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食管腺癌淋巴结转移与肿瘤侵及食管壁深度的关系

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中华胸心血管外科杂志 2006年第5期22卷 302-304页

作者：张逊 David i. Watson Justin R. Bessell 天津市胸科医院胸外科 300051 澳大利亚弗林德斯大学医学中心外科

目的对腺癌侵及食管壁深度与淋巴结转移的关系以及淋巴结转移对预后的影响进行分析研究。方法澳大利亚弗林德斯大学医学中心自1985年～2003年,手术治疗食管腺癌121例。其中男101例,女20例。年龄36～80岁,平均62岁。本组手术切除率为96.7... 详细信息

目的对腺癌侵及食管壁深度与淋巴结转移的关系以及淋巴结转移对预后的影响进行分析研究。方法澳大利亚弗林德斯大学医学中心自1985年～2003年,手术治疗食管腺癌121例。其中男101例,女20例。年龄36～80岁,平均62岁。本组手术切除率为96.7%(117/121例)。手术清扫淋巴结的数目每例为2～30个,平均8个。无淋巴结转移59例(48.8%)、有淋巴结转移62例(51.2%)。本组病例全部得到随访。结果当肿瘤位于黏膜层或黏膜下层(T1)时,淋巴结转移的发生率为22.2%(10/45例)、平均淋巴结转移的个数为0.3个、>4个淋巴结转移的比例为0(0/45例);当肿瘤侵及食管周围组织(T4)时,淋巴结转移的发生率为85.7%(6/7例)、平均淋巴结转移的个数为5.1个、>4个淋巴结转移的比例为71.4%(5/7例),P4个淋巴结转移组的5年生存率为0,P4个淋巴结转移的比例均增加。有无淋巴结转移和淋巴结转移的数量是影响远期生存率的一个重要因素。

关键词：食管肿瘤腺癌肿瘤转移肿瘤分期淋巴结

A Radial Basis Function Method with improved Accuracy for Fourth Order Boundary Value Problems

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Journal of Applied Mathematics and Physics 2024年第7期12卷 2559-2573页

作者： Scott A. Sarra Derek Musgrave Marcus Stone Joseph i. Powell Department of Mathematics Marshall University Huntington WV USA

Accurately approximating higher order derivatives is an inherently difficult problem. it is shown that a random variable shape parameter strategy can improve the accuracy of approximating higher order derivatives with Radial Basis Function methods. The method is used to solve fourth order boundary value problems. The use and location of ghost points are examined in order to enforce the extra boundary conditions that are necessary to make a fourth-order problem well posed. The use of ghost points versus solving an overdetermined linear system via least squares is studied. For a general fourth-order boundary value problem, the recommended approach is to either use one of two novel sets of ghost centers introduced here or else to use a least squares approach. When using either ghost centers or least squares, the random variable shape parameter strategy results in significantly better accuracy than when a constant shape parameter is used.

关键词： Numerical Partial Differential Equations Boundary Value Problems Radial Basis Function Methods Ghost Points Variable Shape Parameter Least Squares

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Pathophysiological mechanisms involved in non-alcoholic steatohepatitis and novel potential therapeutic targets

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World Journal of Hepatology 2015年第10期7卷 1297-1301页

作者： Fatima Higuera-de la Tijera Alfredo i Servin-Caamano Liver Clinic Gastroenterology DepartmentMexico’s General Hospital "Dr. Eduardo Liceaga" Diabetes Obesity and Metabolic Syndrome ClinicInternal Medicine DepartmentMexico’s General Hospital "Dr. Eduardo Liceaga"

Non-alcoholic fatty liver disease(NAFLD) is a major health care problem and represents the hepatic expression of the metabolic syndrome. NAFLD is classified as nonalcoholic fatty liver(NAFL) or simple steatosis,and non-alcoholic steatohepatitis(NASH). NASH is characterized by the presence of steatosis and inflammation with or without fibrosis. The physiopathology of NAFL and NASH and their progression to cirrhosis involve several parallel and interrelated mechanisms,such as,insulin resistance(iR),lipotoxicity,inflammation,oxidative stress,and recently the gut-liver axis interaction has been described. incretin-based therapies could play a role in the treatment of NAFLD. Glucagon-like peptide-1(GLP-1) is an intestinal mucosa-derived hormone which is secreted into the bloodstream in response to nutrient ingestion; it favors glucose-stimulated insulin secretion,inhibition of postprandial glucagon secretion and delayed gastric emptying. it also promotes weight loss and is involved in lipid metabolism. Once secreted,GLP-1 is quickly degraded by dipeptidyl peptidase-4(DPP-4). Therefore,DPP-4 inhibitors are able to extend the activity of GLP-1. Currently,GLP-1 agonists and DPP-4 inhibitors represent attractive options for the treatment of NAFLD and NASH. The modulation of lipid and glucose metabolism through nuclear receptors,such as the farsenoid X receptor,also constitutes an attractive therapeutic target. Obeticholic acid is a potent activator of the farnesoid X nuclear receptor and reduces liver fat content and fibrosis in animal models. Ursodeoxycholic acid(UDCA) is a hydrophilic bile acid with immunomodulatory,antiinflammatory,antiapoptotic,antioxidant and antifibrotic properties. UDCA can improve iR and modulate lipid metabolism through its interaction with nuclear receptors such as,TGR5,farnesoid X receptor-a,or the small heterodimeric partner. Finally,pharmacologic modulation of the gut microbiota could have a role in the therapy of NAFLD and NASH. Probiotics prev

