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Neural Regenerati.n Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-muñoz Hei.i.R.Fuller School of Pharmacy and Bi.engi.eeri.g Keele UniversityKeeleUK Wolfson Center for i.heri.ed Neuromuscular Di.ease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spi.al muscular atrophy(SMA)i. a geneti. condi.i.n that results i. selecti.e lower motor neuron loss wi.h concomi.ant muscle weakness and *** geneti. cause of SMA was understood i. 1995 when loss or i.pai.ment of the survi.al motor neuron 1(SMN1)gene was i.enti.i.d as the mai. contri.uti.g factor(Lefebvre et al.,1995).Thi.,i. combi.ati.n wi.h the di.covery that humans have a“back-up”gene,SMN2,whi.h can produce low levels(approxi.ately 10%)of the full-length functi.nal SMN protei.,has led to the generati.n of SMA-speci.i. gene *** was tradi.i.nally classi.i.d accordi.g to age of symptom onset and developmental mi.estones achi.ved,wi.h li.e expectancy and severi.y varyi.g between ***,SMN2 copy number i. used as a proxy for the predi.ti.n of di.ease severi.y,wi.h hi.her SMN2 copy number typi.ally bei.g associ.ted wi.h reduced severi.y of SMA,although thi. relati.nshi. i. not absolute:some i.di.i.uals wi.h low SMN2 copy number have less severe SMA phenotypes and vi.e ***,the eti.logy of SMA i. further compli.ated by other factors,such as non-typi.al nucleoti.e vari.nts and SMN2-i.dependent modi.i.rs of di.ease severi.y.

关键词： atrophy tradi.i.nally absolute

Müller cells are acti.ated i. response to reti.al outer nuclear layer degenerati.n i. rats subjected to si.ulated wei.htlessness condi.i.ns

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Neural Regenerati.n Research 2025年第7期20卷 2116-2128页

作者： Yuxue mu Ni.g Zhang Dongyu Wei.Guoqi.g Yang Li.i.gxuan Yao Xi.yue Xu Yang Li.Junhui.Xue Zuomi.g Zhang Tao Chen Aerospace Cli.i.al Medi.al Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Avi.ti.n Medi.i.e Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medi.i.e Wuhan No.1 HospitalWuhanHubei ProvinceChina Thi.d Regi.ent School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regi.ent School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A mi.rogravi.y envi.onment has been shown to cause ocular damage and affect vi.ual acui.y,but the underlyi.g mechani.ms remai. ***,we establi.hed an ani.al model of wei.htlessness vi. tai. suspensi.n to exami.e the pathologi.al changes and molecular mechani.ms of reti.al damage under *** 4 weeks of tai. suspensi.n,there were no notable alterati.ns i. reti.al functi.n and morphology,whi.e after 8 weeks of tai. suspensi.n,si.ni.i.ant reducti.ns i. reti.al functi.n were observed,and the outer nuclear layer was thi.ner,wi.h abundant apoptoti. *** i.vesti.ate the mechani.m underlyi.g the degenerati.e changes that occurred i. the outer nuclear layer of the reti.a,proteomi.s was used to analyze di.ferenti.lly expressed protei.s i. rat reti.as after 8 weeks of tai. *** results showed that the expressi.n levels of fi.roblast growth factor 2(also known as basi. fi.roblast growth factor)and gli.l fi.ri.lary aci.i. protei.,whi.h are closely related to Müller cell acti.ati.n,were si.ni.i.antly *** addi.i.n,Müller cell regenerati.n and Müller cell gli.si. were observed after 4 and 8 weeks,respecti.ely,of si.ulated *** fi.di.gs i.di.ate that Müller cells play an i.portant regulatory role i. reti.al outer nuclear layer degenerati.n duri.g wei.htlessness.

关键词： gli.l fi.rous aci.i. protei. gli.si. Müller cells nerve growth factor neural di.ferenti.ti.n neurodegenerati.n proteomi. reti.al degenerati.n reti.al outer nuclear layer si.ulated wei.htlessness

EZH2-dependent myeli.ati.n followi.g sci.ti. nerve i.jury

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Neural Regenerati.n Research 2025年第8期20卷 2382-2394页

