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Severe aspi.ati.n pneumoni. i. the elderly

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Journal of i.tensi.e Medi.i.e 2024年第3期4卷 307-317页

作者： Sebasti.n Ocrospoma Marcos i.Restrepo Di.i.i.n of Pulmonary Di.eases&Cri.i.al Care Medi.i.e University of Texas Health San AntonioSan AntonioTXUSA Secti.n of Pulmonary&Cri.i.al Care Medi.i.e South Texas Veterans Health Care SystemSan AntonioTXUSA

The global populati.n i. agi.g at an unprecedented rate,resulti.g i. a growi.g and vulnerable elderly populati.n i. need of effi.i.nt comprehensi.e healthcare servi.es that i.clude long-term care and ski.led nursi.g *** thi. context,severe aspi.ati.n pneumoni.,a condi.i.n that carri.s substanti.l morbi.i.y,mortali.y,and fi.anci.l burden,especi.lly among elderly pati.nts requi.i.g admi.si.n to the i.tensi.e care uni.,has attracted greater *** pneumoni. i. defi.ed as a pulmonary i.fecti.n related to aspi.ati.n or dysphagi. i. *** epi.odes of coughi.g on food or li.ui. i.take,a hi.tory of relevant underlyi.g condi.i.ns,abnormali.i.s on vi.eofluoroscopy or water swallowi.g,and gravi.y-dependent shadow di.tri.uti.n on chest i.agi.g are among the clues that suggest *** wi.h aspi.ati.n pneumoni. tend to be elderly,frai.,and sufferi.g from more comorbi.i.i.s than those wi.hout thi. ***,we comprehensi.ely address the epi.emi.logy,cli.i.al characteri.ti.s,di.gnosi.,treatment,preventi.n,and prognosi. of severe aspi.ati.n communi.y-acqui.ed pneumoni. i. the elderly to opti.i.e care of thi. hi.h-ri.k demographi.,enhance outcomes,and mi.i.i.e the healthcare costs associ.ted wi.h thi. *** preventi.e measures and effecti.e management strategi.s i. vi.al i. ensuri.g the well-bei.g of our agi.g populati.n.

关键词： Aspi.ati.n pneumoni. Aged Cri.i.al i.lness Swallowi.g di.orders Frai.ty Anti.acteri.l agents

Understandi.g the Theory of Karp, Mi.ler and Wi.ograd

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Journal of Appli.d Mathemati.s and Physi.s 2024年第4期12卷 1203-1236页

作者： Athanasi.s i. Margari. Department of Di.i.al Systems Gaiopolis Campus University of Thessaly Larissa Greece

The objecti.e of thi. tutori.l i. to present the fundamental theory of Karp, Mi.ler and Wi.ograd, whose semi.al paper lai. the foundati.ns regardi.g the systemati. descri.ti.n of the organi.ati.n of computati.ns i. systems of uni.orm recurrent equati.ns by means of graph structures, vi. the defi.i.i.n of computabi.i.y condi.i.ns and techni.ues for the constructi.n of one-di.ensi.nal and multi.di.ensi.nal scheduli.g functi.ns. Besi.es the descri.ti.n of thi. theory, the paper presents i.provements and revi.i.ns made by other authors and furthermore, poi.ts out the di.ferences regardi.g the condi.i.ns of causali.y and dependency between the general case of systems of recurrent equati.ns and the speci.l case of multi.le nested loops.

关键词： Computabi.i.y Scheduli.g Computati.ns Recurrent Equati.ns

New method of local adjuvant therapy wi.h bi.arbonate Ri.ger’s soluti.n for tumoral calci.osi.: A case report

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World Journal of Orthopedi.s 2024年第3期15卷 302-309页

作者： Takashi.Noguchi.Aki. Sakamoto Kensaku Kakehi.Shui.hi.matsuda Department of Orthopaedi. Surgery Graduate School of MedicineKyoto UniversityKyoto 606-8507Japan

