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Concordance among pulse wave velocity assessment methods: A network meta-analysis

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中华医学杂志(英文版) 2024年第17期137卷 2137-2139页

作者： Cavero-Redondo iván Sequí-domínguez irene Saz-Lara Alicia Garcia-Klepzig Jose Luis Lucerón-Lucas-torres Maribel Martínez-García irene álvarez-Bueno Celia Martínez-vizcaíno vicente CarvasCare Research Group Facultad de Enfermería de Cuenca Universidad de Castilla-La Mancha Cuenca Spain Facultad de Ciencias de la Salud Universidad Autónoma de Chile Talca Chile Health and Social Research Center Universidad de Castilla-La Mancha Cuenca Spain internal Medicine Department San Carlos University Hospital Madrid Spain Universidad Politécnica y Artística del Paraguay Asunción Paraguay

Microbial phenolic metabolites are associated with better frontal lobe cognition

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Food Science and Human Wellness 2024年

作者： inés domínguez-López isabella Parilli-Moser Anna vallverdú-Queralt Anna tresserra-Rimbau Cinta valls-Pedret Zenaida vázquez-Ruiz Olga Casta?er Ramon Estruch Emili Ros Rosa M.Lamuela-Raventós Lipid Clinic， Endocrinology and Nutrition Service， institut d'investigacions Biomèdiques August Pi i Sunyer， Hospital Clínic 08036 Barcelona， Spain Unit of Cardiovascular Risk and Nutrition， institut Hospital del Mar de investigaciones Médicas (iMiM) Department of Preventive Medicine and Public Health， University of Navarra Departament de Nutrició， Ciències de l'Alimentació i Gastronomía， Facultat de Farmacia， Universitat de Barcelon (UB)， Av.de Joan XXii Department of Endocrinology， Hospital Clinic IDIBAPS， Barcelona， Spain Department of internal Medicine， Hospital Clinic， institut d'investigació Biomèdica August Pi i Sunyer (iDiBAPS)， University of Barcelona CiBER Fisiopatología de la Obesidad y Nutrición (CiBEROBN)， instituto de Salud Carlos iii institut de Nutrició i Seguretat Alimentària (iNSA)， Universitat de Barcelona (UB)

With increasing life expectancy， neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. Preventive strategies include following healthy diets， such as the Mediterranean diet， which is particularly rich in polyphenols， bioactive compounds with neuroprotective properties. the aim of this study was to assess the association of microbial phenolic metabolites (MPM) with cognition. this cross-sectional analysis was performed with 200 participants of the PREDiMED trial (Barcelona-Clinic recruitment center). A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM (protocatechuic acid， enterodiol glucuronide， enterolactone glucuronide， urolithin B glucuronide， and vanillic acid glucuronide)， and cognitive function was evaluated with neuropsychological tests. Multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and MPM， and a score was calculated as the weighted sum of MPM. A higher MPM score was associated with better frontal lobe function. Among individual metabolites， vanillic acid glucuronide was correlated with frontal cognitive performance. Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color trail test part 2. A higher score for urinary multi-MPM was associated with better frontal cognitive performance in an older Mediterranean population.

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Pig Reproductive and Respiratory Syndrome virus (PRRSv) Does Not Attach to Boar Sperm;it Affects Only the velocity Pattern and the Mobility Pattern

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Journal of Biosciences and Medicines 2024年第4期12卷 216-228页

作者： Néstor Méndez Palacios Netzi Naidí Mendez Palacios Felicitas vázquez Flores José Alfredo Galicia domínguez Edgar Guadalupe Beltrán Rosas Maximino Méndez Mendoza Facultad de Medicina veterinaria and Zootecnia-Benemé rita Universidad Aut&#243noma de Puebla Puebla Mexico independent Advisor in the Porcine Area Puebla Mexico

