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Evolution of Viral Load in Patients infected with HiV-1 at Point G University Hospital

Open Journal of Medical Microbiology 2024年第1期14卷 66-76页

作者： A. Maiga D. Kone D. M. Coulibaly Ag M. Baraika A. Traore S. S. Diakite i. i. Maiga i. Konate A. i. Maiga Faculty of Medicine and Odontostomatology of Bamako (FMOS) University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of Medical Biology and Hospital Hygiene of Point-G University Hospital Bamako Mali Faculty of Pharmacy of Bamako (FaPh) University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of the Luxembourg Mother-Child Hospital Bamako Mali National institute of Public Health Bamako Mali National institute for Training in Health Sciences Bamako Mali Laboratory of the Kati University Hospital Center Bamako Mali infectious and Tropical Diseases Department of Point-G University Hospital Bamako Mali Laboratory of CHU Gabriel Touré Bamako Mali

introduction: HiV, the human immunodeficiency virus, is the etiological agent of acquired immunodeficiency syndrome (AiDS). The aim of this study was to assess the evolution of the viral load in patients under treatment. Methodology: This was a study carried out from July 2017 to June 2022 at the Point G University Hospital laboratory. The determination of the viral load of patients was carried out by PCR on the ABOTT M2000sp/rt platform. Results: A total of 129 patients infected with HiV-1, aged 19 to 72 years with a mean age of 40.05 years ± 10.71;all on antiretroviral chemotherapy. The female gender predominated among our patients. The most common treatment regimen was 2iNTi + 1iNNTi with 72.9% followed by 2iNTi + 1iNi with 13.2%. As for the combinations of molecules, the combination TDF + 3TC + EFV and TDF + 3TC + DTG predominated, respectively 65.1% and 13.2%. 89.9% of our patients had undetectable viremia after 12 months of treatment (p ith an average viral load which had evolved from 681315.65 copies/ml ± 1616908.484 to M0 at 5742.36 copies /ml ± 35756.883 at M12 (p Conclusion: Generally speaking, antiretroviral treatment had contributed to controlling viral loads, however the therapeutic combination TDF + 3TC + DTG had made it possible to obtain more patients with undetectable viremia instead.

关键词： HiV-1 Treatment Viral Load Point G University Hospital

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Harnessing the power of complex light propagation in multimode fibers for spatially resolved sensing

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Photonics Research 2024年第3期12卷 411-422页

作者： DARCY L.SMiTH LiNH V.NGUYEN MOHAMMAD i.REJA ERiK P.SCHARTNER HEiKE EBENDORFF-HEiDEPRiEM DAViD J.OTTAWAY STEPHEN C.WARREN-SMiTH institute for Photonics and Advanced Sensing and School of Physics Chemistry and Earth SciencesThe University of AdelaideAdelaideSA 5005Australia Australian Research Council Centre of Excellence for Gravitational Wave Discovery(OzGrav) AdelaideSAAustralia Future industries institute University of South AustraliaMawson LakesSA 5095Australia Laser Physics and Photonics Devices Laboratory University of South AustraliaMawson LakesSA 5095Australia

The propagation of coherent light in multimode optical fibers results in a speckled output that is both complex and sensitive to environmental *** properties can be a powerful tool for sensing,as small perturbations lead to significant changes in the output of the ***,the mechanism to encode spatially resolved sensing information into the speckle pattern and the ability to extract this information are thus far *** this paper,we demonstrate that spatially dependent mode coupling is crucial to achieving spatially resolved *** leverage machine learning to quantitatively extract the spatially resolved sensing information from three fiber types with dramatically different characteristics and demonstrate that the fiber with the highest degree of spatially dependent mode coupling provides the greatest accuracy.

关键词： fiber spatially resolved

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Nanomotion of bacteria to determine metabolic profile

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Nanotechnology and Precision Engineering 2024年第1期7卷 1-9页

作者： S.N.Pleskova E.V.Lazarenko N.A.Bezrukov R.N.Kriukov A.V.Boryakov M.E.Dokukin S.i.Surodin Research Laboratory of Scanning Probe Microscopy Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Department of Nanotechnology and Biotechnology Nizhny Novgorod State Technical University n.a.R.E.AlekseevNizhny Novgorod 603950Russia Sarov Physics and Technology institute National Research Nuclear University MEPhISarov 607186Russia

in addition to their visible motion such as swimming(e.g.,with the help ofﬂagella),bacteria can also exhibit nanomotion that is detectable only with highly sensitive instruments,and this study shows that it is possible to detect bacterial nanomotion using an AFM detection *** results show that the nanomotion characteristics depend on the bacterial strain,and that nanomotion can be used to sense the metabolic activity of bacteria because the oscillations are sensitive to the food preferences of the bacteria and the type of surrounding medium.

