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Functional mechanism study of the allelochemical myrigalone A identifies a group of ultrapotent inhibitors of ethylene biosynthesis in plants

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Plant Communications 2024年第6期5卷 246-262页

作者： George Heslop-harrison Kazumi Nakabayashi Ana Espinosa-Ruiz Francesca Robertson Robert Baines Christopher R.L.Thompson Katrin Hermann David Alabadí Gerhard Leubner-Metzger Robin S.B.Williams Centre for Biomedical Sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Centre for Plant Molecular Sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK instituto de Biología Molecular y Celular de Plantas(CSiC-UPV) 46022 ValenciaSpain Centre for Life’s Origins and Evolution Department of GeneticsEvolution and EnvironmentUniversity College LondonLondonUK Syngenta Crop Protection AGSteinSwitzerland

Allelochemicals represent a class of natural products released by plants as root,leaf,and fruit exudates that interfere with the growth and survival of neighboring *** how allelochemicals function to regulate plant responses may provide valuable new approaches to better control plant *** such allelochemical,Myrigalone A(MyA)produced by Myrica gale,inhibits seed germination and seedling growth through an unknown ***,we investigate MyA using the tractable modelDictyostelium discoideum and reveal that its activity depends on the conserved homolog of the plant ethylenesynthesis protein 1-aminocyclopropane-1-carboxylic acid oxidase(ACO).Furthermore,in silico modeling predicts the direct binding of MyA to ACO within the catalytic *** ***,ablation of ACO mimics the MyA-dependent developmental delay,which is partially restored by exogenous ethylene,and MyA reduces ethylene *** Arabidopsis thaliana,MyA treatment delays seed germination,and this effect is rescued by exogenous *** also mimics the effect of established ACO inhibitors on root and hypocotyl extension,blocks ethylenedependent root hair production,and reduces ethylene ***,in silico binding analyses identify a rangeof highlypotentethylene inhibitorsthatblock ethylene-dependent responseand reduce ethyleneproduction in ***,we demonstrate a molecular mechanism by which the allelochemical MyA reduces ethylene biosynthesis and identify a range of ultrapotent inhibitors of ethylene-regulated responses.

关键词： 1-aminocyclopropane-1-carboxylic acid ACC ACC oxidase ACO allelochemicals ethylene synthesis inhibitors structure-activity relationship

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植物凝集素类受体激酶研究进展

热带亚热带植物学报 2024年

作者：熊圭 John Seymour HESLOP-harrison 刘青植物多样性与特色经济作物全国重点实验室广东省应用植物学重点实验室中国科学院华南植物园华南国家植物园中国科学院大学莱斯特大学遗传学和基因组生物学系

植物凝集素类受体激酶(lectin receptor-like kinases， LecRLKs)，隶属于植物膜蛋白类受体激酶，LecRLKs主要由胞外凝集素结构域、跨膜结构域和胞内激酶结构域组成，根据胞外结构域的特异性，分为G型、L型和C型，凝集素类受体激酶参与... 详细信息

植物凝集素类受体激酶(lectin receptor-like kinases， LecRLKs)，隶属于植物膜蛋白类受体激酶，LecRLKs主要由胞外凝集素结构域、跨膜结构域和胞内激酶结构域组成，根据胞外结构域的特异性，分为G型、L型和C型，凝集素类受体激酶参与植物的生长发育和环境响应调控。该文总结凝集素类受体激酶的研究历史、结构和分类，阐述植物LecRLKs的发育调控和胁迫响应功能，对功能明确的LecRLKs基因进行归类。提出凝集素类受体激酶研究中存在的不足之处，包括该家族演化历史研究极其缺乏、信号传导途径及其潜在配体亟待开展等方面。在此基础上，提出未来深入研究的方向，以期为植物凝集素类受体激酶基因家族的定向育种提供理论支持。

关键词：凝集素类受体蛋白激酶生长发育生物/非生物胁迫免疫

Pleiotropic attenuating effect of Ginkgo biloba against isoprenalineinduced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na^(+) , K^(+) -ATPase activities

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Chinese Herbal Medicines 2024年第2期16卷 282-292页