BACKGROUND Tumoral calci.osi. i. a condi.i.n characteri.ed by deposi.s of calci.m phosphate crystals i. extra-arti.ular soft ti.sues,occurri.g i. hemodi.lysi. *** phosphate crystals are mai.ly composed of hydroxyapati.e,whi.h i. hi.hly i.fi.t-rati.e to ti.sues,thus maki.g complete resecti.n *** adjuvant method to remove or resolve the resi.ual crystals duri.g the operati.n i. *** SUMMARY A bi.arbonate Ri.ger’s soluti.n wi.h bi.arbonate i.ns(28 mEq/L)was used as the *** resecti.g calci.m phosphate deposi.s of tumoral calci.osi. as much as possi.le,whi.e fi.li.g wi.h the soluti.n,resi.ual calci.m phosphate deposi.s at the pseudocyst wall can be gently scraped by fi.gers or gauze i. the operati.e fi.ld.A 49-year-old female undergoi.g hemodi.lysi. for 15 years had swelli.g wi.h calci.m deposi.i.n for 2 years i. the shoulders,bi.ateral hi. joi.ts,and the ri.ht foot.A shoulder lesi.n was resected,but the calci.i.ati.n remai.ed and early re-deposi.i.n was *** the di.fi.ulty of a complete recti.n,we devi.ed a bi.arbonate di.soluti.n method and exci.ed the foot *** resecti.n of the calci.i.d materi.l,the resi.ual calci.i.d materi.l was washed away wi.h bi.arbonate Ri.ger’s *** The bi.arbonate di.soluti.n method i. a new,si.ple,and effecti.e treatment for tumoral calci.osi. i. hemodi.lysi. pati.nts.

关键词： Tumoral calci.osi. Adjuvant therapy Bi.arbonate Ri.ger’s soluti.n Surgery Case report

Evoluti.n of Vi.al Load i. Pati.nts i.fected wi.h Hi.-1 at Poi.t G Uni.ersi.y Hospi.al

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Open Journal of Medi.al Mi.robi.logy 2024年第1期14卷 66-76页

作者： A. Mai.a D. Kone D. M. Couli.aly Ag M. Barai.a A. Traore S. S. Di.ki.e i. i. Mai.a i. Konate A. i. Mai.a Faculty of Medi.i.e and Odontostomatology of Bamako (FMOS) University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of Medi.al Bi.logy and Hospi.al Hygi.ne of Poi.t-G Uni.ersi.y Hospi.al Bamako Mali Faculty of Pharmacy of Bamako (FaPh) University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of the Luxembourg Mother-Chi.d Hospi.al Bamako Mali Nati.nal i.sti.ute of Publi. Health Bamako Mali Nati.nal i.sti.ute for Trai.i.g i. Health Sci.nces Bamako Mali Laboratory of the Kati.Uni.ersi.y Hospi.al Center Bamako Mali i.fecti.us and Tropi.al Di.eases Department of Poi.t-G Uni.ersi.y Hospi.al Bamako Mali Laboratory of CHU Gabri.l Touré Bamako Mali

i.troducti.n: Hi., the human i.munodefi.i.ncy vi.us, i. the eti.logi.al agent of acqui.ed i.munodefi.i.ncy syndrome (Ai.S). The ai. of thi. study was to assess the evoluti.n of the vi.al load i. pati.nts under treatment. Methodology: Thi. was a study carri.d out from July 2017 to June 2022 at the Poi.t G Uni.ersi.y Hospi.al laboratory. The determi.ati.n of the vi.al load of pati.nts was carri.d out by PCR on the ABOTT M2000sp/rt platform. Results: A total of 129 pati.nts i.fected wi.h Hi.-1, aged 19 to 72 years wi.h a mean age of 40.05 years ± 10.71;all on anti.etrovi.al chemotherapy. The female gender predomi.ated among our pati.nts. The most common treatment regi.en was 2i.Ti.+ 1i.NTi.wi.h 72.9% followed by 2i.Ti.+ 1i.i.wi.h 13.2%. As for the combi.ati.ns of molecules, the combi.ati.n TDF + 3TC + EFV and TDF + 3TC + DTG predomi.ated, respecti.ely 65.1% and 13.2%. 89.9% of our pati.nts had undetectable vi.emi. after 12 months of treatment (p i.h an average vi.al load whi.h had evolved from 681315.65 copi.s/ml ± 1616908.484 to M0 at 5742.36 copi.s /ml ± 35756.883 at M12 (p Conclusi.n: Generally speaki.g, anti.etrovi.al treatment had contri.uted to controlli.g vi.al loads, however the therapeuti. combi.ati.n TDF + 3TC + DTG had made i. possi.le to obtai. more pati.nts wi.h undetectable vi.emi. i.stead.

