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Brazing temperature-dependent interfacial reaction layer features between CBN and Cu-Sn-Ti active filler metal

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Journal of Materials Science & Technology 2019年第10期35卷 2163-2168页

作者： Yonggang fan Junxiang fan Cong Wang School of Metallurgy Northeastern UniversityShenyang110819China Shenyang NEU New industrial Technology Research institute Co.LTD Northeastern UniversityShenyang110819China

CBN/Cu-Sn-Ti(CBN: cubic boron nitride) composites are prepared by active brazing sintering at 1123 K,1173 K, 1223 K and 1273 K, respectively. The effects of brazing temperature on the wettability, interfacial characteristics, and elemental distribution variations are fully investigated. When the brazing temperature is below 1223 K, completely uncoated and/or partially coated CBN particles with sharp edges can still be observed, and the reaction layer, mainly composed of Ti N and Ti B2, appears to be thin and *** the brazing temperature is 1223 K, all CBN particles are completely coated, suggesting that adequate wetting has taken place. Besides, as Ti diffuses thoroughly and enriches the interface, the reaction layer, filled primarily by Ti N, Ti B2 and Ti B, becomes thicker(about 1.30 μm), more uniform, stable and continuous. Further increasing the temperature to 1273 K is unnecessary or even harmful as the reaction layer thickness undergoes negligible change yet some tiny micro-cracks appear on the interface, which may likely deteriorate the grinding capability of the final brazing products.

关键词： Brazing temperature CBN/Cu-Sn-Ti filler metal Wettability Reaction layer

Efficient implementation of quantum arithmetic operation circuits

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Science China(Physics,Mechanics & Astronomy) 2021年第1期64卷 116-117页

作者： Heng fan institute of Physics Chinese Academy of SciencesBeijing100190China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing100190China Songshan Lake Material Laboratory Dongguan523000China

Realization of robust quantum computing is a tremendous *** one hand,one must reduce errors as many as possible using various means[1-3];on the other hand,one may make large error rates tolerable via fault-tolerant *** achieving tolerant against noises,the cost to pay is the increased number of gates ***,an efficient implementation of fault-tolerant gates is *** already evidenced,Clifford gates with a T gate can form a universal set of fault-tolerant gates.

关键词： quantum arithmetic Efficient

Corrosion mechanism of CuAl-NiC abradable seal coating system——The influence of porosity,multiphase,and multilayer structure on the corrosion failure

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Journal of Materials Science & Technology 2021年第29期88卷 258-269页

作者： Yumeng Ni fan Zhang Demian i.Njoku Yingjie Yu Jinshan Pan Meijiang Meng Ying Li Corrosion and Protection Division Shenyang National Laboratory for Materials ScienceInstitute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Material Science and Technology University of Science and Technology of ChinaShenyang110016China Department of Engineering and Design School of Engineering and InformaticsUniversity of SussexBrightonBN19RHUnited Kingdom Division of Surface and Corrosion Science KTH Royal Institute of TechnologyDrottning Kristinas väg.51SE-10044StockholmSweden Shenyang National Laboratory for Materials Science Northeastern UniversityShenyang110819China

in this study,the corrosion behavior of the CuAl-NiC abradable seal coating system in chloride solution was investigated to systematically research the effect of porosity,multiphase,and multilayer structure on the corrosion *** the composition and structure analysis,the corrosion process of the system was predicted and then verified with mercury intrusion porosimetry,cross-section SEM/EDS analysis,and electrochemical *** results demonstrated that the interphase selective corrosion caused the porosity of the top layer to decrease first and then increase during the corrosion *** interlayer galvanic corrosion,determined by the pore connectivity,is crucial for corrosion failure.

