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Neural Regeneration Research 2017年第10期12卷 1640-1647页

作者： Jisu Hong Bo-yong park Hwan-ho Cho hyunjin park Department of Electronic Electrical and Computer EngineeringSungkyunkwan UniversitySuwonKorea Center for Neuroscience Imaging Research(CNIR) Institute for Basic ScienceSuwonKorea School of Electronic and Electrical Engineering Sungkyunkwan UniversitySuwonKorea

Attention deficit and hyperactivity disorder（ADHD） is a disorder characterized by behavioral symptoms including hyperactivity/impulsivity among children,adolescents,and *** ADHD related symptoms are influenced by the complex interaction of brain networks which were under *** explored age-related brain network differences between ADHD patients and typically developing（TD） subjects using resting state f MRI（rs-f MRI） for three age groups of children,adolescents,and *** collected rs-f MRI data from 184 individuals（27 ADHD children and 31 TD children;32 ADHD adolescents and 32 TD adolescents;and 31 ADHD adults and 31 TD adults）.The Brainnetome Atlas was used to define nodes in the network *** compared three age groups of ADHD and TD subjects to identify the distinct regions that could explain age-related brain network differences based on degree centrality,a well-known measure of nodal *** left middle temporal gyrus showed significant interaction effects between disease status（i.e.,ADHD or TD） and age（i.e.,child,adolescent,or adult）（P 0.001）.Additional regions were identified at a relaxed threshold（P 0.05）.Many of the identified regions（the left inferior frontal gyrus,the left middle temporal gyrus,and the left insular gyrus） were related to cognitive *** results of our study suggest that aberrant development in cognitive brain regions might be associated with age-related brain network changes in ADHD *** findings contribute to better understand how brain function influences the symptoms of ADHD.

关键词： nerve regeneration attention deficit and hyperactivity disorder cognitive function connectivity resting-state f MRI Brainnetome Atlas whole brain analysis disease-aging interaction effect neuroscience neural regeneration

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Connectivity differences between adult male and female patients with attention deficit hyperactivity disorder according to resting-state functional MRI

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Neural Regeneration Research 2016年第1期11卷 119-125页

作者： Bo-yong park hyunjin park Department of Electronic Electrical and Computer Engineering Sungkyunkwan University School of Electronic Electrical Engineering Sungkyunkwan University Center for Neuroscience Imaging Research (CNIR) Institute for Basic Science

Attention deficit hyperactivity disorder（ADHD） is a pervasive psychiatric disorder that affects both children and adults. Adult male and female patients with ADHD are differentially affected, but few studies have explored the differences. The purpose of this study was to quantify differences between adult male and female patients with ADHD based on neuroimaging and connectivity analysis. Resting-state functional magnetic resonance imaging scans were obtained and preprocessed in 82 patients. Group-wise differences between male and female patients were quantified using degree centrality for different brain regions. The medial-, middle-, and inferior-frontal gyrus, superior parietal lobule, precuneus, supramarginal gyrus, superior- and middle-temporal gyrus, middle occipital gyrus, and cuneus were identified as regions with significant group-wise differences. The identified regions were correlated with clinical scores reflecting depression and anxiety and significant correlations were found. Adult ADHD patients exhibit different levels of depression and anxiety depending on sex, and our study provides insight into how changes in brain circuitry might differentially impact male and female ADHD patients.

关键词： neural regeneration connectivity attention deficit hyperactivity disorder sex difference functional magnetic resonance imaging depression anxiety network analysis degree centrality diagnostic and statistical manual score

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Development of part-dissolvable chitosan fibers with surface N-succinylation for wound care dressing

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Frontiers of Materials Science 2015年第3期9卷 272-281页

作者： Guohui SUN Chao FENG Ming KONG Xiaojie CHENG Jiaojiao BING Guixue XIA Zixian BAO hyunjin park Xiguang CHEN College of Marine Life Science Ocean University of China Qingdao 266003 China College of Life Sciences and Biotechnology Korea University Seoul 136-701 Korea

To enhance the liquor absorptivity of chitosan fibers （CS-Fs）, N-succinyl surface-modified chitosan fibers （NSCS-Fs） were developed and evaluated for wound healing, The NSCS-Fs exhibited cracks on the surface and high liquor absorbing capacity with absorbing-dissolvable equilibrium state in phosphate buffer solution （PBS）. The bacteriostasis ratios of NSCS-Fs against E. coli, S. aureus and C. albicans were higher than 80%. No cytotoxicity has been found for mouse embryo fibroblasts （MEFs） treated with NSCS-Fs leach liquor, Acute oral toxicity and skin irritation experiment were taken to evaluate the safety of NSCS-Fs in vitro. Muscle implant study showed that NSCS-Fs were biodegradable and non-toxic in vivo. These results suggested that the surface modified NSCS-Fs had favorable biological properties and improved liquor absorptivity, indicating that they could be used as promising dressing materials for wound care.

