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i.trumer:A Multi.Module Di.tri.uted Explai.able i.S/i.S for Securi.g Cloud Envi.onment

Computers, Materi.ls & Conti.ua 2025年第1期82卷 579-607页

作者： Nazreen banu A S.K.b.Sangeetha Department of Computer Sci.nce and Engi.eeri.g SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The i.creasi.g use of cloud-based devi.es has reached the cri.i.al poi.t of cybersecuri.y and unwanted network *** envi.onments pose si.ni.i.ant challenges i. mai.tai.i.g pri.acy and *** approaches,such as i.S,have been developed to tackle these ***,most conventi.nal i.trusi.n Detecti.n System(i.S)models struggle wi.h unseen cyberattacks and complex hi.h-di.ensi.nal *** fact,thi. paper i.troduces the i.ea of a novel di.tri.uted explai.able and heterogeneous transformer-based i.trusi.n detecti.n system,named i.TRUMER,whi.h offers balanced accuracy,reli.bi.i.y,and securi.y i. cloud setti.gs bymulti.lemodulesworki.g together wi.hi. *** traffi. captured from cloud devi.es i. fi.st passed to the TC&TM module i. whi.h the Falcon Opti.i.ati.n Algori.hm opti.i.es the feature selecti.n process,and Nai. bayes algori.hm performs the classi.i.ati.n of *** selected features are classi.i.d further and are forwarded to the Heterogeneous Attenti.n Transformer(HAT)*** thi. module,the contextual i.teracti.ns of the network traffi. are taken i.to account to classi.y them as normal or mali.i.us *** classi.i.d results are further analyzed by the Explai.able Preventi.n Module(XPM)to ensure trustworthi.ess by provi.i.g i.terpretable *** the explanati.ns fromthe classi.i.r,emergency alarms are transmi.ted to nearby i.Smodules,servers,and underlyi.g cloud devi.es for the enhancement of preventi.e *** experi.ents on benchmark i.S datasets Ci.i.S 2017,Honeypots,and NSL-KDD were conducted to demonstrate the effi.i.ncy of the i.TRUMER model i. detecti.g network traffi.wi.h hi.h accuracy for di.ferent *** outperforms state-of-the-art approaches,obtai.i.g better performance metri.s:98.7%accuracy,97.5%preci.i.n,96.3%recall,and 97.8%*** results vali.ate the robustness and effecti.eness of i.TRUMER i. securi.g di.erse cloud envi.onments agai.st sophi.ti.ated cyber threats.

关键词： Cloud computi.g i.trusi.n detecti.n system transformers and explai.able arti.i.i.l i.telli.ence(XAi.

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Neuroi.flammati.n revi.i.ed through the mi.rogli.l lens

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Neural Regenerati.n Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João b.Relvas i.sti.ute of Research and i.novati.n i. Health(i.S)and i.sti.ute for Molecular and Cell bi.logy(i.MC) University of PortoPortoPortugal Department of bi.medi.i.e Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroi.munology i. emergi.g as a pi.otal fi.ld,sheddi.g li.ht on the i.tri.ate dialogues between the central nervous system(CNS)and the i.mune *** explorati.n i. parti.ularly si.ni.i.ant i. understandi.g mi.rogli.,the CNS’s i.nate i.mune cells,beyond the conventi.nal conflati.n of“neuroi.flammati.n”and“mi.rogli.l acti.ati.n.”Thi. conflati.n has clouded the true complexi.y of these processes,potenti.lly stalli.g sci.nti.i. progress and the development of new *** challenge the long-standi.g perspecti.es that have oversi.pli.i.d these i.teracti.ns,advocati.g for a deeper explorati.n of the dynami. relati.nshi. between neuroi.flammati.n and mi.rogli.l *** di.secti.g speci.i. molecular pathways,we ai. to i.lumi.ate thei. elaborate roles i. neuroi.flammatory responses,especi.lly i. the context of Alzhei.er’s di.ease(AD).Here,neuroi.flammati.n i. not merely a passi.e observer or a di.ect antagoni.t but a complex agent i. the di.ease’s *** arti.le calls for a si.ni.i.ant paradi.m shi.t towards an i.tegrati.e,multi.omi.s approach to *** such a comprehensi.e framework i. cruci.l for advanci.g our understandi.g of neuroi.flammatory condi.i.ns and pavi.g the way for targeted therapeuti. strategi.s for brai. di.eases.

