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inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and technology Research of Minimally invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-bV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa b Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

Catalyst–Support interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to boost Oxygen Evolution Activities for Rechargeable Zn‑Air batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou Qian lu Mingcong tang Jie Wu Kouer Zhang Wenzhi Li Yunxia Hu Xiaomin Xu Xiao Zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANi)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANi support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANi are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).the regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

Effect of gamification applications on success of dentistry students

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World Journal of Methodology 2025年第1期15卷 80-87页

作者： Hatice Ahsen Deniz Elif Polat balkan burak incebeyaz Kıvanç Kamburoğlu Department of Dentomaxillofacial Radiology Ankara University Faculty of DentistryAnkara 06500Türkiye

bACKGROUND Gamification,the use of game materials in education,has been used in several scientific fields,and studies have demonstrated its effectiveness in student *** to evaluate whether the success of 4th-and 5th-grade dentistry students increases when using the gamification applications Kahoot!and *** An experimental design was used to measure the effect of gamification applications on students who were taught using the traditional *** this purpose,Mentimeter and Kahoot!applications were used in this experimental *** groups of 4th-and 5th-grade students were formed:Mentimeter,Kahoot!,and control *** effect of gamification applications on achievement was evaluated by administering a post-test to these groups after the instructional ***-way analysis of variance and t-tests were used for statistical *** A total of 35.5%of the students were in the Mentimeter group,29.8%in the Kahoot!group,and 34.6%in the control *** the total number of students,54.8%were female and 45.2%were male,while 52.2%were 5th-grade students and 47.8%were 4th-grade *** overall grade point average was found to be 66.65(range,24-100).there was a statistically significant difference in average success scores between students of different groups(P=0.003the average success score was the highest in the Mentimeter group(71.64)and the lowest in the Kahoot!group(62.15).in the control group,this score was *** average success score was higher for students in the 5thgrade(68.16)and for female students(68.84).CONCluSiON Gamification has a great potential in the education of dentomaxillofacial radiology *** outperformed both the Kahoot!and the traditional method in terms of average student success rates.

关键词： Gamification Mentimeter Kahoot! Education Dentistry

Geometric interpretation of several classical iterative methods for linear system of equations and diverse relaxation parameter of the SOR method

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Applied Mathematics(A Journal of Chinese Universities) 2013年第3期28卷 269-278页

作者： lu Xing-jiang LEi Lai-i Department of Mathematics Zhejiang University Civil Engineering Laboratory of Macao

two kinds of iterative methods are designed to solve the linear system of equations, we obtain a new interpretation in terms of a geometric concept. therefore, we have a better insight into the essence of the iterative methods and provide a reference for further study and design. Finally, a new iterative method is designed named as the diverse relaxation parameter of the SOR method which, in particular, demonstrates the geometric characteristics. Many examples prove that the method is quite effective.

关键词： linear equation iterative method geometric explanation diverse relaxation parameter SORmethod.

ZnCl2 Enhanced Acid Hydrolysis of Pretreated Corncob for Glucose Production:Kinetics,thermodynamics and Optimization Analysis

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Journal of bioresources and bioproducts 2019年第3期4卷 15-24页

作者： A i ADEOGUN b E AGbOOLA M A iDOWU t A SHittU Department of Chemistry Federal University of AgricultureAbeokuta Department of Food Science and technology Federal University of AgricultureAbeokuta

the biomass of agricultural wastes as a source of fermentable sugars for biofuels production will address the food security and environmental preservation *** wastes are rich in lignocellulosic materials which can be hydrolyzed into fermentable ***,low sugar yield and high energy consumption are some of the challenges faced in the process of *** study investigated the low-cost corncob substrate for glucose production by dilute sulphuric acid hydrolysis in the presence of ZnCl_(2) at temperatures below 100℃after pretreatment with 10%*** dependent hydrolysis data were analyzed by Saeman model,thermodynamic parameters were obtained using Erying and Arrhenius equations while box-behnken model(Design Expert 6.0 version)was used for experimental *** the substrate concentration increased from 50 mg/L to 150 mg/L,glucose yield increased from 10.4 mg/g to 14.6 mg/g for pretreated corncob while an increase from 3.4 mg/g to 8.6 mg/g was noted for untreated *** hydrolysis rate constant was two orders of magnitude higher than the degradation rate *** parameters revealed endothermic process with positive Gibb’s free energy of hydrolysis having average values of 84.76 kJ/mol and 79.87 kJ/mol for pretreated and untreated samples *** optimum yield from the model was found to be 177.44 mg/g with 3.94%H_(2)SO_(4) and 0.43 mol/L ZnCl_(2) for 200 g/L compared with optimum yield of 46.37 mg/g obtainable without ZnCl_(2).the results of this study showed that the alkaline pretreatment of corncob increased the accessibility of cellulose from the solid fraction and increase glucose production.

