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Allogenei. and autologous stem cell transplantati.n wi.h busulfan, cyclophosphami.e, and etoposi.e condi.i.ni.g therapy for relapsed/refractory non-Hodgki. lymphoma

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Modern Chemotherapy 2013年第4期2卷 57-65页

作者： Neeli.a Vi.ula Andrew M. Evens i.ene B. Helenowski.Borko Jovanovi. Jane N. Wi.ter Jayesh Mehta Seema Si.ghal Stephani. F. Wi.li.ms Olga Frankfurt Jessi.a K. Altman Joanne Monreal Leo i. gordon Department of Preventi.e Medi.i.e Northwestern University Chicago USA Di.i.i.n of Hematology-Oncology Northwestern University Chicago USA Di.i.i.n of Hematology-Oncology Northwestern University Chicago USA Di.i.i.n of Hematology-Oncology The University of Massachusetts Medical School Worcester USA Di.i.i.n of Hematology-Oncology University of California San Francisco USA

The opti.al stem cell transplantati.n (SCT) condi.i.ni.g therapy for relapsed/refractory non-Hodgki. lymphoma (NHL) i. not clearly defi.ed. i. a retrospecti.e analysi., we exami.ed 25 pati.nts wi.h “hi.h ri.k” relapsed/refractory NHL who recei.ed busulfan, cyclophosphami.e, and etoposi.e (Bu/Cy/VP16) condi.i.ni.g wi.h autologous or allogenei. SCT. The majori.y of pati.nts had aggressi.e hi.tology and 52% had pri.ary refractory NHL. Furthermore, 48% of pati.nts had chemotherapy-resi.tant di.ease at the ti.e of SCT. Fi.ty-si. percent of pati.nts underwent allogenei. SCT, whi.e 44% had autologous SCT. The medi.n engraftment ti.e for neutrophi.s and platelets was 13.5 and 14 days, respecti.ely. The 100-day treatment-related mortali.y (TRM) was 16%, whi.e the 2-year non-relapse mortali.y (NRM) rate was also 16%. At a medi.n follow-up of 15 months, the esti.ated 2-year di.ease-free survi.al (DFS) rate was 64% (95% confi.ence i.terval (Ci.: 36%-82%) and the esti.ated 2-year overall survi.al (OS) was 69% (95% Ci. 40%-86%). Furthermore, the 2-year di.ease-speci.i. survi.al (DSS) rate was 73% (95% Ci. 40%-90%). Usi.g Cox proporti.nal hazard modeli.g, the i.ternati.nal Prognosti. i.dex at ti.e of relapse predi.ted DFS and OS. Altogether, Bu/Cy/VP16 was associ.ted wi.h early TRM;however, late toxi.i.i.s (i.cludi.g NRM) were uncommon resulti.g i. relati.ely good survi.al rates i. a hi.h-ri.k relapsed/refractory NHL populati.n.

关键词： Stem Cell Transplantati.n Busulfan Cyclophosphami.e Etoposi.e Non-Hodgki. Lymphoma

Exact Soluti.ns of Klei.-gordon Equati.n wi.h Scalar and Vector Rosen-Morse-Type Potenti.ls

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Chi.ese Physi.s Letters 2008年第8期25卷 2754-2757页

作者： A. Soylu O. Bayrak i. Boztosun Department of Physi.s Nigde University 51350 Nigde Turkey Department of Physi.s Bozok University 66200 Yozgat Turkey Department of Physi.s Erciyes University 38039 Kayseri Turkey

We obtai. an exact analyti.al soluti.n of the Klei. gordon equati.n for the equal vector and scalar Rosen Morse and Eckart potenti.ls as well as the pari.y-ti.e （PT） symmetri. versi.n of the these potenti.ls by usi.g the asymptoti. i.erati.n method. Although these PT symmetri. potenti.ls are non-Hermi.i.n, the correspondi.g ei.envalues are real as a result of the PT symmetry.