关键词： i.flammati.n si.pli.i.d acti.ati.n

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Federated Learni.g’s Role i. Next-Gen TV Ad Opti.i.ati.n

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Computers, Materi.ls & Conti.ua 2025年第1期82卷 675-712页

作者： Gabri.la Dobri.a Si.ona-Vasi.i.a Oprea Adela bâra Department of Economi. i.formati.s and Cyberneti.s Bucharest University of Economic StudiesBucharest010374Romania

i. the rapi.ly evolvi.g landscape of televi.i.n adverti.i.g,opti.i.i.g ad schedules to maxi.i.e vi.wer engagement and revenue has become *** methods often operate i. si.os,li.i.i.g the potenti.l i.si.hts gai.ed from broader data analysi. due to concerns over pri.acy and data *** arti.le i.troduces a novel approach that leverages Federated Learni.g(FL)to enhance TV ad schedule opti.i.ati.n,combi.i.g the strengths of local opti.i.ati.n techni.ues wi.h the power of global Machi.e Learni.g(ML)models to uncover acti.nable i.si.hts wi.hout compromi.i.g data *** combi.es li.ear programmi.g for i.i.i.l ads scheduli.g opti.i.ati.n wi.h ML—speci.i.ally,a K-Nearest Nei.hbors(KNN)model—for predi.ti.g ad spot *** i.to account the di.ersi.y and the di.fi.ulty of the ad-scheduli.g problem,we propose a prescri.ti.epredi.ti.e approach i. whi.h fi.st the posi.i.n of the ads i. opti.i.ed(usi.g Google’s OR-Tools CP-SAT)and then the scheduled posi.i.n of all ads wi.l be the result of the opti.i.ati.n ***,thi. output becomes the target of a predi.ti.e task that predi.ts the posi.i.n of new entri.s based on thei. characteri.ti.s ensuri.g the i.plementati.n of the scheduli.g at large scale(usi.g KNN,Li.ht Gradi.nt boosti.g Machi.e and Random Forest).Furthermore,we explore the i.tegrati.n of FL to enhance predi.ti.e accuracy and strategi. i.si.ht across di.ferent broadcasti.g networks whi.e preservi.g data *** FL approach resulted i. 8750 ads bei.g preci.ely matched to thei. opti.al category placements,showcasi.g an ali.nment wi.h the i.tended di.ersi.y ***,there was a mi.i.al devi.ti.n observed,wi.h 1133 ads posi.i.ned wi.hi. a one-category vari.nce from thei. i.eal placement i. the ori.i.al dataset.

关键词： Ad scheduli.g prescri.ti.e-predi.ti.e approach federated learni.g KNN

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Nano-Enhanced Dai.y Scum bi.di.sel blends:Unleashi.g the Power of Alumi.i.m Oxi.e for Sustai.able and Effi.i.nt Engi.e Performance

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Journal of Thermal Sci.nce 2025年第1期 283-302页

作者： Veeranna MODi.Prasad b.RAMPURE Suni. Kumar SHETTY Madeva NAGARAL Channa Keshava NAi. N Johar MGM Muhammad i.syad AbDULLAH Abdullah i.AL-MANSOUR Shamshad ALAM KLE College of Engi.eeri.g and Technology ChikodiVisvesvaraya Technological University Ni.te (Deemed to be Uni.ersi.y) NMAM Institute of Technology (NMAMIT)Department of Mechanical Engineering Ai.craft Research and Desi.n Centre HAL Department of Mechani.al Engi.eeri.g BGS College of Engineering and TechnologyBengaluruAffiliated to Visvesvaraya Technological University Management and Sci.nce Uni.ersi.y Department of Ci.i. Engi.eeri.g College of EngineeringKing Saud University

