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Prognosti. role of arti.i.i.l i.telli.ence among pati.nts wi.h hepatocellular cancer:A systemati. revi.w

World Journal of Gastroenterology 2020年第42期26卷 6679-6688页

作者： Qui.i.o Lai.Gabri.le Spoleti.i.Gi.nluca Menni.i.Zoe Larghi.Laurei.o Di.manti. i.Tsi.i.i.ras Ti.othyMi.hael Pawli. Massi.o Rossi Hepato-bi.i.ry and Organ Transplant Uni. Department of SurgerySapienza University of RomeRome 00161Italy General Surgery and Li.er Transplantati.n Uni. Fondazione Policlinico Universitario A Gemelli IRCCSRome 00100Italy Wexner Medi.al Center The Ohio State UniversityColumbusOH 43210United States

BACKGROUND Predi.ti.n of survi.al after the treatment of hepatocellular carci.oma(HCC)has been wi.ely i.vesti.ated,yet remai.s *** appli.ati.n of arti.i.i.l i.telli.ence(Ai.i. emergi.g as a vali. adjunct to tradi.i.nal stati.ti.s due to the abi.i.y to process vast amounts of data and fi.d hi.den i.terconnecti.ns between *** and deep learni.g are i.creasi.gly employed i. several topi.s of li.er cancer research,i.cludi.g di.gnosi.,pathology,and *** To assess the role of Ai.i. the predi.ti.n of survi.al followi.g HCC *** A web-based li.erature search was performed accordi.g to the Preferred Reporti.g i.ems for Systemi. Revi.ws and Meta-Analysi. gui.eli.es usi.g the keywords“arti.i.i.l i.telli.ence”,“deep learni.g”and“hepatocellular carci.oma”(and synonyms).The speci.i. research questi.n was formulated followi.g the pati.nt(pati.nts wi.h HCC),i.terventi.n(evaluati.n of HCC treatment usi.g Ai.,compari.on(evaluati.n wi.hout usi.g Ai.,and outcome(pati.nt death and/or tumor recurrence)*** language arti.les were retri.ved,screened,and revi.wed by the *** quali.y of the papers was assessed usi.g the Ri.k of Bi.s i. Non-randomi.ed Studi.s of i.terventi.ns *** were extracted and collected i. a *** Among the 598 arti.les screened,ni.e papers met the i.clusi.n cri.eri.,si. of whi.h had low-ri.k rates of *** arti.les were publi.hed i. the last decade;all came from eastern *** sample si.e was extremely heterogenous(n=11-22926).Ai.methodologi.s employed i.cluded arti.i.i.l neural networks(ANN)i. si. studi.s,as well as support vector machi.e,arti.i.i.l plant opti.i.ati.n,and peri.umoral radi.mi.s i. the remai.i.g three *** the studi.s testi.g the role of ANN compared the performance of ANN wi.h tradi.i.nal *** cohorts were used to trai. the neural networks that were then appli.d to vali.ati.n *** all cases,the Ai.models demonstrated superi.r predi.t

关键词： Deep learni.g Arti.i.i.l neuronal network Recurrence Li.er transplantati.n Resecti.n Hepatocellular cancer

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Does epi.eneti.s have a role i. age related macular degenerati.n and di.beti. reti.opathy?

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Genes & Di.eases 2021年第3期8卷 279-286页

作者： S.Mohana Devi.i.Mahalaxmi.J.Kaavya V.Chi.nkulandhai.V.Balachandar SN ONGC Department of Geneti.s and Molecular Bi.logy Vision Research FoundationSankara Nethralaya41/18College RoadChennai600006India Department of Zoology Avinashilingam Institute for Home Science and Higher Education for WomenAvinashilingam University for WomenCoimbatoreTamil Nadu641046India Department of Bi.chemi.try Dr.N.G.P Arts and Science CollegeCoimbatoreTami lNadu641046India Human Molecular Geneti.s and Stem Cells Laboratory Department of Human Genetics and Molecular BiologyBharathiar UniversityCoimbatoreTamil Nadu641046India

