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in-silico and in-vitro evaluation of docetaxel and berberine as potential p53 modulating apoptotic inducers in oral squamous cell carcinoma

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Asian Pacific Journal of Tropical Biomedicine 2022年第12期12卷 530-540页

作者： Smrutipragnya Samal Rajesh Kumar Meher Debasmita Dubey Showkat Ahmad Mir Binata Nayak Mahesh Chandra Sahu Pradeep Kumar naik Goutam Rath Santosh Kumar Swain Department of Otorhinolaryngology and Head and Neck Surgery IMS and SUM HospitalSiksha‘O’Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyotiviharBurlaSambalpurOdishaIndia Medical Research Laboratory IMS and SUM HospitalSiksha‘O’Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia School of Life Sciences Sambalpur UnivesityJyotiviharBurlaSambalpurOdishaIndia iCMR-Regional Medical Research Centre ChandrasekharpurBhubaneswar-751023India School of Pharmaceutical Sciences Siksha‘O’Anusandhan Deemed to be UniversityBhubaneswar-751030India

Objective:To investigate the interaction of p53 with docetaxel and berberine and their anticancer activities against oral squamous cell ***:The interaction between p53 with docetaxel and berberine was investigated and their mechanisms of action against oral squamous cell carcinoma were *** studies were performed to determine any toxic impact of the drugs on the vital organs of tested ***:in silico results revealed the molecular interaction of docetaxel and berberine with p53 and the molecules were found to be potential p53 *** and berberine inhibited the proliferation of cancer cells in a concentration-dependent *** cytometry analysis revealed that docetaxel and berberine at iC50 concentrations upregulated the expression of p53 in oral squamous cell carcinoma cells,thus triggering apoptotic cell *** addition,no toxicity was observed in the liver and kidney tissues of mice after docetaxel and berberine ***:Docetaxel and berberine significantly suppressed the proliferation of oral cancer cells by activating p53 expression and causing apoptotic cell *** compounds can be potential agents for the treatment of oral cancer,with little to no toxicity at the tissue level.

关键词： Docetaxel Berberine PC-3 OVCAR-3 OSCC SCC-29B p53 Anticancer Apoptosis

Petrographic characteristics coals, Mahanadi Gondwana and paleomires of Mand-Raigarh Basin, Chhattisgarh, india

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international Journal of Coal Science & Technology 2016年第2期3卷 165-183页

作者： A. S. naik M. P. Singh N. Volkmann P. K. Singh D. Mohantya D. Kumar Banaras Hindu University Varanasi India T U Bergakademie Freiberg Germany CSiR-Central institute of Mining and Fuel ResearchDhanbad India

Mand-Raigarh coalfield is one of the largest coalfields in the Mahanadi basin. The Geological Survey of india carried out initial study primarily on exploration. However, detailed petrographic and geochemical characters of the coals have not been done so far. This investigation is an attempt for petrographic and geochemical appraisal of the coals. Moreover, effort is also made for possible interpretation on development of coal facies. The results drawn from 30 composite coal samples suggest coals are rich in vitrinite, with collotelinite as the dominant maceral while liptinite macerals register low concentration. Dominant mineral assemblages found were clay minerals, pyrite was recorded as disseminated, framboidal and euhedral forms, carbonates recorded were mainly siderites. The vitrinite reflectance random （VRo） mean values range from 0.44 % to 0.56 %, and the rank of coal is suggested as high volatile ＇B＇ to ＇A＇ sub- bituminous in rank. The rock-eval pyrolysis reveal TOC content varying from 37 % to 68.83 %, while low hydrocarbon generating potential is evident from low $2 and Tmax values. The Hydrogen index （Hi） versus Oxygen index （Oi） plot reveal that the samples belong to Kerogen type--ii-iii with input dominantly from terrestrial source, some samples also fall in Kerogen type--ii domain indicating lacustrine input. Vitrinite reflectance result indicate that the samples are immature and approaching oil window, which is in agreement with data of the Rock-Eval parameters. The gelification index （Gi） and tissue preservation index （TPi） indicate that the coal developed in a telematic set up with high tree density. The ground water index （GWi） and vegetation index （Vi） demonstrate that the peat developed as an ombrogenous bog.

