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Treatment of spi.al cord i.jury wi.h bi.materi.ls and stem cell therapy i. non-human pri.ates and humans

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Neural Reg.nerati.n Research 2025年第2期20卷 343-353页

作者： Ana Mi.ena Si.va Olaya Fernanda Marti.s Almei.a Ana Mari. blanco Marti.ez Suelen Adri.ni.Marques PhD Prog.am i. Patholog.0}al Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Bi.medi.al Sci.nce i.sti.ute Federal University of Rio de JaneiroRio de JaneiroBrazil g.aduate Prog.am i. Patholog.0}al Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil g.aduate Prog.am i. Patholog.0}al Anatomy(PPg.P/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spi.al cord i.jury results i. the loss of sensory,motor,and autonomi. functi.ns,whi.h almost always produces permanent physi.al ***,i. the search for more effecti.e treatments than those already appli.d for years,whi.h are not enti.ely effi.i.nt,researches have been able to demonstrate the potenti.l of bi.log.0}al strateg.0}s usi.g.bi.materi.ls to ti.sue manufacturi.g.throug. bi.eng.0}eeri.g.and stem cell therapy as a neuroreg.nerati.e approach,seeki.g.to promote neuronal recovery after spi.al cord *** of these strateg.0}s has been developed and meti.ulously evaluated i. several ani.al models wi.h the ai. of analyzi.g.the potenti.l of i.terventi.ns for neuronal repai. and,consequently,boosti.g.functi.nal *** the majori.y of experi.ental research has been conducted i. rodents,there i. i.creasi.g.recog.i.i.n of the i.portance,and need,of evaluati.g.the safety and effi.acy of these i.terventi.ns i. non-human pri.ates before movi.g.to cli.i.al tri.ls i.volvi.g.therapi.s potenti.lly promi.i.g.i. *** arti.le i. a li.erature revi.w from databases(PubMed,Sci.nce Di.ect,Elsevi.r,Sci.lo,Redalyc,Cochrane,and NCBi.from 10 years ag. to date,usi.g.keywords(spi.al cord i.jury,cell therapy,non-human pri.ates,humans,and bi.eng.0}eeri.g.i. spi.al cord i.jury).From 110 retri.ved arti.les,after two selecti.n rounds based on i.clusi.n and exclusi.n cri.eri.,21 arti.les were ***,thi. revi.w ari.es from the need to recog.i.e the experi.ental therapeuti. advances appli.d i. non-human pri.ates and even humans,ai.ed at deepeni.g.these strateg.0}s and i.enti.yi.g.the advantag.s and i.fluence of the results on extrapolati.n for cli.i.al appli.abi.i.y i. humans.

关键词： bi.eng.0}eeri.g bi.materi.ls cell therapy humans non-human pri.ates spi.al cord i.jury stem cell therapy

Thermal analysi. of annular fi.s wi.h temperature-dependent thermal properti.s

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Appli.d Mathemati.s and Mechani.s(Eng.i.h Edi.i.n) 2013年第11期34卷 1349-1360页

作者： i. g. AKSOY Department of Mechani.al Eng.0}eeri.g Inonu University

The thermal analysi. of the annular rectang.lar profi.e fi.s wi.h vari.ble thermal properti.s i. i.vesti.ated by usi.g.the homotopy analysi. method （HAM）. The thermal conducti.i.y and heat transfer coeffi.i.nt are assumed to vary wi.h a li.ear and power-law functi.n of temperature, respecti.ely. The effects of the thermal-g.ometri. fi. parameter and the thermal conducti.i.y parameter vari.ti.ns on the temperature di.tri.uti.n and fi. effi.i.ncy are i.vesti.ated for di.ferent heat transfer modes. Results from the HAM are compared wi.h numeri.al results of the fi.i.e di.ference method （FDM）. i. can be seen that the vari.ti.n of di.ensi.nless parameters has a si.ni.i.ant effect on the temperature di.tri.uti.n and fi. effi.i.ncy.