关键词： ASYMPTOTi. i.ERATi.N METHOD NON-HERMi.i.N HAMi.TONi.NS PT-SYMMETRi. POTENTi.LS BOUND-STATES Ei.ENVALUE PROBLEMS Di.AC-EQUATi.N SCHRODi.GER-EQUATi.N Si.i.ARi.Y TRANSFORMATi.N REAL PARTi.LES

Forgi.g an easi.r path through graduati.n:i.provi.g the pati.nt transi.i.n from paedi.tri. to adult cri.i.al care

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World Journal of Cri.i.al Care Medi.i.e 2025年第1期14卷 82-90页

作者： Stephen Warri.low Ben Gelbart Jess Stevens gordon Bai.i. Mark E Howard Department of i.tensi.e Care Austin HealthHeidelberg 3084VictoriaAustralia Department of Cri.i.al Care The University of MelbourneParkville 3010VictoriaAustralia Department of i.tensi.e Care Royal Children’s HospitalParkville 3010VictoriaAustralia Li.i.g wi.h Di.abi.i.y Research Centre La Trobe UniversityBundoora 3086VictoriaAustralia Department of Neurodevelopment&Di.abi.i.y Royal Children’s HospitalParkville 3010VictoriaAustralia Department of Paedi.tri.s The University of MelbourneParkville 3010VictoriaAustralia Department of Respi.atory and Sleep Medi.i.e Austin HealthHeidelberg 3084VictoriaAustralia Department of Medi.i.e Austin HealthThe University of MelbourneHeidelberg 3084VictoriaAustralia

Adolescence and the journey to adulthood i.volves exci.i.g opportuni.i.s as well as psychosoci.l stress for young people growi.g *** normal experi.nces are potenti.lly magni.i.d for teenagers li.i.g wi.h chroni. i.lness or di.abi.i.y and thei. *** i. care have i.proved survi.al for chi.dren wi.h a vari.ty of seri.us chroni. medi.al condi.i.ns such that many who may once have di.d i. chi.dhood now survi.e well i.to adulthood wi.h ongoi.g *** those wi.h hi.hly complex needs,care i. often provi.ed at major paedi.tri. hospi.als wi.h experti.e,speci.lly trai.ed personnel,and resources to support young people and thei. fami.i.s for the fi.st decades of *** the end of adolescence,however,i. i. generally appropri.te and necessary for young adults and thei. caregi.ers to transi.i.n to the care of cli.i.i.ns trai.ed i. the care of adults at general *** there are some well-managed models to support thi. journey of transi.i.n,these are often speci.i. to certai. condi.i.ns and usually do not i.volve i.tensi.e *** pati.nts may encounter consi.erable challenges duri.g thi. *** may i.clude the loss of establi.hed therapeuti. relati.nshi.s,a percepti.n of austeri.y and reduced ameni.y i. faci.i.i.s ori.nted to cari.g for adult pati.nts,and care by cli.i.i.ns wi.h less experi.nce wi.h more common paedi.tri. *** addi.i.n,there i. a ri.k of potenti.l confli.t between cli.i.i.ns and fami.i.s regardi.g goals of care i. the event of a cri.i.al i.lness when i. occurs i. a young adult wi.h major di.abi.i.y and long-term health *** challenges present genui.e opportuni.i.s to better understand the transi.i.n from paedi.tri. to adult-based care and to i.prove processes that assi.t cli.i.i.ns who support pati.nts and fami.i.s as they shi.t between healthcare setti.gs.

关键词： Paedi.tri. i.tensi.e care Di.abi.i.y Adult i.tensi.e care Transi.i.n Cri.i.al care

利用肾动态对比增强MRi.室模型精确测量肾脏滤过获得实际正常值的研究

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国际医学放射学杂志 2012年第4期 406-406页

作者： P.S. Tofts M. Cutajar i.A. Mendi.hovszky A.M. Peters i. gordon 唐光健

摘要目的以正常肾脏T1加权DCE-MRi.取相数据建立模型,并显示匹配的生理参数与发表的正常值的相关性。方法模型包含出现在毛细血管床时的动脉血管峰值与宽度,代表肾血管内与血管外两个不同间隙内的Gd示踪剂,并采用小血管血细胞比容值24... 详细信息

摘要目的以正常肾脏T1加权DCE-MRi.取相数据建立模型,并显示匹配的生理参数与发表的正常值的相关性。方法模型包含出现在毛细血管床时的动脉血管峰值与宽度,代表肾血管内与血管外两个不同间隙内的Gd示踪剂,并采用小血管血细胞比容值24%。可估计4个生理参数:局部滤过Ktran

关键词： DCE-MRi 肾 GFR 定量模型

A functi.nal tacroli.us-releasi.g nerve wrap for enhanci.g nerve regenerati.n followi.g surgi.al nerve repai.