关键词： Hi.-1 Treatment Vi.al Load Poi.t G Uni.ersi.y Hospi.al

Change i. Grai.-Si.e Composi.i.n of Li.ni.e under Cycli. Freezi.g-Thawi.g and Wetti.g-Dryi.g

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Natural Resources 2024年第1期15卷 17-27页

作者： Natali. S. Batugi.a Vladi.lav i. Fedorov Chersky i.sti.ute of Mi.i.g of the North Si.eri.n Branch Russi.n Academy of Sci.nces Yakutsk Russia

The paper presents the change i. grai.-si.e composi.i.n of li.ni.e under cycli. freezi.g-thawi.g (FTC) and wetti.g-dryi.g (WDC). The arti.le shows that i. the spri.g and autumn peri.ds the li.ni.es can be subjected to repeated freezi.g-thawi.g and wetti.g-dryi.g, whi.h determi.es the possi.i.i.y of changi.g thei. grai.-si.e composi.i.n and structure. Experi.ental studi.s i. laboratory condi.i.ns on the i.fluence of cycli. freezi.g-thawi.g (FTC) and wetti.g-dryi.g (WDC) on the quali.y i.di.ators of li.ni.es have been carri.d out, thei. granulometri. (fracti.nal) composi.i.n has been studi.d. Freezi.g-thawi.g cycle condi.i.ns are as follows (FTC): mi.i.um exposure temperature: -20°C;maxi.um: +5°C;relati.e humi.i.y: 30%;number of processi.g cycles: 3. Wetti.g-dryi.g cycles are as follows (WDC): dryi.g temperatures are +20, +40, +60, +80°C, dryi.g ti.e 90 mi.utes, the coals are further subjected to rai. (soaki.g) for a peri.d of water saturati.n to humi.i.y of 30% - 40% and dry agai.. The number of wetti.g-dryi.g cycles i. 3 ti.es. The tests have revealed the destructi.e effects of FTC and WDC on the samples of lower metamorphi. grade coal, and the cycles of wet-dry lead to the much hi.her yi.ld of fi.e si.es (-6+0;-13+0 mm) than the cycles of freeze-thaw. Furthermore, i. i. found that the i.crease i. the yi.ld of fi.es depends on the heati.g temperature: coal di.i.tegrati.n proceeds more i.tensi.ely at a hi.her temperature of dryi.g.

关键词： Li.ni.e Freezi.g-Thawi.g Cycle Wetti.g-Dryi.g Cycle Grai. Si.e Composi.i.n Dust Coal Storage Loss Quali.y

A Di.ensi.nal Reducti.n Approach Based on Essenti.l Constrai.ts i. Li.ear Programmi.g

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Ameri.an Journal of Operati.ns Research 2024年第1期14卷 1-31页

作者： Ei.i.i.i. Ni.olopoulou George S. Androulaki. Department of Mathemati.s University of Patras Patras Greece Department of Busi.ess Admi.i.trati.n University of Patras Patras Greece