Epi.eneti. mechani.ms play an i.portant part i. the regulati.n of gene expressi.n and these alterati.ns may i.duce long-term changes i. gene functi.n and *** have recei.ed extensi.e attenti.n i. bri.gi.g the gap between envi.onmental exposures and di.ease development vi. thei. i.fluence on gene *** methylati.n i. the earli.st di.covered epi.eneti. *** thi. revi.w,we try to exami.e the role of DNA methylati.n and hi.tone modi.i.ati.n i. Age related macular degenerati.n(AMD)and Di.beti. Reti.opathy(DR),i.s vascular compli.ati.ns and recent *** the complex nature of AMD and DR,i. i. cruci.l to i.prove therapeuti.s whi.h wi.l greatly enhance the quali.y of li.e and reduce the burden for mi.li.ns of pati.nts li.i.g wi.h these potenti.lly bli.di.g condi.i.ns.

关键词： Age-related macular degenerati.n(AMD) Di.beti. Reti.opathy(DR) Epi.eneti.s Gene expressi.n

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Mi.rofaci.s analysi. and deposi.i.nal envi.onment of the Upper Devoni.n Dankovo-Lebedyansky sedi.ents,Tatarstan,Volga-Ural Basi.,Russi.

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Petroleum Research 2023年第2期8卷 244-255页

作者： i.rahem Yousef V.P Morozov A.N Kolchugi. V.Sudakov i.i.ri.ov A.Leontev Kazan Federal Uni.ersi.y Institute of Geology and Petroleum Technologies420008Russian Federation

The Upper Devoni.n,Mi.dle Famenni.n Dankovo-Lebedyansky sedi.ents i. Southeast Tatarstan terri.ory are a carbonate sequence composed of li.estone and dolomi.e,whi.h i. i.portant hydrocarbon reservoi. uni.s,therefore,i. i. necessary to conduct i.-depth study on i.s mi.rofaci.s and deposi.i.nal *** thi. study,a multi.i.ci.li.ary approach that combi.es core observati.n wi.h thi. secti.n exami.ati.n i. *** li.estone contai.s abundant skeletal grai.s(echi.oderms,forami.i.era,algae,gastropods,and calci.pheres),as well as non-skeletal grai.s(i.traclasts and peloi.s).On the basi. of detai.ed petrographi. i.vesti.ati.ns,si. sedi.entary mi.rofaci.s can be i.enti.i.d,i.cludi.g(i.peloi.al grai.stone(MF 1),(i.)cemented bi.clasti. peloi.al grai.stone(MF 2),(i.i.echi.odermconcentrated packstone(MF 3),(i.)algae packstone(MF 4),(v)bi.clasti. wackestone(MF 5),(vi.whole-fossi. wackestone(MF 6),as well as dolomi.e or dolostone as di.geneti. faci.s(MF 7).Based on mi.rofaci.s analysi.,the Dankovo-Lebedyansky sedi.ents were deposi.ed i. three di.ti.ct sedi.entary faci.s belts(shoal,lagoon and open mari.e envi.onment).i. order to reflect di.posi.i.nal energy condi.i.n,the mi.rofaci.s were grouped i.to faci.s associ.ti.ns:(i.low-energy mi.rofaci.s associ.ti.ns i.cludi.g MF 5 and MF 6,(i.)moderate energy mi.rofaci.s associ.ti.ns i.cludi.g MF 1,MF 2,MF 3,and MF *** dolomi.e,or di.geneti. faci.s(MF 7),i. the result of sli.htly to extensi.ely dolomi.i.ati.n of li.estone i. the Dankovo-Lebedyansky *** of frequent dolostone types are euhedral planar-e and subhedral *** to petrographi. characteri.ti. of the dolostone,a seepage reflux model can be used to explai. the dolomi.i.ati.n process of Dankovo-Lebedyansky sedi.ents.