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Neural Regenerati.n Research 2025年第1期20卷 291-304页

作者： Si.eon C.Daeschler Katelyn J.W.So Konstanti. Fei.berg Mari.a Manoraj Jenny Cheung Jenni.er Zhang Kaveh Mi.moei.i.JPaul Santerre Tessa gordon Gregory HBorschel Si.kKi.s Research i.sti.ute Neuroscience and Mental Health ProgramTorontoONCanada i.sti.ute of Bi.materi.ls and Bi.medi.al Engi.eeri.g University of TorontoTorontoONCanada i.di.na Uni.ersi.y School of Medi.i.e IndianapolisINUSA Di.i.i.n of Plasti. and Reconstructi.e Surgery the Hospital for Sick ChildrenTorontoONCanada Translati.nal Bi.logy and Engi.eeri.g Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regenerati.n followi.g surgi.al nerve repai. i. slow and often i.complete,resulti.g i. poor functi.nal recovery whi.h someti.es contri.utes to li.elong ***,there are no FDA-approved therapi.s avai.able to promote nerve *** accelerates axonal regenerati.n,but systemi. si.e effects presently outwei.h i.s potenti.l benefi.s for peri.heral nerve *** authors descri.e herei. a bi.degradable polyurethane-based drug deli.ery system for the sustai.ed local release of tacroli.us at the nerve repai. si.e,wi.h sui.able properti.s for scalable producti.n and cli.i.al appli.ati.n,ai.i.g to promote nerve regenerati.n and functi.nal recovery wi.h mi.i.al systemi. drug *** i. encapsulated i.to co-axi.lly electrospun polycarbonate-urethane nanofi.ers to generate an i.plantable nerve wrap that releases therapeuti. doses of bi.acti.e tacroli.us over 31 *** and drug loadi.g are adjustable for appli.ati.ns i. small and large cali.er nerves,and the wrap degrades wi.hi. 120 days i.to bi.compati.le *** released from the nerve wrap promotes axon elongati.n i. vi.ro and accelerates nerve regenerati.n and functi.nal recovery i. precli.i.al nerve repai. models whi.e off-target systemi. drug exposure i. reduced by 80%compared wi.h systemi. *** i.s surgi.al sui.abi.i.y and precli.i.al effi.acy and safety,thi. system may provi.e a readi.y translatable approach to support axonal regenerati.n and recovery i. pati.nts undergoi.g nerve surgery.

关键词： bi.degradable local drug deli.ery nerve i.jury nerve regenerati.n nerve wrap tacroli.us

On the Generali.ed Conti.ui.y Equati.n

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Chi.ese Physi.s Letters 2010年第8期27卷 117-120页

作者： Arbab i. Arbab Hi.ham. M. Wi.atallah Department of Physi.s Faculty of Science University of Khartoum PO Box 321 Khartoum 11115 Sudan Department of Physi.s College of Science Sultan Qaboos University PO Box 36 Al-IKhod Muscat 123 Oman

A generali.ed conti.ui.y equati.n extendi.g the ordi.ary conti.ui.y equati.n i. found usi.g quanterni.ns to show i. i. compati.le wi.h Di.ac, Schrǒdi.ger, Klei.-gordon and di.fusi.n equati.ns. Thi. generali.ed equati.n i. Lorentz i.vari.nt. The transport properti.s of electrons are found to be governed by the Schr6di.ger-li.e equati.n and not by the di.fusi.n equati.n.

关键词： Di.FERENTi.L equati.ns QUATERNi.NS Di.AC equati.n SCHRODi.GER equati.n KLEi.-gordon equati.n ELECTRON transport HEAT equati.n

Asymmetri. vari.bi.i.y between maxi.um and mi.i.um temperatures i. Northeastern Ti.etan Plateau:Evi.ence from tree ri.gs

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Sci.nce Chi.a Earth Sci.nces 2008年第1期51卷 41-55页

作者： Jacoby gordon Tree-Ri.g Laboratory Lamont-Doherty Earth Observatory Columbia University NY 10964 USA