关键词： chitosan fiber surface N-succinylation liquor absorptivity part-dissolvability wound dressing

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Planning for selective amygdalohippocampectomy involving less neuronal fiber damage based on brain connectivity using tractography

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Neural Regeneration Research 2015年第7期10卷 1107-1112页

作者： Seung-Hak Lee Mansu Kim hyunjin park Department of Electronic Electrical and Computer Engineering Sungkyunkwan University Graduate School of Human ICT Convergence Sungkyunkwan University School of Electronic and Electrical Engineering Sungkyunkwan University

Temporal lobe resection is an important treatment option for epilepsy that involves removal of potentially essential brain regions. Selective amygdalohippocampectomy is a widely performed temporal lobe surgery. We suggest starting the incision for selective amygdalohippocampectomy at the inferior temporal gyrus based on diffusion magnetic resonance imaging（MRI） tractography. Diffusion MRI data from 20 normal participants were obtained from parkinson＇s Progression Markers Initiative（PPMI） database（***）. A tractography algorithm was applied to extract neuronal fiber information for the temporal lobe, hippocampus, and amygdala. Fiber information was analyzed in terms of the number of fibers and betweenness centrality. Distances between starting incisions and surgical target regions were also considered to explore the length of the surgical path. Middle temporal and superior temporal gyrus regions have higher connectivity values than the inferior temporal gyrus and thus are not good candidates for starting the incision. The distances between inferior temporal gyrus and surgical target regions were shorter than those between middle temporal gyrus and target regions. Thus, the inferior temporal gyrus is a good candidate for starting the incision. Starting the incision from the inferior temporal gyrus would spare the important（in terms of betweenness centrality values） middle region and shorten the distance to the target regions of the hippocampus and amygdala.

关键词： nerve regeneration epilepsy selective amygdalohippocampectomy diffusion tensor imaging tractography connectivity betweenness centrality magnetic resonance imaging network analysis temporal lobe surgery neuronal fibers neural regeneration

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Wearable EEG electronics for a Brain–AI Closed-Loop System to enhance autonomous machine decision-making

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npj Flexible Electronics 2022年第1期6卷 296-307页

作者： Joo Hwan Shin Junmo Kwon Jong Uk Kim Hyewon Ryu Jehyung Ok SJoon Kwon hyunjin park Tae-il Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Electrical and Computer Engineering Sungkyunkwan University(SKKU)Suwon 16419Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan University(SKKU)Suwon 16419Korea Center for Neuroscience Imaging Research Institute for Basic ScienceSuwon 16419Korea Biomedical Institue for Convergence(BICS)SKKU Suwon 16419Korea

Human nonverbal communication tools are very ambiguous and difficult to transfer to machines or artificial intelligence(AI).If the AI understands the mental state behind a user’s decision,it can learn more appropriate decisions even in unclear *** introduce the Brain-AI Closed-Loop System(BACLoS),a wireless interaction platform that enables human brain wave analysis and transfers results to AI to verify and enhance AI *** developed a wireless earbud-like electroencephalography(EEG)measurement device,combined with tattoo-like electrodes and connectors,which enables continuous recording of high-quality EEG signals,especially the error-related potential(ErrP).The sensor measures the ErrP signals,which reflects the human cognitive consequences of an unpredicted machine *** AI corrects or reinforces decisions depending on the presence or absence of the ErrP signals,which is determined by deep learning classification of the received EEG *** demonstrate the BACLoS for AIbased machines,including autonomous driving vehicles,maze solvers,and assistant interfaces.

关键词： autonomous EEG enable

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A thermosensitive chitosan-based hydrogel for controlled release of insulin

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Frontiers of Materials Science 2014年第2期8卷 142-149页

作者： Ting-Ting GAO Ming KONG Xiao-Jie CHENG Gui-Xue XIA Yuan-Yuan GAO Xi-Guang CHEN Dong Su CHA hyunjin park ColLege of Marine Life Science Ocean University of China Qingdao 266003 China College of Life Sciences and Biotechnology Korea University Seoul 136-701 Korea

Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan （HBC） hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25℃. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells （L929）. Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.

关键词： hydroxybutyl chitosan hydrogel thermosensitive insulin controlledrelease

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Enhancement of Power Generation in Microbial Fuel Cells through Supplementation of <i>Platycodon grandiflorum</i>in Doraji Roots

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Journal of Sustainable Bioenergy Systems 2019年第4期9卷 169-178页

作者： Jung-In park hyunjin Kim Dae Kyung Go Peter S. park Sang Heon Lee Min Jung Koh Jonathan Jo Donghoon Lee Seungshin Lee Paul S. Chung Fuzbien Technology Institute Rockville MD USA Youth with Talents Fairfax VA USA St. Johnsbuury Academy Jeju Korea Department of Biology School of Arts and Sciences Cornell University Ithaca NY USA School of Arts and Sciences Johns Hopkins Baltimore MD USA

The current study reports the evidence of enhancement in power generation from cellulosic biomass in microbial fuel cell (MFC) systems by supplementing dried Doraji (Platycodon grandiflorum) roots powder. Mediator-less two chamber H-type MFCs were prepared using rumen fluid as anode inocula to convert finely ground pine tree (Avicel) at 2% (w/v) to electricity. Dried Doraji roots were ground to pass 1 mm sieve and added to the anode of MFC at 0.1% w/v dosage for treatment. MFC power and current across an external resistor were measured daily for 10 d. At the end of incubation on d10, collected gases were measured for total gas volume and analyzed for gas composition on gas chromatography. Supplementation of Doraji roots powder to MFC anode chamber increased power generation and CO2 production. Over the 10d experimental period, power density normalized to anode surface area were between 17.0 and 37.7 with average of 32.5 mW/m2 in Doraji MFCs, and between 16.8 and 19.8 with average of 18.2 mW/m2 in control group. CO2 production increased and methane to CO2 ratio decreased in Doraji root treatment comparing to control group. These observations imply that Doraji root components would inhibit methanogenesis and alter microbial fermentation of cellulose compounds favorable to produce bioenergy efficiently in MFC.

关键词： MFC Platycodon grandiflorum

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