关键词： hydrolysis Saeman’s model Erying equation box behnken model design expert alkaline pretreatment

A corrected particle method with high-order taylor expansion for solving the viscoelastic fluid flow

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Acta Mechanica Sinica 2017年第1期33卷 20-39页

作者： t. Jiang J. L. Ren W. G. lu b. Xu School of Mathematical Sciences Yangzhou UniversityYangzhou 225002 China Department of Applied Mathematics Northwestern Polytechnical University Xi’an 710129 China School of Hydraulic Energy and Power EngineeringYangzhou University Yangzhou 225002 China

in this paper, a corrected particle method based on the smoothed particle hydrodynamics (SPH) method with high-order taylor expansion (CSPH-Ht) for solving the viscoelastic flow is proposed and investigated. the validity and merits of the CSPH-Ht method are first tested by solving the nonlinear high order Kuramoto-Sivishinsky equation and simulating the drop stretching, respectively. then the flow behaviors behind two stationary tangential cylinders of polymer melt, which have been received little attention, are investigated by the CSPH-Ht method. Finally, the CSPH-Ht method is extended to the simulation of the filling process of the viscoelastic fluid. the numerical results show that the CSPH-Ht method possesses higher accuracy and stability than other corrected SPH methods and is more reliable than other corrected SPH methods.

关键词： Smoothed particle hydrodynamics High-order taylor expansion Viscoelastic fluid Extended pom-pom model

On the pressure and stress singularities induced by steady flows of incompressible viscous fluids

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Acta Mechanica Sinica 2009年第4期25卷 451-462页

作者： G.b.Sinclair X.Chi t.i-P.Shih Department of Mechanical Engineering Louisiana State University Department of Aerospace Engineering Iowa State University

Design for structural integrity requires an appreciation of where stress singularities can occur in structural configurations. While there is a rich literature devoted to the identification of such singular behavior in solid mechanics, to date there has been relatively little explicit identification of stress singularities caused by fluid flows. in this study, stress and pressure singularities induced by steady flows of viscous incompressible fluids are asymptotically identified. this is done by taking advantage of an earlier result that the Navier-Stokes equations are locally governed by Stokes flow in angular corners. Findings for power singularities are confirmed by developing and using an analogy with solid mechanics. this analogy also facilitates the identification of flow-induced log singularities. both types of singularity are further confirmed for two global configurations by applying convergence-divergence checks to numerical results. Even though these flow-induced stress singularities are analogous to singularities in solid mechanics, they nonetheless render a number of structural configurations singular that were not previously appreciated as such from identifications within solid mechanics alone.

关键词： incompressible viscous fluids Navier-Stokes equations Fluid-structure interactions Stress singularities

APPLiCAtiON OF COAL GOLD AGGLOMERAtiON PROCESS tO GOLD RECOVERiNG FROM AMALGAMAtiON tAiLiNGS

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中国有色金属学会会刊：英文版 1997年第4期7卷 153-156页

作者： Zhao, b lu, LZ Xie, HQ Chinese Acad Sci Inst Chem Met Beijing 100080 Peoples R China

ＡＰＰＬＩＣＡＴＩＯＮＯＦＣＯＡＬＧＯＬＤＡＧＧＬＯＭＥＲＡＴＩＯＮＰＲＯＣＥＳＳＴＯＧＯＬＤＲＥＣＯＶＥＲＩＮＧＦＲＯＭＡＭＡＬＧＡＭＡＴＩＯＮＴＡＩＬＩＮＧＳ①ＺｈａｏＢｉｎｇ，ＬｕＬｉｚｈｕ，ＸｉｅＨｕｉｑｉｎ... 详细信息

ＡＰＰＬＩＣＡＴＩＯＮＯＦＣＯＡＬＧＯＬＤＡＧＧＬＯＭＥＲＡＴＩＯＮＰＲＯＣＥＳＳＴＯＧＯＬＤＲＥＣＯＶＥＲＩＮＧＦＲＯＭＡＭＡＬＧＡＭＡＴＩＯＮＴＡＩＬＩＮＧＳ①ＺｈａｏＢｉｎｇ，ＬｕＬｉｚｈｕ，ＸｉｅＨｕｉｑｉｎｇＩｎｓｔｉｔｕｔｅｏｆＣｈｅｍｉ...

关键词： CGA process amalgamation tailings gold recovering

investigation of the ^(121)Sb(α,γ)^(125)i reaction cross-section calculations at astrophysical energies

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Nuclear Science and techniques 2023年第11期34卷 85-92页

作者： M.Eroğlu C.Yalcın R.t.Güray Department of Physics Kocaeli UniversityUmuttepe41001 KocaeliTurkey Department of Electronics and Automation Piri Reis University34940 TuzlaIstanbulTurkey

Proton-rich nuclei are synthesized via photodisintegration and reverse *** examine this mechanism and reproduce the observed p-nucleus abundances,it is crucial to know the reaction rates and thereby the reaction cross sections of many *** that the number of experiments on the reactions in astrophysical energy regions is very rare,the reaction cross sections are determined by theoretical methods whose accuracy should be *** this study,given that ^(121)Sb is a stable seed isotope located in the region of medium-mass p-nuclei,we investigated the cross sections and reaction rates of the ^(121)Sb(α,γ)^(125)i reaction using the tALYS computer code with 432 different combinations of input parameters(OMP,LDM,and SFM).the optimal model combinations were determined using the threshold logic unit *** theoretical reaction cross-sectional results were compared with the experimental results reported in the *** reaction rates were determined using the two input parameter sets most compatible with the measurements,and they were compared with the reaction rate databases:StARLib and REACLib.

关键词： Cross section Astrophysical S-factor Astrophysical reaction rate p-process nucleosynthesis threshold logic unit method