关键词： Mand-Raigarh coalfield Organic petrology Geochemistry Source rock

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经常打鼾与血压控制不佳相关

中华高血压杂志（中英文） 2024年第6期32卷 575-575页

作者：袁源(译) 练桂丽(审校) 不详

阻塞性睡眠呼吸暂停综合征(俗称打鼾)是心血管疾病的危险因素,且独立于其他合并症。但是,既往研究依赖于主观的、自我报告的打鼾评估。该研究采用家庭监测技术客观评估数月间的打鼾发生率及其与高血压患病率的关联性。在该研究中,采用... 详细信息

阻塞性睡眠呼吸暂停综合征(俗称打鼾)是心血管疾病的危险因素,且独立于其他合并症。但是,既往研究依赖于主观的、自我报告的打鼾评估。该研究采用家庭监测技术客观评估数月间的打鼾发生率及其与高血压患病率的关联性。在该研究中,采用床垫下传感器技术对12287例参与者进行6月的夜间监测,评估每夜睡眠期间打鼾的平均时间比例以及估算的呼吸暂停低通气指数(estimated apnea hypopnea index,eAHi)。

关键词：呼吸暂停低通气指数阻塞性睡眠呼吸暂停综合征睡眠期间高血压患病率打鼾自我报告客观评估传感器技术

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粗纤度蚕丝包芯丝的制备及性能测试（英文）

蚕业科学 2019年第1期45卷 94-99页

作者： Hariraj Gopal naik Subhas V 中央丝绸委员会蚕丝技术研究中心印度班加罗尔市560068

印度中央丝绸委员会蚕丝技术研究中心研制了一种新的缫丝机。传统缫丝过程中,8～10根茧丝沿着垂直方向缠绕在滚筒上,而新研制的缫丝机可以在缫丝过程中利用一个差速旋转装置使蚕丝与其他纤维沿平行方向混纺制备蚕丝包芯丝,制备的包芯丝... 详细信息

印度中央丝绸委员会蚕丝技术研究中心研制了一种新的缫丝机。传统缫丝过程中,8～10根茧丝沿着垂直方向缠绕在滚筒上,而新研制的缫丝机可以在缫丝过程中利用一个差速旋转装置使蚕丝与其他纤维沿平行方向混纺制备蚕丝包芯丝,制备的包芯丝膨松度是传统缫丝机缫制生丝的3倍。以棉纤维、粘胶纤维和聚酯纤维等为芯丝制备蚕丝包芯丝,对其缫丝性能及品质指标进行测试的结果表明,不同种类蚕丝包芯丝的直径、缫折、出丝率、生丝回收率、质量损失率等缫丝性能指标以及平均纤度、纤度偏差、纤度最大偏差、断裂强度、延展度等品质指标均有显著差异。以蚕丝包芯丝为纬线,蚕丝为经线制作的织物,其克重、厚度、捻度、抗拉强度、撕裂强度、卷曲率、耐磨性和抗挠刚度等比普通蚕丝织物均有明显改善。

关键词：缫丝机包芯丝膨松性缫丝性能品质

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找出组织中的关键岗位

RNAi Mediated Drought and Salinity Stress Tolerance in Plants

商业评论 2024年第10期 108-113页

作者：鲍里斯·格鲁斯伯格埃里克·林阿比吉特·奈克萨沙·施密特李君哈佛商学院欧柏林学院风投公司Quent Capital 德国奥托贝森商学院德国奥托贝森商学院体育与管理中心

领导者喜欢显示他们对员工的重视.领导者常说团队中的每个人都是企业成功的关键.尽管这听上去令人振奋,但事实并非如此.只有给最关键的岗位配备优秀的人,人才才能成为竞争优势.把明星员工放在不重要的岗位上只会大材小用,浪费人才.在战...

