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Microsystems & Nanoengineering 2023年第2期9卷 367-379页

作者： Geon Kook Yehhyun Jo Chaerin Oh Xiaojia Liang Jaewon Kim Sang-Mok lee Subeen Kim Jung-Woo Choi hyunjoo jenny lee School of Electrical Engineering Korea Advanced Institute of Science and Technology291 Daehak-roYuseong-guDaejeon 34141South Korea KAIST Institute for NanoCentury(KINC) 291 Daehak-roYuseong-guDaejeon 34141Republic of Korea

Transcranial focused ultrasound stimulation is a promising therapeutic modality for human brain disorders because of its noninvasiveness,long penetration depth,and versatile spatial control capability through beamforming and beam ***,the skull presents a major hurdle for successful applications of ultrasound ***,skull-induced focal aberration limits the capability for accurate and versatile targeting of brain *** addition,there lacks a fully functional preclinical neuromodulation system suitable to conduct behavioral ***,we report a miniature ultrasound system for neuromodulation applications that is capable of highly accurate multiregion targeting based on acoustic *** work includes the design and implementation of an acoustic lens for targeting brain regions with compensation for skull aberration through time-reversal recording and a phase conjugation ***,we utilize MEMS and 3D-printing technology to implement a 0.75-g lightweight neuromodulation system and present in vivo characterization of the packaged system in freely moving *** preclinical system is capable of accurately targeting the desired individual or multitude of brain regions,which will enable versatile and explorative behavior studies using ultrasound neuromodulation to facilitate widespread clinical adoption.

关键词： versatile utilize recording

Current concepts in the management of pediatric trigger thumb

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Plastic and Aesthetic Research 2023年第1期10卷 56-63页

作者： jenny lee Nguyen Division of Plastic Surgery Baylor College of MedicineHoustonTX 77030USA Division of Plastic Surgery Texas Children’s HospitalHoustonTX 77030USA

Pediatric trigger thumb is an acquired flexion deformity of the interphalangeal(IP)*** presents most commonly as a fixed flexion deformity,but can present as intermittent triggering or even a fixed extension *** one-third of patients will develop bilateral trigger *** have shown that the deformity can resolve with time on its own,but prolonged deformity is concerning for permanent IP joint contracture and/or deviation and metacarpophalangeal(MCP)joint compensatory *** is controversial,ranging from observation,splinting and stretching,to surgical release of the A1 *** is considered the definitive treatment with low complication rates,although the timing of surgery is highly variable among surgeons.

关键词： Congenital trigger thumb pediatric trigger thumb locked trigger thumb congenital hand pediatric hand

Perfluoroalkyl acid transformation and mitigation by nNiFe-activated carbon nanocomposites in steady-state flow column studies

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Journal of Environmental Sciences 2023年第5期127卷 678-687页

作者： Mahsa Modiri-Gharehveran Younjeong Choi jenny E.Zenobio Linda S.lee Department of Agronomy Purdue UniversityWest LafayetteIN 47907USA Interdisciplinary Ecological Sciences&Engineering Purdue UniversityWest LafayetteIN 47907USA

The ongoing contamination of groundwater with per-and polyfluoroalkyl substances(PFAS)has resulted in a global and rapidly growing interest in PFAS groundwater *** technologies that lead to PFAS destruction are often limited by not addressing all PFAS,being energy-intensive or not being suited for in-situ *** developed nNiFeactivated carbon(AC)nanocomposites and demonstrated varying degrees of PFAS reduction and fluoride generation with these nanocomposites in batch reactors for several *** we explore nNiFe-AC’s effectiveness to transform perfluoroalkyl acid acids(PFAAs)under steady-state flow(0.0044 to 0.15 mL/min)in nNiFe-AC:sand packed *** experiments included,two perfluorooctane sulfonate(PFOS)in deionized water and two PFAA mixtures in deionized water or bicarbonate buffer containing five perfluoroalkyl carboxylates(PFCAs,C5-C9)and three perfluoroalkyl sulfonates(PFSAs,C4,C6 and C8)at temperatures of 50 or 60℃ were *** transformation was similar in PFOS-only and PFAA mixture column ***,%PFAA transformation under flow conditions exceeded what we observed previously in batch reactors with up to 53%transformation of a PFAA mixture with∼8%*** chain PFAS dominated the PFAAs transformed and a bicarbonate matrix appeared to reduce overall *** breakthrough was slower than predicted from only sorption due to transformation;some longer chain PFAS like PFOS did not ***,nNiFe-AC technology with both in-situ and ex-situ potential application was shown to be a plausible part of a treatment train needed to address the ongoing challenge for cleaning up PFAS-contaminated waters.