作者： Jerome Ndudi Asiwe Abodunrin Adebayo Ojetola Nwoke Enekabokom Ekene Esthinsheen Osirim Anthony Chibuzor Nnamudi Benjamin Oritsemuelebi Jackson Erozueme Onuelu Nicholas Asiwe harrison Ogheneochuko Eruotor Saviour inegbenehi Department of Physiology Delta State UniversityAbraka 1Nigeria Department of Physiology University of IbadanIbadan 3017Nigeria Department of Physiology Adeleke UniversityEde 250Nigeria Department of Pharmacology Rivers State UniversityNkpolu-Oroworukwo 5080Nigeria Department of Physiology Redeemer’s UniversityEde 230Nigeria Department of Biochemistry PAMO University of Medical SciencesPort Harcourt 500211Nigeria Department of Pharmacology Delta State UniversityAbraka 1Nigeria Department of Anatomy University of Port HarcourtChoba 5323Nigeria Department of Medical Laboratory Sciences University of Port HarcourtChoba 5323Nigeria

Objective:Myocardial infarction(Mi)is linked to an imbalance in the supply and demand of blood oxygen in the heart ***-blockers and calcium antagonists are just two of the common medications used to treat ***,these have reportedly been shown to be either ineffective or to have undesirable side *** of Ginkgo biloba leaves(GBE),a Chinese herbal product offers special compatibility benefits in therapeutic settings relating to inflammatory diseases and oxidative *** order to better understand how GBE affects Mi in rats insulted by isoprenaline(iSO),the current study was ***:The heart weight index,serum lipid profile,cardiac marker enzymes,endogenous antioxidants[catalase(CAT),superoxide dismutase(SOD),glutathione(GSH),nitrites and malondialdehyde(MDA)],inflammatory mediators[tumour necrosis factor alpha(TNF-a)and interleukin-6(iL-6)],immunohistochemical expressions of B-cell lymphoma factor-2(Bcl-2),extracellular signal-regulated kinase(ERK1/2),and mammalian target of rapamycin(mTOR)and histopathological analysis were used to assess the cardioprotective properties of ***:The findings showed that GBE effectively attenuated myocardial infarction by boosting the body’s natural antioxidant defense system and reducing the release of inflammatory cytokines as well as heart injury marker *** expression of Bcl-2,ERK1/2 and mTOR was increased while the histomorphological alterations were ***:The cardioprotective effects of GBE may be due to a mechanism involving increased Bcl-2/mTOR/ERK1/2/Na^(+),K^(+)-ATPase activity.

关键词： antioxidants extracellular signal-regulated kinase Ginkgo biloba extract isoprenaline mammalian target of rapamycin myocardial infarction Na^(+),K^(+)-ATPase

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Assessment of Heavy Metal Exposure in Soils of ihwrekreka Communities, Delta State, Nigeria

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Journal of Geoscience and Environment Protection 2024年第3期12卷 279-303页

作者： Adedoyin Olubunmi Bankole Akinyemi Olufemi Ogunkeyede Taofik Adewale Adedosu Uche Udeochu harrison Agboro Efe Jeffery isukuru Department of Environmental Management and Toxicology College of Science Federal University of Petroleum Resources Effurun Delta State Nigeria Department of Chemistry Faculty of Science Ladoke Akintola University Oyo State Nigeria Chemistry Program Division of Science and Mathematics College of Arts and Sciences University of the District of Columbia Washington District of Columbia USA Department of Biology and Environmental Science College of Arts and Sciences University of New Haven West Haven CT USA

Crude oil pollution in the Niger Delta, perpetrated by both local communities and industrial actors, has brought about soil pollution with its consequent ecological, human health and food challenges. The purpose of this research was to examine the concentration and distribution of heavy metals in soil from communities contaminated by crude oil in Niger Delta, and to evaluate the potential health risks to residents from exposure to these contaminants. To achieve this, soil samples were collected from the ihwrekreka community and analyzed for heavy metal content using inductively coupled plasma mass spectrometry (iCP-MS). The analytical results in mg/kg revealed a significant metals pollution level derived from the oil spill in the soil ranging from 4.85 - 17,078 (Cu), 1.01 - 16.1 (Cd), 0.22 - 36.8 (Cr), 8.28 - 40.9 (Ni), 7.51 - 6474 (Pb), and 8.84 - 12,851 (Zn) respectively. Most of the metals were above the permissible limits of World Health Organization, with Cu, Zn, and Pb as the most contaminating metals. Lead was found to be the main contributor to the hazard index (Hi) values for both children and adults in the study area, with its concentration exceeding the permitted limits set by the WHO and the EC. The hazard index (Hi) values of Pb, Cu, Zn, Cd, Ni, and Cr were significantly higher than 1. These findings suggest that the release of heavy metals from an oil-contaminated site may pose a risk to human health and the environment.