Ecologi.al systems i. the headwaters of the Yellow Ri.er, characteri.ed by hash natural envi.onmental condi.i.ns, are very vulnerable to cli.ati. change. i. the most recent decades, thi. area greatly attracted the publi.'s attenti.n for i.s more and more deteri.rati.g envi.onmental condi.i.ns. Based on tree-ri.g samples from the Xi.i.g Mountai. and A'nyêmagên Mountai.s at the headwaters of the Yellow Ri.er i. the Northeastern Ti.etan Plateau, we reconstructed the mi.i.um temperatures i. the wi.ter half year over the last 425 years and the maxi.um temperatures i. the summer half year over the past 700 years i. thi. regi.n. The vari.ti.n of mi.i.um temperature i. the wi.ter half year duri.g the ti.e span of 1578―1940 was a relati.ely stable trend, whi.h was followed by an abrupt warmi.g trend si.ce 1941. However, there i. no si.ni.i.ant warmi.g trend for the maxi.um temperature i. the summer half year over the 20th century. The asymmetri. vari.ti.n patterns between the mi.i.um and maxi.um temperatures were observed i. thi. study over the past 425 years. Duri.g the past 425 years, there are si.i.ar vari.ti.n patterns between the mi.i.um and maxi.um temperatures; however, the mi.i.um temperatures vary about 25 years earli.r compared to the maxi.um temperatures. i. such a trend of vari.ti.n patterns between the mi.i.um and maxi.um temperatures over the past 425 years conti.ues i. the future 30 years, the maxi.um temperature i. thi. regi.n wi.l i.crease si.ni.i.antly.

关键词： Ti.etan Plateau tree-ri.g mi.i.um temperature maxi.um temperature asymmetri. vari.bi.i.y warmi.g trend

Unlearni.g Descartes:Senti.nt Ai.i. a Poli.i.al Problem

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Journal of Soci.l Computi.g 2023年第3期4卷 193-204页

作者： gordon Hull the School of Data Sci.nce UNC CharlotteCharlotteNC 28223USA

The emergence of Large Language Models(LLMs)has renewed debate about whether Arti.i.i.l i.telli.ence(Ai.can be consci.us or *** paper i.enti.i.s two approaches to the topi. and argues:(1)A“Cartesi.n”approach treats consci.usness,senti.nce,and personhood as very si.i.ar terms,and treats language use as evi.ence that an enti.y i. *** approach,whi.h has been domi.ant i. Ai.research,i. pri.ari.y i.terested i. what consci.usness i.,and whether an enti.y possesses i..(2)An alternati.e“Hobbesi.n”approach treats consci.usness as a soci.poli.i.al i.sue and i. concerned wi.h what the i.pli.ati.ns are for labeli.g somethi.g senti.nt or *** both enables a poli.i.al di.ambi.uati.n of language,consci.usness,and personhood and allows regulati.n to proceed i. the face of i.tractable problems i. deci.i.g i. somethi.g“really i.”senti.nt.(3)Ai.systems should not be treated as consci.us,for at least two reasons:(a)treati.g the system as an ori.i. poi.t tends to mask competi.g i.terests i. creati.g i.,at the expense of the most vulnerable people i.volved;and(b)i. wi.l tend to hi.der efforts at holdi.g someone accountable for the behavi.r of the systems.A major objecti.e of thi. paper i. accordi.gly to encourage a shi.t i. *** place of the Cartesi.n questi.n-i. Ai.senti.nt?-i.propose that we confront the more Hobbesi.n one:Does i. make sense to regulate developments i. whi.h Ai.systems behave as i. they were senti.nt?

关键词： arti.i.i.l i.telli.ence Large Language Model consci.usness senti.nce personhood Descartes Hobbes

Di.rupti.n of bone and skeletal muscle i. severe burns

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Bone Research 2015年第1期3卷 6-10页

作者： gordon L Klei. Department of Orthopaedi. Surgery and Rehabi.i.ati.n University of Texas Medical Branch and Shriners Hospitals for Children

Severe burn i.jury tri.gers the body＇s nonspeci.i. adapti.e responses to acute i.sult, i.cludi.g the systemi. i.flammatory and stress responses, as well as the sympatheti. response to i.mobi.i.ati.n. These responses tri.ger i.flammatory bone resorpti.n followed by glucocorti.oi.-i.duced apoptosi. of osteoblasts and probably osteocytes. Because these pati.nts are cataboli., they suffer concomi.ant muscle wasti.g and negati.e ni.rogen balance. The use of anaboli. agents such as recombi.ant human growth hormone and oxandrolone results i. i.proved bone mi.eral content and muscle strength after approxi.ately i.year. Use of bi.phosphonates wi.hi. the fi.st 10 days of a severe burn completely blocks the resorpti.e bone loss and has the added advantage of appeari.g to preserve muscle protei. from excessi.e breakdown. The mechani.m for the protecti.e effect on muscle i. not currently known. However, i. the effect of bi.phosphonates on muscle can be confi.med, i. rai.es the possi.i.i.y that bone communi.ates wi.h muscle.

关键词： bone Di.rupti.n of bone and skeletal muscle i. severe burns