关键词： PFAAs PFAS Zero valent iron Nanoparticles Remediation Groundwater

Ex vivo 3D osteocyte network construction with primary murine bone cells

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Bone Research 2015年第3期3卷 152-163页

作者： Qiaoling Sun Yexin Gu Wenting Zhang Leah Dziopa jenny Zilberberg Woo lee Department of Materials Science and Chemical Engineering Stevens Institute of Technology John Theurer Cancer Center Hackensack University Medical Center

Osteocytes reside as three-dimensionally（3D） networked cells in the lacunocanalicular structure of bones and regulate bone and mineral homeostasis. Despite of their important regulatory roles, in vitro studies of osteocytes have been challenging because：（1） current cell lines do not sufficiently represent the phenotypic features of mature osteocytes and（2） primary cells rapidly differentiate to osteoblasts upon isolation. In this study, we used a 3D perfusion culture approach to：（1） construct the 3D cellular network of primary murine osteocytes by biomimetic assembly with microbeads and（2） reproduce ex vivo the phenotype of primary murine osteocytes, for the first time to our best knowledge. In order to enable 3D construction with a sufficient number of viable cells, we used a proliferated osteoblastic population of healthy cells outgrown from digested bone chips. The diameter of microbeads was controlled to：（1） distribute and entrap cells within the interstitial spaces between the microbeads and（2） maintain average cell-to-cell distance to be about 19 mm. The entrapped cells formed a 3D cellular network by extending and connecting their processes through openings between the microbeads. Also, with increasing culture time, the entrapped cells exhibited the characteristic gene expressions（SOST and FGF23） and nonproliferative behavior of mature osteocytes. In contrast, 2D-cultured cells continued their osteoblastic differentiation and proliferation. This 3D biomimetic approach is expected to provide a new means of：（1） studying flow-induced shear stress on the mechanotransduction function of primary osteocytes,（2） studying physiological functions of 3D-networked osteocytes with in vitro convenience,and（3） developing clinically relevant human bone disease models.

关键词： cell Figure Ex vivo 3D osteocyte network construction with primary murine bone cells bone

Covariance estimation via fiducial inference

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Statistical Theory and Related Fields 2021年第4期5卷 316-331页

作者： W.jenny Shi Jan Hannig Randy C.S.Lai Thomas C.M.lee Financial Planning&Analysis MassMutualBostonMAUSA Department of Statistics&Operations Research University of North CarolinaChapel HillNCUSA Department of Statistics University of CaliforniaDavisCAUSA

As a classical problem,covariance estimation has drawn much attention from the statistical com-munity for *** work has been done under the frequentist and Bayesian *** to quantify the uncertainty of the estimators without having to choose a prior,we have developed a fiducial approach to the estimation of covariance *** upon the Fiducial Berstein-von Mises Theorem,we show that the fiducial distribution of the covariate matrix is consistent under our ***,the samples generated from this fiducial distri-bution are good estimators to the true covariance matrix,which enable us to define a meaningful confidence region for the covariance ***,we also show that the fiducial approach can be a powerful tool for identifying clique structures in covariance matrices.

关键词： covariance estimation sparsity fiducial inference cliques

Nuclear mass predictions based on a deep neural network and finite-range droplet model(2012)

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Chinese Physics C 2024年第2期48卷 112-123页

作者：姚道驄梁豪兆李曉菁 Department of Physics The University of Hong KongHong Kong 999077China Department of Physics Graduate School of ScienceThe University of TokyoTokyo 113-0033Japan Interdisciplinary Theoretical and Mathematical Sciences Program(iTHEMS) RIKENWako 351-0198Japan

A neural network with two hidden layers is developed for nuclear mass prediction,based on the finiterange droplet model(FRDM12).Different hyperparameters,including the number of hidden units,choice of activation functions,initializers,and learning rates,are adjusted explicitly and *** resulting mass predictions are achieved by averaging the predictions given by several different sets of hyperparameters with different regularizers and seed *** can provide not only the average values of mass predictions but also reliable estimations in the mass prediction *** overall root-mean-square deviations of nuclear mass are reduced from 0.603 MeV for the FRDM12 model to 0.200 MeV and 0.232 MeV for the training and validation sets,respectively.

关键词： nuclear mass machine learning deep neural network

Separation and purification of human tissue kaUikrein and its biological functions

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Separation and purification of human tissue kaUikrein and it...

30th International Symposium on Capillary Chromatography、4th GC×GC Symposium、16th National Symposium and Exhibition on Chromatography,i.e. 1st Dalian International Symposium and Exhibition on Chromatography

作者： jenny J.Zhang lee Chao National Chromatographic Research ＆ Analysis Center Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China Medical University of South Carolina Department of Biochemistry and Molecular Biology CharlestonSC USA.