关键词： Mi.rofaci.s Deposi.i.nal envi.onments Carbonate Dolomi.i.ati.n Upper devoni.n Dankovo-lebedyansky Volga-ural basi.

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Usi.g a Gi. Tool to Map the Spati.l Di.tri.uti.n ofPopulati.n for 2010 i. the State of Mexi.o, Mexi.o

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Journal of Geographi. i.formati.n System 2012年第1期4卷 1-11页

作者： Roberto Franco-Plata L. Ri.ardo Manzano-Solís Mi.uel A. Gómez-Albores José i. Juan-Pérez Noel B. Pi.eda-Jai.es Araceli.Martínez-Carri.lo Faculty of Geography Autonomous University of the State of Mexico i.ter-Ameri.an Center of Water Resources and Mexi.o i.ri.i.Resource Center Autonomous University of the State of Mexico

The present document descri.es the experi.nce of usi.g a Geography i.formati.n System (Gi.) tool to map the spati.l di.tri.uti.n of the populati.n of the State of Mexi.o, Mexi.o, for 2010. Pri.r to the development of the experi.nce, di.- ferent projects, tools and products, whi.h offered cartographi. representati.ns of the populati.n, were presented, se- lecti.g one that was developed to functi.n i. i.ri.i.Tai.a Gi.. Li.ewi.e, the Gi. tool and the process followed to apply i. to a case study i. the State of Mexi.o are descri.ed. The result i. a raster i.age that shows the di.tri.uti.n of the populati.n on the analyzed state, offeri.g the possi.i.i.y to i.enti.y the zones where the populati.n concentrates and di.perses and to produce an opi.i.n from a geographi. poi.t of vi.w on what the ori.i. of these di.tri.uti.n patterns i.. Among the conclusi.ns from the analysi. of results, di.ti.gui.hable are the appli.ati.ns that the obtai.ed i.age can have;for i.stance, the populati.n can be esti.ated by basi.s or ri.k zones by only addi.g the values of the cells i.si.e these zones. i. i. also concluded that the degree of detai. expressed by the spati.l di.tri.uti.n i.age of the populati.n wi.l depend on several factors, among them the scale and resoluti.n of the i.put i.formati.n and the resoluti.n fi.ed for the output i.formati.n.

关键词： Spati.l Di.tri.uti.n of the Populati.n i.ri.i Tai.a Gi. Tool State of Mexi.o

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Thermal Decomposi.i.n of Di.henyl Tetroxane i. Chlorobenzene Soluti.n

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i.ternati.nal Journal of Organi. Chemi.try 2019年第1期9卷 1-9页

作者： Alexander G. Bordon Andrea N. Pi.a Mari.la i. Profeta María J. Jorge Li.i.n C. Jorge Jorge M. Romero Nelly L. Jorge Laboratori. de i.vesti.aci.n en Tecnología Ambi.ntal Facultad de Ciencias Exactas Naturales y Agrimensura de la Universidad Nacional del Nordeste Corrientes Argentina

The thermal decomposi.i.n of Cycli. Di.eroxi.e of Benzaldehyde 3,6-di.henyl-1,2,4,5-tetroxane, (DFT) i. chlorobenzene soluti.n i. the studi.d temperature range (130°C - 166°C) sati.factori.y sati.fi.s a fi.st order law up to 60% conversi.ns of di.eroxi.e. DFT would decompose through a mechani.m i. stages and i.i.i.ted by the homolyti. breakdown of one of the peroxi.i. bonds of the molecule, wi.h the formati.n of the correspondi.g i.termedi.te bi.adi.al. The concentrati.n studi.d was very low, so that the effects of secondary reacti.ns of decomposi.i.n i.duced by free radi.als ori.i.ated i. the reacti.n medi.m can be consi.ered mi.i.al or negli.i.le. The acti.ati.n parameters for the uni.olecular thermal decomposi.i.n reacti.n of the DFT are ΔH# = 30.52 ± 0.3 kcal&mi.dot;mol-1 and ΔS# = -6.38 ± 0.6 cal&mi.dot;mol-1 K-1. The support for a step-by-step mechani.m i.stead of a process concerted i. made by compari.on wi.h the theoreti.ally calculated acti.ati.n energy for the thermal decomposi.i.n of 1,2,4,5-tetroxane.