Thi. study i.vesti.ates the effect of alumi.i.m oxi.e nanoparti.lesaddi.i.n to bi.di.sel blends made from dai.y mi.k scum on performance and combusti.n characteri.ti.s of the di.sel *** di.persi.n of Al2O3nanoparti.les i. b20 blends at di.ferent concentrati.ns was done wi.h the help of *** number of blends were prepared for the *** Machi.e learni.g algori.hms(Random Forest（RF）and Catboost) was used for the *** results show that i. compari.on to bi.di.sel blends wi.hout nanoparti.les,the ki.emati. vi.cosi.y and densi.y i. hi.her for fuel blends wi.h *** these Fuel blends have hi.her calori.i. *** blends exhi.i.ed reduced brake Speci.i. Fuel Consumpti.n（bSFC） of2.85% than the blends wi.hout nano parti.les(Dai.y Scum Methyl Ester bi.di.sel 20%+Neat Di.sel 80%（i. volume）,DSMEb20),57.14% less CO,40.8% less hydrocarbon,and i.creased NOxemi.si.ns compared to conventi.nal di.sel,contri.uti.g to the development of envi.onmentally fri.ndly and renewable bi.fuel blends wi.h *** b20NP30 i. the opti.al blend for performance and emi.si.n *** study concludes wi.h fi.di.gs on enhanced brake Thermal Effi.i.ncy（bTE） of 26.29% i. 3×10-5（i. volume） Al2O3nanoparti.le-blended DSME b20 and other DSME b20 fuel blends,emphasi.i.g the i.portance of opti.al nanoparti.le *** correlati.n matri. shows how engi.e load,effi.i.ncy measures（bTE,bSFC）,and emi.si.ns（CO,CO2,NOx,Smoke） are connected i. complex *** results help us understand the compli.ated dynami.s of engi.e performance and emi.si.n characteri.ti.s ***'s diagram for bTE and bSFC shows that Catboost-based bTE models perform superi.r to RF-based models duri.g the trai.i.g as well as testi.g *** results were obtai.ed for CO and CO2emi.si.n results.

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Deep learni.g i.enti.i.ati.n of novel autophagi. protei.-protei. i.teracti.ns and experi.ental vali.ati.n of becli. 2-Ubi.ui.i. 1 axi. i. tri.le-negati.e breast cancer

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Oncology research 2025年第1期33卷 67-81页

作者： Xi.ng Li.Wenke Ji. Li.eng Wu Huan Wang Xi. Xi. Wei.Huang b O Li. State Key Laboratory of Southwestern Chi.ese Medi.i.e Resources School of Pharmacy and College of Medical Technology Chengdu University of Traditional Chinese Medicine Chengdu 611137 China. Department of bi.therapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China.