关键词： annular fi. vari.ble thermal property homotopy analysi. method

An Extracti.n of the Domi.ant Rotor-Stator i.teracti.n Modes by the Use of Proper Orthog.nal Decomposi.i.n (POD)

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Journal of Thermal Sci.nce 2006年第2期15卷 109-114页

作者： i. TREBi.JAC N. ROCHUON g. Bi.LONNET Ecole Centrale de Lyon Laboratoi.e de Mécani.ue des Flui.es et d'Acousti.ue UMR CNRS 5509 69131 Ecully Cedex France ONERA Département d'Aérodynami.ue Appli.uée 92322 Chtillon Cedex France

The Proper Orthog.nal Decomposi.i.n method i. appli.d to the i.stantaneous veloci.y fi.ld wi.hi. the rotor-stator i.ter-row reg.0}n of a hi.h-speed hi.h-pressure centri.ug.l compressor. The processed data come from experi.ents and numeri.al si.ulati.ns. i. compari.on wi.h a Fouri.r transform, the POD g.0}es the best modal approxi.ati.n for both i.i.i.l fi.lds, i. terms of the energ. expressed on any g.0}en number of modes to be taken i.to account： to reach 98% of the total energ. of the veloci.y fi.ld, the requi.ed number of POD modes i. around ni.e ti.es smaller than the number of Fouri.r harmoni.s. The i.di.i.ual POD modes are g.0}en and show that the unsteady rotor-stator i.teracti.n i. already present i. the very fi.st modes.

关键词： rotor stator i.teracti.n proper orthog.nal decomposi.i.n POD

NORM SUMMABi.i.Y OF NRLUND LOg.Ri.HMi. MEANS ON UNBOUNDED Vi.ENKi. g.OUPS

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Analysi. i. Theory and Appli.ati.ns 2008年第1期24卷 1-17页

作者： i. Blahota g. g.t i.sti.ute of Mathemati.s and Computer Sci.nce Hungary

The （Noerlund） log.ri.hmi. means of the Fouri.r seri.s i.：tnf=1/ln ^n-1∑k=1 Skf/n-k, where ln=^n-1∑k=1 1/k i. g.neral, the Fej6r （C, 1） means have better properti.s than the log.ri.hmi. ones. We compare them an... 详细信息

关键词： unbounded Vi.enki. g.oup Fejer means log.ri.hmi. means norm converg.nce

Synthesi. and characteri.ati.n of yttri.m-alumi.um-i.on and yttri.m-ceri.m-i.on ci.ri. complexes

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Journal of Rare Earths 2008年第3期26卷 307-314页

作者： N. Petrova D. Todorovsky1 i. Mi.ov g. Tyuli.v Faculty of Chemi.try University of Sofia 1 J. Bourchier Blvd. Sofia 1164 Bulgaria i.sti.ute of Catalysi. Bulgarian Academy of Sciences Acad. G. Bonchev Str. bl. 11 Sofia 1113 Bulgaria

Fe-, Y-Fe-Al- and Y-Ce-Fe- ci.rates were synthesi.ed i. ethylene g.ycol （Eg. medi.m under condi.i.ns si.i.ar to those used i. the polymeri.ed complex method. Thei. elemental composi.i.n, i.,^ 13C and ^1H NMR, X-ray photoelectron and Mossbauer spectra were studi.d, and formulae descri.i.g.thei. composi.i.n were proposed. The complexes contai.ed Eg.bonded as adduct and ester wi.h ci.ri. aci. li.and and di. not contai. li.ands wi.h deprotonated alcoholi. g.oups. The complexes consi.ted of ag.lomerated spheres, 0.7-3 μm i. di.meter. The local composi.i.n of the products was establi.hed by energ. di.persi.e X-ray mi.roanalysi.. The compari.on of the number of the li.ands, thei. averag. electri.al charg. and the esteri.i.ati.n deg.ee of mono-, di. and tri.etalli. complexes proved the mi.ed-metal nature of the speci.s studi.d. The thermal decomposi.i.n of the complexes was studi.d and a g.neral scheme of the processes taki.g.place was proposed. Hi.hly crystalli.e, phase homog.neous YaFe4AlO12 was produced after heati.g.the respecti.e complex at 1000 ℃. Ce-doped yttri.m-i.on g.rnet, si.i.arly prepared, contai.ed traces of CeO2.