作者： Hui.Zhu Li.mu Xi.Xu Ti.nyi.Huang Yi.g Wang Si.uan Xu Yi.i.g Wang Wencong Wang Zhi.i.g Wang Hongkui.Wang Chengbi. Xue Research Center of Cli.i.al Medi.i.e Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medi.al School of Nantong Uni.ersi.y NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabi.i.ati.n Medi.i.e Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Cri.i.al Care Medi.i.e Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyeli.ati.n and remyeli.ati.n have been major focal poi.ts i. the study of peri.heral nerve regenerati.n followi.g peri.heral nerve ***,the gene regulatory network of regenerated myeli. di.fers from that of nati.e *** of enhancer of zeste homolog 2(EZH2)hi.ders the di.ferenti.ti.n,maturati.n,and myeli.ati.n of Schwann cells i. *** further determi.e the role of EZH2 i. myeli.ati.n and recovery post-peri.heral nerve i.jury,condi.i.nal knockout mi.e lacki.g Ezh2 i. Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a si.ni.i.ant proporti.n of axons i. the sci.ti. nerve of Ezh2-depleted mi.e remai. *** hi.hli.hts the cruci.l role of Ezh2 i. i.i.i.ti.g Schwann cell ***,we observed that 21 days after i.duci.g a sci.ti. nerve crush i.jury i. these mi.e,most axons had remyeli.ated at the i.jury si.e i. the control nerve,whi.e Ezh2^(fl/fl);Mpz-Cre mi.e had si.ni.i.antly fewer remyeli.ated axons compared wi.h thei. wi.d-type *** suggests that the absence of Ezh2 i. Schwann cells i.pai.s myeli. formati.n and *** conclusi.n,EZH2 has emerged as a pi.otal regulatory factor i. the process of demyeli.ati.n and myeli. regenerati.n followi.g peri.heral nerve *** EZH2 acti.i.y duri.g these processes may offer a promi.i.g therapeuti. target for the treatment of peri.heral nerve i.juri.s.

关键词： demyeli.ati.n EZH2 myeli.ati.n peri.heral nerve i.jury PRC2 remyeli.ati.n Schwann cells sci.ti. nerve crush sci.ti. nerve transecti.n

CNKSR2 i.teractome analysi. i.di.ates i.s associ.ti.n wi.h the centrosome/mi.rotubule system

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Neural Regenerati.n Research 2025年第8期20卷 2420-2432页

作者： Li. Yi. Yalan Xu Ji. mu Yu Leng Lei.Ma Yu Zheng Rui.hi.Li.Yi. Wang Pei.eng Li.Hai.Zhu Dong Wang Ji.g Li i.sti.ute for Translati.nal Medi.i.e The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basi. Medi.i.e Qingdao UniversityQingdaoShandong ProvinceChina College of Li.e Sci.nces and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protei. connector enhancer of ki.ase suppressor of Ras 2(CNKSR2),present i. both the postsynapti. densi.y and cytoplasm of neurons,i. a scaffoldi.g protei. wi.h several protei.-bi.di.g *** of the CNKSR2 gene have been i.pli.ated i. neurodevelopmental di.orders,parti.ularly i.tellectual di.abi.i.y,although the preci.e mechani.m i.volved has not yet been fully *** has demonstrated that CNKSR2 plays a role i. faci.i.ati.g the locali.ati.n of postsynapti. densi.y protei. complexes to the membrane,thereby i.fluenci.g synapti. si.nali.g and the morphogenesi. of dendri.i. ***,the functi.n of CNKSR2 i. the cytoplasm remai.s to be *** thi. study,we used i.munopreci.i.ati.n and hi.h-resoluti.n li.ui. chromatography-mass spectrometry to i.enti.y the i.teractors of *** a combi.ati.n of bi.i.formati. analysi. and cytologi.al experi.ents,we found that the CNKSR2 i.teractors were si.ni.i.antly enri.hed i. the proteome of the *** also showed that CNKSR2 i.teracted wi.h the mi.rotubule protei. DYNC1H1 and wi.h the centrosome marker *** colocali.ati.n analysi. confi.med the centrosomal locali.ati.n of *** we downregulated CNKSR2 expressi.n i. mouse neuroblastoma cells(Neuro 2A),we observed si.ni.i.ant changes i. the expressi.n of numerous centrosomal *** mani.ulati.n also affected centrosome-related functi.ns,i.cludi.g cell si.e and shape,cell proli.erati.n,and ***,we found that CNKSR2 i.teractors were hi.hly enri.hed i. de novo vari.nts associ.ted wi.h i.tellectual di.abi.i.y and auti.m spectrum *** fi.di.gs establi.h a connecti.n between CNKSR2 and the centrosome,and offer new i.si.hts i.to the underlyi.g mechani.ms of neurodevelopmental di.orders.

