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Stromal and Tumor Glioma-derived Cells with Similar Characteristics Have Differences in α-Smooth Muscle Actin Expression and Localization

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Journal of Oncology Research 2021年第2期3卷 8-21页

作者： i.Gin i.chistyakova V.Zenin S.Koshkin A.Musorina Y.Lahina G.Timin V.Pospelov S.Prikhodko A.Petukhov E.Tolkunova institute of Cytology Russian Academy of SciencesSt.Petersburg194064Russia Almazov National Medical Research Centre St.Petersburg197341Russia Peter the Great Saint-Petersburg Polytechnic University St.Petersburg195251Russia Scientific Technological University«Sirius» Sochi354340Russia

Gliomas are solid brain tumors composed of tumor cells and recruited heterogenic stromal *** study of the interactions between the perivascular niche and its surrounding cells is of great value in unraveling mechanisms of drug resistance in malignant *** this study,we isolated the stromal diploid cell population from oligodendroglioma and a mixed population of tumor aneuploid and stromal diploid cells from astrocytoma *** stromal cells expressed neural stem/progenitor and mesenchymal markers showing the same discordant phenotype that is typical for glioma ***,some of the stromal cells expressed *** the first time,we demonstrated that this type of stromal cells had the typical myofibroblastic phenotype as theα-SMA+cells formedα-SMA fibers and exhibited the specific function to deposit extracellular matrix(ECM)proteins at least in *** analysis showed diffuse or focalα-SMA staining in the cytoplasm of the astrocytoma-derived,A172,T98G,and U251MG glioma *** could suggest thatα-SMA may be one of the main molecules,bearing protective *** mechanisms and consequences ofα-SMA disruptions in gliomas are discussed.

关键词： Oligodendroglioma Astrocytoma Primary cell cultures Tumor microenvironment Myofibroblasts Extracellular matrix

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Augustinian Understanding of Human Freedom and the Divine Predestination as the Phenomenon of the Medieval Culture

Augustinian Understanding of Human Freedom and the Divine Pr...

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作者： Olga chistyakova Department of History of Philosophy Faculty of Humanities and Social Sciences Peoples' Friendship University of Russia

The author considers the important problem of the Medieval culture relating to the interrelation between human freedom and divine predestination. This theoretical issue is presented throughout the history of Christianity but it was revealed and most actively discussed at the period of Patristics when the Western and the Eastern Church Fathers were elaborating the Christian creed. This paper focuses on the philosophical and theological doctrine of Augustine of Hippo about human's freedom and God's predestination stressing that thereafter the Augustinian viewpoint has been determining the evaluation of Western Christianity. At the same time, it also analyzes Augustine's point of view representing Western Patristics with the corresponding teaching of Eastern Patristics. Special attention is paid to the difference in understanding the role and importance of man in the relationship between personal freedom and the divine predestination.

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On solvability of singular systems of quasilinear integro-diferential equations

On solvability of singular systems of quasilinear integro-di...

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2010 Chinese Control and Decision Conference

作者： Elena V.chistyakova Victor F.Chistyakov Milimir R.Pjescic Dragutin Lj.Debeljkovic institute of system dynamics and control theory Siberian branch Russian academy of sciences IrkutskRussia

＜正＞General form of singular systems represented as a first order of quasilinear integro-differential first order vector equations is *** theorem of existence is proved and a numerical method of solution is proposed.

关键词： singular integro-differential-algebraic matrix pencil

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