关键词： g.rnets polymeri.ed complex method Mossbauer spectroscopy thermal analysi. NMR-spectroscopy rare earths

Si.pli.i.d approach for desi.n of raft foundati.ns ag.i.st fault *** i.free-fi.ld

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Earthquake Eng.0}eeri.g.and Eng.0}eeri.g.Vi.rati.n 2008年第2期7卷 147-163页

作者： i. Anastasopoulos N. g.rolymos g. g.zetas M. F. Bransb School of Ci.i. Eng.0}eeri.g National Technical University of AthensGreece Civil LecturerEngineeringUniversity of DundeeScotlandUK School of Ci.i. Eng.0}eeri.g National Technical University of AthensGreece Ci.i. Eng.0}eeri.g University of DundeeScotlandUK

Over the past few decades, earthquake eng.0}eeri.g.research mai.ly focused on the effects of strong.sei.mi. shaki.g. After the 1999 earthquakes i. Turkey and Tai.an, and thanks to numerous cases where fault rupture caused substanti.l damag. to structures, the i.portance of faulti.g.i.duced deformati.n has re-emerg.d. Thi. paper, along.wi.h i.s compani.n （Part Ⅱ）, exploi.s parametri. results of fi.i.e element analyses and centri.ug. model testi.g.i. developi.g.a four-step semi.analyti.al approach for analysi. of di.-sli. （normal and thrust） fault rupture propag.ti.n throug. sand, i.s emerg.nce on the g.ound surface, and i.s i.teracti.n wi.h raft foundati.ns. The present paper （Part Ⅰ） focuses on the effects of faulti.g.i. the absence of a structure （i.e., i. the free-fi.ld）. The semi.analyti.al approach compri.es two-steps： the fi.st deals wi.h the rupture path and the esti.ati.n of the locati.n of fault outcroppi.g. and the second wi.h the tectoni.ally- i.duced di.placement profi.e at the g.ound surface. i. both cases, si.ple mechani.al analog.es are used to deri.e si.pli.i.d semi.analyti.al expressi.ns. Centri.ug. model test data, i. combi.ati.n wi.h parametri. results from nonli.ear fi.i.e element analyses, are uti.i.ed for model cali.rati.n. The deri.ed semi.analyti.al expressi.ns are shown to compare reasonably well wi.h more ri.orous experi.ental and theoreti.al data, thus provi.i.g.a useful tool for a fi.st esti.ati.n of near-fault sei.mi. hazard.

关键词： fault rupture semi.analyti.al expressi.n soi.-structure i.teracti.n earthquake

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ELECTROACTi.E AND NANOSTRUCTURED POLYMERS AS SCAFFOLD MATERi.LS FOR NEURONAL AND CARDi.C Ti.SUE ENg.0}EERi.g

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Chi.ese Journal of Polymer Sci.nce 2007年第4期25卷 331-339页

作者： Paul Bi.ez Eli.abeth g.terman-Tretter Alan g. MacDi.rmi. Peter i. Lelkes 危岩 School of Bi.medi.al Eng.0}eeri.g Science & Health SystemsDrexel UniversityPhiladelphiaPA 19104USA School of Bi.medi.al Eng.0}eeri.g Science & Health SystemsDrexel UniversityPhiladelphiaPA 19104USA Department of ChemistryDrexel UniversityPhiladelphiaPA 19104USA Department of Chemi.try University of PennsylvaniaPhiladelphiaPA 19104USA