关键词： Nanomotion Bacteria Cantilever Oscillation Atomic force microscopy Metabolism

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Physico−mathematical model of the voltage−current characteristics of light-emitting diodes with quantum wells based on the Sah−Noyce−Shockley recombination mechanism

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Journal of Semiconductors 2024年第8期45卷 25-33页

作者： Fedor i.Manyakhin Dmitry O.Varlamov Vladimir P.Krylov Lyudmila O.Morketsova Arkady A.Skvortsov Vladimir K.Nikolaev Dinamics Strength of Machines and Resisance of MaterialsMoscow Polytechnic UniversityRussia Biomedical and Electronic Means and Technologies Vladimir State UniversityRussia Computer-Aided Design and Engineering National University of Science and Technology"MISiS"Russia

Herein,a physical and mathematical model of the voltage−current characteristics of a p−n heterostructure with quantum wells(QWs)is prepared using the Sah−Noyce−Shockley(SNS)recombination mechanism to show the SNS recombination rate of the correction function of the distribution of QWs in the space charge region of diode configuration.A comparison of the model voltage−current characteristics(VCCs)with the experimental ones reveals their *** technological parameters of the structure of the VCC model are determined experimentally using a nondestructive capacitive approach for determining the impurity distribution profile in the active region of the diode structure with a profile depth resolution of up to 10Å.The correction function in the expression of the recombination rate shows the possibility of determining the derivative of the VCCs of structures with QWs with a nonideality factor of up to 4.

关键词： light-emitting diodes with quantum wells voltage−current relation nonideality factor recombination mechanism Sah−Noyce−Shockley model

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interaction of edge dislocations with voids in tungsten

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Tungsten 2024年第3期6卷 633-646页

作者： Arseny Kazakov Rita i.Babicheva Aleksandr Zinovev Dmitry Terentyev Kun Zhou Elena A.Korznikova Sergey V.Dmitriev Research Laboratory for Metals and Alloys under Extreme impacts Ufa University of Science and Technology institute for Metals Superplasticity Problems of RAS School of Mechanical and Aerospace Engineering Nanyang Technological University institute for Nuclear Energy Technology Belgian Nuclear Research Center Technological Machines and Equipment Department Ufa State Petroleum Technological University institute of Mechanical Science Problems of RAS institute of Molecule and Crystal Physics UFRC of Russian Academy of Sciences

Tungsten is widely used as a material capable of withstanding extreme operating conditions and is one of the candidates for use in fusion and Generation Ⅳ fission *** modelling implemented to solve various material science problems is an indispensable approach for improving material *** work analyzes the interaction of an edge dislocation with a void in single-crystal tungsten with the help of molecular dynamics *** different approaches for studying the dynamics of dislocations in tungsten that differ in boundary conditions are *** interactions of the dislocation and void at different temperatures are investigated,and based on the obtained stress-strain curves,the dislocation obstacle strength for voids having various diameters is *** is shown that when applied to a crystal with small voids,the model with the fixed boundary conditions returns incorrect ***,the influence of the cell size for the model with periodic boundary conditions is analyzed,and the case of a non-central interaction of a dislocation with a void is *** obtained results improve our understanding of the mechanical response of irradiated materials.

关键词： Tungsten Molecular dynamics method Dislocations Voids Boundary conditions

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influence of donor age on liver transplantation outcomes: A multivariate analysis and comparative study

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 331-344页

作者： Miran Bezjak ivan Stresec Branislav Kocman Stipislav Jadrijević Tajana Filipec Kanizaj Miro Antonijević Bojana Dalbelo Bašić Danko Mikulić Department of Surgery University Hospital MerkurZagreb 10000Croatia Department of Electronics MicroelectronicsComputer and Intelligent SystemsFaculty of Electrical Engineering and ComputingZagreb 10000Croatia Department of Gastroenterology University Hospital MerkurZagreb 10000Croatia Development of Software Nanobit Ltd.Zagreb 10000Croatia