关键词： insulin resistance Lipotoxicity Non-alcoholic steatohepatitis Physiopathology Therapeutic targets

Obstetrical Complications of Female Genital Mutilation: Management Maternal-Fetal Medical Care and Prognosis, Obstetrical Gynecology Regional Hospital, Unit of N'zérékoré

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Open Journal of Obstetrics and Gynecology 2019年第2期9卷 196-206页

作者： B. A. Diallo E. M. Bah O. H. Bah i. Conté i. K. Bah i. S. Diallo B. S. Diallo i. S. Sow S. Touré D. Sidibé M. D. Baldé Donka National Hospital Gamal Abdel Nasser University Conakry Guinea ignace-Deen National Hospital Gamal Abdel Nasser University Conakry Guinea institute of Nutrition and Child Health (iNCH) Donka Guinea N’zerekoré Regional Hospital N’zérékoré Guinea

introduction: Female Genital Mutilation (FGM) is a public health problem. There are 100 to 140 million girls and women who suffer every year in the world [1]. The aim of this study is to improve the medical care and reduce complications of FGM at the Regionalhospital of N’zérékoré, to determine their frequency, and to evaluate the maternal-fetalprognosis. Methods: The study was conducted at the Regional Hospital of N’zérékoré. This was a cross-sectional, descriptive and analytic study of 6 months, from 1 September 2016 to 28 February 2017, including all pregnant women admitted for childbirth who had a complication of female genital mutilation. Results: A total of 1295 women gave birth in the service, of which 1204 women were women with female genital mutilation. Given a frequency of 92.97%, of these 1204 mutilated women, 223 presented obstetrical complications during their delivery, a proportion of 17.22%. They were mostly young patients, mostly housewives who were not in school. Type ii FGM was the most common (53.06%). Obstetric complications were dominated by complicated perinatal tears (54.08%), and hemorrhages (40.81%). The catch was dominated by perineorrhaphy. Conclusion: The frequency of FGM was 92.97% and that of their obstetric complications 17.22%. Most were house-wives, not in school. There was FGM type ii. The abandonment of FGM would reduce maternal and perinatal morbidity and mortality.

关键词： Female Genital Mutilation Obstetric Complications Maternal Fetal Prognosis

Adaptive Sliding Mode Roll Control of a Canard-Controlled Missile

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Adaptive Sliding Mode Roll Control of a Canard-Controlled Mi...

2010 Chinese Control and Decision Conference

作者： M.Zamurad Shah Raza Samar A.i.Bhatti Mohammad Ali Jinnah University IslamabadPakistan

This work is meant to design a roll controller for a short range missile with a free-spinning tail using the sliding mode control *** canards located near the nose of the missile provide aerodynamic ***/yaw stability is achieved through four rotating fins located at the tail of the *** of the missile dictates the whole trajectory in the atmosphere where dynamic pressure varies between 0 and 7 *** the missile can be fired at different launch angles,which implies that the profile of dynamic pressure is not *** strategy strongly depends on dynamic pressure in the case of canard-controlled *** the case of varying dynamic pressure,design of a robust roll controller that can keep roll angle near zero is a challenging *** this paper,a roll controller is designed for a canard-controlled short range missile using sliding mode control *** is done in some control parameters to cater the variation in dynamic pressure and different launch *** robustness of the roll controller is tested in the presence of aerodynamic and other *** is established that the proposed roll controller is capable of rejecting aerodynamic and other disturbances and keep the roll angle close to zero.

关键词： Missile sliding mode control adaptive control autopilot aerodynamics canards.

The association between SNPs at BnVTE4 andα-/γ- tocopherol ratio in oilseed rape(Brassica napus)

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The association between SNPs at BnVTE4 andα-/γ- tocopherol...