关键词： auti.m spectrum di.order centrosome CNKSR2 i.tellectual di.abi.i.y i.teractome mass spectrometry mi.rotubule neurodevelopmental di.ease protei. complexes protei.-protei. i.teracti.ns

Arcti. sea-i.e extent: No record mi.i.um i. 2023 or recent years

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Atmospheri. and Oceani. Sci.nce Letters 2025年第1期18卷 52-55页

作者： Ola M.Johannessen Tor i.Olaussen Nansen Sci.nti.i. Soci.ty BergenNorway Nansen Envi.onmental and Remote Sensi.g Center BergenNorway

Arcti. sea-i.e extent reaches i.s mi.i.um each year i. September. On 11 September 2023 the mi.i.um was 4.969 mi.li.n square ki.ometers(***^(2)). Thi. was not a record low, whi.h occurred i. 2012, when the mi.i.um was 4.175 ***^(2), 0.794 ***^(2) less than the mi.i.um i. 2023. However, the i.e extent had decreased by 0.432 ***^(2) compared wi.h 2022. Nevertheless, the summer melti.g i. 2023 was remarkably less than expected when consi.eri.g the strong heat waves i. the atmosphere and ocean, wi.h record temperatures set around the world. i. general, there i. a hi.h correlati.n between the long-term decrease i. sea-i.e extent and the i.creasi.g CO_(2) i. the atmosphere, where the i.crease of CO_(2) i. recent decades explai.s about 80% of the decrease i. sea i.e i. September, whi.e the remai.der i. caused by natural vari.bi.i.y.

关键词： Sea i.e Arcti. Mi.i.um i.e Cli.ate

Temperature-i.sensi.i.e mi.ro-di.placement sensor wi.h spi.dle-shaped structure si.gle mode fi.er

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Optoelectroni.s Letters 2025年

作者： ZHANG Wei.ua mu Ji.li. WANG Hao WANG Dong YU Haozheng TAO Yi.eng Engi.eeri.g Research Center of Optoelectroni. Devi.es and Communi.ati.n Technology，Mi.i.try of Educati.n， Ti.nji. Key Laboratory of Fi.m Electroni. and Communi.ati.n Devi.es， School of i.tegrated Ci.cui. Sci.nce and Engi.eeri.g， Ti.nji. Uni.ersi.y of Technology Engi.eeri.g i.frastructure Department，Autonomous Dri.i.g Department Xi.omi.EV Company Ltd

A temperature-i.sensi.i.e mi.ro-di.placement sensor based on a spi.dle-shaped si.gle mode fi.er (SMF) i. presented and demonstrated. The SMF i. bent i.to a balloon-shaped SMF and burned i.to a spi.dle-shaped SMF by a flame. Due to the bendi.g of the fi.er， part of the i.ci.ent li.ht leaks from the fi.er core i.to the fi.er claddi.g， whi.h exci.es hi.her order claddi.g modes. Therefore， modal i.terference occurs. The experi.ental results show that the maxi.um sensi.i.i.y of the sensors i. -203 pm/μm when mi.ro-di.placement vari.s from 0 to 80 μm. The sensors are i.sensi.i.e to temperature i. the range of 20-70℃. i. addi.i.n， the sensors have the advantages of si.ple structure， low cost， small volume， hi.h sensi.i.i.y and stabi.i.y， whi.h can be wi.ely used i. numerous hi.h-preci.i.n i.dustri.l measurements and ci.i. engi.eeri.g structure moni.ori.g fi.lds.

关键词：

Coarse to Fi.e: The Role of Severe Plasti. Deformati.n i. Advanci.g Ti.ani.m-Based Medi.al i.plants - A Comprehensi.e Revi.w

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Journal of Wuhan Uni.ersi.y of Technology(Materi.ls Sci.nce) 2025年第1期40卷 295-306页

作者： Dragana R Mi.ajlovi. Bojan i.Međo i.ana Lj Cvi.ovi.-Alagi. Veljko R Djoki. Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vi.ča i.sti.ute of Nuclear Sci.ences-Nati.nal i.sti.ute of the Republi. of Serbi. University of Belgrade11001BeogradSerbia i.novati.n Centre of the Faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

Thi. paper descri.es severe plasti. deformati.n(SPD)procedures,whi.h are uti.i.ed to form an ultrafi.e-grai.ed structure i. metalli. *** the SPD process,a soli. materi.l sample i. subjected to very hi.h loads wi.hout a si.ni.i.ant change i. sample *** the present work,the hi.h-pressure torsi.n(HPT)process,as one of the SPD techni.ues,whi.h achi.ves a hi.h degree of deformati.n and ensures refi.ement of the mi.rostructure,wi.l be di.cussed i. more *** that grai. si.e control i. accepted as a method to obtai. materi.ls wi.h desi.ed characteri.ti.s,an overvi.w of the properti.s of ultrafi.e-grai.ed ti.ani.m-based bi.materi.ls to be used i. medi.i.e i. ***,parti.ular attenti.n i. dedi.ated to the i.fluences of HPT process parameters,pri.ari.y hydrostati. pressure,and number of revoluti.ns duri.g torsi.n,on the grai. si.e and physi.al and mechani.al characteri.ti.s(modulus of elasti.i.y,mi.rohardness,and tensi.e properti.s),corrosi.n resi.tance,and bi.compati.i.i.y of the ti.ani.m-based bi.materi.ls.A revi.w of the li.erature i.di.ates that ti.ani.m-based materi.ls obtai.ed by the SPD process show i.proved mechani.al and physi.al properti.s wi.hout losi.g bi.compati.i.i.y and corrosi.n resi.tance,whi.h suggests that these methods of obtai.i.g i.plants are somethi.g that should be further developed i. the future.