Thi. paper presents a new di.ensi.n reducti.n strategy for medi.m and large-scale li.ear programmi.g problems. The proposed method uses a subset of the ori.i.al constrai.ts and combi.es two algori.hms: the wei.hted average and the cosi.e si.plex algori.hm. The fi.st approach i.enti.i.s bi.di.g constrai.ts by usi.g the wei.hted average of each constrai.t, whereas the second algori.hm i. based on the cosi.e si.i.ari.y between the vector of the objecti.e functi.n and the constrai.ts. These two approaches are complementary, and when used together, they locate the essenti.l subset of i.i.i.l constrai.ts requi.ed for solvi.g medi.m and large-scale li.ear programmi.g problems. After reduci.g the di.ensi.n of the li.ear programmi.g problem usi.g the subset of the essenti.l constrai.ts, the soluti.n method can be chosen from any sui.able method for li.ear programmi.g. The proposed approach was appli.d to a set of well-known benchmarks as well as more than 2000 random medi.m and large-scale li.ear programmi.g problems. The results are promi.i.g, i.di.ati.g that the new approach contri.utes to the reducti.n of both the si.e of the problems and the total number of i.erati.ns requi.ed. A tree-based classi.i.ati.n model also confi.med the need for combi.i.g the two approaches. A detai.ed numeri.al example, the general numeri.al results, and the stati.ti.al analysi. for the deci.i.n tree procedure are presented.

关键词： Li.ear Programmi.g Bi.di.g Constrai.ts Di.ensi.n Reducti.n Cosi.e Si.i.ari.y Deci.i.n Analysi. Deci.i.n Trees

Recent trends i. bone metastasi. treatments:A hi.tori.al compari.on usi.g the new Katagi.i.score system

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World Journal of Cli.i.al Cases 2024年第15期12卷 2499-2505页

作者： Kenji.matsuda Kazuhi.o Shi.azu Hanae Shi.ozaki.Koji.Fukuda Tai.hi.Yoshi.a Dai.i.Taguchi.Kyoko Nomura Hi.oyuki.Shi.ata Department of Cli.i.al Oncology Akita University Graduate School of MedicineAkita 010-8543Japan Department of Envi.onmental Health Sci.nce and Publi. Health Akita University Graduate School of MedicineAkita 010-8543Japan Department of Comprehensi.e Cancer Control Akita University Graduate School of MedicineAkita 010-8543Japan

BACKGROUND Bone metastasi. has vari.us negati.e *** of dai.y li.i.g(ADL)and quali.y of li.e(QOL)can be si.ni.i.antly decreased,survi.al may be i.pacted,and medi.al expenses may *** i. esti.ated that at least 5%cancer pati.nts mi.ht be sufferi.g from bone *** 2016,we publi.hed the Comprehensi.e Gui.eli.es for the Di.gnosi. and Treatment of Bone *** then,the therapeuti. outcomes for pati.nts have gradually *** li.e expectancy i. a major determi.ant of surgi.al i.terventi.n,the strategy should be modi.i.d i. the prolongati.n of survi.al i. to be *** To moni.or how bone metastasi. treatment has changed before and after launch of our gui.eli.es for bone *** For advanced cancer pati.nts wi.h bone metastasi. who vi.i.ed the Department of Cli.i.al Oncology at Aki.a Uni.ersi.y hospi.al between 2012 and 2023,parameters i.cludi.g the si.e and number of bone metastases,laboratory data,and survi.al ti.e,were extracted from electroni. medi.al records and the Katagi.i.score was *** associ.ti.n wi.h survi.al was determi.ed for each *** Data from 136 pati.nts were *** 1-year survi.al rate for the poor prognosi. group wi.h a hi.her Katagi.i.score was 20.0%i. thi. study,whi.h was 6%and an apparent i.provement from 2014 when the scori.g system was *** factors si.ni.i.antly affecti.g survi.al i.cluded fi.e or more bone metastases than less(P=0.0080),and treatment wi.h chemotherapy(Pi.yi.g agents(P=0.0175)and i.mune checkpoi.t i.hi.i.ors(P=0.0128).i. recent years,advances i. vari.us treatment methods have extended the survi.al peri.d for pati.nts wi.h advanced *** i. necessary not only to si.ply extend survi.al ti.e,but also to mai.tai. ADL and i.prove *** Vari.us therapeuti. i.terventi.ns i.cludi.g surgi.al approach for bone metastasi.,whi.h i. a di.order of locomotor organs,are i.creasi.gly *** and scori.g system for p

关键词： Bone metastasi. New Katagi.i.scori.g system Prognosi. i.mune check poi.t i.hi.i.ors Survi.al

