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SEDiMENT TrANSPOrT PrOCESSES iN AGriCULTUrAL WATErSHEDS

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international journal of Sediment research 2000年第2期 182-197页

作者： roger A. Kuhnle Sean j. Bennett Carlos V. alonso ronald L. Bingner Eddy Langendoen(National Sedimentation Laboratory, U.S. Department of Agriculture, Agricultural research Service, P.O. Box 1157,Oxford, Mississippi 38655, USA)

Determination of the total sediment load at selected points in agricultural Watersheds is important forevaltating the status of a land area. Total sediment load date allows the identification of problem areaswhere the land surface is eroding at rates too high to allow sustainable agriculture and/or is producingsediment at rales such that aquatic organisms in nearby streams will be adversely affected. Thedevelopment of effective sampling strategies and accurate computaional models requires accurateinformation on the processes by which sediment is transported. researchers at the NationalSedimentation Laboratory are developing and testing new methods to measure and predict sedimentbospoft. These new methods are providing an improved understanding of the processes involved insediment transport and are leading to important advancements in the measurement and prediction ofsediment transport.

关键词： Total sediment load Sediment transport Sustainable agriculture Water quality Agricultural watershed

Magnetic Moment of Proton Halo Nucleus 28P

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Magnetic Moment of Proton Halo Nucleus 28P

Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOr regulation

第十三届全国核物理大会暨第八届会员代表大会

作者： K.Matusta M.Mihara M.Fukuda D.Nishimura j.Komurasaki D.ishikawa r.Matsumiya T.Nagatomo T.Sumikama T.izumikawa S.Momota Y.Nojiri S.Takahashi H.Hirano T.Ohtsubo A.Kitagawa M.Kanazawa M.Torikoshiv S.Sato T.Minamisono j.r.alonso G.E Krebs T.j.M.Symons Department of Physics Osaka UniversityToyonakaOsaka 560-0043Japan riKEN WakoSaitama 351-0198Japan ri Center Niigata UniversityNiigata 951-8510Japan Kochi University of Technology Kochi 782-8502Japan Department of Physics Niigata UniversityNiigata 950-2181Japan National institute of radiological Sciences Inage-kuChiba 263-8555Japan Fukui University of Technology Fukui 910-8505Japan Lawrence Berkeley Laboratory BerkeleyCA94720USA

The β-emitting nucleus p is a proton halo nucleus with one neutron in *** and one proton in 2s orbit the separation energy of which is 2.065 *** far,there have been no data of the magnetic and quadrupole moments for *** the present work the magnetic moment of P(i=3+,T=268ms)has been measured by the β-NMr method for the first time.

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World journal of Gastroenterology 2020年第34期26卷 5101-5117页

作者： David Fernández-ramos Fernando Lopitz-Otsoa Laura Delacruz-Villar jon Bilbao Martina Pagano Laura Mosca Maider Bizkarguenaga Marina Serrano-Macia Mikel Azkargorta Marta iruarrizaga-Lejarreta jesús Sot Darya Tsvirkun Sebastiaan Martijn van Liempd Felix M Goni Cristina alonso María Luz Martínez-Chantar Felix Elortza Liat Hayardeny Shelly C Lu joséM Mato Precision Medicine and Metabolism Laboratory Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160BizkaiaSpain CiBErehd-Centro de investigación Biomédica en red de enfermedades hepáticas y digestivas Madrid 28029Spain Department of Precision Medicine University of Campania"Luigi Vanvitelli"Naples 80138Italy Liver Disease Laboratory Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain Proteomics Platform Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain OWL Metabolomics Derio 48160Spain instituto Biofisika(UPV/EHU CSIC)Leioa 48940SpainDepartamento de Bioquímica y Biología MolecularUniversidad del País VascoLeioa 48940Spain Pre-clinical and Chemistry Manufacturing and ControlsGalmed PharmaceuticalsTel Aviv 6578317Israel Metabolomics Platform Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain Division of Digestive and Liver Diseases Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGrOUND Arachidyl amido cholanoic acid(Aramchol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(SCD1)protein expression that reduces liver triglycerides and fibrosis in animal models of *** a phase iib clinical trial in patients with nonalcoholic steatohepatitis(NASH),52 wk of treatment with Aramchol reduced blood levels of glycated hemoglobin A1c,an indicator of glycemic *** To assess lipid and glucose metabolism in mouse hepatocytes and in a NASH mouse model[induced with a 0.1%methionine and choline deficient diet(0.1MCD)]after treatment with *** isolated primary mouse hepatocytes were incubated with 20μmol/L Aramchol or vehicle for 48 ***,analyses were performed including Western blot,proteomics by mass spectrometry,and fluxomic analysis with 13C-uniformly labeled *** the in vivo part of the study,male C57BL/6j mice were randomly fed a control or 0.1MCD for 4 wk and received 1 or 5 mg/kg/d Aramchol or vehicle by intragastric gavage for the last 2 *** metabolomics were assessed using ultra-high-performance liquid chromatography-time of flight-MS for the determination of glucose metabolism-related *** Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTOrC1 was decreased by Aramchol in *** translated into changes in the content of their downstream targets including proteins involved in fatty acid(FA)synthesis and oxidation[PACCα/β(S79),SCD1,CPT1A/B,HADHA,and HADHB],oxidative phosphorylation(NDUFA9,NDUFB11,NDUFS1,NDUFV1,ETFDH,and UQCrC2),tricarboxylic acid(TCA)cycle(MDH2,SUCLA2,and SUCLG2),and ribosome(P-p70S6K[T389]and P-S6[S235/S236]).Flux experiments with 13Cuniformely labeled glucose showed that TCA cycle cataplerosis was reduced by Aramchol in hepatocytes,as indicated by the increase in the number of rounds that malate remained in the TCA ***,liver metabolomic analysis showed

