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Experimental status of the HANBiT Facility

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Plasma science and Technology 2004年第4期6卷 2367-2370页

作者： s.J.Yoo M.Kwon J.G.Bak K.Choh i.s.choi J.H.choi J.W.choi A.C.England J.Hong H.s.Jeon H.G.Jhang J.s.Ju M.Jung J.Y.Kim s.s.Kim W.H.Ko K.Y.Kwak M.C.Kyum B.J.Lee D.K.Lee J.H.Lee H.G.Lee s.G.Lee T.Lho H.K.Na B.H.Park M.K.Park D.C.seo s.H.seo J.H.Yeom J.s.Yoon K.i.You Korea Basic science institute Daejeon305-333Korea Hanbit User Group

HANBiT is a magnetic mirror confinement device. Recent physics experimentshave been mainly focused on identifying discharge characteristics and on getting stable plasmaproduction and operation modes, by using a 500 kW slot antenna system at a fixed RF frequency of 3.5MHz and varying discharge conditions such as fueling rate, RF power, and B-field intensity incentral cell. Two distinct operation modes are found to be very sensitive to the RF power as well asthe ratio of the RF frequency to the ion cyclotron frequency. A MHD interchange mode of m = - 1 isclearly observed and the stabilizing mechanism can be explained by the sideband coupling theory.

关键词： mirror discharge stabilization

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利用磁性变化测量疲劳寿命的新方法

兵器材料科学与工程 1986年第9期 68-71页

作者： i.s.choi s.W.Nam K.-T.Rie 史洪刚

为了工程构件的安全,必须准确地了解构件的疲劳寿命。从实验便利的角度考虑,直至断裂的循环数N;被用作设计判据。在低周疲劳条件下,断裂前的循环数N;与塑性应变幅△ε;间符合柯芬-曼森（Coffin-Manson）关系:

关键词：导磁率变化法循环数磁导率电动势磁性疲劳寿命疲劳力学性质

Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee Kim Rudolph ETanzi se Hoon choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： shan Ping Yu Emily choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young choi Department of Brain science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Activated sericite:An Efficient and Effective Natural Clay Material for Attenuation of Cesium from Aquatic Environment

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Pedosphere 2014年第6期24卷 731-742页

作者： D.TiWARi LALHMUNsiAMA s.i.choi s.M.LEE Department of Chemistry School of Physical SciencesMizoram University Department of Health and Environment Kwandong University Department of Environmental Engineering Kwangwoon University

sericite is mica-based natural clay that is annealed at 800 ℃ for 4 h, followed by acid activation using 3.0 mol L-1HCl at 100℃. The interaction of cesium(i), Cs(i), with sericite could provide useful data for the study of soil erosion or mass water movement utilizing the natural radioactive Cs. in this study sericite and activated sericite were used to assess their suitability in the attenuation of Cs from the aquatic environment under both batch and column experiments. The surface morphological studies indicated that a disordered and heterogeneous surface structure was exhibited by the activated sericite, whereas the native sericite exhibited a compact and layered structure. The Brunauer-Emmett-Teller(BET) specific surface area results indicated a significant increase in the surface area due to the activation of sericite. The batch reactor data collected for various parametric studies revealed that an increase in p H(from 2.0 to 8.0) and sorbate concentration(from 10.0 to 100.0 mg L-1) apparently favored the attenuation of Cs(i). The timedependent sorption data revealed that Cs(i) uptake was very rapid, and it achieved its saturation value within just 50 min of *** kinetic modeling studies indicated that the uptake of Cs(i) followed a pseudo-second-order rate equation; hence, the attenuation capacity of these solids for Cs(i) was estimated to be 0.858 and 4.353 mg g-1for sericite and activated sericite solids, *** adsorption isotherm modeling data showed a reasonably good applicability of the Freundlich model than the Langmuir *** effect of background electrolyte concentrations(0.001 to 0.1 mol L-1) of Mg(NO3)2indicated that the presence of this electrolyte could not significantly affect the percent removal of Cs(i) by activated sericite. Furthermore, the fixed-bed column reactor operations were performed to obtain the breakthrough data, which were fitted well to the Thomas non-linear equation. Therefore, the loading capacity of Cs(i) wa

关键词： adsorption isotherms breakthrough data electrolyte kinetics radionuclide

Relation between etching profile and voltage-current shape of sintered siC etching by atmospheric pressure plasma

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Plasma science and Technology 2019年第4期21卷 137-144页