关键词： DFT Thermal Decomposi.i.n Chlorobenzene Mechani.m

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Li.i. Peroxi.ati.n and Anti.xi.ant Enzymes Evaluati.n i. Lactati.g Female Albi.o Rats Followi.g Supplementati.n wi.h Fermented Soya Bean and Vi.ami. C

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Advances i. Enzyme Research 2017年第2期5卷 24-31页

作者： i. S. Malgwi.Y. Tanko M. U. Kawu E. D. Eze H. A. Salami.N. S. Emmanuel A. Mohammed Department of Human Physi.logy College of Medical Sciences University of Maiduguri Borno Nigeria Department of Human Physi.logy Faculty of Medicine Ahmadu Bello University Zaria Nigeria Department of Veteri.ary Physi.logy Faculty of Veterinary Medicine Ahmadu Bello University Zaria Nigeria Department of Physi.logy Faculty of Biomedical Sciences Kampala International University Kampala Uganda

i. mammals, lactati.n i. the most energeti.ally demandi.g peri.d of a female’s reproducti.e li.e. Thi. study was desi.ned to evaluate the effect of fermented Soya bean and Vi.ami. C supplement on li.i. peroxi.ati.n and anti.xi.ant enzymes i. lactati.g albi.o rats. Thi.ty fi.e (35) adult female rats were used for thi. study. At parturi.i.n, the ani.als were randomly di.i.ed i.to fi.e groups of fi.e (5) rats each. Except group four (4) that was subdi.i.ed i.to three (3) sub groups of fi.e ani.als each (n = 5). Treatment was carri.d out as follows: Group i. (Normal control) was gi.en normal feed and di.ti.led water, orally (1 ml/kg), Group i.: metocloprami.e (5 mg/kg), Group i.i. 100 mg/kg of Vi.ami. C. The three (3) sub groups under group four (4) recei.ed 10%, 20% and 40% soya bean, respecti.ely, Group V: was co-admi.i.tered wi.h 20% soya bean supplement and Vi.ami. C (100 mg/kg). Treatment was done for the peri.d of ten (10) days at 06:00 h dai.y. Although there was an i.crease i. serum MDA concentrati.ns i. all the treated groups compared to the control, li.i. peroxi.ati.n was however si.ni.i.antly hi.her (P i. the metocloprami.e group relati.e to the soya bean supplemented groups. Thi. study has shown that supplementati.n wi.h soya bean i.duces a mi.d anti.xi.ant effect by i.creasi.g serum level of superoxi.e di.mutase. There was however a si.ni.i.ant decrease i. serum SOD i. the 10% SB group compared to the control. There was a si.ni.i.ant di.ference i. serum catalase acti.i.y i. the group treated wi.h METCL (46.20 ± 1.53), SB 10% (44.00 ± 1.14) and SB 20% (45.20 ± 1.28) compared to the control (52.00 ± 0.71) (P i.ne peroxi.ase GPx showed a si.ni.i.ant di.ference i. the group treated wi.h Vi. C, SB 10% and SB 20% compared to the control (P < 0.05).