领导者喜欢显示他们对员工的重视.领导者常说团队中的每个人都是企业成功的关键.尽管这听上去令人振奋,但事实并非如此.只有给最关键的岗位配备优秀的人,人才才能成为竞争优势.把明星员工放在不重要的岗位上只会大材小用,浪费人才.在战略执行中,人们普遍认为,集中力量——识别、培养并利用关键的能力——是取得成功的关键.然而,在将这些能力转化到具体的职位之前,如果缺乏相应的制度来确保由高素质的员工担任这些职位,战略就只能是纸上谈兵.

关键词：

来源：博看期刊评论

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American Journal of Plant Sciences 2015年第12期6卷 1990-2008页

作者： Akash Pradhan Nupur naik Khirod Kumar Sahoo Department of Botany Ravenshaw University Cuttack India

RNAi mediated gene silencing demonstrated to serve as a defence mechanism against abiotic stress. Some endogenous small RNAs (microRNA and siRNA) have emerged as important players in plant abiotic stress response. Drought and salinity are the major environmental stresses that limit the agricultural food production. miRNA involved in drought and salinity stress response, including ABA response, auxin signalling, osmoprotection and antioxidant defence by downregulating the response target gene. it is observed that some of the microRNAs are upregulated or downregulated in response to drought and salt stress. We reviewed that miR167, miR393, mir474, miR169g are upregulated whereas miR168, miR396, miR397 are downregulated in rice plant during drought stress. Moreover, our detail categorical analysis on the basis of mechanism of action found that miRNA involved in drought stress was 28% in ABA signalling and response, 14.2% in auxin signalling, 9.52% in miRNA processing, 14.2% in cell growth, 9.52% in antioxidant defence, 4.76% in CO2 fixation and 9.52% in osmotic adjustment. Similarly, miRNA involved in salinity stress was 5.8% in auxin signalling, 23.5% in vegetative phase change and root, shoot, leaf and vascular development, 11.76% in gynoecium and stamens development, 8.82% in metabolic adaptation, 2.74% in early embryogenesis and 41.17% not known. importantly, some common miRNAs such as miR159, miR167, miR169, miR393 and miR397 play an important role in both drought and salinity stress conditions. Here, in this review, we mainly focused on the current status of miRNAs, mechanism of action and their regulatory network during drought and salinity stress in plants.

关键词： RNAi miRNA siRNA Drought Stress Salinity Stress Rice Plant Gene Regulation

Optimization of friction stir welding parameters for improved corrosion resistance of AA2219 aluminum alloy joints

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Defence Technology（防务技术） 2015年第4期11卷 330-337页

作者： G.RAMBABU D.BALAJi.naik C.H.VENKATA RAO K.SRiNiVASA RAO G.MADHUSUDAN REDDY Department of Mechanical Engineering Andhra University Department of Metallurgical Engineering Andhra University Defence Metallurgical Research Laboratory

The aluminium alloy AA2219(Al—Cu—Mg alloy) is widely used in the fabrication of lightweight structures with high strength-to-weight ratio and good corrosion *** is main fabrication method of AA2219 alloy for manufacturing various engineering *** stir welding(FSW) is a recently developed solid state welding process to overcome the problems encountered in fusion *** process uses a non-consumable tool to generate frictional heat on the abutting *** welding parameters,such as tool pin profile,rotational speed,welding speed and axial force,play major role in determining the microstructure and corrosion resistance of welded *** main objective of this work is to develop a mathematical model to predict the corrosion resistance of friction stir welded AA2219 aluminium alloy by incorporating FSW process *** this work a central composite design with four factors and five levels has been used to minimize the experimental *** polarization testing was carried out to determine critical pitting potential in millivolt,which is a criteria for measuring corrosion resistance and the data was used in *** the response surface method(RSM) was used to develop the *** developed mathematical model was optimized using the simulated annealing algorithm optimizing technique to maximize the corrosion resistance of the friction stir welded AA2219 aluminium alloy joints.