作者： D C sEOK s R YOO K i LEE Y s choi Y H JUNG Plasma Technology Research Center National Fusion Research InstituteGunsan City 54004Republic of Korea

sintered silicon carbide(siC)was etched by a dielectric barrier discharge source.A high voltage bipolar pulse was used with helium gas for the plasma *** stable filament plasma was generated and could be used for siC *** the processing gas(NF3)mixing rate increased,the width and depth of the etching profile became narrower and *** differentiated V-Q Lissajous method was used for measuring the capacitances(Ceq)of the electrode after the plasma turned *** width of the etching profile was proportional to *** the current peak value/smx of the substrate current in creased,the volume removal rate of siC *** etch depth was proportional to the ratio of/smx to ***,because of the different characteristics of the plasma disks on siC substrate by the voltage polarity,the etching profile was ***,in high NF3 mixing process,the etching profile became stable and deeper.

关键词： dielectric barrier discharge silicon carbide plasma etching、filament discharge,surface charge

Numerical modelling of a low power non-transferred arc plasma reactor for methane conversion

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Plasma science and Technology 2019年第6期21卷 29-37页

作者： B i MiN D K DiNH D H LEE T H KiM s choi institute for Nuclear science and Technology Jeju National University 102 Jejudaehak-ro Jeju 63243Republic of Korea University of science and Technology(UsT) 217 Gajeong-ro Yuseong-gu Daejeon 34113 Republic of Korea Korea institute of Machinery and Materials 156 Gajeongbuk-ro Yuseong-gu Daejeon 34103 Republic of Korea Department of Nuclear and Energy Engineering Jeju National University 102 Jejudaehak-ro Jeju 63243Republic of Korea

Thermal flow characteristics and the methane conversion reaction in a low power arc plasma reactor for efficient storage and transport of methane,which is the main component of shale gas,were *** temperature and velocity distributions were calculated according to the type of discharge gases and arc current level by a self-developed magnetohydrodynamics (MHD)code and a commercial ANsYs-FLUENT code;the transport of chemical species was analyzed as including the chemical reactions of methane *** simulated results were verified by the comparison of calculated and measured arc voltages with permissible low error as under 4%.Three C2 hydrocarbon gases with ethane (C2H6),ethylene (C2H4),and acetylene (C2H2)were selected as the converted species of methane from experimental *** mass fraction of C2 hydrocarbons and hydrogen as the product of the conversion reaction at the reactor was also *** values show good agreement with the actual experimental results in that the major conversion reaction occurred in C2H2 and hydrogen,and the conversions to C2H6,C2H4,and hydrogen were minor reactions of methane pyrolysis conversion.

关键词： numerical modelling non-transferred arc plasma methane chemical reaction

CORROsiON AND MECHANiCAL PROPERTiEs OF Ti_3Al-Nb-Mo COMPOsiTEs FOR BiO-AND ENViRONMENTAL MATERiALs PREMRED BY sELF-PROMGATiNG HiGH TEMPERATURE REACTiON

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Acta Metallurgica sinica(English Letters) 2002年第2期15卷 149-153页

作者： Y.choi N.i.Baik H.D.Cho s.i.Hong Department of Metallurgical and Materials Engineering Sunmoon University#100 Kalsan-RiTangjeoung-MyunAsanChungnam336-840Korea Department of Environmental Engineering Sunmoon University#100 Kalsan-RiTangjeoung-MyunAsanChungnam336-840Korea Department of Metallurgical Engineering Chungnam National UniversityDaejeon305-764Korea Manuscript received 31 July 2001

Ti3 AL-Nb-Mo composites were prepared by sHs using initial powder mixtures of Ti-Al-Nb-Mo and their corrosion and mechanical properties were studied to develop bioand environmental materials. The composites reached 99.8% of theoretical density after the direct consolidation. The composites shows equiaxed primary a2 in a matrix of fine secondary a2 plates and ordered 82 (Bo) forming a basket weave structure. The strain rate sensitivity (m = dlnσ/dlne) at 2% strain is 0.008. Corrosion potential and corrosion rate of the composites formed by sHs were -151. 5m VsHE and 5. 72× 10^(-8)A/cm2 for Ti3 Al-10Nb-1. 5Mo and - 138.4m VsHE and 4. 12×10^(-8)cm2 for Ti3 Al-12Nb-1.5Mo in a 50% NaOH-10%FeCi3 solution, respectively. Corrosion resistance decreased with niobium content in the composites and chloride content in the aqueous solution. selective corrosion of a2 phase in a matrix occurred in the corrosion environment which suggests that the corrosion potential and rate changes are related to the niobium content and Q2 phase in a matrix.

关键词： Ti3 Al alloy corrosion strength sHs