关键词： Cancer Exposure Pathway Toxic Metals Health Risks

A Cross-Sectional Study on the impact of Operation Triple Zero (OTZ) Program on Viral Load Suppression amongst Members of the Adolescent Club in 68 Nigerian Army Reference Hospital Yaba Lagos, Nigeria

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World Journal of AiDS 2024年第2期14卷 35-44页

作者： Nkechinyere harrison ismail Lawal Yakubu Adamu Kehinde Aribisala Adegbenga Olarinoye Uzoamaka Agbaim Funmilayo Owolabi Dooshima Okonkwo Laura Chittenden Nathan Okeji Centre for infectious Disease Clinic 68 Nigerian Army Reference Hospital Lagos Nigeria United States Army Medical Research Directorate-Africa Abuja Nigeria Henry Jackson Foundation Medical Research international LTD/GTE Abuja Nigeria Nigerian Ministry of Defence Health implementation Program Abuja Nigeria

Background: in Nigeria, adolescents and young people (AYP) aged 10 - 24, comprise 22.3% of the population and with HiV prevalence of 3.5%. The AYP living with HiV enrolled at the 68 NARHY, Lagos reflects the national challenges with poor viral suppression. The OTZ program aligns with the UNAiDS 95-95-95 goals. it seeks to empower AYPLHiV to be in charge of their treatment and commit to triple zero outcomeszero missed appointments, zero missed drugs, and zero viral loads. The purpose of the study was to assess the impact of the OTZ program on viral load suppression among members of the adolescent club in 68 NARHY, Lagos. Method: A cross-sectional retrospective study to evaluate the impact of the OTZ program on the viral load of 53 AYP enrolled in the OTZ program between March 2019 to December 2019 was analyzed. The Percentage of viral load suppression before enrollment compared with 6 and 12 months after enrollment into the OTZ program. The AYP is grouped into 10 - 14, 15 - 19, and 20 - 24 years. Activities conducted were peer driven monthly meetings with the AYP during which the adolescents interacted on issues relating to improving their treatment outcomes, healthcare workers reviewed their clinical status, viral load result, provider peer counseling, and caregivers engagement to support adherence to medication and ARV refills. Results: Before OTZ, 81% aged 10 - 14 years, 75% aged 15 - 19 years, and 25% aged 20 - 24 years were virally suppressed (VL less than 1000 copies/ml). Six months after enrollment, 94% were virally suppressed95% aged 10 - 14 years, 96% aged 15 - 19 years, and 66% aged 20-24 years. Twelve months after enrollment, 96% of AYP were virally suppressed100% aged 10-14 years, 93% aged 15 - 19 years, and 100% aged 20 - 24 years. Males viral load (VL) suppression improved from 79% to 96% and 92%, while females VL suppression improved from 69% to 93% and 100% at 6 and 12 months respectively. Conclusion: The OTZ activities contributed to improved viral l

关键词： impact Operation Triple Zero Adolescent Viral Load Nigeria

Air Quality Assessment of Ubeji Community near Petroleum-Related Activities

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Open Journal of Air Pollution 2024年第2期13卷 57-71页

作者： Adedoyin Olubunmi Bankole Akinyemi Olufemi Ogunkeyede Oluwafunmilayo Mary Haruna harrison Agboro Prince Alex Ekhorutomwen Osasenaga israel Otuomagie Christabel ifuwe Efe Jeffery isukuru Department of Environmental Management and Toxicology College of Science Federal University of Petroleum Resources Effurun Delta State Nigeria Department of Biology and Environmental Science College of Arts and Sciences University of New Haven West Haven USA Department of Surveying and Geoinformatics Faculty of Environmental Science Dennis Osadebay University Asaba Asaba Nigeria