中国作物学会2013年学术年会

作者： N.Hussain i.H.Shamsi Lixi Jiang Department of Agronomy Key Laboratory of Crop Germplasm Resource of Zhejiang ProvinceZhejiang University

Rapeseed is the most important oil crop of temperate *** is grown mainly for vegetable oil for human consumption,but also for other purposes such as animal feed and raw industrial *** oil contains tocopherols(Toc),an indispensable nutrient for humans and animals due to its antioxidant and radical scavenging *** comprises of four isomers(α,β,γ,andδ-Toc).in rapeseed oil,γ-Toc is the most predominant isoforms, followed byα-Toc,which exhibits 100%biological activity of vitamin ***,seed oil with increased

关键词： Brassica napus Genotypic variation Tocopherol SNP VTE4 EMS HRM α-/γ-Tocopherol ratio

SCREENiNG OF RABBiT COMPLEMENT FOR MiCROCYTOTOXiCiTY TEST ACCORDiNG TO THE EXPERiENCE OF ***'S LABORATOTY

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中南大学学报(医学版) 1982年第3期 228-232页

作者： M.S.Park ,P.i.Terasaki Tissue Typing Laboratory University of California at Los Angeles U.S.A. Typing Laboratory University of California at Los Angeles U.S.A.

This paper described screening of rabbit complement for microcytotoxi-city,according to the experience of ***'s *** by nor-mal serum test,dilute anti HLA test,HLA—A, —B, —C and —DR typing test,it was proved that complement activity of a pool of nearly 300 rabbits'mixedsera(H1)was similar to that of the 8th reference complement which is thesame used at the 8th international Histocompatibility *** human O blood group RBC reduced the title of *** was shown that thecontent of complement in H1 could be satisfactory both for T and for B cellmicrocytotoxicity test.

关键词： test HLA SCREENiNG OF RABBiT COMPLEMENT FOR MiCROCYTOTOXiCiTY TEST ACCORDiNG TO THE EXPERiENCE OF DR.TERASAKi’S LABORATOTY DRS

Antimicrobial activities of silver dressings:an in vitro comparison

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Antimicrobial activities of silver dressings:an in vitro com...

第八届全国烧伤外科学年会

作者： ip M Lui SL Poon VK Lung i Burd A Department of Microbiology and Department of SurgeryThe Chinese University of Hong KongPrince of Wales HospitalHong Kong

＜正＞A range of silver-coated or -impregnated dressings are now commercially available for use but comparative data on their antimicrobial efficacies are *** antibacterial activities of five commercially available silver-coated/impregnated dressings were compared against nine common burn-wound pathogens,namely methicillin-sensitive and -resistant Staphylococcus aureus （MRSA）, Enterococcus faecalis,Pseudomonas aeruginosa,Escherichia coli,Enterobacter cloacae,Proteus vulgaris, Acinetobacter baumannii and a multi-drug-efflux-positive Acinetobacter baumannii （BM4454）,using a broth culture *** rapidity and extent of killing of these pathogens under in vitro conditions were *** five silver-impregnated dressings investigated exerted bactericidal activity,particularly against Gram-negative bacteria,including Enterobacter species,Proteus species and *** spectrum and rapidity of action,however,ranged widely for different *** and Contreet had a broad spectrum of bactericidal activities against both Gram-positive and -negative bacteria,Contreet was characterized by a very rapid bactericidal action and achieved a reduction of ＞or=10,000 c.f.u,ml（-1） in the first 30 min for Enterobacter cloacae,Proteus vulgaris,Pseudomonas aeruginosa and Acinetobacter *** dressings demonstrated a narrower range of bactericidal *** the characteristics of these dressings may enable them to be targeted more appropriately according to the specific requirements for use of a particular dressing,as in for prophylaxis in skin grafting or for an infected wound with MRSA.

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Stem cells, gene therapy, and advanced medical management hold promise in the treatment of male infertility

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Asian Journal of Andrology 2016年第3期18卷 364-364页

作者： Ryan P Smith Larry i Lipshultz Jason R Kovac University of Virginia Department of Urology Charlottesville VA 22908 USA Scott Department of Urology Baylor College of Medicine Houston Texas 77030USA Men's Health Center 8240 Naab Road Suite 220 Indianapolis Indiana46260 USA.

Medical management of male infertility has traditionally involved therapies directed toward manipulation of the hypothalamic-pituitary-gonadal axis. The medications available currently are essentially identical to those utilized decades ago. Moreover, these agents require that the infertile patient can produce at least a small number of functional sperm.

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