background:Tri.le-negati.e breast cancer (TNbC), characteri.ed by i.s lack of tradi.i.nal hormone receptors and HER2, presents a si.ni.i.ant challenge i. oncology due to i.s poor response to conventi.nal therapi.s. Autophagy i. an i.portant process for mai.tai.i.g cellular homeostasi., and there are currently autophagy bi.markers that play an effecti.e role i. the cli.i.al treatment of tumors. i. contrast to targeti.g protei. acti.i.y, i.terventi.n wi.h protei.-protei. i.teracti.n (PPi. can avoi. unrelated crosstalk and regulate the autophagy process wi.h mi.i.al i.terference pathways.Methods:Here, we employed Nai.e bayes, Deci.i.n Tree, and k-Nearest Nei.hbors to eluci.ate the complex PPi.network associ.ted wi.h autophagy i. TNbC, ai.i.g to uncover novel therapeuti. targets. Meanwhi.e, the candi.ate protei.s i.teracti.g wi.h becli. 2 were i.i.i.lly screened i. MDA-Mb-231 cells usi.g becli. 2 as bai. protei. by i.munopreci.i.ati.n-mass spectrometry assay, and the i.teracti.n relati.nshi. was veri.i.d by molecular docki.g and CO-i. experi.ents after i.tersecti.n. Colony formati.n, cellular i.munofluorescence, cell scratch and 3-(4,5-Di.ethylthi.zol-2-yl)-2,5-di.henyltetrazoli.m bromi.e (MTT) tests were used to predi.t the cli.i.al therapeuti. effects of mani.ulati.g candi.ate PPi.Results:by developi.g three PPi.classi.i.ati.n models and analyzi.g over 13,000 datasets, we i.enti.i.d 3733 previ.usly unknown autophagy-related PPi.. Our network analysi. revealed the central role of becli. 2 i. autophagy regulati.n, uncoveri.g i.s i.teracti.ns wi.h 39 newly i.enti.i.d protei.s. Notably, the CO-i. studi.s i.enti.i.d the substanti.l i.teracti.n between becli. 2 and Ubi.ui.i. 1, whi.h was anti.i.ated by our model and di.covered i. i.munopreci.i.ati.n-mass spectrometry assay results. Subsequently, i.vesti.ati.ns showed that overexpressi.g becli. 2 i.creased Ubi.ui.i. 1, promoted autophagy-dependent cell death, and i.hi.i.ed proli.erati.n and metastasi. i. MDA-Mb-231 cells.

关键词： Arti.i.i.l i.telli.ence (Ai. Autophagy becli. 2 Protei.-protei. i.teracti.ns (PPi. Tri.le-negati.e breast cancer (TNbC) Ubi.ui.i. 1

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Pi.i.g up multi.ecker pyrgos[n]cages as anti.acteri.l materi.ls

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Sci.nce Chi.a Materi.ls 2025年第01期 314-316页

作者： Mi.uel A.Li.zzi.Vaamonde Jackson b.Lancaster Samantha A.Mason Yuanni.g Feng Department of Chemi.try and bi.chemi.try The University of Oklahoma

The development of anti.i.ti.s i. regarded as one of the most si.ni.i.ant sci.nti.i. advances i. modern medi.i.e. before the commerci.li.ati.n of anti.i.ti.s, i.fecti.us di.eases were catastrophi. throughout hi.tory [1]. Peni.i.li. was used to treat seri.us i.fecti.ns i. the 1940s, but unfortunately, wi.h the i.troducti.n of anti.i.ti.s came the emergence of anti.i.ti. resi.tance [2,3]. Evolved and adapted methi.i.li.-resi.tant Staphylococcus aureus (MRSA) strai.s are presently i.pacti.g communi.y and healthcare systems across the globe [4].

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A Comprehensi.e Survey on Federated Learni.g Appli.ati.ns i. Computati.nal Mental Healthcare

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Computer Modeli.g i. Engi.eeri.g & Sci.nces 2025年第1期142卷 49-90页

作者： Vajrati.a Vajrobol Geeti.a Jai. Saxena Ami. Pundi. Sanjeev Si.gh Akshat Gaurav Savi.bansal Razaz Waheeb Attar Mosi.r Rahman bri. b.Gupta i.sti.ute of i.formati.s and Communi.ati.n University of DelhiDelhi110021India Maharaja Agrasen College University of DelhiDelhi110096India Computer Engi.eeri.g Ronin InstituteMontclairNJ 07043USA Department of Research and i.novati.n Insights2TechinfoJaipur302001India Uni.ersi.y Centre for Research and Development(UCRD) Chandigarh UniversityChandigarh140413India Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia CCRi.Department of Computer Sci.nce and i.formati.n Engi.eeri.g Asia UniversityTaichung413Taiwan Symbi.si. Centre for i.formati.n Technology(SCi.) Symbiosis International UniversityPune411057India Center for i.terdi.ci.li.ary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India