The escalating global concern over air pollution requires rigorous investigations. This study assesses air quality near residential areas affected by petroleum-related activities in Ubeji Community, utilizing Aeroqual handheld mobile multi-gas monitors and air quality multi-meters. Air sampling occurred on three distinct days using multi-gas monitors and meters, covering parameters such as CO, NO2, CH4, NH3, VOCs, Particulate Matter, Temperature, Relative Humidity, and Air Quality index. Soil and plant samples were collected and analyzed for physicochemical and organic components. Air pollutant concentrations showed significant fluctuations. Carbon monoxide (CO) ranged from 0.00 to 3.22 ppm, NO2 from 0.00 to 0.10 ppm, CH4 from 4.00 to 2083 ppm, NH3 from 371 to 5086 ppm, and VOCs from 414 to 6135 ppm. Soil analysis revealed low total nitrogen, and undetected BTEX levels. Plant samples displayed a pH range of 7.72 to 9.45. CO concentrations, although below WHO limits, indicated potential vehicular and industrial influences. Fluctuations in NO2 and CH4 were linked to traffic, industrial activities, and gas flaring. NH3 levels suggested diverse pollution sources. The result in this study highlights the dynamic nature of air pollution in Ubeji community, emphasizing the urgent need for effective pollution control measures. Although CO concentrations were within limits, continuous monitoring is essential. Elevated NO2 levels gave information on the impact of industrial activities, while high CH4 concentrations may be associated with gas flaring and illegal refining. The study recommends comprehensive measures and collaborative efforts to address these complex issues, safeguarding both the environment and public health. This study shows the potential synergy between air quality sensors and plants for holistic environmental health assessments, offering valuable insights for environmental assessments and remediation endeavours. The findings call for stringent regulations and

关键词： Air Quality Assessment Bioindicators Ubeji Community Pollution Assessment

Heavy Metal Levels and Ecological Risk in Crude Oil-Contaminated Soils from Okpare-Olomu, Niger Delta, Nigeria

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Journal of Environmental Protection 2024年第4期15卷 415-438页

作者： Adedoyin Olubunmi Bankole Akinyemi Olufemi Ogunkeyede harrison Agboro Prince Alex Ekhorutomwen Osasenaga israel Otuomagie Khadijah Ateda isimekhai Ekaette Akpan Fadairo Efe Jeffery isukuru Department of Environmental Management and Toxicology College of Science Federal University of Petroleum Resources Effurun Nigeria Department of Biology and Environmental Science College of Arts and Sciences University of New Haven West Haven USA Department of Chemistry University of Abuja Abuja Nigeria Department of Science Laboratory Technology Petroleum Training Institute Effurun Nigeria

Crude oil spills have inflicted extensive disruption upon the Niger Delta ecosystem, resulting in crop loss and severe environmental damage. Such spills exacerbate heavy metal concentration within soil due to the presence of metallic ions. The Okpare-Olomu community has borne the brunt of crude oil pollution from illicit bunkering, sabotage, and equipment malfunction. This study targets an evaluation of ecological hazards linked to heavy metals (HMs) in crude oil impacted agriculturally soils within Okpare-Olomu in Ughelli South LGA of Delta State. in this study, 24 topsoil samples were obtained from areas affected by crude oil pollution;the heavy metal content was evaluated through atomic absorption spectrometry. The concentration ranges for HMs (mg/kg) in soil were: 24.1 - 23,174 (Cu);0.54 - 37.1 (Cd);9.05 - 54 (Cr);12 - 174 (Ni);18.5 - 8611 (Pb);and 148 - 9078 (Zn) at a soil depth of 0 - 15 cm. Notably, metal concentrations were recorded to be above permissible World Health Organization limits. Predominantly, Zn and Pb recorded higher heavy metal concentration when compared to other heavy metals analysed, notably at sampling points PT7 through PT24. Zinc and Pb contamination exhibited highly significant contamination factors, and contamination severity was evidenced across all sample points, signifying a grave risk level. Pollution load indices indicated pervasive extreme pollution levels. Geoaccumulation indices signaled moderate to strong pollution, mainly by Pb and Zn. Ecological risk assessments revealed variable levels of heavy metal contamination, from low to very high, with potential ecological risk reflecting markedly elevated levels. This study underscores the imperative for soil remediation to rectify ecological imbalances in agriculturally affected soil constituents.