关键词： Abradable seal coating system Galvanic corrosion Multilayer Porosity

Evaluating the material strength from fracture angle under uniaxial loading

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Frontiers of Structural and Civil Engineering 2019年第2期13卷 288-293页

作者： Jitang fan State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Advanced Research institute for Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China

The most common experimental methods of measuring material strength are the uniaxial compressive and tensile tests. Generally, shearing fracture model occurs in both the tests. Compressive strength is higher than tensile strength for a material. Shearing fracture angle is smaller than 45° under uniaxial compression and greater than 45° under uniaxial tension. in this work, a unified relation of material strength under uniaxial compression and tension is developed by correlating the shearing fracture angle in theory. This constitutive relation is quantitatively illustrated by a function for analyzing the material strength from shear fracture angle. A computational simulation is conducted to validate this theoretical function. it is full of interest to give a scientific illustration for designing the high-strength materials and engineering structures.

关键词： strength fracture mechanics

Stress-controlled fatigue of HfNbTaTiZr high-entropy alloy and associated deformation and fracture mechanisms

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Journal of Materials Science & Technology 2022年第19期114卷 191-205页

作者： Shuying Chen Weidong Li Ling Wang Tao Yuan Yang Tong Ko-Kai tseng Jien-Wei Yeh Qingang Xiong Zhenggang Wu fan Zhang Tingkun Liu Kun Li Peter KLiaw institute for Advanced Studies in Precision Materials Yantai UniversityYantai 264005China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA Department of industrial and Systems Engineering Ohio UniversityAthensOH 45701USA Department of Materials Science and Engineering High Entropy Materials CenterNational Tsing Hua UniversityHsinchu30013TaiwanChina State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China School of Light industry and Engineering South China University of TechnologyGuangzhou 510640China College of Materials Science and Engineering Hunan UniversityChangsha 410082China WPi Advanced institute for Materials Research Tohoku UniversitySendai 980-8577Japan State Key Laboratory of Mechanical Transmission Chongqing UniversityChongqing 400044China

The stress-controlled fatigue tests are carried out at a stress ratio of 0.1 and a frequency of 10 Hz,and span both low-cycle and high-cycle regimes by varying the applied stress *** high-cycle fa-tigue regime gives a fatigue strength of 497 MPa and a fatigue ratio of *** equivalent conditions,the alloy’s fatigue strength is greater than all other high-entropy alloys(HEAs)with reported high-cycle fatigue data,dilute body-centered cubic alloys,and many structural alloys such as steels,titanium al-loys,and aluminum *** in-depth analyses of crack-propagation trajectories,fracture-surface morphologies and deformation plasticity by means of various microstructural analysis techniques and theoretical frameworks,the alloy’s remarkable fatigue resistance is attributed to delayed crack initiation in the high-cycle regime,which is achieved by retarding the formation of localized persistent slip bands,and its good resistance to crack propagation in the low-cycle regime,which is accomplished by intrin-sic toughening backed up by extrinsic ***,the stochastic nature of the fatigue data is neatly captured with a 2-parameter Weibull model.

关键词： Fatigue mechanisms intrinsic toughening Extrinsic toughening Probabilistic modeling

circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： Dan Wang Sicheng Zuo Junshang Ge Hongke Qu Jie Wu Na Yi Lei Shi Yumin Wang Yongzhen Mo Chunmei fan Yi He Pan Chen Ming Zhou Bo Xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. in this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including iNHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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Skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders

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Science China Life Sciences 2025年

作者： Xiangping Yao Xudong Mai Ye Tian Yifan Liu Guanghui Jin Ze Li Shujie Chen Xiaoshuang Dai Liujing Huang Zijing fan Guihua Pan Xiaohan Pan Xiangmin Li Michael C Yu Jia Sun Jingxing Ou Hong Chen Liwei Xie College of Life and Health Sciences Guangdong Industry Polytechnic Department of Endocrinology and Metabolism Zhujiang Hospital Southern Medical University State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied MicrobiologyInstitute of Microbiology Guangdong Academy of Sciences institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics School of Medical Technology Guangdong Medical University Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital Organ Transplantation Institute Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong province engineering laboratory for transplantation medicine Guangdong Provincial Key Laboratory of Liver Disease Research School of Public Health Xinxiang Medical University BGi institute of Applied Agriculture BGI-Shenzhen Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Biological Sciences State University of New York at Buffalo Department of internal Medicine Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan) Guangdong Medical University

