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creeping fat and gut microbiota in crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello imbrizi Ellen cS de Oliveira Luiz c Di Stasi Ligia Y Sassaki Verum ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil department of internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

in this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of crohn’s disease(cD).cD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in cD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing cD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and cD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with cD.

关键词： creeping fat Mesenteric adipose tissue Gut microbiota crohn’s disease inflammatory bowel disease

Arctic sea-ice extent: No record minimum in 2023 or recent years

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 52-55页

作者： Ola M.Johannessen Tor i.Olaussen Nansen Scientific Society BergenNorway Nansen Environmental and Remote Sensing center BergenNorway

Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(***^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 ***^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. in general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing cO_(2) in the atmosphere, where the increase of cO_(2) in recent decades explains about 80% of the decrease in sea ice in September, while the remainder is caused by natural variability.

关键词： Sea ice Arctic Minimum ice climate

Gut-liver axis in sepsis-associated liver injury:Epidemiology,challenges and clinical practice

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World Journal of Gastroenterology 2025年第1期31卷 163-166页

作者： Fabiana Andréa Moura Aryana isabelle de Almeida Neves Siqueira college of Nutrition Federal University of AlagoasMaceio 57072-970AlagoasBrazil college of Medicine Federal University of AlagoasMaceio 57072-970AlagoasBrazil

Although the liver has a remarkable regenerative capacity,sepsis-associated liver injury(SLi)is a complication often seen in intensive care *** to its role in immune and inflammatory regulation,the liver is particularly vulnerable during severe *** the global prevalence,causes,and management of SLi is essential to improve outcomes and reduce healthcare *** paper aims to explore these factors,with an emphasis on identifying effective strategies for clinical *** et al’s bibliometric analysis of 787 publications(745 original articles and 42 reviews,mostly in animal models)from 2000 to 2023 highlights the growing interest in SLi,focusing on oxidative stress,gut microbiota,and inflammatory *** components such as nuclear factor-kappa B and the NOD-like receptor thermal protein domain associated protein 3 inflammasome pathway,along with their links to gut microbiota imbalance and oxidative stress,are crucial for understanding SLi *** gut-liver axis,particularly the role of intestinal permeability and bacterial translocation in liver inflammation,is *** this context,bacterial translocation is especially relevant for critically ill patients,as it can exacerbate liver *** findings underscore the need for integrated care in intensive care units,prioritizing gut health and careful antibiotic use to prevent *** extensive research,there remains a lack of clinical trials to validate therapeutic *** abundance of experimental studies highlights potential therapeutic targets,stressing the need for high-quality randomized clinical trials to translate these findings into clinical practice.

关键词： Dysbiosis Oxidative stress inflammation Microbiota Sepsis-associated liver injury

ON DiFFERENTiAL STRUcTURES OF POLYNOMiAL SPAcES iN cONTROL THEORY

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Journal of Systems Science and Systems Engineering 2012年第3期21卷 372-382页

作者： Baltazar aguirre HERNANdeZ Martn Eduardo FRiAS-ARMENTA Fernando VERDUZcO depto.de Matematicas Universidad Autonoma Metropolitana-lztapalapa.Av.Sn.Rafael Atlixco no.186.Col.Vicentinalztapalapa 09340MexicoD.F. depto.de Matematicas Universidad de Sonora.Blvd.Luis Encinas y Rosales s/n.Col.CentroHermosilloSonoraMexico.

A valuable number of works has been published about Hurwitz and Schur polynomials in order to known better their properties. For example it is known that the sets of Hurwitz and Schur polynomials are open and no convex sets. Besides, the set of monic Schur polynomials is contractible. Now we study this set using ideas from differential topology, and we prove that the space of Schur complex polynomials with positive leading coefficient, and the space of Hurwitz complex polynomials which leading coefficient having positive real part, have structure of trivial vector bundle, and each space of （Schur complex and real, Hurwitz complex） polynomials has a differential structure diffeomorphic to some known spaces.

关键词： Schur polynomials Hurwitz complex polynomials trivial vector bundle

Evaluation of Early Action Mechanisms in Peru Regarding Preparedness for El Nino

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international Journal of Disaster Risk Science 2019年第4期10卷 493-510页

作者： Julio aguirre Daniel de La Torre Ugarte Juan Bazo Paulo Quequezana Mauricio collado department of Economics Universidad del Pacifico15072 LimaPeru Red cross Red crescent climate centre 2502 KC The HagueThe Netherlands centro de investigacion de Riesgo Resiliencia y Cambio Climatico(CIRCA)Universidad Tecnologica del Peru(UTP)15046 LimaPeru

in this article,we provide an impact evaluation of an intervention in Peru regarding preparedness for El Nino impacts in Picsi District of chiclayo Province in Peru’s northwestern coastal Lambayeque *** effort involved the provision of special kits that reduce the potential damage to homes as a consequence of rainfall and floods associated with an El Nino-Southern Oscillation *** was collected in 2016 when this Forecast-based Financing early action was activated by an El Nino forecast,and after a coastal El Nino actually struck in *** dual database permits us to estimate the impact of the intervention on the damage level of homes by comparing those homes supported by the program with those homes not receiving pilot-program *** comparison is achieved by using propensity score matching techniques,which identify the most comparable homes to the ones that were supported by the *** main findings of the study suggest a positive impact of the program in terms of its effectiveness in mitigating the damage caused by the 2017 El Ni?*** results suggest a drop in the scale of house damage(less damage)by around 63%for a home that received the modular kit *** considering other specifications of the model,the decrease in the scale of house damage improves up to approximately 66%.