the purpose of the study was to evaluate the sperm viability of semen infected with PRRSv viral particles, observing the effect of the virus on the motility of boar sperm. the work was carried out at the FMvZ-BUAP Genetics and Reproduction Laboratory. 5 stallions were used. Each sample contained 1 × 106 sperm, the PRRS virus strain was AtCC-vR-2332 (0, 102, 104 and 106 copies of RNA/mL in triplicate), it was observed daily at the CASA;Hamilton thorne®. Cells with Mt (P valuation with 201 ± 7.3, 167 ± 10.1, 165 ± 14.6, 134 ± 8.2 and 120 ± 8.8, respectively. the % MP between control and virus concentrations (P ≥ 0.05). the LCv on day 1 and 7 Pi at 10X2 and 10X6 (P vs control. in the Correlation Matrix, where it is observed that there is a correlation between vSL and vAP, vSL and vCL, vCL and ALH, vAP with ALH. there is a correlation of vSL and ALH, StR and ALH. in this study there were (P ≤ 0.01) in the vCL, in the concentrations (102) 162.81 ± 10.65 and (106) 177.12 ± 5.77 vs 193.04 ± 4.62 of control. this indicates that altering these parameters would be related to fertility and the PRRS virus affects the LCv. Regarding the vSL, it was observed that the sperm infected with viruses 102, 104 and 106 of 48.00 ± 3.38, 49.88 ± 1.83 and 50.55 ± 2.24 vs. 56.66 ± 1.68 of control respectively, the control would have greater possibilities of fertilizing the oocyte. in this study, it was found (P ≤ 0.01) in the vAP with 102 of 77.26 ± 5.16, 104 with 83.35 ± 2.41 and 106 with 81.29 ± 3.14 vs the control with 90.56 ± 2.07. Regarding the ALH there is (P 4 with 8.70 ± .26 and 106 with 9.64 ± 0.23 vs control 8.50 ± 0.27. the presence of different concentrations of PRRSv in boar semen induces changes in different types of sperm motility. infection of ej

关键词： PRRSv Boar Sperms velocity Pattern and Mobility Pattern

A confined growth strategy to construct 3dom SiO_(2) nanoreactor insitu embedded Co_(3)O_(4) nanoparticles catalyst for the catalytic combustion of vOCs:Superior H_(2)O and SO_(2) resistance

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Nano Research 2024年第1期17卷 207-220页

作者： Weigao Han Shilin Wu Fang dong Weiliang Han Yinghao Chu Linghui Su Zhicheng tang State Key Laboratory for Oxo Synthesis and Selective Oxidation National Engineering Research Center for Fine Petrochemical IntermediatesLanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Dalian National Laboratory for Clean Energy Dalian 116023China College of Architecture and Environment Sichuan UniversityChengdu 610000China

SO_(2)poisoning is a common problem in the catalytic combustion of volatile organic compounds(vOCs).in this work,we took three-dimensionally ordered macroporous and mesoporous(3dom)SiO_(2)as the nanoreactor to protect active sites from SO_(2)erosion in the catalytic combustion of ***,the confined growth of metal active nanoparticles in the multi-stage pore is also full of *** we successfully confined Co_(3)O_(4)nanoparticles(NPs)in macroporous and mesoporous ***,the precursors’growth in the pore was controlled and nanoreactors with different pore sizes were prepared by adjusting the loading amount and preparation *** is discovered that the Co_(3)O_(4)NPs confined in 3dom SiO_(2)nanoreactor showed superior sulfur and water *** functional theory(DFt)calculations verified that the Co-Si catalyst had high SO_(2)adsorption energy(-0.48 ev),which illustrated that SO_(2)was hard to attach to the surface of the Co-Si *** SiO_(2)nanoreactor had low SO_(2)adsorption energy(-5.15 ev),which indicated that SO_(2)was easily absorbed on SiO_(2)*** illustrated that the SiO_(2)nanoreactor could protect effectively active sites from SO_(2)erosion.

关键词： zeolitic imidazolate frameworks(ZiFs) Co_(3)O_(4) benzene catalytic combustion nanoreactor sulfur and water resistance

Behavior of ductile steel X-braced RC frames in seismic zones

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Earthquake Engineering and Engineering vibration 2019年第4期18卷 845-869页

作者： Eber Alberto Godínez-domínguez Arturo tena-Colunga Facultad de ingeniería Universidad Autónoma de Chiapas Tuxtla Gutiérrez 29050 Mexico Departamento de Materiales Universidad Autónoma Metropolitana México City 02200 Mexico