BACKGROUND The growing disparity between the rising demand for liver transplantation(LT)and the limited availability of donor organs has prompted a greater reliance on older liver ***,utilizing livers from elderly donors has been associated with outcomes inferior to those achieved with grafts from younger *** accounting for additional risk factors,we hypothesize that the utili-zation of older liver grafts has a relatively minor impact on both patient survival and graft *** To evaluate the impact of donor age on LT outcomes using multivariate analysis and comparing young and elderly donor *** in the period from April 2013 to December 2018,656 adult liver transplants were performed at the University Hospital *** multivariate Cox propor-tional hazards models were developed to independently assess the significance of donor *** age was treated as a continuous *** approach involved univariate and multivariate analysis,including variable selection and assessment of interactions and ***,to exemplify the similarity of using young and old donor liver grafts,the group of 87 recipients of elderly donor liver grafts(≥75 years)was compared to a group of 124 recipients of young liver grafts(≤45 years)from the *** rates of the two groups were estimated using the Kaplan-Meier method and the log-rank test was used to test the differences between *** Using multivariate Cox analysis,we found no statistical significance in the role of donor age within the constructed *** when retained during the entire model development,the donor age's impact on survival remained insignificant and transformations and interactions yielded no substantial effects on *** insigni-ficance and low coefficient values suggest that donor age does not impact patient survival in our ***,there was no statistical evidence that the five developed models did not adhe

关键词： Liver transplantation Elderly donors Survival analysis Postoperative complications Cox proportional hazard models

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Lithium-Metal Free Sulfur Battery Based on Waste Biomass Anode and Nano-Sized Li2S Cathode

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Energy & Environmental Materials 2024年第2期7卷 43-51页

作者： Pejman Salimi Eleonora Venezia Somayeh Taghaνi Sebastiano Tieuli Lorenzo Carbone Mirko Prato Michela Signoretto Jianfeng Qiu Remo Proietti Zaccaria istituto italiano di Tecnologia Department of Chemistry and industrial Chemistry University of Genova CATMAT Lab Department of Molecular Sciences and Nanosystems Ca’ Foscari University Venice and INSTM Consortium Department of Physics Shaoxing University

The realization of a stable lithium-metal free（LiMF） sulfur battery based on amorphous carbon anode and lithium sulfide（Li2S） cathode is here *** particular,a biomass waste originating full-cell combining a carbonized brewer's spent grain（CBSG） biochar anode with a Li2S-graphene composite cathode（Li2S70Gr30） is *** design is particularly attractive for applying a cost-effective,high performance,environment friendly,and safe anode material,as an alternative to standard graphite and metallic lithium in emerging battery *** anodic and cathodic materials are characterized in terms of structure,morphology and composition through Xray diffraction,scanning and transmission electron microscopy,X-ray photoelectron and Raman ***,an electrochemical characterization comprising galvanostatic cycling,rate capability and cyclic voltammetry tests were carried out both in half-cell and full-cell *** systematic investigation reveals that unlike graphite,the biochar electrode displays good compatibility with the electrolyte typically employed in sulfur *** CBSG/Li2S70Gr30 full-cell demonstrates an initial charge and discharge capacities of 726 and 537 mAh g-1,respectively,at 0.05C with a coulombic efficiency of 74%.Moreover,it discloses a reversible capacity of 330 mAh g-1（0.1 C） after over 300 *** on these achievements,the CBSG/Li2S70Gr30 battery system can be considered as a promising energy storage solution for electric vehicles（EVs）,especially when taking into account its easy scalability to an industrial level.

关键词： biochars ether-based electrolytes lithium sulfide lithium-metal free batteries superior cycling stability

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Genotypic effects on accelerated propagation of oil palm breeding materials selected(Elaeis guineensis jacq.)using somatic embryogenesis

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Oil Crop Science 2024年第2期9卷 111-120页

作者： Retno Puji Astari Mohammad Basyuni Luthfi A.M. Siregar Revandy i.M. Damanike Deni Arifiyanto Dadang Affandi indra Syahputra Doctoral Program of Agricultural Sciences Faculty of AgricultureUniversitas Sumatera UtaraMedan20155North SumatraIndonesia PT.Socfin indonesia Jl.K.L.Yos Sudarso No.106Medan20244North SumatraIndonesia Department of Forestry Faculty of ForestryUniversitas Sumatera UtaraJl.Tri Dharma Ujung No.1Medan20155North SumatraIndonesia Center of Excellence for Mangrove Universitas Sumatera UtaraMedan20155Indonesia Department of Agrotechnology Faculty of AgricultureUniversitas Sumatera UtaraMedan20155North SumatraIndonesia