Mental health i. a si.ni.i.ant i.sue worldwi.e,and the uti.i.ati.n of technology to assi.t mental health has seen a growi.g *** ai.s to allevi.te the workload on healthcare professi.nals and ai. *** appli.ati.ns have been developed to support the challenges i. i.telli.ent healthcare ***,because mental health data i. sensi.i.e,pri.acy concerns have *** learni.g has gotten some *** research revi.ws the studi.s on federated learni.g and mental health related to solvi.g the i.sue of i.telli.ent healthcare *** explores vari.us di.ensi.ns of federated learni.g i. mental health,such as datasets(thei. types and sources),appli.ati.ns categori.ed based on mental health symptoms,federated mental health frameworks,federated machi.e learni.g,federated deep learni.g,and the benefi.s of federated learni.g i. mental health *** research conducts surveys to evaluate the current state of mental health appli.ati.ns,mai.ly focusi.g on the role of Federated Learni.g(FL)and related pri.acy and data securi.y *** survey provi.es valuable i.si.hts i.to how these appli.ati.ns are emergi.g and evolvi.g,speci.i.ally emphasi.i.g FL’s i.pact.

关键词： Depressi.n emoti.nal recogni.i.n i.telli.ent healthcare systems mental health federated learni.g stress detecti.n sleep behavi.ur

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Numeri.al i.vesti.ati.n of vari.ble vi.cosi.i.s and thermal strati.i.ati.n effects on MHD mi.ed convecti.e heat and mass transfer past a porous wedge i. the presence of a chemi.al reacti.n

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Appli.d Mathemati.s and Mechani.s(Engli.h Edi.i.n) 2009年第11期30卷 1353-1364页

作者： i. Muhai.i. R. Kandasamy Azme b. Khami. Computati.nal Flui. Dynami.s FSSWUniversiti Tun Hussein Onn MalaysiaParit Raja 86400Batu PahatJohorMalaysia

An analysi. i. presented to i.vesti.ate the effects of vari.ble vi.cosi.i.s and thermal strati.i.ati.n on the MHD mi.ed convecti.e heat and mass transfer of a vi.cous, i.compressi.le, and electri.ally conducti.g flui. past a porous wedge i. the presence of a chemi.al reacti.n. The wall of the wedge i. embedded i. a uni.orm nonDarci.n porous medi.m i. order to allow for possi.le flui. wall sucti.n or i.jecti.n. The governi.g boundary layer equati.ns are wri.ten i.to a di.ensi.nless form by si.i.ari.y transformati.ns. The transformed coupled nonli.ear ordi.ary di.ferenti.l equati.ns are solved numeri.ally wi.h fi.i.e di.ference methods. Numeri.al calculati.ns up to the thi.dorder level of truncati.n are carri.d out for di.ferent values of di.ensi.nless parameters. The results are presented graphi.ally, and show that the flow fi.ld and other quanti.i.s of physi.al i.terest are si.ni.i.antly i.fluenced by these parameters. The results are compared wi.h those avai.able i. literature, and show excellent agreement.

关键词： vari.ble vi.cosi.y chemi.al reacti.n non-Darcy flow mi.ed convecti.n,thermal strati.i.ati.n magneti. effect

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Anti.permatogeni. and hormonal effects of Crotalari. junceaLi.n. seed extracts i. male mi.e

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Asi.n Journal of Andrology 2004年第1期6卷 67-70页

作者： b. Vi.aykumar i. Sangamma A. Sharanabasappa Saraswati.b. Pati. Laboratory of Reproducti.e bi.logy Department of Post-Graduate Studies and Research in Zoology Gulbarga University Gulbarga-585 106 India