关键词： Heavy Metals Crude Oil Pollution Degree of Contamination Potential Risk index

New insight into the phylogenetic and biogeographic history of genus Ficus:Vicariance played a relatively minor role compared with ecological opportunity and dispersal

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Journal of Systematics and Evolution 2011年第6期49卷 546-557页

作者： Rhett D.harrison Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences

Studies on the evolution of tropical taxa emphasize the role of vicariance and the break-up of Gondwana in explaining modern *** studies on figs(Ficus spp.)support this *** the current study,we used an expanded sample(208 spp.)and improved molecular dating techniques to reconstruct the phylogenetic and biogeographic history of *** with previous studies,our biogeographic analysis indicated that the ancestor of Ficus was present in ***,a relaxed clock analysis relying on uncorrelated rates in BEAST suggested that the Neotropical section Pharmacosycea split-off in South America 86.67 Mya,and that other Ficus lineage ancestors originated in *** of the basal lineages appeared to have diverged following KT extinction,then rapidly diversified after india collided with continental *** Afrotropical species most likely evolved initially in the indian subcontinent then dispersed to Africa,either in the late Cretaceous of Madagascar or even later,following the Eocene collision of india with *** Neotropical section Americana,either islandhopped to South America or took a northern route to the Americas through Europe prior to the terminal Eocene global cooling *** may have arrived in eastern Malesia following the collision of india with Asia,then widely dispersed *** the wide ranges in our date estimates,several other scenarios are ***,contrary to earlier reports,our analyses suggest that vicariance played a relatively minor role compared with ecological opportunity and dispersal in the diversification of genus Ficus.

关键词： biogeographic history evolution Ficus molecular phylogeny vicariance.

Long‑term outcomes of two first‑generation trabecular micro‑bypass stents(iStent)with phacoemulsification in primary open‑angle glaucoma:eight‑year results

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Eye and Vision 2021年第4期8卷 431-442页

作者： Ali Salimi.harrison Watt Paul Harasymowycz Department of Ophthalmology Faculty of MedicineMcGill UniversityMontrealQCCanada Montreal Glaucoma institute MontrealQCCanada Faculty of Medicine McGill UniversityMontrealQCCanada Department of Ophthalmology University of Montreal4135 de RouenMontrealQC H1V1G5Canada

Background:The short-and medium-term outcomes of iStent have been extensively studied;however,only few studies have investigated its long-term ***,we assessed the long-term efficacy and safety of two iStents with concomitant cataract surgery in glaucomatous eyes while also evaluating measures of disease stability using visual field and optical coherence tomography(OCT)of the optic nerve and the macula throughout 8 years of ***:This longitudinal,single-center consecutive case series included glaucomatous eyes that underwent implantation of two first-generation trabecular micro-bypass stents(iStent)with concomitant cataract ***-year efficacy outcomes included mean intraocular pressure(iOP)and medications,as well as surgical ***-year safety outcomes included best-corrected visual acuity(BCVA),visual field mean deviation(VF-MD),cup-todisc ratio(CDR),retinal nerve fiber layer(RNFL)thickness,ganglion cell-inner plexiform layer(GC-iPL)thickness,and adverse ***:A total of 62 eyes with primary open-angle glaucoma(POAG)were *** 8 years postoperative,iOP reduced by 26%from 19.2±3.9 mmHg preoperatively to 14.2±2.4 mmHg(Pieved iOP≤18 mmHg(vs.51.6%preoperatively),69.6%of eyes achieved iOP≤15 mmHg(vs.14.5%preoperatively),and 25%of eyes achieved iOP≤12 mmHg(vs.1.6%preoperatively).Medication use decreased by 17.9%from 2.8±1.1 preoperatively to 2.3±1.2(P=0.018).Surgical success was 90%,as six eyes underwent subsequent glaucoma *** measures of BCVA,CDR,RNFL thickness and GC-iPL thickness remained stable through 8 years ***-MD remained stable until postoperative year 5 and subsequently progressed according to the natural history of glaucomatous ***:implantation of two iStents with concomitant cataract surgery is an effective and safe treatment option for surgery-naïve POAG eyes,evidenced by significant iOP and medication reductions,reasonable surgical success

关键词： Minimally invasive glaucoma surgery MiGS Trabecular micro-bypass stent iStent Glaucoma Cataract surgery Long-term outcomes