关键词： Early warning Early action El NinoSouthern Oscillation Forecast-based Financing Matching propensity score Perú Red cross

The domestication of cucurbita argyrosperma as revealed by the genome of its wild relative

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Horticulture Research 2021年第1期8卷 1287-1300页

作者： Josue Barrera-Redondo Guillermo Sanchez-de la Vega Jonas A.aguirre-Liguori Gabriela castellanos-Morales Yocelyn T.Gutierrez-Guerrero Xitlali.aguirre-Dugua Erika aguirre-Planter Maud i.Tenaillon Rafael Lira-Saade Luis E.Eguiarte departamento de Ecologia Evolutiva Instituto de EcologiaUniversidad Nacional Autonoma de MexicoCircuito Exterior s/n Anexo al Jardin Botanico04510 Ciudad de MexicoMexico department of Ecology and Evolutionary Biology University of CaliforniaIrvineCA 92697USA departamento de conservacion de la Biodiversidad El Colegio de la Frontera SurVillahermosaCarretera Villahermosa‐Reforma km 15.5 Rancheria El Guineo 2ªseccion86280 VillahermosaTabascoMexico Genetique Quantitative et Evolution-Le Moulon Universite Paris-SaclayInstitut National de Recherche pour l’Agriculturel’Alimentation et l’EnvironnementCentre National de la Recherche ScientifiqueAgroParisTechGif-sur-Yvette 91190France UBiPRO Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoAv.de los Barrios#1Col.Los Reyes IztacalaTlalnepantlaEdo.de Mex 54090Mexico

despite their economic importance and well-characterized domestication syndrome,the genomic impact of domestication and the identification of variants underlying the domestication traits in cucurbita species(pumpkins and squashes)is currently *** argyrosperma,also known as cushaw pumpkin or silver-seed gourd,is a Mexican crop consumed primarily for its seeds rather than fruit *** makes it a good model to study cucurbita domestication,as seeds were an essential component of early Mesoamerican diet and likely the first targets of human-guided selection in pumpkins and *** obtained population-level data using tunable Genotype by Sequencing libraries for 192 individuals of the wild and domesticated subspecies of *** across *** also assembled the first high-quality wild cucurbita *** genomic analyses revealed several structural variants and presence/absence of genes related to *** results indicate a monophyletic origin of this domesticated crop in the lowlands of *** found evidence of gene flow between the domesticated and wild subspecies,which likely alleviated the effects of the domestication *** uncovered candidate domestication genes that are involved in the regulation of growth hormones,plant defense mechanisms,seed development,and *** presence of shared selected alleles with the closely related species cucurbita moschata suggests domestication-related introgression between both taxa.

关键词： cucurbita likely pump

Altitudinal seasonality as a potential driver of morphological diversification in rear-edge bird populations

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Avian Research 2022年第3期13卷 267-274页

作者： José Luis Tellería irene Hernández-Tellez iván de la Hera José ignacio aguirre Alejandro Onrubia department of Biodiversity Ecology and EvolutionUniversidad Complutense28040MadridSpain department of integrative Biology Oklahoma State UniversityStillwaterOKUSA Fundaci on Migres Tarifa11380CadizSpain

Populations at the low latitude limits of a species range(rear-edge populations)are often considered more vulnerable to climate ***,their ability to track different environmental settings at a regional scale has been widely overlooked,although this may be relevant to accurately assess their adaptive capacity to cope with ongoing *** we tested whether the endemic African chaffinch(Fringilla coelebs africana)tracks environmental changes(*** temperatures,snow cover)by rearranging their numbers between seasons(spring ***)along the altitude gradients of its northwestern African *** additionally tested whether these seasonal changes in abundance were paralleled by morphological variation,suggesting a process of population *** assessed African chaffinch abundance in tree covered farmland and woodland sites distributed along an altitude gradient in spring and *** addition,we captured and measured chaffinches within the study gradient to explore the patterns of morphological *** results showed that chaffinches shifted to lowlands from snow covered highlands during *** addition,highland individuals showed longer and more concave wings than their lowland *** morphological traits are usually related to flight efficiency in migratory birds,which suggest the presence of altitudinal movements aimed to track the environmental seasonality caused by *** results suggest a potential role of altitudinal seasonality as a driver of regional diversification within the African chaffinch populations,which could be occurring in other North African avian species given their relatively high endemicity in the *** evolutionary and conservation implications of these displacements have been often overlooked despite they can shape the adaptive capacity of rear-edge bird populations to face the ongoing environmental changes in this peripheral area of the Palearctic.