A satisfactory ductile performance of moment-resisting reinforced concrete concentric braced frame structures (RC-MRCBFs) is not warranted by only following the provisions proposed in Mexico’s Federal District Code (MFDC-04). the nonlinear behavior of low to medium rise ductile RC-MRCBFs using steel X-bracing susceptible to buckling is evaluated in this study. the height of the studied structures ranges from 4 to 20 stories and they were located for design in the lakebed zone of Mexico City. the design of RC-MRCBFs was carried out considering variable contribution of the two main lines of defense of the dual system (RC columns and steel braces). in order to observe the principal elements responsible for dissipating the earthquake input energy, yielding mappings for diff erent load-steps were obtained using both nonlinear static and dynamic analyses. Some design parameters currently proposed in MFDC-04 as global ductility capacities, overstrength reduction factors and story drifts corresponding to diff erent limit states were assessed as a function of both the considered shear strength and slenderness ratios for the studied RC-MRCBFs using pushover analyses. Additionally, envelopes of response maxima of dynamic parameters were obtained from the story and global hysteresis curves. Finally, a brief discussion regarding residual drifts, residual drift ratios, mappings of residual deformations in steel braces and residual rotations in RC beams and columns is presented. From the analysis of the obtained results, it is concluded that when a suitable design criterion is considered, good structural behavior of RC-MRCBFs with steel-X bracing can be obtained. it is also observed that the shear strength balance has an impact in the height-wise distribution of residual drifts, and an important “shake-down” eff ect is obtained for all cases. there is a need to improve design parameters currently proposed in MFDC to promote an adequate seismic performance of RC-MRCBFs.

关键词： RC braced-frames seismic design nonlinear dynamic analyses steel-X bracing overstrength collapse mechanism story drifts residual drifts

Common interacting genetic variation shapes susceptibility to type 1 diabetes in a Colombian Caribbean community:in search of shared genetic markers

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Genes & Diseases 2024年第4期11卷 106-108页

作者： Gloria Garavito-De Egea Alex dominguez-vargas Jorg e l.velez Gustavo Aroca Luis Fagng Elkin Navarro-Quiroz Zilac Espitaleta Kenny Del toro-Camargo Leticia Martinez-Ariza tatiana Gonzalez-vargas Susana Garcia Mauricio Arcos-Burgos Eduardo Egea Universidad del Norte Division Ciencias de la SaludBarranquillaColombia Universidad Simon Bolivar Facultad de Ciencias de la SaludBarranquillaColombia Clinica de la Costa Grupo de Investigacion en NefrologiaBarranquillaColombia Universidad de Antioquia Grupo de Investigacion en Psiquiatria(GIPSI)Departamento de PsiquiatriaInstituto de Investigaciones MedicasFacultad de MedicinaMedellinColombia

Genome-wide association studies(GWASs)have identified hundreds of loci across the human genome conferring susceptibility to autoimmune diseases(AiDs),some of which are shared between more than two ***,this univariate ... 详细信息

关键词： susceptibility diseases diabetes

Proper progression of neurogenesis relies on a defined pattern of SUMO-modified proteins

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Neural Regeneration Research 2022年第8期17卷 1731-1732页

作者： Mario García-domínguez Andalusian Centre for Molecular Biology and Regenerative Medicine-CABiMER CSiC-Universidad de Sevilla-Universidad Pablo de Olavide SevilleSpain

Neurogenesis is a complex process involving the orchestration of many transcription factors and other *** regulation of their activities is crucial for proper progression of neurogenesis.A few decades ago,covalent attachment of Small Ubiquitin-like MOdifier(SUMO)to other proteins was revealed as a major regulator of protein activities,constituting an essential posttranslational modification system in *** then,hundreds of proteins have been shown to be targets of SUMO,which is implicated in controlling many relevant processes in eukaryotic *** include the development and function of the nervous system,with SUMO tightly linked to synapsis and to neurodegenerative diseases(Yau et al.,2020).the SUMO protease SENP7 has been involved in neurogenesis(Juárez-vicente et al.,2016),while sumoylation of BRAF35,a subunit of the LSD1 histone demethylase complex,assures the undifferentiated state of neural progenitors(Ceballos-Chávez et al.,2012).in addition,increased sumoylation in mouse brain-derived neural stem cells results in enhanced neuronal differentiation(Bernstock et al.,2019).