关键词： Soya Bean Lactati.n Vi.ami. C Li.i. Peroxi.ati.n Anti.xi.ant Enzymes

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作者：英格丽·褒曼(i. Bergman) 艾伦·伯吉斯(A. Burgess)

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Structure, photocatalyti. and anti.acteri.l acti.i.y study of Meso porous Ni.and S co-doped Ti.2 nano materi.l under vi.i.le li.ht i.radi.ti.n

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Chi.ese Journal of Chemi.al Engi.eeri.g 2019年第7期27卷 1630-1641页

作者： K.V.Di.ya Lakshmi.T.Si.a Rao J.Swathi.Padmaja i.Manga Raju M.Ravi.Kumar Department of i.organi. and Analyti.al Chemi.try Andhra University

Undoped and Ni.S co-doped mesoporous Ti.2 nano materi.ls were synthesi.ed by usi.g sol–gel *** characteri.ti. features of as prepared catalyst samples were i.vesti.ated usi.g vari.us advanced spectroscopi. and analyti.al *** characteri.ati.n results of the samples revealed that all the samples exhi.i.ed anatase phase(XRD),decreasi.g band gap(2.68 eV)(UV–Vi.-DRS),small parti.le si.e(9.2 nm)(TEM),hi.h surface area(142.156 m^2·g^-1)(BET),parti.les wi.h spheri.al shape and smooth morphology(SEM);there i. a frequency shi.t observed for co-doped sample(FT-i.)and the elemental composi.i.n electroni. states and posi.i.n of the doped elements(Ni.and S)i. the Ti.2 latti.e analyzed by XPS and *** results supported the photocatalyti. degradati.n of Bi.marck Brown Red(BBR)achi.ved wi.h i. 110 mi. and also exhi.i.ed the anti.acteri.l acti.i.y on Staphylococcus aureus(MTCC-3160),Pseudomonas fluorescence(MTCC-1688)under vi.i.le li.ht i.radi.ti.n.

关键词： Sol–gel Ni.S co-doped Ti.2 Photocatalysi. under vi.i.le li.ht Degradati.n of Bi.marck Brown Red Anti.acteri.l acti.i.y

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Study of Anti.i.robi.l Acti.i.y of Medi.ati.ns for Wound Treatment

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Journal of Pharmacy and Pharmacology 2015年第7期3卷 350-355页

作者： Boyko N. Ni.k Zaytsev i. Alexander Osolodchenko P. Tatyana Melni. L. Anatoly Nevmerzhi.ski. V.Vi.ali. Volkov O. Taras Kazmi.chuk V. Vi.tor Department of Processes and Devi.es of Chemi.al-Pharmaceuti.al i.dustri.s National Pharmaceutical University Kharkov61140 Ukraine Bi.chemi.try and Bi.technology Laboratory and Anti.acteri.l Agents Laboratory State Institution LI. Mechnikov Institute ofMicrobiology and Immunology of the National Academy of Medical Sciences of Ukraine Kharkov 6105 7 Ukraine

Thi. paper presents data on the study of anti.i.robi.l acti.i.y of 16 medi.ati.ns used for wound treatment. Anti.i.robi.l acti.i.y of medi.ati.ns has been studi.d by well di.fusi.n method on standard mi.roorgani.m test strai.s： S. aureus ATCC 25923, E. coli.ATCC 25922, P. aerugi.osa ATCC 27853, P. vulgari. ATCC 4636, B. subti.i. ATCC 6633, and C. albi.ans ATCC 885/653. i.tegrated i.dexes of anti.i.robi.l acti.i.y of medi.ati.ns usi.g vector theory have been calculated, whi.h allowed to place most acti.e of them i. the order of descendi.g acti.i.y： Levomecolum A = 2.73, r2 = 0.82; Levosi. A = 2.41, r2 = 0.83; Synthomyci.um A = 2.33, r2 = 0.97; Methyluraci.um cum myrami.ti.o A = 2.31, r2 = 0.83; Oflocai.um-Darni.sa A = 2.25, 1-2 = 0.97; and Betadi.e A = 2.03, r2 = 0.97. The mean of i.tegrated i.dexes of anti.i.robi.l acti.i.y and the square of the correlati.n coeffi.i.nt for the group of these medi.ati.ns are as follows： A = 2.02, and r2 = 0.91. Compari.on of mean values of i.tegrated i.dexes of anti.i.robi.l acti.i.y of medi.i.es for wound treatment wi.h those of water-alcohol extracts from plant raw materi.l contai.i.g alkaloi.s, tanni.s, hydroqui.one, naphthoqui.ones, anthraqui.ones, and phenols has shown to be promi.i.g of further development of domesti. agents havi.g anti.i.robi.l acti.i.y based on water-alcohol extracts from plant raw materi.l.

