eastern correction verification backward qualified degraded morning

Occupational Health Risk Assessment of Benzene,toluene,and Xylene in Shanghai

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Biomedical and Environmental Sciences 2021年第4期34卷 290-298页

作者： WANG tong Shuai SONG Bo SUN Qing Hua LiN yong Xin SUN Yuan SUN Pin JiA Xiao Dong William W.au MEi Can Hua XiA Zhao Lin Department of Occupation Health and toxicology School of Public HealthFudan UniversityShanghai 200000China Department of Occupation Health Shanghai Municipal Health CommissionShanghai 200000China Shanghai institute of Occupational Disease for Chemical industry(Shanghai institute of Occupational Safety&Health) Shanghai 200000China Division of Health Risk Factors Monitoring and Control Shanghai Municipal Center for Disease Control and PreventionShanghai 200000China University of Medicine PharmacyScience and TechnologyTargu MuresRomania and Shantou University Medical CollegeShantou 515000GuangdongChina

Objective this study was designed to conduct a retrospective and systematic occupational health risk assessment(OHRA)of enterprises that used benzene,toluene,and xylene(BtX)in Shanghai,*** All data for the study were obtained from 1,705 occupational health examination and evaluation reports from 2013 to 2017,and a semiquantitative model following Chinese OHRA guidelines(GBZ/t 298-2017)was applied for the *** the selected enterprises using BtX were mainly involved in manufacturing of *** the exposure level method,health risk levels associated with exposure to BtX were classified as medium,negligible,or ***,the risk levels associated with benzene and toluene were significantly different according to job types,with gluers and inkers exhibiting greater health *** the same job type,the health risk levels assessed using the comprehensive index method were higher than those using the exposure level *** Our OHRA reveals that workers who are exposed to BtX still face excessive health ***,the risk level varied depending on job categories and exposure to specific ***,additional control measures recommended by OHRA guidelines are essential to reduce worker exposure levels.

关键词： Benzene toluene Xylene Occupational health risk assessment Exposure level method Comprehensive index method

Constitutive modeling of ultra?fine?grained titanium flow stress for machining temperature prediction

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Bio-Design and Manufacturing 2019年第3期2卷 153-160页

作者： Jinqiang Ning Vinh Nguyen yong Huang Karl t.Hartwig Steven Y.Liang George W.Woodruff School of Mechanical Engineering Georgia Institute of Technology801 Ferst DriveAtlantaGA 30332USA Department of Mechanical and Aerospace Engineering University of Florida231 MAE-AP.O.Box 116250GainesvilleFL 32611USA Department of Mechanical Engineering Texas A&M University3123 TAMUCollege StationTX 77843?3123USA

this work investigates the machining temperatures of ultra-fine-grained titanium(UFG ti),prepared by equal channel angular extrusion,through analytical *** ti has great usefulness in biomedical applications because of its high mechanical strength,sufficient manufacturability,and high *** temperatures were predicted using a physics-based predictive model based on material constitutive relation and mechanics of the orthogonal cutting *** minimization between the stress calculated using Johnson–Cook constitutive model and the same stress calculated using mechanics model yields the estimation of machining temperatures at two deformation *** agreements are observed upon validation to the values reported in the *** machinability of UFG ti is investigated by comparing its machining temperature to that of ti–6Al–4V alloy under the same cutting *** lower temperatures are observed in machining UFG *** computational efficiency of the presented model is investigated by comparing its average computational time(~0.5 s)to that of a widely used modified chip formation model(8900 s)with comparable prediction *** work extends the applicability of the presented temperature model to a broader class of materials,specifically ultra-fine-grained *** high computational efficiency allows the in situ temperature prediction and optimization of temperature condition with process parameters planning.

关键词： Ultra-fine-grained titanium Analytical modeling High computational efficiency Johnson–Cook model Cutting mechanics