＜正＞Human Tissue kallikrein（HTK）,a 42 kDa serine protease,cleaves kininogen to generate bioactive peptide kinin, which binds to its receptors and triggers a wide spectrum of biological *** is purified from urine by ion-exchange radial flow membrane chromatography and aprotinin-conjugated affinity chromatography The separation condition was *** kallikrein was confirmed by SDS-PAGE followed by comassie staining,matrix-assisted laser desorption:ionization mass spectrometery（MALDI）,kllikrein activity assay and specific HTK *** functions of kallikrein have been studied in various animal models. Here,by using Dahl Salt-sensitive rats,we found that systemic kallikrein gene delivery can significantly reduce blood pressure,attenuate salt-induced cardiac hypertrophy,cerebral ischemia and improve salt-reduced renal functions as well as renal *** findings suggest the therapeutic potential of kallikrein on salt-induced organ *** most important finding is that higher expression of circulation kallikrein was detected by ELISA in clinical serum samples from seventy cerebral ischemia patients as compared to normal *** correlation between circulation kallikrein and cerebral ischemia suggested that kallikein is also a potential diagnostic marker for ischemic stroke.

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选择性溶剂中胶束结构的耗散粒子动力学研究

选择性溶剂中胶束结构的耗散粒子动力学研究

作者： jenny Cheng Oi lee（曾爱丽）北京化工大学

学位级别：硕士

本文采用耗散粒子动力学的方法模拟了两性梳形共聚物在溶液中的自组装过程。文章选择两种比较常见的梳形共聚物结构,分别是疏水主链—亲水侧链和亲水主链—疏水侧链。通过改变主链长度、侧链长度和侧链数对两种共聚物自组装结构特性进... 详细信息

本文采用耗散粒子动力学的方法模拟了两性梳形共聚物在溶液中的自组装过程。文章选择两种比较常见的梳形共聚物结构,分别是疏水主链—亲水侧链和亲水主链—疏水侧链。通过改变主链长度、侧链长度和侧链数对两种共聚物自组装结构特性进行分析。通过不断的改变模拟参数,我们得到很多稳定的共聚物自组装结构。包括球形、柱形胶束结构,环形、扁平状、长条形胶囊结构,以及类海马状、梯形、骨形、蝴蝶状、K形、Y形等特殊胶束结构。其中大部分结构已被实验观测证实存在,同时我们模拟厨实验中还没有发现的一些特殊结构。本文为充分了解梳形共聚物在溶液中的自组装过程提供了有用的信息,有助于更加全面地理解梳形共聚物的形貌和性质,进一步促进了它在各领域的应用。

关键词：嵌段共聚物自组装梳形共聚物耗散粒子动力学亲水性疏水性

香港大学在束伽玛谱学研究与新一代伽玛探测器阵列（英文）

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原子核物理评论 2017年第3期34卷 332-337页

作者：李晓菁香港大学物理系香港999077

探索原子核的壳层演化,验证奇特核的幻数结构是香港大学核物理研究的重要方向。目前,科研团队利用在束伽玛谱学技术已经研究了^(30)Ne的N=20幻数消失和^(78)Ni(Z=28,N=50)附近原子核的双幻数结构,而即将开展的^(53,56)Ca在束伽玛谱学实... 详细信息

探索原子核的壳层演化,验证奇特核的幻数结构是香港大学核物理研究的重要方向。目前,科研团队利用在束伽玛谱学技术已经研究了^(30)Ne的N=20幻数消失和^(78)Ni(Z=28,N=50)附近原子核的双幻数结构,而即将开展的^(53,56)Ca在束伽玛谱学实验会对新幻数N=34的定量研究,以及到N=40核的壳层演化提供重要的数据。下一步的研究目标是探索^(100)Sn(N=Z=50)的奇特结构,特别是研究它的第一个2+激发态与其邻近原子核的低激发态性质。^(100)Sn处于质子滴线以及核天体快质子俘获路径上,因此,它的幻数结构及其临近原子核单粒子性能研究将会极大增强对核力和核合成机制的认识。为了进一步提高物理实验统计,香港大学在数量上增加了30% NaI(Tl)晶体从而全面升级了DALI2伽玛探测阵列。此外,为了探索远离稳定线核区的新物理,开展更高精度在束伽玛谱学实验,香港大学与中国科学院近代物理研究所、中国原子能科学研究院计划合作研制基于溴化镧晶体的新一代伽玛探测器阵列。这套阵列主要在兰州重离子加速器(HIRFL)和将来建成的强流重离子加速器(HIAF)等大科学装置上开展实验,从而在奇特核研究方面取得大量重要的成果,促进科研人员全面认识、理解核力以及天体核合成过程。

关键词：奇特核结构幻数在束伽玛谱学碘化钠探测阵列溴化镧探测阵列

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冰爽怡悦水漾夏色

品位 2008年第8期 114-121页

作者： jenny Dean lee（摄影）

在热力阳光的照耀下，你心中是否渐渐生起了度假的念池逃离都市，在碧海蓝天间享受慵懒假日……而在这悠闲的时刻，追求完美的你当然也不会错过任何一个绽放美丽的机会，让自己在阳光下尽情展现性感之美。

关键词：化妆技巧美容方法夏季美容产品