Ai.: To evaluate the anti.erti.i.y acti.i.y of vari.us extracts of Crotalari. juncea seeds i. male mi.e. Methods: Adult male mi.e were gavaged the petroleum ether, benzene and ethanol extracts of C. juncea seeds, 25 mg·(100g)-1·day-1 for 30 days. On day 31 the ani.als were sacri.i.ed by cervi.al di.locati.n and the testes, epi.i.ymi., vas deferens, semi.al vesi.les, prostate gland, bulbourethral gland and levator ani.were di.sected out and wei.hed. The organs were processed for bi.chemi.al and hi.tologi.al exami.ati.n. Results: i. petroleum ether, benzene and ethanol extracts treated rats, there was a decrease i. the wei.hts of testi. and accessory reproducti.e organs. The diameters of the testi. and semi.i.erous tubules were decreased. Spermatogoni., spermatocytes and spermati.s i. the testi. and the sperm count i. cauda epi.i.ymi. were also decreased. There was a si.ni.i.ant reducti.n i. the protei. and glycogen contents and an i.crease i. the cholesterol content i. the testi., epi.i.ymi. and vas deferens. Of the 3 extracts, the ethanol extract appeared to be the most potent i. anti.permatogeni. acti.i.y. When the ethanol extract was tested i. i.mature male mi.e, there was an anti.ndrogeni. effect as the wei.hts of accessory organs were reduced. Conclusi.n: The vari.us extracts of C. juncea seeds arrest spermatogenesi. and are li.ely to have an anti.ndrogeni. acti.i.y.

关键词： Crotalari. juncea testi. accessory reproducti.e organs anti.permatogeni. effect anti.ndrogeni. effect

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Chi.al uni.ersali.y class of normal-superconducti.g and exci.on condensati.n transi.i.ns on surface of topologi.al i.sulator

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Fronti.rs of physi.s 2015年第3期10卷 65-82页

作者： Di.gpi.g Li.baruch Rosenstei. b. Ya. Shapi.o i. Shapi.o School of Physi.s Peking University Beijing 100871 China Collaborati.e i.novati.n Center of Quantum Matter Beijing 100084 China Electrophysi.s Department National Chiao Tung University Hsinchu 30050 Taiwan China physi.s Department Ariel University Ariel 40700 Israel Physi.s Department Bar-Ilan University 52900 Ramat-Gan Israel

New two-di.ensi.nal systems such as the surfaces of topologi.al i.sulators （Ti.） and graphene offer the possi.i.i.y of experi.entally i.vesti.ati.g si.uati.ns consi.ered exoti. just a decade ago. These si.uati.ns i.clude the quantum phase transi.i.n of the chi.al type i. electroni. systems wi.h a relati.i.ti. spectrum. Phonon-mediated （conventi.nal） pai.i.g i. the Di.ac semi.etal appeari.g on the surface of a Ti.causes a transi.i.n i.to a chi.al superconducti.g state, and exci.on condensati.n i. these gapless systems has long been envi.i.ned i. the physi.s of narrow-band semi.onductors. Starti.g from the mi.roscopi. Di.ac Hami.toni.n wi.h local attracti.n or repulsi.n, the bardeen- Cooper-Schri.ffer type of Gaussi.n approxi.ati.n i. developed i. the framework of functi.nal i.tegrals. i. i. shown that owi.g to an ultrarelati.i.ti. di.persi.n relati.n, there i. a quantum cri.i.al poi.t governi.g the zero-temperature transi.i.n to a superconducti.g state or the exci.on condensed state. Quantum transi.i.ns havi.g cri.i.al exponents di.fer greatly from conventi.nal ones and belong to the chi.al uni.ersali.y class. We di.cuss the appli.ati.n of these results to recent experi.ents i. whi.h surface superconducti.i.y was found i. Ti. and esti.ate the feasi.i.i.y of phonon pai.i.g.

关键词： topologi.al i.sulator Weyl semi.etal superconducti.i.y quantum cri.i.ali.y

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