关键词： Nonalcoholic fatty liver disease Steatohepatitis Methionine and choline deficient diet Tricarboxylic acid cycle Hemoglobin A1c Stearoyl-CoA desaturase 1

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高温环境中训练和比赛的共识性建议

中国运动医学杂志 2016年第2期35卷 192-203页

作者： Sébastien racinais juan-Manuel alonso Aaron j.Coutts Andreas D.Flouris Olivier Girard josé González -alonso Christophe Hausswirth Ollie jay jason K.W.Lee Nigel Mitchell George P.Nassis Lars Nybo Babette M.Pluim Bart roelands Michael N.Sawka jonathan Wingo julien D.Périard. 徐金成高璨赵杰修国家体育总局体育科学研究所运动生物科学中心北京100061 国家体育总局运动医学研究所北京100061

高温环境中运动会引起体温调节和其它生理压力,继而可导致耐力运动能力的损害。本共识性声明的目的是提供最新的建议以使热环境中体育活动时的运动能力最优化。可用于降低热应激压力和优化运动能力的最重要干预方式是热习服,其应包括1~... 详细信息

高温环境中运动会引起体温调节和其它生理压力,继而可导致耐力运动能力的损害。本共识性声明的目的是提供最新的建议以使热环境中体育活动时的运动能力最优化。可用于降低热应激压力和优化运动能力的最重要干预方式是热习服,其应包括1~2周以上反复的运动—高温环境暴露。此外,运动员应在正常水合状态下开始比赛和训练,并将运动中的脱水最小化。随着商用降温系统（如降温背心）的发展,在高温环境中训练或比赛前,运动员可以采取降温策略来促进热的散发或提高蓄热能力。而且,赛事组织者应该设计大面积的遮阳区域,并提供降温和补水设施,按照最小化运动员的健康风险来安排赛事,尤其是在大众参与的赛事中及一年之中炎热天气开始之初。以最近的2008年奥运会和2014年国际足联世界杯为例,当比赛在高温环境中举行时,赛事主管机构应考虑在比赛中或比赛之间允许额外的（或更长的）恢复期以提供补水和降温的时机。

关键词：共识性高温环境习服耐力运动能力国际足联体温调节降温系统体育活动最优化身体水分

提高第二代杂交捕获法中人乳头瘤病毒载量界值能否改进检出率

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世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 44-44页

作者： Ordi j. alonso i. Torné A. 马超 Department of Anatomical Pathology IDIBAPS-Hospital Clnic University of Barcelona C/Villarroel 170 08036-Barcelona Spai