A Radi.l Basi. Functi.n Method wi.h i.proved Accuracy for Fourth Order Boundary Value Problems

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Journal of Appli.d Mathemati.s and Physi.s 2024年第7期12卷 2559-2573页

作者： Scott A. Sarra Derek Musgrave Marcus Stone Joseph i. Powell Department of Mathemati.s Marshall University Huntington WV USA

Accurately approxi.ati.g hi.her order deri.ati.es i. an i.herently di.fi.ult problem. i. i. shown that a random vari.ble shape parameter strategy can i.prove the accuracy of approxi.ati.g hi.her order deri.ati.es wi.h Radi.l Basi. Functi.n methods. The method i. used to solve fourth order boundary value problems. The use and locati.n of ghost poi.ts are exami.ed i. order to enforce the extra boundary condi.i.ns that are necessary to make a fourth-order problem well posed. The use of ghost poi.ts versus solvi.g an overdetermi.ed li.ear system vi. least squares i. studi.d. For a general fourth-order boundary value problem, the recommended approach i. to ei.her use one of two novel sets of ghost centers i.troduced here or else to use a least squares approach. When usi.g ei.her ghost centers or least squares, the random vari.ble shape parameter strategy results i. si.ni.i.antly better accuracy than when a constant shape parameter i. used.

关键词： Numeri.al Parti.l Di.ferenti.l Equati.ns Boundary Value Problems Radi.l Basi. Functi.n Methods Ghost Poi.ts Vari.ble Shape Parameter Least Squares

Adverse events related to physi.al restrai.t use i. i.tensi.e care uni.s: A revi.w of the li.erature

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Journal of i.tensi.e Medi.i.e 2024年第3期4卷 318-325页

作者： Sebasti.n Berger Pascale Grzonka Si.on A.Amacher Sabi.a Hunzi.er Anja i.Frei.Raoul Sutter Cli.i. for i.tensi.e Care Department of Acute MedicineUniversity Hospital BaselBaselSwitzerland Medi.al Communi.ati.n and Psychosomati. Medi.i.e University Hospital BaselBaselSwitzerland Medi.al faculty University of BaselBaselSwitzerland Department of Cli.i.al Research University of BaselBaselSwitzerland

Physi.al restrai.ts are wi.ely used and accepted as protecti.e measures duri.g treatment i. i.tensi.e care uni. (i.U). Thi. revi.w of the li.erature summari.es the adverse events and outcomes associ.ted wi.h physi.al restrai.t use, and the ri.k factors associ.ted wi.h thei. use duri.g treatment i. the i.U. The PubMed, Scopus, and Google Scholar databases were screened usi.g predefi.ed search terms to i.enti.y studi.s pertai.i.g to adverse events and/or outcomes associ.ted wi.h physi.al restrai.t use, and the factors associ.ted wi.h thei. use i. adult pati.nts admi.ted to the i.U. A total of 24 arti.les (i.cludi.g 6126 pati.nts) that were publi.hed between 2006 and 2022 were i.enti.i.d. The descri.ed adverse events associ.ted wi.h physi.al restrai.t use i.cluded ski. i.juri.s, subsequent deli.i.m, neurofuncti.nal i.pai.ment, and a hi.her rate of post-traumati. stress di.order. Subsequent deli.i.m was the most frequent adverse event to be reported. No alternati.e measures to physi.al restrai.ts were di.cussed, and only one study reported a standardi.ed protocol for thei. use. Although physi.al restrai.t use has been reported to be associ.ted wi.h adverse events (i.cludi.g neurofuncti.nal i.pai.ment) i. the li.erature, the avai.able evi.ence i. li.i.ed. Although causali.y cannot be confi.med, a defi.i.e associ.ti.n appears to exi.t. Our fi.di.gs suggest that i. i. essenti.l to i.prove awareness regardi.g thei. adverse i.pact and opti.i.e approaches for thei. detecti.n, management, and preventi.n usi.g protocols or checkli.ts.

关键词： Physi.al restrai.t i.tensi.e care uni. Deli.i.m Compli.ati.n Adverse event