Skeletal muscle plays a significant role in both local and systemic energy metabolism. The current investigation aims to explore the role of the Bambi gene in skeletal muscle, focusing on its implications for muscle hypertrophy and systemic metabolism. We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy, improves metabolic performance, and activates thermogenic adipocytes via the reprogramming of progenitor of i WAT, offering potential therapeutic strategies for metabolic syndromes. Leveraging the Chromatin immunoprecipitation(ChiP)-seq and bioinformatics analysis, Bambi gene is shown to be a direct target of HiF2α, which is further confirmed by ChiP-qPCR and promoter luciferase assay. Skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters, even under high-fat diet conditions. This deletion induced metabolic reprogramming of stromal vascular fractions(SVFs) into thermogenic adipocytes, contributing to systemic metabolic improvements, potentially through the secretory ***, mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders, highlighting a potential therapeutic pathway for metabolic syndrome management. Thus, skeletal muscle-specific deletion of Bambi triggers muscle growth, enhances metabolic performance, and activates thermogenic adipocytes. These findings suggest Bambi as a novel therapeutic target for metabolic syndromes, providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement. The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism, offering a novel perspective on treating metabolic disorders.

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Detailing interfacial reaction layer products between cubic boron nitride and Cu-Sn-Ti active filler metal

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Journal of Materials Science & Technology 2021年第9期68卷 35-39页

作者： Yonggang fan Junxiang fan Cong Wang School of Metallurgy Northeastern UniversityShenyang 110819China

in the present study,we offer an in-depth analysis over the microstructure,thickness and product composition of the interfacial reaction layer generated upon CBN/Cu-Sn-Ti active filler metal at 1223 *** findings demonstrate that adequate wettability and satisfactory bonding have been achieved via chemical reactions between Ti and N,*** importantly,we report,for the first time,the formation of a three-layer juxtaposition of reaction products,namely,TiN,TiB2 and TiB,along the diffusion path of ***,we determine the average layer thickness to be 1.24 μ*** deep etching,we unambiguously present morphologies of the newly formed TiN and TiB2,which are columnar and bulky,re spectively,and constitute the formation of a high strength metallu rgical interfacial bonding layer,and is crucial towards gaining enhanced grinding ***,we propose a possible reaction sequence and mechanism that govern the nucleation and growth of corre s ponding crystals.

关键词： Brazing Cubic boron nitride Cu-Sn-Ti interfacial products

碳纳米管改性混凝土的应力应变与动态强度研究

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合成纤维 2025年第1期54卷 86-90页

作者：范宝宝中煤科工集团北京华宇工程有限公司北京100120

为深入探究碳纳米管(CNTs)对混凝土不同受力阶段的增强效果,利用100 mm直径的分离式霍普金森压杆试验,研究冲击速度、CNTs含量等因素对混凝土韧性和抗冲击性能的影响。试验结果表明:CNTs的加入对水泥基材料的冲击性能有显著的改善作用,... 详细信息

为深入探究碳纳米管(CNTs)对混凝土不同受力阶段的增强效果,利用100 mm直径的分离式霍普金森压杆试验,研究冲击速度、CNTs含量等因素对混凝土韧性和抗冲击性能的影响。试验结果表明:CNTs的加入对水泥基材料的冲击性能有显著的改善作用,动态抗压强度、动态强度增大因子随冲击速度的增加而呈直线上升;在同一加载程度下,随CNTs含量的增大,水泥基材料的动态抗压强度先增大后减小,最大增幅可达23.7%;在混凝土中加入适量的CNTs,能够提高混凝土的整体强度、致密性,进而提高其动态力学性能。

关键词：碳纳米管混凝土霍普金森压杆应力应变动态强度