关键词： Altitudinal movements Flight apparatus Population diversification Snow cover effects

Sustainable Materials Based on cellulose from Food Sector Agro-Wastes

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Journal of Renewable Materials 2018年第7期6卷 688-696页

作者： T.côto i.Moura A.de Sá c.Vilarinho A.V.Machado institute of Polymers and composites(iPc)and institute of Nanostructures Nanomodelling and Nanofabrication(i3N)University of MinhoCampus de Azurém4800-058 GuimarãesPortugal Mechanical Engineering department University of MinhoCampus de Azurém4800-058 GuimarãesPortugal

Biopolymers exhibit unique properties and can be produced from plants’ and crops’ wastes. cellulose has beenused for the production of sustainable materials, nevertheless due to the difficulty inherent to its extraction,several methods have been studied in order to optimize the process. Therefore, this paper reports the extractionof natural polymers from food sector agro-food wastes, including cellulose, following a green chemistry *** cellulose extracted from pumpkin peel was acetylated and dispersed in a polylactic acid (PLA) matrix. Thedeveloped materials were characterized in terms of their structure, morphology and thermal stability. Theresults demonstrated the efficient chemical modification of cellulose and confirmed its good dispersion withinthe PLA matrix.

关键词： Food sector agro-wastes cellulose ionic liquid acetylation polylactic acid bioplastics

Serological surveillance for SARS-coV-2 antibodies among students,faculty and staff within a large university system during the pandemic

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World Journal of Virology 2025年第1期14卷 99-107页

作者： Marcos G Pinheiro Gabriela G O Alves Maria Eduarda R conde Sofia L costa Regina c S Sant’Anna isa M F Antunes Mônica c carneiro Fabio S Ronzei Julia c Scaffo Felipe R Pinheiro Lialyz S Andre Helvecio c Povoa Valéria T Baltar Fabíola Giordani Eduarda S Hemerly Gisele c Alexandre Karla c de Paula Márcio Watanabe Antonio claudio L da Nóbrega Jackeline christiane P Lobato Fabio Aguiar-Alves Laboratory of Molecular Epidemiology and Biotechnology Rodolpho Albino University LaboratoryFluminense Federal UniversityNiterói 24241000Rio de JaneiroBrazil Estácio de SáUniversity Nova Friburgo 28611135Rio de JaneiroBrazil Pathology Program Medicine schoolFluminense Federal UniversityNiterói 24070090Rio de JaneiroBrazil department of Pharmaceutical Sciences Lloyd L.Gregory School of PharmacyPalm Beach Atlantic UniversityWest Palm BeachFL 33401United States Health institute of Nova Friburgo Fluminense Federal UniversityNova Friburgo 28613001Rio de JaneiroBrazil department of Epidemiology and Biostatistics Institute of Collective Health(ISC)Fluminense Federal UniversityNiterói 24033900Rio de JaneiroBrazil institute of Physical Education Fluminense Federal UniversityNiterói 24020005Rio de JaneiroBrazil department of Statistics Fluminense Federal UniversityNiterói 24210200Rio de JaneiroBrazil department of Physiology and Pharmacology Fluminense Federal UniversityNiterói 24210130Rio de JaneiroBrazil

BAcKGROUND At the end of december 2019,the world faced severe acute respiratory syndrome-coronavirus 2(SARS-coV-2),which led to the outbreak of coronavirus disease 2019(cOViD-19),associated with respiratory *** virus has shown significant challenges,especially for senior citizens,patients with other underlying illnesses,or those with a sedentary *** tests conducted early on have helped identify how the virus is transmitted and how to curb its *** study hypothesis was that the rapid serological test for SARS-coV-2 antibodies could indicate the immunoreactive profile during the cOViD-19 pandemic in a university *** To conduct active surveillance for serological expression of anti-SARS-coV-2 antibodies in individuals within a university setting during the cOViD-19 *** This sectional study by convenience sampling was conducted in a large university in Niteroi-RJ,Brazil,from March 2021 to July *** study population consisted of students,faculty,and administrative staff employed by the university.A total of 3433 faculty members,60703 students,and 3812 administrative staff were invited to *** were gathered through rapid serological tests to detect immunoglobulin(ig)M and igG against ***χ²or Fisher's exact test was used to conduct statistical analysis.A 0.20 significance level was adopted for variable selection in a multiple logistic regression model to evaluate *** A total of 1648 individuals were enrolled in the *** proportion of cOViD-19 positivity was 164/1648(9.8%).The adjusted logistic model indicate a positive association between the expression of igM or igG and age[odds ratio(OR)=1.16,95%ci:1.02-1.31](Pindividuals who had been in contact with a cOViD-19-positive case(OR=3.49,95%ci:2.34-5.37)(Pceived the cOViD-19 vaccine(OR=2.33,95%ci:1.61-3.35)(Pcial isolation(OR=0.59,95%ci:0.41-0.84)(Pikelihood of sho

关键词： Serological surveillance SARS-coV-2 antibodies cOViD-19 Serological rapid test Risk factors for cOViD-19