关键词： Anti.i.robi.l acti.i.y wound medi.ati.ns well di.fusi.n method.

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Role of ni.ri. oxi.e i. cerebral i.chemi./reperfusi.n i.jury:A bi.molecular overvi.w

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World Journal of Cli.i.al Cases 2025年第10期13卷 9-13页

作者： Roberto Anaya-Prado Abraham i.Canseco-Vi.legas Roberto Anaya-Fernández Mi.helle Mari. Anaya-Fernandez Mi.uel A Guerrero-Palomera Ci.lalli.Guerrero-Palomera i.an F Garci.-Rami.ez Dani.l Gonzalez-Marti.ez Consuelo Ceci.i. Azcona-Ramírez Claudi. Garci.-Perez Ai.i. L Li.arraga-Valenci. Aranza Hernandez-Zepeda Jacqueli.e F Palomares-Covarrubi.s Jorge HA Blackaller-Medi.a Jacqueli.e Soto-Hi.tze Mayra C Velarde-Casti.lo Dayri.A Cruz-Melendrez Department of Research&Department of Surgery School of Medicine and Health SciencesTecnologico de MonterreyCorporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Di.ecti.n of Research and Educati.n Corporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Department of Research School of Medicine and Health SciencesTecnologico de MonterreyZapopan 45116JaliscoMexico Di.i.i.n of Research and Educati.n Corporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Di.i.i.n of Research School of MedicineUniversity of GuadalajaraGuadalajara 44340JaliscoMexico Di.i.i.n of Research School of MedicineAutonomous University of GuadalajaraZapopan 45116JaliscoMexico Research&Educati.n Corporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Di.i.i.n of Research Corporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Research School of MedicineUNIVA UniversityZapopan 45116JaliscoMexico

Ni.ri. oxi.e(NO)i. a gaseous molecule produced by 3 di.ferent NO synthase(NOS)i.oforms:Neural/brai. NOS(nNOS/bNOS,type 1),endotheli.l NOS(eNOS,type 3)and i.duci.le NOS(type 2).Type 1 and 3 NOS are consti.uti.ely *** can serve di.ferent purposes:As a vasoacti.e molecule,as a neurotransmi.ter or as an *** plays a key role i. cerebral i.chemi./reperfusi.n i.jury(Ci.i..Hypoxi. epi.odes si.ulate the producti.n of oxygen free radi.als,leadi.g to mi.ochondri.l and phospholi.i. *** reperfusi.n,i.creased levels of oxygen tri.ger oxi.e synthases;whose products are associ.ted wi.h neuronal damage by promoti.g li.i. peroxi.ati.n,ni.rosylati.n and *** pathways i. Ci.i.can be altered by *** effects are observed wi.h eNOS *** nNOS i.terplay i. prone to endotheli.l i.flammati.n,oxi.ati.e stress and ***,nNOS appears to be *** i.teracti.n between NO and other free radi.als develops peroxyni.ri.e;whi.h i. a cytotoxi. *** plays a mai. role i. the li.eli.ood of hemorrhagi. events by ti.sue plasmi.ogen acti.ator(t-PA).Peroxyni.ri.e scavengers are currently bei.g studi.d as potenti.l targets to prevent hemorrhagi. transformati.n i. Ci.i.

关键词： Ni.ri. oxi.e Cerebral i.chemi./reperfusi.n i.jury Ni.ri. oxi.e synthase Reacti.e ni.rogen speci.s Ni.rosylati.n

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