Objective. The aim of the study was to evaluate whether the results of the Hybrid Capture ii (HCii) assay for detecting high-grade squamous intraepithelial lesions (H-SiL) or cervical carcinoma can be improved by increasing the relative light units (rLU) level. Study design. We included 2271 women (mean age 38.7 ±12.3, range 15-92) referred to a colposcopic clinic due to cytology of atypical cells of unknown significance, SiL or carcinoma. All women underwent a new Pap test, Hr-HPV detection using HCii and colposcopy with biopsy of suspicious areas when present. results. Hr-HPV was detected in 91.7%of carcinomas, 96.6%of H-SiL, 85.1%of low-grade SiL and 21.6%of cases with no lesion. The probability of harboring an H-SiL or a carcinoma significantly increased as rLU increased (P = 0.01). The sensitivity and specificity for H-SiL or carcinoma at different cutoffs were 95.7 and 54.6 at 1 rLU, 93.9 and 59.6 at 2 rLU, 90.1 and 65.1 at 5 rLU and 85.7 and 68.7 at 10 rLU. The percentage of cases not detected with HCii increased from 2.4%for cases with rLU to 9.5%for cases between 1 and 2 rLU, 14.8%between 2 and 3 rLU, 21.7%between 3 and 5 rLU and 28.4%between 5 and 10 rLU. Conclusion. The use of a higher cutoff (higher viral load) in the HCii should not be recommended because it significantly increases the number of cases with H-SiL or carcinoma not detected, reducing the sensitivity and negative predictive value of the test. All rights reserved.

关键词：人乳头瘤病毒载量界值巴氏涂片可疑部位鳞状上皮内病变检测敏感度不典型细胞阴道镜检查阴

Examination of the therapeutic potential of Delta-24-rGD in brain tumor stem cells： role of autophagic cell death

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中国神经肿瘤杂志 2007年第3期5卷 168-168页

作者： jiang H Gomez-Manzano C Aoki H alonso MM Kondo S McCormick F Xu j Kondo Y Bekele BN Colman H Lang FF Fueyo j Brain Tumor Center The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd Houston TX 77030 USA.

The eradication of brain tumor stem cells is essential for long-term brain tumor remission after *** this study, we examined the therapeutic potential of an oncolytic adenovirus, Deha-24-rGD, targeted to the abnormal p16iNK4/rb pathway in brain tumor stem *** brain tumor stem cell lines from surgical glioblastoma specimens expressed high levels of adenoviral receptors and allowed for efficient viral infection, replication, and oncolysis in an rb-dependent ***-24-rGD induced autophagic cell death, as indicated by accumulation of Atg5 and LC3-Ⅱprotein and autophagic vacuoles.

关键词：治疗脑肿瘤干细胞自我吞噬作用细胞死亡

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GrADE：证据质量和推荐强度分级的共识

中国循证医学杂志 2009年第1期9卷 8-11页

作者： Gordon H Guyatt Andrew D Oxman Gunn E Vist regina Kunz Yngve Falck-Ytter Pablo alonso-Coello Holger j Schünemann GrADE工作组陈佩贤陈耀龙李幼平单位不详 GrADE工作组

GrADE工作组致中国读者:推荐分级的评估、制定与评价(GrADE)工作组已取得长足进步。我们制定了系列指南文件,除发表文章外,该非正式组织已经发展成为一个评价证据、转化卫生保健领域知识用以指导决策者的智囊团。80余位国际专家研究和... 详细信息

GrADE工作组致中国读者:推荐分级的评估、制定与评价(GrADE)工作组已取得长足进步。我们制定了系列指南文件,除发表文章外,该非正式组织已经发展成为一个评价证据、转化卫生保健领域知识用以指导决策者的智囊团。80余位国际专家研究和制定了该评价系统。正如其他科学一样,证据评价和指南制定科学不会停滞不前。经过十年发展,GrADE的工作将借助中国Cochrane中心的推广在中国的卫生保健领域更加广为人知。GrADE工作组的成员期待与中国的指南制定组织、方法学家、临床医生和决策者合作,实现我们的共同目标:人人享有更好的卫生保健。中国Cochrane中心翻译GrADE工作组在BMj上发表的系列文章,是朝这个方向迈出的重要一步,也是对下一步在中国推广GrADE工作的直接贡献。感兴趣的读者可登录我们的网站***和在以下网址获取我们的软件GrADEprohttp://***-ims.

关键词：证据质量强度非正式组织评价证据卫生保健评价系统证据评价工作组