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interleukin-1 gene polymorphism disease activity and bone mineral metabolism in rheumatoid arthritis

Chinese Medical Journal 2002年第1期115卷 46-49,145页

作者：张晓中 L Llamado i pillay P Price R Will 山医科大学第三附属医院风湿科广州510630

Objective To determine whether interleukin-1α and 1β gene polymorphism is associated with rheumatoid arthritis disease activity and bone mineral metabolism, and whether there is any relationship between iL-1β and rheumatoid arthritis (RA) motif gene. Methods iL-1 gene polymorphisms were analyzed in 65 RA patients who met American College of Radiology (ACR) criteria and 60 controls. From genomic DNA, 2 polymorphisms in each gene for iL1α-889 and iL-1β+3953 were typed by PCR-RFLP and HLA-DRB1 allele typing was also undertaken by PCR-SSOP. Some clinical and laboratory parameters were collected. The allelic frequencies and carriage rates were compared between RA patients and controls and between patients with active and quiescent disease. Comparison was also made between iL-1 polymorphism and parameters of bone mineral metabolism and between patients with the HLA-DRB1 RA motif plus iL-1β 2 and patients without the two alleles. Fisher test and the analysis of variance was used to analyze the *** There was no significant difference in the frequency and carriage rate of iL-1α polymorphisms between RA patients and the controls. The β2/2 genotype of iL-1β was more common in female RA patients compared with controls (P=0.001). A lower carriage rate of iL-1β 2 occurred in male RA patients (P=0.001). A higher carriage rate of iL-1α2 is associated with a higher ESR (P=0.008), HAQ score (P=0.03), and vit-D 3 (Pine (P=0.001). A higher frequency of iL-1α1 is associated with a lower CRP value (P=0.009). An increased iL-1β2 carriage is associated with active rheumatoid disease as indicated by a higher CRP (Pin score (P=0.001) and a higher BMD at the lumbar spine (P=0.007), lower vit-D 3 and. Udpd/Crea level The presence of the HLA DRB1 RA motif and iL-1β allele 2 at same time did not contribute to disease ***

关键词： rheumatoid arthritis · interleukin-1 · gene polymorphism · disease activity · bone mineral metabolism

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Heavy Metals and the Alternate Bearing Effect in the Date Palm (<i>Phoenix dactylifera</i>)

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Journal of Environmental Protection 2015年第9期6卷 995-1002页

作者： John R. Williams Avin E. pillay Department of Chemistry University of Hull Cottingham Road Hull UK Department of Chemistry The Petroleum Institute Abu Dhabi UAE

The alternate bearing effect is when plants produce abundant crops of fruit in some years, but sparse yields in others. This review summarises recent studies that suggest a connection between the alternate bearing effect in the date palm, Phoenix dactylifera, and the presence of certain chemical elements (mostly metals) in the tree tissues. So far, there is evidence that levels of Ag, B, Ba, Ca, Cd, Cu, Fe, K, La, Mg, Mn, N, Na, Se, Tl, and Zn in the dates and leaflets are affected by the alternate bearing phenomenon. The significance of this work, therefore, emphasises the prospect of using our experimental data to overcome sparse yields, due to the alternate bearing effect, and producing more prolific growth of fruits. The potential agricultural, economic, environmental and health implications of these findings are considered.

关键词： Alternate Bearing Date Palm Chemical Elements Heavy Metals Review

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应用Filterwire远端保护装置行经皮冠状动脉介入治疗时发生过滤器无复流

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 33-34页

作者： Porto i. Choudhury R.P. pillay P. 黄浙勇 Department of Cardiology John Radcliffe HospitalHeadley WayHeadingtonOxfordUnited Kingdom

Background: Distal protection devices are increasingly used to prevent emboliz ation during percutaneous coronary interventions(PCi) in saphenous vein grafts(S VG) and native coronary arteries(NV). During interventions with the Filterwire d evice we have observed reduced flow that is reversible following removal of the filter(filter no reflow, FNR), which might be erroneously interpreted as true no reflow and might be associated with reduced capture efficiency of the basket. M ethods: We analyzed the incidence of FNR in 58 patients(60 lesions) at high risk of embolization undergoing PCi of either a SVG or a NV using the Filterwire(Bos ton Scientific, Natick, MA). Qualitative and quantitative angiographic analysis was performed, and the volume of collected debris was estimated using a photogra phic technique. Results: in our population, about 1/3 of the cases showed FNR, w hich was associated with angiographically visible filling defects within the bas ket, indicating macroembolism. However some patients (especially those undergoing vein graft interventions) showed filling defects without FNR, and some others FNR without filling defects. Thus we tried to under stand the predictors of FNR: FNR was associated with higher amount of collected debris(36.97±42.98 mm3 vs. 11.31±18.47 mm3, p=0.005), was neither prevented by abciximab, nor predicted by high thrombotic burden, increasing stent volume or need for predilatation. When patient with and without angiographically evident m acroembolisation were separately analyzed, a linear correlation of FNR with the quantity of debris was only apparent in the macroembolization group. Conclusions : interventionalists should be aware of the “Filter No Reflow”, a common but r eversible angiographic complication when the Filterwire device is used. Reduced flow seen during these procedures should be treated conservatively. Mechanical o bstruction of the filter, but also other mechanisms(pharmacologically active deb ris? platelet aggrega

关键词：经皮冠状动脉介入治疗远端保护装置过滤器无复流 Ⅱb/Ⅲa受体拮抗剂充盈缺损冠状动脉造影血流减少

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