关键词： pattern diseases

the detrimental effects of lipopolysaccharideinduced neuroinflammation on adult hippocampal neurogenesis depend on the duration of the pro-inflammatory response

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Neural Regeneration Research 2019年第5期14卷 817-825页

作者： Martha Pérez-domínguez Evangelina ávila-Mu?oz Eduardo domínguez-Rivas Angélica Zepeda Departamento de Medicina Genómica y toxicología Ambiental Instituto de Investigaciones Biomédicas.Universidad Nacional Autónoma de MéxicoCDMX

Adult hippocampal neurogenesis is a finely tuned process regulated by extrinsic factors. Neuroinflammation is a hallmark of several pathological conditions underlying dysregulation of neurogenesis. in animal models, lipopolysaccharide(LPS)-induced neuroinflammation leads to a neurogenic decrease mainly associated to the early inflammatory response. However, it is not well understood how the neuroinflammatory response progresses over time and if neurogenesis continues to be diminished during the late neuroinflammatory response. Moreover, it is unknown if repeated intermittent administration of LPS along time induces a greater reduction in neurogenesis. We administered one single intraperitoneal injection of LPS or saline or four repeated injections(one per week) of LPS or saline to young-adult mice. A cohort of new cells was labeled with three 5-bromo-2-deoxyuridine injections(one per day) 4 days after the last LPS injection. We evaluated systemic and neuroinflammation-associated parameters and compared the effects of the late neuroinflammatory response on neurogenesis induced by each protocol. Our results show that 1) a single LPS injection leads to a late pro-inflammatory response characterized by microglial activation, moderate astrocytic reaction and increased interleukin-6 levels. this response correlates in time with decreased neurogenesis and 2) a repeated intermittent injection of LPS does not elicit a late pro-inflammatory response although activated microglia persists. the latter profile is not accompanied by a continued longterm hippocampal neurogenic decrease. Hereby, we provide evidence that the neuroinflammatory response is a dynamic process that progresses in a milieu-dependent manner and does not necessarily lead to a neurogenic decrease, highlighting the complex interaction between the immune system and neurogenesis.

关键词： dentate gyrus subgranular zone inflammation microglia astrocytes iL-6 cytokines cell proliferation neural progenitor cells immature neurons long-term short-term adult hippocampal neurogenesis

Fully integrated and broadband Si-rich silicon nitride wavelength converter based on Bragg scattering intermodal four-wave mixing

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Photonics Research 2024年第3期12卷 I0001-I0010页

作者： vALERiO vitALi tHALÍA domÍnguez BUCiO HAO LiU JOSÉMANUEL LUQUE GONZÁLEZ FRANCiSCO JURADO-ROMERO ALEJANDRO ORtEGA-MOÑUX GLENN CHURCHiLL JAMES C.GAtES JAMES HiLLiER NiKOLAOS KALFAGiANNiS DANiELE MELAti JENS H.SCHMiD iLARiA CRiStiANi PAvEL CHEBEN J.GONZALO WANGÜEMERt-PÉREZ ÑiGO MOLiNA-FERNÁNDEZ FREDERiC GARDES COSiMO LACAvA PERiKLiS PEtROPOULOS Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Electrical Computer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy telecommunication Research institute(tELMA) Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain School of Science and technology Nottingham Trent UniversityNottingham NG118NSUK Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands Department of Materials Science and Engineering University of IoanninaIoannina 45110Greece Centre de Nanosciences et de Nanotechnologies UniversitéParis-SaclayCNRS91120 PalaiseauFrance Advanced Electronics and Photonics Research Center National Research Council CanadaOttawaOntario K1A 0R6Canada

intermodal four-wave mixing(FWM)processes have recently attracted significant interest for all-optical signal processing applications thanks to the possibility to control the propagation properties of waves exciting distinct spatial modes of the same *** allows,in principle,to place signals in different spectral regions and satisfy the phase matching condition over considerably larger bandwidths compared to intramodal ***,the demonstrations reported so far have shown a limited bandwidth and suffered from the lack of on-chip components designed for broadband manipulation of different *** demonstrate here a silicon-rich silicon nitride wavelength converter based on Bragg scattering intermodal FWM,which integrates mode conversion,multiplexing and de-multiplexing functionalities *** system enables wavelength conversion between pump waves and a signal located in different telecommunication bands(separated by 60 nm)with a 3 dB bandwidth exceeding 70 nm,which represents,to our knowledge,the widest bandwidth ever achieved in an intermodal FWM-based system.

关键词： scattering pump modal