Vegetable oil production from oil palm(Elaeis guineensis Jacq.)is an important industry due to the rising demand every *** somatic embryogenesis culture can propagate oil palm duplicate as parent plant,which can be selected as breeding material to produce new planting germplasm with high production or disease *** study aims to evaluate the genotypic effect of somatic embryogenesis,while immature leaflets were employed as *** culture used embryo induction medium based on Murashige and Skoog(MS)modifications that contained 5 mg/L Naphthalene Acetic acid(NAA)and 0.5 mg/L Benzyl Amino Purine(BAP).The genotypic effect was statistically significant in the percentage of callus induction,producing somatic embryos,and germination *** this study,we successfully cloned thirteen oil palm genotypes(GE-02,GE-03,GE-06,GE-07,GE-09,GE-23,GE-24,GE-27,GE-28,GE-32,GE-33,GE-34,and GE-35),with the highest number of somatic embryos formed on GE-27 with a percentage of 70.1%.The cloning was successful in accelerating the propagation of oil palm for materials breeding programs to create new varieties with high production and disease *** is necessary to observation the performance of these clones in the field in terms of mantle flower appearance.

关键词： Somatic embryogenesis Oil palm Genotypic effect Support breeding

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Exploring the impact of tacrolimus on kidney transplant recipients:insights into immunological outcomes

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Journal of Chinese Pharmaceutical Sciences 2024年第8期33卷 737-750页

作者： Zainab A Abbood Ahmed Hamza AL-Shammari Eman M.Jasim Amjad i.Oraibi Department of Pharmacy Kut University CollegeAlkutWasitIraq52001 AL-Manara College For Medical Science/Department of Pharmacy MisanIraq62001

To minimize graft rejection,it is crucial to reduce *** the present study,we investigated immunological markers in the blood of transplant patients who did not receive *** also assessed alloreactive CD4+CD25+FoxP3+Tregs both before transplantation and after tacrolimus *** comparative analysis included 50 individuals experiencing early rejection after tacrolimus discontinuation and 100 *** reducing tacrolimus,rejectors exhibited elevated levels of memory CD8+T cells compared to Tregs,while non-rejectors displayed a lower ratio of memory CD4+T cells to *** tacrolimus removal,rejectors showed an increase in naïve T cells and a decrease in effector T *** transplantation,CD4+Treg levels declined,but their anti-donor regulatory function remained consistent in both rejectors and *** correlation revealed an association between acute rejection after tacrolimus discontinuation and the pre-reduction ratio of memory T cells to regulatory T *** indicators identified individuals whose immunosuppression could be safely reduced.

关键词： Tacrolimus Kidney Transplant immune system Rejection

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Experimental test of a building thermal system for preventive maintenance based on thermoeconomic analysis

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Energy Storage and Saving 2024年第1期3卷 42-51页

作者： i.Prol-Godoy A.Picallo-Perez J.M.Sala-Lizarraga J.Rey-Martínez Research group ENEDi Department of Thermal EngineeringUniversity of the Basque Country(UPV/EHU)Bilbao48013Spain Research Group Termotecnia University of ValladolidValladolid47002Spain

An analysis of the sectorial structure of energy consumption shows that residential and tertiary sector buildings are the third-highest consumers,responsible for 29.5%of a city’s final energy *** Building Quality Control Laboratory of the Basque Government aims to promote quality,innovation,and sustainability in *** accomplish this goal,it has constructed an experimental facility with different energy generation technologies and a very versatile control system for testing different energy systems and operation *** this study,we tested a facility for supplying domestic hot water and heating for a multi-family house by means of a condensing boiler and an aerothermal heat pump(together with the corresponding control).This installation could reproduce the thermal demands required to be satisfied by the generation equipment through a programmed operation of the installation based on real ***,this installation was analyzed using thermoeconomics(TE)to solve problems unable to be solved using traditional energy analyses based on the First Law of *** problems include:(1)Determining the costs of the products of the installation based on physical criteria,(2)detecting the places where losses actually occur,evaluating their costs,and proposing cost-effective improvements,and(3)diagnosing issues in the *** a result,this paper suggests a solution to the preventive maintenance problems confronting the technical maintenance personnel for thermal installations in buildings by applying TE knowledge and using real data collected from sensors.

关键词： Experimental essay Energy savings in thermal systems Thermoeconomics Thermoeconomic costs Diagnosis

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