关键词： 2219铝合金耐腐蚀性能搅拌摩擦焊焊接接头参数优化数学模型摩擦搅拌焊接模拟退火算法

Eocene lignites from Cambay basin, Western india： An excellent source of hydrocarbon

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Geoscience Frontiers 2016年第5期7卷 811-819页

作者： P.K.Singh V.K.Singh P.K.Rajak M.P.Singh A.S.naik S.V.Raju D.Mohanty Coal & Organic Petrology Lab Centre of Advanced Study in Geology Banaras Hindu University Varanasi 221005 Uttar Pradesh India Research & Development Oil India Limited Duliajan Assam 786 602 India Central institute of Mining and Fuel Research Barwa Road Dhanbad 826015 India

in the present paper lignites from the Cambay basin have been studied for their hydrocarbon *** samples were collected from three lignite fieldse Vastan, Rajpardi and Tadkeshwar, and were investigated by petrography, chemical analyses and Rock-Eval pyrolysis. The results are well comparable with the empirically derived values. The study reveals that these ‘low rank C＇ lignites are exceedingly rich in reactive macerals（huminite t liptinite） while inertinite occurs in low concentration. These high volatile lignites generally have low ash yield except in few sections. The Rock-Eval data indicates the dominance of kerogen type-iii with a little bit of type-ii. The study reveals that the lignites of Vastan（lower and upper seams） and Tadkeshwar upper seam are more gas-prone while Rajpardi and Tadkeshwar lower seams are oil-prone. Further, the fixed hydrocarbons are several times higher than the free hydrocarbons. The relation between TOC and fixed hydrocarbon indicates that these lignites are excellent source rock for hydrocarbon which could be obtained mainly through thermal cracking. The empirically derived values reveal a high conversion（94e96%） and high oil yield（64e66%） for these lignites.

关键词： Eocene lignites Cambay basin Rock-Eval Maceral Hydrocarbon

Fascial space odontogenic infections: Ultrasonography as an alternative to magnetic resonance imaging

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World Journal of Clinical Cases 2021年第3期9卷 573-580页

作者： Sreenivasarao Ghali Girish Katti Syed Shahbaz Parita K Chitroda Anukriti V Darshan Devang Divakar Aftab Ahmed Khan Sachin naik Abdulaziz A Al-Kheraif Chitra Jhugroo Department of Oral Medicine and Radiology Nanded Rural Dental College and Research CenterNanded 431606MaharashtraIndia Department of Oral Medicine and Radiology Al-Badar Dental College and HospitalKalaburagi 585102KarnatakaIndia Department of Dental Health College of Applied Medical SciencesKing Saud UniversityRiyadh 11433Saudi Arabia

BACKGROUND The introduction of modern diagnostic tools has transformed the field of maxillofacial *** infection and fascial space involvement have been evaluated with many diagnostic tools,including ultrasonography(USG)and magnetic resonance imaging(MRi).AiM To explore USG as an alternative model to MRi in the detection of fascial space spread of odontogenic *** Among 20 patients,50 fascial spaces were clinically diagnosed with odontogenic infection and included in this prospective *** space infection involvement was examined by USG and *** were compared for both and confirmed by microbiological *** Ultrasonography identified 42(84%)of 50 involved fascial *** MRi identified all 50(100%).USG could stage the infections from edematous change to cellulitis to complete abscess *** MRi was superior in recognizing deep fascial space infections compared to ***, USG is a significant addition and has a definite role in prognosticatingthe stage of infection and exact anatomic location in superficial space infections.

关键词： Abscess Cellulitis Facial space Magnetic resonance imaging Odontogenic infection Ultrasonography