Conducti.g.polymer, polyani.i.e （PANi., has been studi.d as a novel electroacti.e and electri.ally conducti.e materi.l for ti.sue eng.0}eeri.g.appli.ati.ns. The bi.compati.i.i.y of the conducti.e polymer can be i.proved by （i. covalently g.afti.g.vari.us adhesi.e pepti.es onto the surface of prefabri.ated conducti.g.polymer fi.ms or i.to the polymer structures duri.g.the synthesi., （i.） co-electrospi.ni.g.or blendi.g.wi.h natural protei.s to form conducti.g.nanofi.ers or fi.ms, and （i.i. prepari.g.conducti.g.polymers usi.g.bi.polymers, such as collag.n, as templates. i. thi. paper, we mai.ly descri.e and revi.w the approaches of covalently attachi.g.oli.opepti.es to PANi.and electrospi.ni.g.PANi.g.lati. blend nanofi.ers. The employment of such modi.i.d conducti.g.polymers as substrates for enhanced cell attachment, proli.erati.n and di.ferenti.ti.n has been i.vesti.ated wi.h neuronal PC-12 cells and H9c2 cardi.c myoblasts. For the electrospun PANi. g.lati. fi.ers, dependi.g.on the concentrati.ns of PANi. H9c2 cells i.i.i.lly di.played di.ferent morpholog.0}s on the fi.rous substrates, but after one week all cultures reached confluence of si.i.ar densi.i.s and morpholog.0}s. Furthermore, we observed, that conducti.e PANi. when mai.tai.ed i. an aqueous physi.log.0} envi.onment, retai.ed a si.ni.i.ant level of electri.al conducti.i.y for at least 100 h, even thoug. thi. conducti.i.y was decreasi.g.over ti.e. Preli.i.ary data show that the appli.ati.n of mi.ro-current sti.ulates the di.ferenti.ti.n of PC-12 cells. All the results demonstrate the potenti.l for usi.g.PANi.as an electroacti.e polymer i. the culture of exci.able cells and open the possi.i.i.y of usi.g.thi. materi.l as an electroacti.e scaffold for cardi.c and/or neuronal ti.sue eng.0}eeri.g.appli.ati.ns that requi.e bi.compati.i.i.y of conducti.e polymers.

关键词： Polyani.i.e Conducti.e polymer Bi.compati.i.i.y Ti.sue eng.0}eeri.g.

Cosmolog.0}al appli.ati.ns i. Kaluza-Klei. theory

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Chi.ese Physi.s B 2012年第4期21卷 631-637页

作者： M. i. Wanas g.mal g. L. Nashed A. A. Nowaya Astronomy Department Faculty of Science Cairo University Giza Egypt Mathemati.s Department Faculty of Science Ain Shams University Cairo 11566 Egypt Center for Theoreti.al Physi.s British University of Egypt Sherouk City 11837 P.O. Box 43 Egypt Mathemati.s Department Faculty of Science King Faisal University P.O. Box 380 Al-Ahsaa 31982 the Kingdom of Saudi Arabia Eg.pti.n Relati.i.y g.oup (ERg. Physics Department Faculty of Science Monofia University Monofia Egypt

The fi.ld equati.ns of Kaluz-Klei. （KK） theory have been appli.d i. the domai. of cosmolog.. These equati.ns are solved for a fi.t uni.erse by taki.g.the g.avi.ati.nal and the cosmolog.0}al constants as a functi.n of ti.e t. We use Taylor＇s expansi.n of cosmolog.0}al functi.n, A（t）, up to the fi.st order of the ti.e t. The cosmolog.0}al parameters are calculated and some cosmolog.0}al problems are di.cussed.

关键词： Kaluz-Klei. theory cosmolog. Taylor's expansi.n of cosmolog.0}al functi.n

Arcti. sea-i.e extent: No record mi.i.um i. 2023 or recent years

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Atmospheri. and Oceani. Sci.nce Letters 2025年第1期18卷 52-55页

作者： Ola M.Johannessen Tor i.Olaussen Nansen Sci.nti.i. Soci.ty BergenNorway Nansen Envi.onmental and Remote Sensi.g.Center BergenNorway

Arcti. sea-i.e extent reaches i.s mi.i.um each year i. September. On 11 September 2023 the mi.i.um was 4.969 mi.li.n square ki.ometers(***^(2)). Thi. was not a record low, whi.h occurred i. 2012, when the mi.i.um was 4.175 ***^(2), 0.794 ***^(2) less than the mi.i.um i. 2023. However, the i.e extent had decreased by 0.432 ***^(2) compared wi.h 2022. Nevertheless, the summer melti.g.i. 2023 was remarkably less than expected when consi.eri.g.the strong.heat waves i. the atmosphere and ocean, wi.h record temperatures set around the world. i. g.neral, there i. a hi.h correlati.n between the long.term decrease i. sea-i.e extent and the i.creasi.g.CO_(2) i. the atmosphere, where the i.crease of CO_(2) i. recent decades explai.s about 80% of the decrease i. sea i.e i. September, whi.e the remai.der i. caused by natural vari.bi.i.y.

关键词： Sea i.e Arcti. Mi.i.um i.e Cli.ate