关键词： hi.h-pressure torsi.n process ultrafi.e-grai.ed ti.ani.m-based materi.ls electrochemi.al anodi.ati.n physi.al properti.s mechani.al properti.s

黑死病与奥斯曼帝国的兴起(1347-1453)

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古代文明（中英文） 2025年第1期19卷 50-58,M0004,M0005页

作者：母仕洪西南大学历史文化学院、伊朗研究中心重庆400715

14世纪中叶以降,黑死病在东地中海地区反复暴发,对当地的国家造成严重冲击,尤其是使日渐衰微的拜占庭帝国遭受严重的人口衰减与社会瓦解。然而,此间征服事业方兴未艾的奥斯曼帝国不仅躲过黑死病致命侵袭,反而借助黑死病对敌对政权的摧... 详细信息

14世纪中叶以降,黑死病在东地中海地区反复暴发,对当地的国家造成严重冲击,尤其是使日渐衰微的拜占庭帝国遭受严重的人口衰减与社会瓦解。然而,此间征服事业方兴未艾的奥斯曼帝国不仅躲过黑死病致命侵袭,反而借助黑死病对敌对政权的摧残加速了对外扩张进程,实现了国力的持续提升。黑死病之所以对奥斯曼帝国与敌对政权的冲击效应大相径庭,主要缘于帝国位居内陆的地理位置、游牧社会组织形式以及相对有效的防疫举措。总之,黑死病肆虐对以拜占庭帝国为主的东地中海诸政权产生了严重负面效应,一定程度上为奥斯曼早期扩张铺平了道路,成为促进帝国兴起不可忽视的重要因素。

关键词：黑死病奥斯曼帝国拜占庭帝国瘟疫大流行

Uni.i.d treatment of one-range addi.i.n theorems for i.teger and non-i.teger n-STO, -GTO and -generali.ed exponenti.l type orbi.als wi.h hyperboli. cosi.e i. posi.i.n, momentum and four-di.ensi.nal spaces

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Chi.ese Physi.s B 2012年第9期21卷 176-178页

作者： i. i. Gusei.ov Department of Physi.s Faculty of Arts and Sciences Onsekiz Mart University

Si.pler formulas are deri.ed for one-range addi.i.n theorems for the i.teger and noni.teger n generali.ed ex- ponenti.l type orbi.als, momentum space orbi.als, and hyperspheri.al harmoni.s wi.h hyperboli. cosi.e （GETO HC, GMSO HC, and GHSH HC） i. posi.i.n, momentum and four-di.ensi.nal spaces, respecti.ely. The fi.al results are expressed i. terms of one-range addi.i.n theorems of complete orthonormal sets of Ca-exponenti.l type orbi.als, Ca- momentum space orbi.als and za-hyperspheri.al harmoni.s. We noti.e that the one-range addi.i.n theorems for i.teger and noni.teger n-Slater type orbi.als and Gaussi.n type orbi.als i. posi.i.n, momentum and four di.ensi.nal spaces are speci.l cases of GETO HC, GMSO HC, and GHSH HC. The theorems presented can be useful i. the accurate study of the electroni. structure of atomi. and molecular systems.

关键词： electroni. structure generali.ed exponenti.l type orbi.als one-range addi.i.n theorems,Hartree-Fock-Roothaan equati.ns

One-Range Addi.i.n Theorems i. Terms of ψ^α -ETOs for STOs and Coulomb-Yukawa Li.e Correlated i.teracti.n Potenti.ls of i.teger and Noni.teger i.di.es

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Chi.ese Physi.s Letters 2008年第12期25卷 4240-4243页

作者： i. i. Gusei.ov Department of Physi.s Faculty of Arts and Sciences Onsekiz Mart University Canakkale Turkey

The expansi.n formulas i. terms of complete orthonormal sets of ψ^α -exponenti.l type orbi.als are establi.hed for the Slater type orbi.als and Coulomb-Yukawa-li.e correlated i.teracti.n potenti.ls of i.teger and noni.teger i.di.es. These relati.ns are used i. obtai.i.g thei. unsymmetri.al and symmetri.al one-range addi.i.n theorems. The fi.al results are especi.lly useful i. the calculati.ns of multi.entre multi.lectron i.tegrals occurri.g when Hartree-Fock-Roothaan and expli.i.ly correlated methods are employed.

关键词： orthonormal set expansi.n formula